메뉴 건너뛰기




Volumn 90, Issue 1, 2011, Pages 77-89

Implications of obesity for drug therapy: Limitations and challenges

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; ATRACURIUM; CIPROFLOXACIN; CISATRACURIUM; CYCLOSPORIN; DALTEPARIN; DIAZEPAM; DIGOXIN; ESTRADIOL; ESTRONE; FOLLITROPIN; FONDAPARINUX; FROVATRIPTAN; GENTAMICIN; ILOPERIDONE; INSULIN ASPART; INSULIN GLULISINE; LORAZEPAM; METHYLPREDNISOLONE; NARATRIPTAN; ORAL CONTRACEPTIVE AGENT; RANITIDINE; SUFENTANIL; TOBRAMYCIN; TRAZODONE; UNINDEXED DRUG; VANCOMYCIN; VERAPAMIL;

EID: 79959376671     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2011.104     Document Type: Review
Times cited : (170)

References (83)
  • 1
    • 4444228888 scopus 로고    scopus 로고
    • World Health Organization
    • World Health Organization. Obesity and Overweight. (2011).
    • (2011) Obesity and Overweight
  • 2
    • 22144457930 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention Accessed 10 February 2011
    • Centers for Disease Control and Prevention. Overweight and Obesity. (2011). Accessed 10 February 2011.
    • (2011) Overweight and Obesity
  • 3
    • 3843089634 scopus 로고    scopus 로고
    • A standard weight descriptor for dose adjustment in the obese patient
    • DOI 10.2165/00003088-200443150-00007
    • Duffull, S.B., Dooley, M.J., Green, B., Poole, S.G. & Kirkpatrick, C.M. A standard weight descriptor for dose adjustment in the obese patient. Clin. Pharmacokinet. 43, 1167-1178 (2004). (Pubitemid 40013182)
    • (2004) Clinical Pharmacokinetics , vol.43 , Issue.15 , pp. 1167-1178
    • Duffull, S.B.1    Dooley, M.J.2    Green, B.3    Poole, S.G.4    Kirkpatrick, C.M.J.5
  • 4
  • 6
    • 0023875191 scopus 로고
    • Sudden cardiac arrest in morbidly obese surgical patients unexplained after autopsy
    • Drenick, E.J. & Fisler, J.S. Sudden cardiac arrest in morbidly obese surgical patients unexplained after autopsy. Am. J. Surg. 155, 720-726 (1988).
    • (1988) Am. J. Surg. , vol.155 , pp. 720-726
    • Drenick, E.J.1    Fisler, J.S.2
  • 8
    • 0022346313 scopus 로고
    • Weight and thirty-year mortality of men in the Framingham Study
    • Garrison, R.J. & Castelli, W.P. Weight and thirty-year mortality of men in the Framingham Study. Ann. Intern. Med. 103, 1006-1009 (1985). (Pubitemid 16211922)
    • (1985) Annals of Internal Medicine , vol.103 , Issue.6 , pp. 1006-1009
    • Garrison, R.J.1    Castelli, W.P.2
  • 9
    • 0026598692 scopus 로고
    • Mortality of severely obese subjects
    • Sjostrom, L.V. Mortality of severely obese subjects. Am. J. Clin. Nutr. 55, 516S-523S (1992).
    • (1992) Am. J. Clin. Nutr. , vol.55
    • Sjostrom, L.V.1
  • 10
    • 3843141820 scopus 로고    scopus 로고
    • What is the best size descriptor to use for pharmacokinetic studies in the obese?
    • DOI 10.1111/j.1365-2125.2004.02157.x
    • Green, B. & Duffull, S.B. What is the best size descriptor to use for pharmacokinetic studies in the obese? Br. J. Clin. Pharmacol. 58, 119-133 (2004). (Pubitemid 39043992)
    • (2004) British Journal of Clinical Pharmacology , vol.58 , Issue.2 , pp. 119-133
    • Green, B.1    Duffull, S.B.2
  • 11
    • 0033800745 scopus 로고    scopus 로고
    • Effects of obesity on pharmacokinetics implications for drug therapy
    • Cheymol, G. Effects of obesity on pharmacokinetics implications for drug therapy. Clin. Pharmacokinet. 39, 215-231 (2000).
