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Volumn 35, Issue 3, 2013, Pages 391-398

Reversal of novel oral anticoagulants in patients with major bleeding

Author keywords

Anticoagulant reversal; Apixaban; Bleeding; Dabigatran; Edoxaban; Rivaroxaban

Indexed keywords

ACTIVATED CARBON; ACTIVATED PROTHROMBIN COMPLEX; AMINOCAPROIC ACID; ANTICOAGULANT AGENT; ANTIVITAMIN K; APIXABAN; BLOOD CLOTTING FACTOR 10A; DABIGATRAN; DABIGATRAN ETEXILATE; DESMOPRESSIN; ECARIN; EDOXABAN; FRESH FROZEN PLASMA; IMMUNOGLOBULIN F(AB) FRAGMENT; PLACEBO; PROTHROMBIN COMPLEX; RECOMBINANT BLOOD CLOTTING FACTOR 7A; RIVAROXABAN; THROMBIN; TRANEXAMIC ACID;

EID: 84876681725     PISSN: 09295305     EISSN: 1573742X     Source Type: Journal    
DOI: 10.1007/s11239-013-0885-0     Document Type: Conference Paper
Times cited : (78)

References (65)
  • 2
    • 34548031359 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    • DOI 10.1111/j.1365-2125.2007.02899.x
    • Stangier J, Rathgen K, Stahle H, Gansser D, Roth W (2007) The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol 64(3):292-303 (Pubitemid 47283865)
    • (2007) British Journal of Clinical Pharmacology , vol.64 , Issue.3 , pp. 292-303
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3    Gansser, D.4    Roth, W.5
  • 3
    • 38749131205 scopus 로고    scopus 로고
    • The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
    • DOI 10.1124/dmd.107.019083
    • Blech S, Ebner T, Ludwig-Schwellinger E, Stangier J, Roth W (2008) The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans. Drug Metab Dispos 36(2):386-399 (Pubitemid 351185753)
    • (2008) Drug Metabolism and Disposition , vol.36 , Issue.2 , pp. 386-399
    • Blech, S.1    Ebner, T.2    Ludwig-Schwellinger, E.3    Stangier, J.4    Roth, W.5
  • 4
    • 22844442726 scopus 로고    scopus 로고
    • In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939 - An oral, direct Factor Xa inhibitor
    • DOI 10.1111/j.1538-7836.2005.01166.x
    • Perzborn E, Strassburger J, Wilmen A, Pohlmann J, Roehrig S, Schlemmer KH, Straub A (2005) In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939-an oral, direct Factor Xa inhibitor. J Thromb Haemost 3(3):514-521. doi: 10.1111/j.1538-7836.2005.01166.x (Pubitemid 41632877)
    • (2005) Journal of Thrombosis and Haemostasis , vol.3 , Issue.3 , pp. 514-521
    • Perzborn, E.1    Strassburger, J.2    Wilmen, A.3    Pohlmann, J.4    Roehrig, S.5    Schlemmer, K.-H.6    Straub, A.7
  • 5
    • 64849114048 scopus 로고    scopus 로고
    • Apixaban, an oral direct factor Xa inhibitor, inhibits human clot-bound factor Xa activity in vitro
    • 19350128 1:CAS:528:DC%2BD1MXltVerurk%3D
    • Jiang X, Crain EJ, Luettgen JM, Schumacher WA, Wong PC (2009) Apixaban, an oral direct factor Xa inhibitor, inhibits human clot-bound factor Xa activity in vitro. Thromb Haemost 101(4):780-782
    • (2009) Thromb Haemost , vol.101 , Issue.4 , pp. 780-782
    • Jiang, X.1    Crain, E.J.2    Luettgen, J.M.3    Schumacher, W.A.4    Wong, P.C.5
  • 6
    • 49849099533 scopus 로고    scopus 로고
    • DU-176b, a potent and orally active factor Xa inhibitor: In vitro and in vivo pharmacological profiles
    • 10.1111/j.1538-7836.2008.03064.x 18624979 1:CAS:528:DC%2BD1cXhtFyqurzN
    • Furugohri T, Isobe K, Honda Y, Kamisato-Matsumoto C, Sugiyama N, Nagahara T, Morishima Y, Shibano T (2008) DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost 6(9):1542-1549. doi: 10.1111/j.1538-7836.2008.03064.x
    • (2008) J Thromb Haemost , vol.6 , Issue.9 , pp. 1542-1549
    • Furugohri, T.1    Isobe, K.2    Honda, Y.3    Kamisato-Matsumoto, C.4    Sugiyama, N.5    Nagahara, T.6    Morishima, Y.7    Shibano, T.8
