Minocycline prevents dynorphin-induced neurotoxicity during neuropathic pain in rats

Neuropharmacology

Volumn 86, Issue , 2014, Pages 301-310

  Rojewska, Ewelina ^a   Makuch, Wioletta ^a   Przewlocka, Barbara ^a   Mika, Joanna ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

Dynorphin; Interleukins; Microglia; Minocycline; MMP 9; Neuropathic pain

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; COMPLEMENT COMPONENT C1Q; DYNORPHIN A; GELATINASE B; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MATRIX METALLOPROTEINASE INHIBITOR; MESSENGER RNA; MINOCYCLINE; NORBINALTORPHIMINE; PRODYNORPHIN; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ANALGESIC AGENT; DYNORPHIN; IL1B PROTEIN, RAT; MMP9 PROTEIN, RAT; NEUROPROTECTIVE AGENT;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CELL FUNCTION; CELL INTERACTION; CHRONIC CONSTRICTION INJURY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; FLACCID PARALYSIS; GENE EXPRESSION REGULATION; HYPERALGESIA; LOW DRUG DOSE; MALE; MICROGLIA; NEUROPATHIC PAIN; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; RAT; REAL TIME POLYMERASE CHAIN REACTION; SCIATIC NERVE INJURY; SPINAL CORD; SPINAL GANGLION; UPREGULATION; ANIMAL; DISEASE MODEL; DRUG EFFECTS; INTRASPINAL DRUG ADMINISTRATION; METABOLISM; NEURALGIA; PARAPLEGIA; PATHOPHYSIOLOGY; SCIATIC NEUROPATHY; WISTAR RAT;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANALGESICS, NON-NARCOTIC; ANIMALS; DISEASE MODELS, ANIMAL; DYNORPHINS; GANGLIA, SPINAL; INJECTIONS, SPINAL; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; MATRIX METALLOPROTEINASE 9; MINOCYCLINE; NEURALGIA; NEUROPROTECTIVE AGENTS; PARAPLEGIA; RATS, WISTAR; RNA, MESSENGER; SCIATIC NEUROPATHY; SPINAL CORD;

EID: 84907702677     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.08.001     Document Type: Article

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