    • (2000) Clin. Pharmacokinet. , vol.39 , pp. 215-231
    • Cheymol, G.1
  • 12
    • 0034106774 scopus 로고    scopus 로고
    • Dosage adjustments for antibacterials in obese patients: Applying clinical pharmacokinetics
    • Bearden, D.T. & Rodvold, K.A. Dosage adjustments for antibacterials in obese patients: applying clinical pharmacokinetics. Clin. Pharmacokinet. 38, 415-426 (2000). (Pubitemid 30265261)
    • (2000) Clinical Pharmacokinetics , vol.38 , Issue.5 , pp. 415-426
    • Bearden, D.T.1    Rodvold, K.A.2
  • 13
    • 0036738186 scopus 로고    scopus 로고
    • The pharmacokinetics and pharmacodynamics of enoxaparin in obese volunteers
    • Sanderink, G.J. et al. The pharmacokinetics and pharmacodynamics of enoxaparin in obese volunteers. Clin. Pharmacol. Ther. 72, 308-318 (2002).
    • (2002) Clin. Pharmacol. Ther. , vol.72 , pp. 308-318
    • Sanderink, G.J.1
  • 14
    • 0029076433 scopus 로고
    • Absorption of rapid-acting insulin in obese and nonobese NIDDM patients
    • Clauson, P.G. & Linde, B. Absorption of rapid-acting insulin in obese and nonobese NIDDM patients. Diabetes Care 18, 986-991 (1995).
    • (1995) Diabetes Care , vol.18 , pp. 986-991
    • Clauson, P.G.1    Linde, B.2
  • 15
    • 0021192084 scopus 로고
    • Effect of age, gender, and obesity on midazolam kinetics
    • Greenblatt, D.J., Abernethy, D.R., Locniskar, A., Harmatz, J.S., Limjuco, R.A. & Shader, R.I. Effect of age, gender, and obesity on midazolam kinetics. Anesthesiology 61, 27-35 (1984). (Pubitemid 14089351)
    • (1984) Anesthesiology , vol.61 , Issue.1 , pp. 27-35
    • Greenblatt, D.J.1    Abernethy, D.R.2    Locniskar, A.3
  • 16
    • 0023010417 scopus 로고
    • A comparison of the pharmacokinetics of propranolol in obese and normal volunteers
    • Bowman, S.L., Hudson, S.A., Simpson, G., Munro, J.F. & Clements, J.A. A comparison of the pharmacokinetics of propranolol in obese and normal volunteers. Br. J. Clin. Pharmacol. 21, 529-532 (1986). (Pubitemid 17175027)
    • (1986) British Journal of Clinical Pharmacology , vol.21 , Issue.5 , pp. 529-532
    • Bowman, S.L.1    Hudson, S.A.2    Simpson, G.3
  • 17
    • 0024364410 scopus 로고
    • The impact of body weight on cyclosporine pharmacokinetics in renal transplant recipients
    • Flechner, S.M., Kolbeinsson, M.E., Tam, J. & Lum, B. The impact of body weight on cyclosporine pharmacokinetics in renal transplant recipients. Transplantation 47, 806-810 (1989). (Pubitemid 19139118)
    • (1989) Transplantation , vol.47 , Issue.5 , pp. 806-810
    • Flechner, S.M.1    Kolbeinsson, M.E.2    Tam, J.3    Lum, B.4
  • 19
    • 77956910985 scopus 로고    scopus 로고
    • Metabolism and pharmacokinetics of contraceptive steroids in obese women: A review
    • Edelman, A.B., Cherala, G. & Stanczyk, F.Z. Metabolism and pharmacokinetics of contraceptive steroids in obese women: a review. Contraception 82, 314-323 (2010).
    • (2010) Contraception , vol.82 , pp. 314-323
    • Edelman, A.B.1    Cherala, G.2    Stanczyk, F.Z.3
  • 20
  • 21
    • 0025260145 scopus 로고
    • Pharmacokinetics of ranitidine in morbidly obese women
    • Davis, R.L., Quenzer, R.W., Bozigian, H.P. & Warner, C.W. Pharmacokinetics of ranitidine in morbidly obese women. DICP 24, 1040-1043 (1990).