  • 7
    • 25844525489 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor
    • DOI 10.1016/j.clpt.2005.06.011, PII S000992360500281X
    • Kubitza D, Becka M, Voith B, Zuehlsdorf M, Wensing G (2005) Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor. Clin Pharmacol Ther 78(4):412-421. doi: 10.1016/j.clpt.2005.06.011 (Pubitemid 41393676)
    • (2005) Clinical Pharmacology and Therapeutics , vol.78 , Issue.4 , pp. 412-421
    • Kubitza, D.1    Becka, M.2    Voith, B.3    Zuehlsdorf, M.4    Wensing, G.5
  • 8
    • 29144518504 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939 - An oral, direct Factor Xa inhibitor - After multiple dosing in healthy male subjects
    • DOI 10.1007/s00228-005-0043-5
    • Kubitza D, Becka M, Wensing G, Voith B, Zuehlsdorf M (2005) Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939 - an oral, direct Factor Xa inhibitor-after multiple dosing in healthy male subjects. Eur J Clin Pharmacol 61(12):873-880 (Pubitemid 41803696)
    • (2005) European Journal of Clinical Pharmacology , vol.61 , Issue.12 , pp. 873-880
    • Kubitza, D.1    Becka, M.2    Wensing, G.3    Voith, B.4    Zuehlsdorf, M.5
  • 9
    • 84856784474 scopus 로고    scopus 로고
    • Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    • 22315269 10.1378/chest.11-2292 1:CAS:528:DC%2BC38XnsVOrt7Y%3D
    • Ageno W, Gallus AS, Wittkowsky A, Crowther M, Hylek EM, Palareti G (2012) Oral anticoagulant therapy: antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 141(2 Suppl):e44S-e88S
    • (2012) Chest , vol.141 , Issue.2 SUPPL.
    • Ageno, W.1    Gallus, A.S.2    Wittkowsky, A.3    Crowther, M.4    Hylek, E.M.5    Palareti, G.6
  • 10
    • 77952118055 scopus 로고    scopus 로고
    • Bayer PHarma AG. Xarelto Accessed 12 May 2012
    • Bayer PHarma AG. Xarelto (2011) summary of product characteristics http://www.xarelto.com/html/downloads/Xarelto-Summary-of-Product- Characteristics-Dec2011.pdf Accessed 12 May 2012
    • (2011) Summary of Product Characteristics
  • 11
    • 66449099711 scopus 로고    scopus 로고
    • Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs, and humans
    • 10.1124/dmd.108.025569 19196845 10.1124/dmd.108.025569 1:CAS:528:DC%2BD1MXlsVWitbg%3D
    • Weinz C, Schwarz T, Kubitza D, Mueck W, Lang D (2009) Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs, and humans. Drug Metab Dispos 37(5):1056-1064. doi: 10.1124/dmd.108.025569
    • (2009) Drug Metab Dispos , vol.37 , Issue.5 , pp. 1056-1064
    • Weinz, C.1    Schwarz, T.2    Kubitza, D.3    Mueck, W.4    Lang, D.5
  • 13
    • 57449094606 scopus 로고    scopus 로고
    • Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors in development
    • 19071881 10.2165/0003088-200948010-00001 1:CAS:528:DC%2BD1MXis12nt7g%3D
    • Eriksson BI, Quinlan DJ, Weitz JI (2009) Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors in development. Clin Pharmacokinet 48(1):1-22
    • (2009) Clin Pharmacokinet , vol.48 , Issue.1 , pp. 1-22
    • Eriksson, B.I.1    Quinlan, D.J.2    Weitz, J.I.3
  • 14
    • 84860511290 scopus 로고    scopus 로고
    • A randomised assessment of the pharmacokinetic, pharmacodynamic and safety interaction between apixaban and enoxaparin in healthy subjects
    • 10.1160/TH11-09-0634 22398784 10.1160/TH11-09-0634 1:CAS:528: DC%2BC38XosFaqtLc%3D
    • Barrett YC, Wang J, Song Y, Pursley J, Wastall P, Wright R, Lacreta F, Frost C (2012) A randomised assessment of the pharmacokinetic, pharmacodynamic and safety interaction between apixaban and enoxaparin in healthy subjects. Thromb Haemost 107(5):916-924. doi: 10.1160/TH11-09-0634
