Physical training prevents depressive symptoms and a decrease in brain-derived neurotrophic factor in Parkinson's disease

Brain Research Bulletin

Volumn 108, Issue , 2014, Pages 106-112

  Tuon, T ^a   Valvassori, S S ^a   Dal Pont, G C ^a   Paganini, C S ^a   Pozzi, B G ^a   Luciano, T F ^a   Souza, P S ^a   Quevedo, J ^a   Souza, C T ^a   Pinho, R A ^a  

^a UNIVERSIDADE DO EXTREMO SUL CATARINENSE   (Brazil)

Author keywords

6 Hydroxydopamine; Depression; Neurotrophins; Parkinson's disease; Physical exercise

Indexed keywords

APOMORPHINE; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; NEUROTROPHIN RECEPTOR P75; OXIDOPAMINE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN LEVEL; CIRCLING BEHAVIOR; CONTROLLED STUDY; CORPUS STRIATUM; DEPRESSION; EXERCISE; FORCED SWIM TEST; HIPPOCAMPUS; IMMOBILITY; IMMUNOBLOTTING; MALE; MOUSE; MUSCLE STRENGTH; NEUROPROTECTION; NONHUMAN; OPEN FIELD TEST; PARKINSON DISEASE; PHYSICAL PERFORMANCE; RESISTANCE TRAINING; RUNNING; TRAINING; TREADMILL EXERCISE; ANIMAL; C57BL MOUSE; COMPLICATION; DISEASE MODEL; KINESIOTHERAPY; METABOLISM; MOTOR ACTIVITY;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSION; DISEASE MODELS, ANIMAL; EXERCISE THERAPY; MALE; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; OXIDOPAMINE; PARKINSON DISEASE; RECEPTOR, TRKB;

EID: 84907755455     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2014.09.006     Document Type: Article

References (59)