    • (1990) DICP , vol.24 , pp. 1040-1043
    • Davis, R.L.1    Quenzer, R.W.2    Bozigian, H.P.3    Warner, C.W.4
  • 23
    • 0027223897 scopus 로고
    • Clinical pharmacokinetics of drugs in obesity - An update
    • Cheymol, G. Clinical pharmacokinetics of drugs in obesity. An update. Clin. Pharmacokinet. 25, 103-114 (1993). (Pubitemid 23232390)
    • (1993) Clinical Pharmacokinetics , vol.25 , Issue.2 , pp. 103-114
    • Cheymol, G.1
  • 24
    • 0028960747 scopus 로고
    • Antipyrine disposition in obesity: Evidence for negligible effect of obesity on hepatic oxidative metabolism
    • Caraco, Y., Zylber-Katz, E., Berry, E.M. & Levy, M. Antipyrine disposition in obesity: evidence for negligible effect of obesity on hepatic oxidative metabolism. Eur. J. Clin. Pharmacol. 47, 525-530 (1995).
    • (1995) Eur. J. Clin. Pharmacol. , vol.47 , pp. 525-530
    • Caraco, Y.1    Zylber-Katz, E.2    Berry, E.M.3    Levy, M.4
  • 25
    • 79959377827 scopus 로고    scopus 로고
    • Special pharmacokinetic considerations in the obese
    • 4th edn. (eds. Schentag, J.J., Burton, M.E., Shaw, L.M., & Evans, W.E.) Lippincott Williams & Wilkins, Baltimore, MD
    • Blouin, R.A. & Ensom, M.H.H. Special pharmacokinetic considerations in the obese. In Applied Pharmacokinetics and Pharmacodynamics: Principles of Therapeutic Drug Monitoring 4th edn. (eds. Schentag, J.J., Burton, M.E., Shaw, L.M., & Evans, W.E.) 231-241 (Lippincott Williams & Wilkins, Baltimore, MD, 2006).
    • (2006) Applied Pharmacokinetics and Pharmacodynamics: Principles of Therapeutic Drug Monitoring , pp. 231-241
    • Blouin, R.A.1    Ensom, M.H.H.2
  • 26
    • 79959374121 scopus 로고    scopus 로고
    • DrugBank. (2011).
    • (2011) DrugBank
  • 27
    • 0742306111 scopus 로고    scopus 로고
    • CYP2E1: From ASH to NASH
    • DOI 10.1016/j.hepres.2003.08.001, PII S1386634603003577
    • Lieber, C.S. CYP2E1: from ASH to NASH. Hepatol. Res. 28, 1-11 (2004). (Pubitemid 38145781)
    • (2004) Hepatology Research , vol.28 , Issue.1 , pp. 1-11
    • Lieber, C.S.1
  • 28
    • 79951633215 scopus 로고    scopus 로고
    • Does hepatic steatosis affect drug metabolizing enzymes in the liver?
    • Buechler, C. & Weiss, T.S. Does hepatic steatosis affect drug metabolizing enzymes in the liver? Curr. Drug Metab. 12, 24-34 (2011).
    • (2011) Curr. Drug Metab. , vol.12 , pp. 24-34
    • Buechler, C.1    Weiss, T.S.2
  • 30
    • 0028037221 scopus 로고
    • Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: A putative probe of CYP2E1 activity
    • O'Shea, D., Davis, S.N., Kim, R.B. & Wilkinson, G.R. Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: a putative probe of CYP2E1 activity. Clin. Pharmacol. Ther. 56, 359-367 (1994). (Pubitemid 24339082)
    • (1994) Clinical Pharmacology and Therapeutics , vol.56 , Issue.4 , pp. 359-367
    • O'Shea, D.1    Davis, S.N.2    Kim, R.B.3    Wilkinson, G.R.4
  • 34
    • 79951948280 scopus 로고    scopus 로고
    • Drug disposition in obesity and protein-energy malnutrition
    • Boullata, J.I. Drug disposition in obesity and protein-energy malnutrition. Proc. Nutr. Soc. 69, 543-550 (2010).