    • (2012) Thromb Haemost , vol.107 , Issue.5 , pp. 916-924
    • Barrett, Y.C.1    Wang, J.2    Song, Y.3    Pursley, J.4    Wastall, P.5    Wright, R.6    Lacreta, F.7    Frost, C.8
  • 15
    • 84872260247 scopus 로고    scopus 로고
    • Apixaban, an oral, direct factor Xa inhibitor: Single-dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects
    • 10.1111/j.1365-2125.2012.04369.x
    • Frost C, Wang J, Nepal S, Schuster A, Barrett YC, Mosqueda-Garcia R, Reeves RA, Lacreta F (2012) Apixaban, an oral, direct factor Xa inhibitor: single-dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects. Br J Clin Pharmacol. doi: 10.1111/j.1365-2125.2012.04369.x
    • (2012) Br J Clin Pharmacol
    • Frost, C.1    Wang, J.2    Nepal, S.3    Schuster, A.4    Barrett, Y.C.5    Mosqueda-Garcia, R.6    Reeves, R.A.7    Lacreta, F.8
  • 16
    • 77953787643 scopus 로고    scopus 로고
    • Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers
    • 10.1177/0091270009351883 20081065 10.1177/0091270009351883 1:CAS:528:DC%2BC3cXpt1ejtLw%3D
    • Ogata K, Mendell-Harary J, Tachibana M, Masumoto H, Oguma T, Kojima M, Kunitada S (2010) Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers. J Clin Pharmacol 50(7):743-753. doi: 10.1177/0091270009351883
    • (2010) J Clin Pharmacol , vol.50 , Issue.7 , pp. 743-753
    • Ogata, K.1    Mendell-Harary, J.2    Tachibana, M.3    Masumoto, H.4    Oguma, T.5    Kojima, M.6    Kunitada, S.7
  • 17
    • 79958241510 scopus 로고    scopus 로고
    • Effect of edoxaban on markers of coagulation in venous and shed blood compared with fondaparinux
    • 10.1160/TH10-11-0705 21544313 10.1160/TH10-11-0705 1:CAS:528: DC%2BC3MXovVyrtLY%3D
    • Wolzt M, Samama MM, Kapiotis S, Ogata K, Mendell J, Kunitada S (2011) Effect of edoxaban on markers of coagulation in venous and shed blood compared with fondaparinux. Thromb Haemost 105(6):1080-1090. doi: 10.1160/TH10-11-0705
    • (2011) Thromb Haemost , vol.105 , Issue.6 , pp. 1080-1090
    • Wolzt, M.1    Samama, M.M.2    Kapiotis, S.3    Ogata, K.4    Mendell, J.5    Kunitada, S.6
  • 18
    • 84869236631 scopus 로고    scopus 로고
    • Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: A systematic review and meta-analysis of the literature
    • 10.1161/CIRCULATIONAHA.112.115410 23071159 10.1161/CIRCULATIONAHA.112. 115410 1:CAS:528:DC%2BC38Xhs1Oltb7N
    • Dentali F, Riva N, Crowther M, Turpie AG, Lip GY, Ageno W (2012) Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature. Circulation 126(20):2381-2391. doi: 10.1161/CIRCULATIONAHA.112.115410
    • (2012) Circulation , vol.126 , Issue.20 , pp. 2381-2391
    • Dentali, F.1    Riva, N.2    Crowther, M.3    Turpie, A.G.4    Lip, G.Y.5    Ageno, W.6
  • 19
    • 84869838484 scopus 로고    scopus 로고
    • Efficacy and safety of novel oral anticoagulants for treatment of acute venous thromboembolism: Direct and adjusted indirect meta-analysis of randomised controlled trials
    • 10.1136/bmj.e7498 23150473 10.1136/bmj.e7498
    • Fox BD, Kahn SR, Langleben D, Eisenberg MJ, Shimony A (2012) Efficacy and safety of novel oral anticoagulants for treatment of acute venous thromboembolism: direct and adjusted indirect meta-analysis of randomised controlled trials. BMJ 345:e7498. doi: 10.1136/bmj.e7498
    • (2012) BMJ , vol.345 , pp. 7498
    • Fox, B.D.1    Kahn, S.R.2    Langleben, D.3    Eisenberg, M.J.4    Shimony, A.5
  • 21
    • 84876673673 scopus 로고    scopus 로고
    • EudraVigilance Database, European Medicines Agency Accessed 12 May 2012
    • EudraVigilance Database, European Medicines Agency. http:// eudravigilance.ema.europa.eu/human/index.asp. Accessed 12 May 2012
