메뉴 건너뛰기




Volumn 307, Issue 5, 2014, Pages E456-E461

Testosterone alters iron metabolism and stimulates red blood cell production independently of dihydrotestosterone

Author keywords

Androgen; Finasteride; Hematocrit; Hepcidin; Hypogonadal; Testosterone

Indexed keywords

ANDROSTANOLONE; FERRITIN; FINASTERIDE; HEMOGLOBIN; HEPCIDIN; IRON; PLACEBO; STEROID 5ALPHA REDUCTASE; TESTOSTERONE; TESTOSTERONE ENANTATE; TRANSFERRIN; ANDROGEN; DRUG DERIVATIVE;

EID: 84907764334     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00184.2014     Document Type: Article
Times cited : (48)

References (38)
  • 1
    • 0014148007 scopus 로고
    • Erythropoietin excretion in man following androgens
    • Alexanian R, Vaughn WK, Ruchelman MW. Erythropoietin excretion in man following androgens. J Lab Clin Med 70: 777-785, 1967.
    • (1967) J Lab Clin Med , vol.70 , pp. 777-785
    • Alexanian, R.1    Vaughn, W.K.2    Ruchelman, M.W.3
  • 5
    • 84907805467 scopus 로고    scopus 로고
    • Testosterone regulates hepcidin
    • e-letter
    • Beggs LA, Borst SE, Yarrow JF. Testosterone regulates hepcidin. J Clin Invest 2013. e-letter: http://www.jci.org/eletters/view/67225#sec1.
    • (2013) J Clin Invest
    • Beggs, L.A.1    Borst, S.E.2    Yarrow, J.F.3
  • 6
    • 77954409942 scopus 로고    scopus 로고
    • Testosterone therapy in men with androgen deficiency syndromes: An Endocrine Society clinical practice guideline
    • Task Force, Endocrine Society
    • Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM; Task Force, Endocrine Society. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 95: 2536-2559, 2010.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2536-2559
    • Bhasin, S.1    Cunningham, G.R.2    Hayes, F.J.3    Matsumoto, A.M.4    Snyder, P.J.5    Swerdloff, R.S.6    Montori, V.M.7
  • 9
    • 16644402976 scopus 로고    scopus 로고
    • Inhibition of 5-reductase blocks prostate effects of testosterone without blocking anabolic effects
    • Borst SE, Lee JH, Conover CF. Inhibition of 5-reductase blocks prostate effects of testosterone without blocking anabolic effects. Am J Physiol Endocrinol Metab 288: E222-E227, 2005.
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , pp. E222-E227
    • Borst, S.E.1    Lee, J.H.2    Conover, C.F.3
  • 11
    • 29144469309 scopus 로고    scopus 로고
    • Adverse events associated with testosterone replacement in middle-aged and older men: A meta-analysis of randomized, placebocontrolled trials
    • Calof OM, Singh AB, Lee ML, Kenny AM, Urban RJ, Tenover JL, Bhasin S. Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebocontrolled trials. J Gerontol A Biol Sci Med Sci 60: 1451-1457, 2005.
    • (2005) J Gerontol A Biol Sci Med Sci , vol.60 , pp. 1451-1457
    • Calof, O.M.1    Singh, A.B.2    Lee, M.L.3    Kenny, A.M.4    Urban, R.J.5    Tenover, J.L.6    Bhasin, S.7
  • 15
    • 0014433969 scopus 로고
    • The erythropoietic-stimulating effects of androgens
    • Fried W, Gurney CW. The erythropoietic-stimulating effects of androgens. Ann NY Acad Sci 149: 356-365, 1968.
    • (1968) Ann NY Acad Sci , vol.149 , pp. 356-365
    • Fried, W.1    Gurney, C.W.2
  • 18
    • 2942541820 scopus 로고    scopus 로고
    • Effects of androgenic-anabolic steroids in athletes
    • Hartgens F, Kuipers H. Effects of androgenic-anabolic steroids in athletes. Sports Med 34: 513-554, 2004.
    • (2004) Sports Med , vol.34 , pp. 513-554
    • Hartgens, F.1    Kuipers, H.2
  • 19
    • 13444257462 scopus 로고    scopus 로고
    • Pubertal upregulation of erythropoiesis in boys is determined primarily by androgen
    • Hero M, Wickman S, Hanhijarvi R, Siimes MA, Dunkel L. Pubertal upregulation of erythropoiesis in boys is determined primarily by androgen. J Pediatr 146: 245-252, 2005.
    • (2005) J Pediatr , vol.146 , pp. 245-252
    • Hero, M.1    Wickman, S.2    Hanhijarvi, R.3    Siimes, M.A.4    Dunkel, L.5
  • 20
    • 84868193427 scopus 로고    scopus 로고
    • Estrogen regulates iron homeostasis through governing hepatic hepcidin expression via an estrogen response element
    • Hou Y, Zhang S, Wang L, Li J, Qu G, He J, Rong H, Ji H, Liu S. Estrogen regulates iron homeostasis through governing hepatic hepcidin expression via an estrogen response element. Gene 511: 398-403, 2012.
    • (2012) Gene , vol.511 , pp. 398-403