    • (2010) Proc. Nutr. Soc. , vol.69 , pp. 543-550
    • Boullata, J.I.1
  • 35
    • 68849088725 scopus 로고    scopus 로고
    • Obesity in the intensive care unit
    • x
    • Honiden, S. & McArdle, J.R. Obesity in the intensive care unit. Clin. Chest Med. 30, 581-99, x (2009).
    • (2009) Clin. Chest Med. , vol.30 , pp. 581-99
    • Honiden, S.1    McArdle, J.R.2
  • 36
    • 79952197484 scopus 로고    scopus 로고
    • Availability of information for dosing injectable medications in underweight or obese patients
    • J acques, K.A. & Erstad, B.L. Availability of information for dosing injectable medications in underweight or obese patients. Am. J. Health. Syst. Pharm. 67, 1948-1950 (2010).
    • (2010) Am. J. Health. Syst. Pharm. , vol.67 , pp. 1948-1950
    • Jacques, K.A.1    Erstad, B.L.2
  • 39
    • 0026738042 scopus 로고
    • Renal hemodynamics in recent-onset type II diabetes
    • Nowack, R., Raum, E., Blum, W. & Ritz, E. Renal hemodynamics in recent-onset type II diabetes. Am. J. Kidney Dis. 20, 342-347 (1992).
    • (1992) Am. J. Kidney Dis. , vol.20 , pp. 342-347
    • Nowack, R.1    Raum, E.2    Blum, W.3    Ritz, E.4
  • 42
    • 0004245626 scopus 로고
    • Her Majesty's Stationery Office, London
    • J ames, W. Research on Obesity. Her Majesty's Stationery Office, London (1976).
    • (1976) Research on Obesity
    • James, W.1
  • 45
    • 57749203554 scopus 로고    scopus 로고
    • Influence of lean body weight on anticancer drug clearance
    • author reply 24 2009
    • Mathijssen, R.H. & Sparreboom, A. Influence of lean body weight on anticancer drug clearance. Clin. Pharmacol. Ther. 85, 23; author reply 24 (2009).
    • Clin. Pharmacol. Ther. , vol.85 , pp. 23
    • Mathijssen, R.H.1    Sparreboom, A.2
  • 47
    • 16244404633 scopus 로고    scopus 로고
    • Anesthesia in the obese patient: Pharmacokinetic considerations
    • DOI 10.1016/j.jclinane.2004.01.009
    • Casati, A. & Putzu, M. Anesthesia in the obese patient: pharmacokinetic considerations. J. Clin. Anesth. 17, 134-145 (2005). (Pubitemid 40462234)
    • (2005) Journal of Clinical Anesthesia , vol.17 , Issue.2 , pp. 134-145
    • Casati, A.1    Putzu, M.2
  • 48
    • 77954941113 scopus 로고    scopus 로고
    • Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5
    • Choi, J.H. et al. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature 466, 451-456 (2010).
    • (2010) Nature , vol.466 , pp. 451-456
    • Choi, J.H.1
  • 49
    • 52449085359 scopus 로고    scopus 로고
    • Effects of obesity on the pharmacodynamics of nitroglycerin in conscious rats
    • Wang, E.Q. & Fung, H.L. Effects of obesity on the pharmacodynamics of nitroglycerin in conscious rats. AAPS PharmSci 4, E28 (2002).
    • (2002) AAPS PharmSci , vol.4
    • Wang, E.Q.1    Fung, H.L.2
  • 50
    • 0029079408 scopus 로고
    • Pharmacokinetics and pharmacodynamics of triazolam after two intermittent doses in obese and normal-weight men
    • Derry, C.L., Kroboth, P.D., Pittenger, A.L., Kroboth, F.J., Corey, S.E. & Smith, R.B. Pharmacokinetics and pharmacodynamics of triazolam after two intermittent doses in obese and normal-weight men. J. Clin. Psychopharmacol. 15, 197-205 (1995).
    • (1995) J. Clin. Psychopharmacol. , vol.15 , pp. 197-205
    • Derry, C.L.1    Kroboth, P.D.2    Pittenger, A.L.3    Kroboth, F.J.4    Corey, S.E.5    Smith, R.B.6
  • 52
    • 70949095710 scopus 로고    scopus 로고
    • Increased insulin dose requirement of long-acting insulin analogues in obese patients with type 2 diabetes
    • Schmid, C., Krayenbuhl, P. & Wiesli, P. Increased insulin dose requirement of long-acting insulin analogues in obese patients with type 2 diabetes. Diabetologia 52, 2668-2669 (2009).