  • 22
    • 77953168824 scopus 로고    scopus 로고
    • Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity
    • 20352166 10.1160/TH09-11-0758
    • van Ryn J, Stangier J, Haertter S, Liesenfeld KH, Wienen W, Feuring M, Clemens A (2010) Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity. Thromb Haemost 103(6):1116-1127
    • (2010) Thromb Haemost , vol.103 , Issue.6 , pp. 1116-1127
    • Van Ryn, J.1    Stangier, J.2    Haertter, S.3    Liesenfeld, K.H.4    Wienen, W.5    Feuring, M.6    Clemens, A.7
  • 24
    • 79955480110 scopus 로고    scopus 로고
    • Coagulation parameters in patients receiving dabigatran etexilate or rivaroxaban: Two observational studies in patients undergoing total hip or total knee replacement
    • 21277622 10.1016/j.thromres.2011.01.001 1:CAS:528:DC%2BC3MXltFels70%3D
    • Freyburger G, Macouillard G, Labrouche S, Sztark F (2011) Coagulation parameters in patients receiving dabigatran etexilate or rivaroxaban: two observational studies in patients undergoing total hip or total knee replacement. Thromb Res 127(5):457-465
    • (2011) Thromb Res , vol.127 , Issue.5 , pp. 457-465
    • Freyburger, G.1    MacOuillard, G.2    Labrouche, S.3    Sztark, F.4
  • 25
    • 84856593171 scopus 로고    scopus 로고
    • Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran
    • 22227958 10.1097/MBC.0b013e32834f1b0c 1:CAS:528:DC%2BC38XhtlSqtL4%3D
    • Stangier J, Feuring M (2012) Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran. Blood Coagul Fibrinolysis 23(2):138-143
    • (2012) Blood Coagul Fibrinolysis , vol.23 , Issue.2 , pp. 138-143
    • Stangier, J.1    Feuring, M.2
  • 27
    • 78649736882 scopus 로고    scopus 로고
    • Clinical laboratory measurement of direct factor Xa inhibitors: Anti-Xa assay is preferable to prothrombin time assay
    • 20978714 10.1160/TH10-05-0328 1:CAS:528:DC%2BC3MXht1aksLs%3D
    • Barrett YC, Wang Z, Frost C, Shenker A (2010) Clinical laboratory measurement of direct factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay. Thromb Haemost 104(6):1263-1271
    • (2010) Thromb Haemost , vol.104 , Issue.6 , pp. 1263-1271
    • Barrett, Y.C.1    Wang, Z.2    Frost, C.3    Shenker, A.4
  • 28
    • 77952044405 scopus 로고    scopus 로고
    • Assessment of laboratory assays to measure rivaroxaban-an oral, direct factor Xa inhibitor
    • 20135059 10.1160/TH09-03-0176 1:CAS:528:DC%2BC3cXls1ansro%3D
    • Samama MM, Martinoli JL, LeFlem L, Guinet C, Plu-Bureau G, Depasse F, Perzborn E (2010) Assessment of laboratory assays to measure rivaroxaban-an oral, direct factor Xa inhibitor. Thromb Haemost 103(4):815-825
    • (2010) Thromb Haemost , vol.103 , Issue.4 , pp. 815-825
    • Samama, M.M.1    Martinoli, J.L.2    Leflem, L.3    Guinet, C.4    Plu-Bureau, G.5    Depasse, F.6    Perzborn, E.7
  • 29
    • 84856632988 scopus 로고    scopus 로고
    • Evaluation of the anti-factor Xa chromogenic assay for the measurement of rivaroxaban plasma concentrations using calibrators and controls
    • 22187012 10.1160/TH11-06-0391 1:CAS:528:DC%2BC38XkvVKmu7k%3D
    • Samama MM, Contant G, Spiro TE, Perzborn E, Guinet C, Gourmelin Y, Le Flem L, Rohde G, Martinoli JL (2012) Evaluation of the anti-factor Xa chromogenic assay for the measurement of rivaroxaban plasma concentrations using calibrators and controls. Thromb Haemost 107(2):379-387
    • (2012) Thromb Haemost , vol.107 , Issue.2 , pp. 379-387
    • Samama, M.M.1    Contant, G.2    Spiro, T.E.3    Perzborn, E.4    Guinet, C.5    Gourmelin, Y.6    Le Flem, L.7    Rohde, G.8    Martinoli, J.L.9
  • 30
    • 79954534386 scopus 로고    scopus 로고