1. Aarsland D., Pahlhagen S., Ballard C.G., Ehrt U., Svenningsson P. Depression in Parkinson disease - epidemiology, mechanisms and management. Nat. Rev. Neurol. 2011, 8:35-47.
2. Aguiar A.S., Tuon T., Pinho C.A., Silva L.A., Andreazza A.C., Kapczinski F., Quevedo J., Streck E.L., Pinho R.A. Mitochondrial IV complex and brain neurotrophic derived factor responses of mice brain cortex after downhill training. Neurosci. Lett. 2007, 22:171-174.
3. Aguiar A.S., Tuon T., Soares F.S., da Rocha L.G., Silveira P.C., Pinho R.A. The effect of n-acetylcysteine and deferoxamine on exercise-induced oxidative damage in striatum and hippocampus of mice. Neurochem. Res. 2008, 33:729-736.
4. Aguiar A.S., Castro A.A., Moreira E.L., Glaser V., Santos A.R., Tasca C.I., Latini A., Prediger R.D. Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: involvement of hippocampal plasticity via AKT, CREB and BDNF signaling. Mech. Ageing Dev. 2011, 132:560-567.
5. Arcoverde C., Deslandes A., Rangel A., Rangel A., Pavão R., Nigri F., Engelhardt E., Laks J. Role of physical activity on the maintenance of cognition and activities of daily living in elderly with Alzheimer's disease. Arq. Neuropsiquiatr. 2008, 66:323-327.
6. Bower J.H., Grossardt B.R., Maraganore D.M., Ahlskog J.E., Colligan R.C., Geda Y.E., Therneau T.M., Rocca W.A. Anxious personality predicts an increased risk of Parkinson's disease. Mov. Disord. 2010, 25:2105-2113.
7. Bradford M.M. Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
8. Carvalho M.M., Campos F.L., Coimbra B., Pêgo J.M., Rodrigues C., Lima R., Rodrigues A.J., Sousa N., Salgado A.J. Behavioral characterization of the 6-hydroxidopamine model of Parkinson's disease and pharmacological rescuing of non-motor deficits. Mol. Neurodegener. 2013, 8:14.
9. Chan-Palay V., Asan E. Alterations in catecholamine neurons of the locus coeruleus in senile dementia of the Alzheimer type and in Parkinson's disease with and without dementia and depression. J. Comp. Neurol. 1989, 287:373-392.
10. Chen H., Weber A.J. Brain-derived neurotrophic factor reduces TrkB protein and mRNA in the normal retina and following opticnerve crush in adult rats. Brain Res. 2004, 1011:99-106.
11. Coelho M., Ferreira J.J. Late-stage Parkinson disease. Nat. Rev. Neurol. 2012, 8:435-442.
12. Costa M.S., Ardais A.P., Fioreze G.T., Mioranzza S., Botton P.H., Souza D.O., Rocha J.B., Porciúncula L.O. The impact of the frequency of moderate exercise on memory and brain-derived neurotrophic factor signaling in young adult and middle-aged rats. Neuroscience 2012, 11:100-109.
13. Cummings J.L. Depression and Parkinson's disease: a review. Am. J. Psychiatry 1992, 149:443-454.
14. Dibble L.E., Hale T.F., Marcus R.L., Gerber J.P., LaStayo P.C. High intensity eccentric resistance training decreases bradykinesia and improves Quality of Life in persons with Parkinson's disease: a preliminary study. Parkinsonism Relat. Disord. 2009, 15:752-757.
15. Drzyzga L.R., Marcinowska A., Obuchowicz E. Antiapoptotic and neurotrophic effects of antidepressants: a review of clinical and experimental studies. Brain Res. Bull. 2009, 79:248-257.
16. Ghasemi M., Sadeghipour H., Poorheidari G., Dehpour A.R. A role for nitrergic system in the antidepressant-like effects of chronic lithium treatment in the mouse forced swimming test. Behav. Brain Res. 2009, 200:76-82.
17. Goldman J.G., Litvan I. Mild cognitive impairment in Parkinson's disease. Minerva Med. 2011, 102:441-459.
18. Goodwin G.M., Martinez-Aran A., Glahn D.C., Vieta E. Cognitive impairment in bipolar disorder: neurodevelopment or neurodegeneration? An ECNP expert meeting report. Eur. Neuropsychopharmacol. 2008, 18:787-793.
19. Hirsch E.C. Future drug targets for Parkinson's disease. Bull. Acad. Natl. Med. 2012, 196:1369-1377.
20. Hornberger T.A., Farrar R.P. Physiological hypertrophy of the FHL muscle following 8 weeks of progressive resistance exercise in the rat. Can. J. Appl. Physiol. 2004, 29:16-31.
21. Je H.S., Yang F., Ji Y., Nagappan G., Hempstead B.L., Lu B. Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:15924-15929.
22. Kaster M.P., Santos A.R., Rodrigues A.L. Involvement of 5-HT1A receptors in the antidepressant-like effect of adenosine in the mouse forced swimming test. Brain Res. Bull. 2005, 67:53-61.
23. Ke Z., Yip S.P., Li L., Zheng X.X., Tong K.Y. The effects of voluntary, involuntary, and forced exercises on brain-derived neurotrophic factor and motor function recovery: a rat brain ischemia model. PLoS ONE 2011, 6:e16643.
24. Kish S.J. What is the evidence that Ecstasy (MDMA) can cause Parkinson's disease?. Mov. Disord. 2003, 18:1219-1223.
25. Koshimizu H., Kiyosue K., Hara T., Hazama S., Suzuki S., Uegaki K., Nagappan G., Zaitsev E., Hirokawa T., Tatsu Y., Ogura A., Lu B., Kojima M. Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival. Mol. Brain 2009, 2:27.
26. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
27. Lautenschlager N.T., Cox K.L., Flicker L., Foster J.K., Van Bockxmeer F.M., Xiao J., Greenop K.R., Almeida O.P. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA 2008, 300:1027-1037.
28. Lesemann A., Reinel C., Hühnchen P., Pilhatsch M., Hellweg R., Klaissle P., Winter C., Steiner B. MPTP-induced hippocampal effects on serotonin, dopamine, neurotrophins, adult neurogenesis and depression-like behavior are partially influenced by fluoxetine in adult mice. Brain Res. 2012, 1457:51-69.
29. Liu W., Sheng H., Xu Y., Liu Y., Lu J., Ni X. Swimming exercise ameliorates depression-like behavior in chronically stressed rats: relevant to proinflammatory cytokines and IDO activation. Behav. Brain Res. 2013, 242:110-116.