    • (2009) Diabetologia , vol.52 , pp. 2668-2669
    • Schmid, C.1    Krayenbuhl, P.2    Wiesli, P.3
  • 53
    • 80052325915 scopus 로고    scopus 로고
    • Pilot study examining the frequency of several gene polymorphisms involved in morphine pharmacodynamics and pharmacokinetics in a morbidly obese population
    • e-pub ahead of print 22 April 2010
    • Lloret Linares, C.et al. Pilot study examining the frequency of several gene polymorphisms involved in morphine pharmacodynamics and pharmacokinetics in a morbidly obese population. Obes. Surg. (2010); e-pub ahead of print 22 April 2010.
    • (2010) Obes. Surg.
    • Lloret Linares, C.1
  • 54
    • 77956199207 scopus 로고    scopus 로고
    • The adverse effects of obesity on conception and implantation
    • Brewer, C.J. & Balen, A.H. The adverse effects of obesity on conception and implantation. Reproduction 140, 347-364 (2010).
    • (2010) Reproduction , vol.140 , pp. 347-364
    • Brewer, C.J.1    Balen, A.H.2
  • 55
    • 79959373908 scopus 로고    scopus 로고
    • US Food and Drug Administration
    • US Food and Drug Administration. Drugs@FDA database. .
    • Drugs@FDA Database
  • 56
    • 79959380602 scopus 로고    scopus 로고
    • PDR Network PDR Electronic Library
    • PDR Network. Safety Communication Compliance. PDR Electronic Library. (2011).
    • (2011) Safety Communication Compliance
  • 61
    • 0019965058 scopus 로고
    • Vancomycin pharmacokinetics in normal and morbidly obese subjects
    • Blouin, R.A., Bauer, L.A., Miller, D.D., Record, K.E. & Griffen, W.O. Jr. Vancomycin pharmacokinetics in normal and morbidly obese subjects. Antimicrob. Agents Chemother. 21, 575-580 (1982). (Pubitemid 12070524)
    • (1982) Antimicrobial Agents and Chemotherapy , vol.21 , Issue.4 , pp. 575-580
    • Blouin, R.A.1    Bauer, L.A.2    Miller, D.D.3
  • 63
    • 41149180911 scopus 로고    scopus 로고
    • Mechanism-based concepts of size and maturity in pharmacokinetics
    • DOI 10.1146/annurev.pharmtox.48.113006.094708
    • Anderson, B.J. & Holford, N.H. Mechanism-based concepts of size and maturity in pharmacokinetics. Annu. Rev. Pharmacol. Toxicol. 48, 303-332 (2008). (Pubitemid 351738156)
    • (2008) Annual Review of Pharmacology and Toxicology , vol.48 , pp. 303-332
    • Anderson, B.J.1    Holford, N.H.G.2
  • 64
    • 34447512467 scopus 로고    scopus 로고
    • Prediction of drug clearance in children: Impact of allometric exponents, body weight, and age
    • DOI 10.1097/FTD.0b013e318042d3c4, PII 0000769120070600000002
    • Mahmood, I. Prediction of drug clearance in children: impact of allometric exponents, body weight, and age. Ther. Drug Monit. 29, 271-278 (2007). (Pubitemid 47262255)
    • (2007) Therapeutic Drug Monitoring , vol.29 , Issue.3 , pp. 271-278
    • Mahmood, I.1
  • 65
    • 77955160409 scopus 로고    scopus 로고
    • Ovarian suppression in normal-weight and obese women during oral contraceptive use: A randomized controlled trial
    • Westhoff, C.L. et al. Ovarian suppression in normal-weight and obese women during oral contraceptive use: a randomized controlled trial. Obstet. Gynecol. 116, 275-283 (2010).
    • (2010) Obstet. Gynecol. , vol.116 , pp. 275-283
    • Westhoff, C.L.1
  • 66
    • 70449523691 scopus 로고    scopus 로고
    • Contraceptive considerations in obese women: Release date 1 September 2009, SFP Guideline 20091
    • Society of Family Planning
    • Higginbotham, S.; Society of Family Planning. Contraceptive considerations in obese women: release date 1 September 2009, SFP Guideline 20091. Contraception 80, 583-590 (2009).