    • Laboratory assessment of new anticoagulants
    • 21288169 10.1515/cclm.2011.134 1:CAS:528:DC%2BC3MXnvVGqsr8%3D
    • Samama MM, Guinet C (2011) Laboratory assessment of new anticoagulants. Clin Chem Lab Med 49(5):761-772
    • (2011) Clin Chem Lab Med , vol.49 , Issue.5 , pp. 761-772
    • Samama, M.M.1    Guinet, C.2
  • 32
    • 80052408267 scopus 로고    scopus 로고
    • Dabigatran anticoagulant activity is neutralized by an antibody selective to dabigatran in in vitro and in vivo models
    • 10.1016/S0735-1097(11)61130-3
    • Van Ryn J, Litzenburger T, Waterman A, Canada K, Hauel N, Kroe-Barrett R, Singh S, Park J (2011) Dabigatran anticoagulant activity is neutralized by an antibody selective to dabigatran in in vitro and in vivo models. J Am Coll Cardiol 57:E1130
    • (2011) J Am Coll Cardiol , vol.57 , pp. 1130
    • Van Ryn, J.1    Litzenburger, T.2    Waterman, A.3    Canada, K.4    Hauel, N.5    Kroe-Barrett, R.6    Singh, S.7    Park, J.8
  • 33
    • 84876684507 scopus 로고    scopus 로고
    • In vitro characterization, pharmacokinetics and reversal of supratherapeutic doses of dabigatran-induced bleeding in rats by a specific antibody fragment antidote to dabigatran
    • van Ryn J, Litzenburger T, Gan G, Coble K, Schurer J (2012) In vitro characterization, pharmacokinetics and reversal of supratherapeutic doses of dabigatran-induced bleeding in rats by a specific antibody fragment antidote to dabigatran. ASH Annual Meet Abstr 120(21):3418
    • (2012) ASH Annual Meet Abstr , vol.120 , Issue.21 , pp. 3418
    • Van Ryn, J.1    Litzenburger, T.2    Gan, G.3    Coble, K.4    Schurer, J.5
  • 34
    • 84876675451 scopus 로고    scopus 로고
    • Reversal of dabigatran's anticoagulant activity in the monkey by a specific antidote and pharmacokinetic and pharmacodynamic modeling
    • Toth J, Gan G, van Ryn J, Dursema H, Isler J, Coble K, Burke J, Lalovic B, Olson S (2012) Reversal of dabigatran's anticoagulant activity in the monkey by a specific antidote and pharmacokinetic and pharmacodynamic modeling. ASH Annual meet abstr 120(21):22
    • (2012) ASH Annual Meet Abstr , vol.120 , Issue.21 , pp. 22
    • Toth, J.1    Gan, G.2    Van Ryn, J.3    Dursema, H.4    Isler, J.5    Coble, K.6    Burke, J.7    Lalovic, B.8    Olson, S.9
  • 37
    • 84876694586 scopus 로고    scopus 로고
    • PRT064445 but not recombinant Fviia reverses rivaroxaban induced anticoagulation as measured by reduction in blood loss in a rabbit liver laceration model
    • Hollenbach SJ, Lu G, Tan S, Lee G, Athiwat H, Inagaki M, Sinha U (2012) PRT064445 but not recombinant Fviia reverses rivaroxaban induced anticoagulation as measured by reduction in blood loss in a rabbit liver laceration model. ASH Annual Meet Abstr 120(21):3414
    • (2012) ASH Annual Meet Abstr , vol.120 , Issue.21 , pp. 3414
    • Hollenbach, S.J.1    Lu, G.2    Tan, S.3    Lee, G.4    Athiwat, H.5    Inagaki, M.6    Sinha, U.7
  • 38
    • 84856936368 scopus 로고    scopus 로고
    • Epidural hematoma & intra-operative hemorrhage in a spine trauma patient on pradaxa (R) [Dabigatran]
    • 22343277 10.1097/BRS.0b013e31824ee320
    • Truumees E, Gaudu T, Dieterichs C, Geck M, Stokes J (2012) Epidural hematoma & intra-operative hemorrhage in a spine trauma patient on pradaxa (R) [Dabigatran]. Spine 37(14):E863-E865
    • (2012) Spine , vol.37 , Issue.14
    • Truumees, E.1    Gaudu, T.2    Dieterichs, C.3    Geck, M.4    Stokes, J.5
  • 39
    • 84856214360 scopus 로고    scopus 로고
    • Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran
    • 21998060 10.1161/STROKEAHA.111.624650