30. Lu B., Pang P.T., Woo N.H. The yin and yang of neurotrophin action. Nat. Rev. Neurosci. 2005, 6:603-614.
31. Marais L., Stein D.J., Daniels W.M. Exercise increases BDNF levels in the striatum and decreases depressive-like behavior in chronically stressed rats. Metab. Brain Dis. 2009, 24:587-597.
32. Martínez-Martín P., Damián J. Parkinson disease: depression and anxiety in Parkinson disease. Nat. Rev. Neurol. 2010, 6:243-245.
33. Martinowich K., Manji H., Lu B. Review: new insights into BDNF function in depression and anxiety. Nat. Neurosci. 2007, 10:1089-1093.
34. Masi G., Brovedani P. The hippocampus, neurotrophic factors and depression: possible implications for the pharmacotherapy of depression. CNS Drugs 2011, 25:913-931.
35. McDonald W.M., Richard I.H., DeLong M.R. Prevalence, etiology, and treatment of depression in Parkinson's disease. Biol. Psychiatry 2003, 54:363-375.
36. Miller N., Mshana G., Msuya O., Dotchin C., Walker R., Aris E. Assessment of speech in neurological disorders: development of a Swahili screening test. S. Afr. J. Commun. Disord. 2012, 59:27-33.
37. Minagar A., Shulman L.M., Weiner W.J. Transderm-induced psychosis in Parkinson's disease. Neurology 1999, 53:433-434.
38. Paxinos G., Franklin K.B.J. The Mouse Brain in Stereotaxic Coordinates 2000, Academic Press, New York.
39. Porsolt R.D., Le Pichon M., Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature 1977, 266:730-732.
40. Rangasamy S.B., Soderstrom K., Bakay R.A., Kordower J.H. Neurotrophic factor therapy for Parkinson's disease. Prog. Brain Res. 2010, 184:237-264.
41. Ravina B., Camicioli R., Como P.G., Marsh L., Jankovic J., Weintraub D., Elm J. The impact of depressive symptoms in early Parkinson disease. Neurology 2007, 69:342-347.
42. Reijnders J.S., Ehrt U., Weber W.E., Aarsland D., Leentjens A.F. A systematic review of prevalence studies of depression in Parkinson's disease. Mov. Disord. 2008, 23:183-189.
43. Salehi-Sadaghiani M., Javadi-Paydar M., Gharedaghi M.H., Zandieh A., Heydarpour P., Yousefzadeh-Fard Y., Dehpour A.R. NMDA receptor involvement in antidepressant-like effect of pioglitazone in the forced swimming test in mice. Psychopharmacology (Berl.) 2012, 223:345-355.
44. Santiago R.M., Barbiero J., Gradowski R.W., Bochen S., Lima M.M., Da Cunha C., Andreatini R., Vital M.A. Induction of depressive-like behavior by intra-nigral 6-OHDA is directly correlated with deficits in striatal dopamine and hippocampal serotonin. Behav. Brain Res. 2014, 259:70-77.
45. Smith L.M., Schiess M.C., Coffey M.P., Klaver A.C., Loeffler D.A. α-Synuclein and anti-α-synuclein antibodies in Parkinson's disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls. PLoS ONE 2012, 7:e52285.
46. Speck A.E., Tromm C.B., Pozzi B.G., Paganini C.S., Tuon T., Silveira P.C., Aguiar A.S., Pinho R.A. The dose-dependent antioxidant effects of physical exercise in the hippocampus of mice. Neurochem. Res. 2014, (in press). 10.1007/s11064-014-1339-6.
47. Starkstein S.E., Brockman S., Hayhow B.D. Psychiatric syndromes in Parkinson's disease. Curr. Opin. Psychiatry 2012, 25:468-472.
48. Tan L.C.S. Mood disorders in Parkinson's disease. Parkinsonism Rel. Disord. 2012, 18:S74-S76.
49. Teng H.K., Teng K.K., Lee R., Wright S., Tevar S., Almeida R.D., Kermani P., Torkin R., Chen Z.Y., Lee F.S., Kraemer R.T., Nykjaer A., Hempstead B.L. ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J. Neurosci. 2005, 25:5455-5463.
50. Teo W.P., Rodrigues J.P., Mastaglia F.L., Thickbroom G.W. Modulation of corticomotor excitability after maximal or sustainable-rate repetitive finger movement is impaired in Parkinson's disease and is reversed by levodopa. Clin. Neurophysiol. 2014, 125:562-568.
51. Tripanichkul W., Gerdprasert O., Jaroensuppaperch E.O. Estrogen reduces BDNF level, but maintains dopaminergic cell density in the striatum of MPTP mouse model. Int. J. Neurosci. 2010, 120:489-495.
52. Tsai S.J., Hong C.J., Yu Y.W., Chen T.J. Association study of a brain-derived neurotrophic factor (BDNF) Val66 metpolymorphism and personality trait and intelligence in healthy young females. Neuropsychobiology 2004, 49:13-16.
53. Tuon T., Valvassori S.S., Lopes-Borges J., Fries G.R., Silva L.A., Kapczinski F., Quevedo J., Pinho R.A. Effects of moderate exercise on cigarette smoke exposure-induced hippocampal oxidative stress values and neurological behaviors in mice. Neurosci. Lett. 2010, 475:16-19.
54. Tuon T., Valvassori S.S., Lopes-Borges J., Luciano T., Trom C.B., Silva L.A., Quevedo J., Souza C.T., Lira F.S., Pinho R.A. Physical training exerts neuroprotective effects in the regulation of neurochemical factors in an animal model of Parkinson's disease. Neuroscience 2012, 227:305-312.
55. Uemura Y., Wada-Isoe K., Nakashita S., Nakashima K. Depression and cognitive impairment in patients with mild Parkinsonian signs. Acta Neurol. Scand. 2013, 128:153-159.
56. Ungerstedt U., Arbuthnott G.W. Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system. Brain Res. 1970, 24:485-493.
57. Weintraub D., Morgan J.C. Both the body and brain benefit from exercise: potential win-win for Parkinson's disease patients. Mov. Disord. 2011, 26:607-612.
58. Woo N.H., Teng H.K., Siao C.J., Chiaruttini C., Pang P.T., Milner T.A., Hempstead B.L., Lu B. Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nat. Neurosci. 2005, 8:1069-1077.
59. Worth P.F. When the going gets tough: how to select patients with Parkinson's disease for advanced therapies. Pract. Neurol. 2013, 13:140-152.