    • (2009) Contraception , vol.80 , pp. 583-590
    • Higginbotham, S.1
  • 67
    • 78650781153 scopus 로고    scopus 로고
    • Effectiveness of oral contraceptive pills in a large U.S. cohort comparing progestogen and regimen
    • Dinger, J., Minh, T.D., Buttmann, N. & Bardenheuer, K. Effectiveness of oral contraceptive pills in a large U.S. cohort comparing progestogen and regimen. Obstet. Gynecol. 117, 33-40 (2011).
    • (2011) Obstet. Gynecol. , vol.117 , pp. 33-40
    • Dinger, J.1    Minh, T.D.2    Buttmann, N.3    Bardenheuer, K.4
  • 68
    • 63049102389 scopus 로고    scopus 로고
    • Obesity and oral contraceptive pill failure
    • Trussell, J., Schwarz, E.B. & Guthrie, K. Obesity and oral contraceptive pill failure. Contraception 79, 334-338 (2009).
    • (2009) Contraception , vol.79 , pp. 334-338
    • Trussell, J.1    Schwarz, E.B.2    Guthrie, K.3
  • 69
    • 36248998874 scopus 로고    scopus 로고
    • Obesity and oral contraceptive failure: Findings from the 2002 National Survey of Family Growth
    • DOI 10.1093/aje/kwm221
    • Brunner Huber, L.R. & Toth, J.L. Obesity and oral contraceptive failure: findings from the 2002 National Survey of Family Growth. Am. J. Epidemiol. 166, 1306-1311 (2007). (Pubitemid 350129421)
    • (2007) American Journal of Epidemiology , vol.166 , Issue.11 , pp. 1306-1311
    • Brunner Huber, L.R.1    Toth, J.L.2
  • 70
    • 67651005121 scopus 로고    scopus 로고
    • Impact of obesity on oral contraceptive pharmacokinetics and hypothalamic-pituitary-ovarian activity
    • Edelman, A.B. et al. Impact of obesity on oral contraceptive pharmacokinetics and hypothalamic-pituitary-ovarian activity. Contraception 80, 119-127 (2009).
    • (2009) Contraception , vol.80 , pp. 119-127
    • Edelman, A.B.1
  • 71
    • 77952108626 scopus 로고    scopus 로고
    • Pharmacokinetics of a combined oral contraceptive in obese and normalweight women
    • Westhoff, C.L., Torgal, A.H., Mayeda, E.R., Pike, M.C. & Stanczyk, F.Z. Pharmacokinetics of a combined oral contraceptive in obese and normalweight women. Contraception 81, 474-480 (2010).
    • (2010) Contraception , vol.81 , pp. 474-480
    • Westhoff, C.L.1    Torgal, A.H.2    Mayeda, E.R.3    Pike, M.C.4    Stanczyk, F.Z.5
  • 72
    • 78249248916 scopus 로고    scopus 로고
    • BMI pharmacokinetics, and OCP failure
    • reply 581-582; reply 582
    • Cherala, G. & Edelman, A. BMI, pharmacokinetics, and OCP failure. Contraception 82, 582; reply 581-582; reply 582 (2010).
    • (2010) Contraception , vol.82 , pp. 582
    • Cherala, G.1    Edelman, A.2
  • 73
    • 0037529325 scopus 로고    scopus 로고
    • Effect of topiramate or carbamazepine on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in healthy obese and nonobese female subjects
    • Doose, D.R., Wang, S.S., Padmanabhan, M., Schwabe, S., Jacobs, D. & Bialer, M. Effect of topiramate or carbamazepine on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in healthy obese and nonobese female subjects. Epilepsia 44, 540-549 (2003).