    • Zhou W, Schwarting S, Illanes S, Liesz A, Middelhoff M, Zorn M, Bendszus M, Heiland S, van Ryn J, Veltkamp R (2011) Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran. Stroke 42(12):3594-3599
    • (2011) Stroke , vol.42 , Issue.12 , pp. 3594-3599
    • Zhou, W.1    Schwarting, S.2    Illanes, S.3    Liesz, A.4    Middelhoff, M.5    Zorn, M.6    Bendszus, M.7    Heiland, S.8    Van Ryn, J.9    Veltkamp, R.10
  • 40
    • 84876694374 scopus 로고    scopus 로고
    • Reversal agents for edoxaban, a factor Xa inhibitor: Effects of factor VIIa, anti-inhibitor coagulant complex, prothrombin complex concentrate, fresh plasma, and vitamin K
    • Morishima Y, Honda Y, Kamisato C, Furugohri T, Shibano T (2011) Reversal agents for edoxaban, a factor Xa inhibitor: effects of factor VIIa, anti-inhibitor coagulant complex, prothrombin complex concentrate, fresh plasma, and vitamin K. J Thromb Haemost 9:135
    • (2011) J Thromb Haemost , vol.9 , pp. 135
    • Morishima, Y.1    Honda, Y.2    Kamisato, C.3    Furugohri, T.4    Shibano, T.5
  • 41
    • 84855358507 scopus 로고    scopus 로고
    • Transfusion-associated circulatory overload after plasma transfusion
    • 10.1111/j.1537-2995.2011.03247.x 21762464 10.1111/j.1537-2995.2011.03247. x
    • Narick C, Triulzi DJ, Yazer MH (2012) Transfusion-associated circulatory overload after plasma transfusion. Transfusion 52(1):160-165. doi: 10.1111/j.1537-2995.2011.03247.x
    • (2012) Transfusion , vol.52 , Issue.1 , pp. 160-165
    • Narick, C.1    Triulzi, D.J.2    Yazer, M.H.3
  • 43
    • 80053571188 scopus 로고    scopus 로고
    • Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: A randomized, placebo-controlled, crossover study in healthy subjects
    • 21900088 10.1161/CIRCULATIONAHA.111.029017 1:CAS:528:DC%2BC3MXht1GjsLfO
    • Eerenberg ES, Kamphuisen PW, Sijpkens MK, Meijers JC, Buller HR, Levi M (2011) Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation 124(14):1573-1579
    • (2011) Circulation , vol.124 , Issue.14 , pp. 1573-1579
    • Eerenberg, E.S.1    Kamphuisen, P.W.2    Sijpkens, M.K.3    Meijers, J.C.4    Buller, H.R.5    Levi, M.6
  • 44
    • 84876681877 scopus 로고    scopus 로고
    • Prothrombin complex concentrates reduce blood loss in mice rendered coagulopathic by warfarin but not dabigatran etexilate
    • 10.1111/j.1537-2995.2012.03624.x
    • Lambourne MD, Eltringham-Smith LJ, Gataiance S, Arnold DM, Crowther MA, Sheffield W (2012) Prothrombin complex concentrates reduce blood loss in mice rendered coagulopathic by warfarin but not dabigatran etexilate. Transfusion 52:56A-57A
    • (2012) Transfusion , vol.52
    • Lambourne, M.D.1    Eltringham-Smith, L.J.2    Gataiance, S.3    Arnold, D.M.4    Crowther, M.A.5    Sheffield, W.6
  • 45
    • 84655176578 scopus 로고    scopus 로고
    • Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model
    • 22042412 10.1097/ALN.0b013e318238c036 1:CAS:528:DC%2BC3MXhs1Gls7nN
    • Godier A, Miclot A, Le Bonniec B, Durand M, Fischer AM, Emmerich J, Marchand-Leroux C, Lecompte T, Samama CM (2012) Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model. Anesthesiology 116(1):94-102
    • (2012) Anesthesiology , vol.116 , Issue.1 , pp. 94-102
    • Godier, A.1    Miclot, A.2    Le Bonniec, B.3    Durand, M.4    Fischer, A.M.5    Emmerich, J.6    Marchand-Leroux, C.7    Lecompte, T.8    Samama, C.M.9
  • 46
    • 84874256149 scopus 로고    scopus 로고
    • Reversal of apixaban induced alterations of hemostasis by different coagulation factor concentrates: Studies in vitro with circulating human blood
    • 10.1161/CIR.0b013e3182611cc2