    • Hou, Y.1    Zhang, S.2    Wang, L.3    Li, J.4    Qu, G.5    He, J.6    Rong, H.7    Ji, H.8    Liu, S.9
  • 22
    • 0034743536 scopus 로고    scopus 로고
    • Steroid 5alpha-reductases and 3alpha-hydroxysteroid dehydrogenases: Key enzymes in androgen metabolism
    • Jin Y, Penning TM. Steroid 5alpha-reductases and 3alpha-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism. Best Pract Res Clin Endocrinol Metab 15: 79-94, 2001.
    • (2001) Best Pract Res Clin Endocrinol Metab , vol.15 , pp. 79-94
    • Jin, Y.1    Penning, T.M.2
  • 23
    • 77951977749 scopus 로고    scopus 로고
    • Evolution of steroid 5alpha-reductases and comparison of their function with 5beta-reductase
    • Langlois VS, Zhang D, Cooke GM, Trudeau VL. Evolution of steroid 5alpha-reductases and comparison of their function with 5beta-reductase. Gen Comp Endocrinol 166: 489-497, 2010.
    • (2010) Gen Comp Endocrinol , vol.166 , pp. 489-497
    • Langlois, V.S.1    Zhang, D.2    Cooke, G.M.3    Trudeau, V.L.4
  • 24
    • 84893655780 scopus 로고    scopus 로고
    • Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin
    • Latour C, Kautz L, Besson-Fournier C, Island ML, Canonne-Hergaux F, Loreal O, Ganz T, Coppin H, Roth MP. Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin. Hepatology 59: 683-694, 2014.
    • (2014) Hepatology , vol.59 , pp. 683-694
    • Latour, C.1    Kautz, L.2    Besson-Fournier, C.3    Island, M.L.4    Canonne-Hergaux, F.5    Loreal, O.6    Ganz, T.7    Coppin, H.8    Roth, M.P.9
  • 27
    • 84892657750 scopus 로고    scopus 로고
    • The liver: Conductor of systemic iron balance
    • Meynard D, Babitt JL, Lin HY. The liver: conductor of systemic iron balance. Blood 123: 168-176, 2014.
    • (2014) Blood , vol.123 , pp. 168-176
    • Meynard, D.1    Babitt, J.L.2    Lin, H.Y.3
  • 28
  • 29
    • 15944404290 scopus 로고    scopus 로고
    • Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T
    • Page ST, Amory JK, Bowman FD, Anawalt BD, Matsumoto AM, Bremner WJ, Tenover JL. Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. J Clin Endocrinol Metab 90: 1502-1510, 2005.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1502-1510
    • Page, S.T.1    Amory, J.K.2    Bowman, F.D.3    Anawalt, B.D.4    Matsumoto, A.M.5    Bremner, W.J.6    Tenover, J.L.7
  • 30
    • 61349136872 scopus 로고    scopus 로고
    • Testosterone action on erythropoiesis does not require its aromatization to estrogen: Insights from the testosterone and estrogen treatment of two aromatase-deficient men
    • Rochira V, Zirilli L, Madeo B, Maffei L, Carani C. Testosterone action on erythropoiesis does not require its aromatization to estrogen: Insights from the testosterone and estrogen treatment of two aromatase-deficient men. J Steroid Biochem Mol Biol 113: 189-194, 2009.
    • (2009) J Steroid Biochem Mol Biol , vol.113 , pp. 189-194
    • Rochira, V.1    Zirilli, L.2    Madeo, B.3    Maffei, L.4    Carani, C.5
  • 31
    • 0013914798 scopus 로고
    • Inhibition of erythropoietic stimulation by testosterone in polycythemic mice receiving anti-erythropoietin
    • Schooley JC. Inhibition of erythropoietic stimulation by testosterone in polycythemic mice receiving anti-erythropoietin. Proc Soc Exp Biol Med 122: 402-403, 1966.
    • (1966) Proc Soc Exp Biol Med , vol.122 , pp. 402-403
  • 33
    • 0015921748 scopus 로고
    • Androgens and erythropoiesis
    • Shahidi NT. Androgens and erythropoiesis. N Engl J Med 289: 72-80, 1973.
    • (1973) N Engl J Med , vol.289 , pp. 72-80
    • Shahidi, N.T.1
  • 34
    • 0033305020 scopus 로고    scopus 로고
    • A critical evaluation of simple methods for the estimation of free testosterone in serum
    • Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84: 3666-3672, 1999.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3666-3672
    • Vermeulen, A.1    Verdonck, L.2    Kaufman, J.M.3
  • 37
    • 84859927249 scopus 로고    scopus 로고
    • Intracrine and myotrophic roles of 5alpha-reductase and androgens: A review
    • Yarrow JF, McCoy SC, Borst SE. Intracrine and myotrophic roles of 5alpha-reductase and androgens: a review. Med Sci Sports Exerc 44: 818-826, 2012.
    • (2012) Med Sci Sports Exerc , vol.44 , pp. 818-826
    • Yarrow, J.F.1    McCoy, S.C.2    Borst, S.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.