    • (2003) Epilepsia , vol.44 , pp. 540-549
    • Doose, D.R.1    Wang, S.S.2    Padmanabhan, M.3    Schwabe, S.4    Jacobs, D.5    Bialer, M.6
  • 74
    • 34848828529 scopus 로고    scopus 로고
    • Risk of venous thrombosis: Obesity and its joint effect with oral contraceptive use and prothrombotic mutations
    • DOI 10.1111/j.1365-2141.2007.06780.x
    • Pomp, E.R., le Cessie, S., Rosendaal, F.R. & Doggen, C.J. Risk of venous thrombosis: obesity and its joint effect with oral contraceptive use and prothrombotic mutations. Br. J. Haematol. 139, 289-296 (2007). (Pubitemid 47493087)
    • (2007) British Journal of Haematology , vol.139 , Issue.2 , pp. 289-296
    • Pomp, E.R.1    Le Cessie, S.2    Rosendaal, F.R.3    Doggen, C.J.M.4
  • 75
    • 0037341535 scopus 로고    scopus 로고
    • Obesity: Risk of venous thrombosis and the interaction with coagulation factor levels and oral contraceptive use
    • Abdollahi, M., Cushman, M. & Rosendaal, F.R. Obesity: risk of venous thrombosis and the interaction with coagulation factor levels and oral contraceptive use. Thromb. Haemost. 89, 493-498 (2003). (Pubitemid 36329240)
    • (2003) Thrombosis and Haemostasis , vol.89 , Issue.3 , pp. 493-498
    • Abdollahi, M.1    Cushman, M.2    Rosendaal, F.R.3
  • 76
    • 0031242252 scopus 로고    scopus 로고
    • Obesity and reproduction
    • Bray, G.A. Obesity and reproduction. Hum. Reprod. 12 (suppl. 1), 26-32 (1997).
    • (1997) Hum. Reprod. , vol.12 , Issue.SUPPL. 1 , pp. 26-32
    • Bray, G.A.1
  • 77
    • 33845413360 scopus 로고    scopus 로고
    • ABC of obesity Obesity and reproduction
    • Ramsay, J.E., Greer, I. & Sattar, N. ABC of obesity. Obesity and reproduction. BMJ 333, 1159-1162 (2006).
    • (2006) BMJ , vol.333 , pp. 1159-1162
    • Ramsay, J.E.1    Greer, I.2    Sattar, N.3
  • 78
    • 79959377919 scopus 로고    scopus 로고
    • Wayne NJ: Bayer HealthCare Pharmaceuticals
    • Natazia [prescribing information]. Wayne, NJ: Bayer HealthCare Pharmaceuticals, 2010. .
    • (2010) Natazia [Prescribing Information]
  • 79
  • 81
    • 77953021388 scopus 로고    scopus 로고
    • EMAS position statement: Managing obese postmenopausal women
    • Lambrinoudaki, I. et al. EMAS position statement: managing obese postmenopausal women. Maturitas 66, 323-326 (2010).
    • (2010) Maturitas , vol.66 , pp. 323-326
    • Lambrinoudaki, I.1
  • 82
    • 0027401831 scopus 로고
    • Effect of obesity on vancomycin pharmacokinetic parameters as determined by using a Bayesian forecasting technique
    • Vance-Bryan, K., Guay, D.R., Gilliland, S.S., Rodvold, K.A. & Rotschafer, J.C. Effect of obesity on vancomycin pharmacokinetic parameters as determined by using a Bayesian forecasting technique. Antimicrob. Agents Chemother. 37, 436-440 (1993). (Pubitemid 23072585)
    • (1993) Antimicrobial Agents and Chemotherapy , vol.37 , Issue.3 , pp. 436-440
    • Vance-Bryan, K.1    Guay, D.R.P.2    Gilliland, S.S.3    Rodvold, K.A.4    Rotschafer, J.C.5
  • 83
    • 0035093453 scopus 로고    scopus 로고
    • Soft tissue concentrations of ciprofloxacin in obese and lean subjects following weight-adjusted dosing
    • DOI 10.1038/sj.ijo.0801555
    • Hollenstein, U.M., Brunner, M., Schmid, R. & Muller, M. Soft tissue concentrations of ciprofloxacin in obese and lean subjects following weightadjusted dosing. Int. J. Obes. Relat. Metab. Disord. 25, 354-358 (2001). (Pubitemid 32209810)
    • (2001) International Journal of Obesity , vol.25 , Issue.3 , pp. 354-358
    • Hollenstein, U.M.1    Brunner, M.2    Schmid, R.3    Muller, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.