    • Escolar G, Arellano-Rodrigo E, Reverter JC, Villalta J, Sanz V, Molina P, Diaz-Ricart M, Galan AM (2012) Reversal of apixaban induced alterations of hemostasis by different coagulation factor concentrates: studies in vitro with circulating human blood. Circulation 126:520-521
    • (2012) Circulation , vol.126 , pp. 520-521
    • Escolar, G.1    Arellano-Rodrigo, E.2    Reverter, J.C.3    Villalta, J.4    Sanz, V.5    Molina, P.6    Diaz-Ricart, M.7    Galan, A.M.8
  • 47
    • 84856631805 scopus 로고    scopus 로고
    • Reversal of anticoagulant effects of edoxaban, an oral, direct factor Xa inhibitor, with haemostatic agents
    • 22186946 10.1160/TH11-09-0668 1:CAS:528:DC%2BC38XkvVKmtb8%3D
    • Fukuda T, Honda Y, Kamisato C, Morishima Y, Shibano T (2012) Reversal of anticoagulant effects of edoxaban, an oral, direct factor Xa inhibitor, with haemostatic agents. Thromb Haemost 107(2):253-259
    • (2012) Thromb Haemost , vol.107 , Issue.2 , pp. 253-259
    • Fukuda, T.1    Honda, Y.2    Kamisato, C.3    Morishima, Y.4    Shibano, T.5
  • 48
    • 84876669493 scopus 로고    scopus 로고
    • Partial reversal of dabigatran effect by a prothrombin complex concentrate in a model of thrombin generation
    • Hoffman MR, Volovyk Z, Monroe DM III (2012) Partial reversal of dabigatran effect by a prothrombin complex concentrate in a model of thrombin generation. ASH Annual Meet Abstr 120(21):3420
    • (2012) ASH Annual Meet Abstr , vol.120 , Issue.21 , pp. 3420
    • Hoffman, M.R.1    Volovyk, Z.2    Monroe Iii, D.M.3
  • 50
    • 34547436844 scopus 로고    scopus 로고
    • Coagulation factor concentrates: past, present, and future
    • DOI 10.1016/S0140-6736(07)61199-4, PII S0140673607611994
    • Key NS, Negrier C (2007) Coagulation factor concentrates: past, present, and future. Lancet 370(9585):439-448 (Pubitemid 47176658)
    • (2007) Lancet , vol.370 , Issue.9585 , pp. 439-448
    • Key, N.S.1    Negrier, C.2
  • 51
    • 78149465761 scopus 로고    scopus 로고
    • Potential of activated prothrombin complex concentrate and activated factor VII to reverse the anticoagulant effects of rivaroxaban in primates
    • Gruber A, Marzec UM, Buetehorn U, Hanson S, Perzborn E (2008) Potential of activated prothrombin complex concentrate and activated factor VII to reverse the anticoagulant effects of rivaroxaban in primates. ASH Annual Meet Abstr 112(11):3825
    • (2008) ASH Annual Meet Abstr , vol.112 , Issue.11 , pp. 3825
    • Gruber, A.1    Marzec, U.M.2    Buetehorn, U.3    Hanson, S.4    Perzborn, E.5
  • 52
    • 64549107759 scopus 로고    scopus 로고
    • FEIBA reverses the effects of a high-dose of rivaroxaban in rats
    • Perzborn E, Tinel H (2008) FEIBA reverses the effects of a high-dose of rivaroxaban in rats. Pathophysiol Haemost Thromb 36:A40
    • (2008) Pathophysiol Haemost Thromb , vol.36 , pp. 40
    • Perzborn, E.1    Tinel, H.2
  • 53
    • 84864370719 scopus 로고    scopus 로고
    • Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban. A randomised crossover ex vivo study in healthy volunteers
    • 22627883 10.1160/TH12-03-0179 1:CAS:528:DC%2BC38Xht1GitbrN
    • Marlu R, Hodaj E, Paris A, Albaladejo P, Crackowski JL, Pernod G (2012) Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban. A randomised crossover ex vivo study in healthy volunteers. Thromb Haemost 108(2):217-224
    • (2012) Thromb Haemost , vol.108 , Issue.2 , pp. 217-224
    • Marlu, R.1    Hodaj, E.2    Paris, A.3    Albaladejo, P.4    Crackowski, J.L.5    Pernod, G.6
  • 54
    • 84859951446 scopus 로고    scopus 로고
    • Reversal of dabigatran using recombinant activated factor VII and activated prothrombin complex concentrates in thromboelastography assay
    • Chan HHW, Atkinson HM, Goncharenko M, Berry LR, Chan AKC (2011) Reversal of dabigatran using recombinant activated factor VII and activated prothrombin complex concentrates in thromboelastography assay. J Thromb Haemost 9:576-577
    • (2011) J Thromb Haemost , vol.9 , pp. 576-577
    • Chan, H.H.W.1    Atkinson, H.M.2    Goncharenko, M.3    Berry, L.R.4    Chan, A.K.C.5
  • 55
    • 0036489638 scopus 로고    scopus 로고
    • Safety of factor VIII inhibitor bypass activity (FEIBA®): 10-year compilation of thrombotic adverse events
    • DOI 10.1046/j.1365-2516.2002.00532.x
    • Ehrlich HJ, Henzl MJ, Gomperts ED (2002) Safety of factor VIII inhibitor bypass activity (FEIBA): 10-year compilation of thrombotic adverse events. Haemophilia 8(2):83-90 (Pubitemid 35238060)
    • (2002) Haemophilia , vol.8 , Issue.2 , pp. 83-90
    • Ehrlich, H.J.1    Henzl, M.J.2    Gomperts, E.D.3
  • 56
    • 13244262642 scopus 로고    scopus 로고
    • Comparative thrombotic event incidence after infusion of recombinant factor VIIa versus factor VIII inhibitor bypass activity
    • DOI 10.1111/j.1538-7836.2004.00944.x
    • Aledort LM (2004) Comparative thrombotic event incidence after infusion of recombinant factor VIIa versus factor VIII inhibitor bypass activity. J Thromb Haemost 2(10):1700-1708 (Pubitemid 40192708)
    • (2004) Journal of Thrombosis and Haemostasis , vol.2 , Issue.10 , pp. 1700-1708
    • Aledort, L.M.1
  • 58
    • 78049498149 scopus 로고    scopus 로고
    • Safety of recombinant activated factor VII in randomized clinical trials
    • 21047223 10.1056/NEJMoa1006221 1:CAS:528:DC%2BC3cXhtl2gsbrI
    • Levi M, Levy JH, Andersen HF, Truloff D (2010) Safety of recombinant activated factor VII in randomized clinical trials. N Engl J Med 363(19):1791-1800
    • (2010) N Engl J Med , vol.363 , Issue.19 , pp. 1791-1800
    • Levi, M.1    Levy, J.H.2    Andersen, H.F.3    Truloff, D.4
  • 59
    • 77949421739 scopus 로고    scopus 로고
    • Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: An open-label, parallel-group, single-centre study
    • 20214409 10.2165/11318170-000000000-00000 1:CAS:528:DC%2BC3cXlsFCktLg%3D
    • Stangier J, Rathgen K, Stahle H, Mazur D (2010) Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study. Clin Pharmacokinet 49(4):259-268
    • (2010) Clin Pharmacokinet , vol.49 , Issue.4 , pp. 259-268
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3    Mazur, D.4
  • 60
    • 84865851374 scopus 로고    scopus 로고
    • Safe use of hemodialysis for dabigatran removal before cardiac surgery
    • 10.1345/aph.1R081 22872748 10.1345/aph.1R081
    • Wanek MR, Horn ET, Elapavaluru S, Baroody SC, Sokos G (2012) Safe use of hemodialysis for dabigatran removal before cardiac surgery. Ann Pharmacother 46(9):e21. doi: 10.1345/aph.1R081
    • (2012) Ann Pharmacother , vol.46 , Issue.9 , pp. 21
    • Wanek, M.R.1    Horn, E.T.2    Elapavaluru, S.3    Baroody, S.C.4    Sokos, G.5
  • 62
    • 84874245591 scopus 로고    scopus 로고
    • Bristol-Myers Squibb Accessed 12 May 2012
    • Bristol-Myers Squibb. Eliquis Product Monograph (2011) http://www.bmscanada.ca/static/products/en/pm-pdf/Eliquis-EN-PM.pdf. Accessed 12 May 2012
    • (2011) Eliquis Product Monograph
  • 65
    • 84874251027 scopus 로고    scopus 로고
    • Acute management of bleeding in patients on novel oral anticoagulants
    • 10.1093/eurheartj/ehs408 23220847
    • Siegal DM, Crowther MA (2012) Acute management of bleeding in patients on novel oral anticoagulants. Eur Heart J. doi: 10.1093/eurheartj/ehs408
    • (2012) Eur Heart J
    • Siegal, D.M.1    Crowther, M.A.2


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