Metabolic hyperemia requires ATP-sensitive K+ channels and H2O2 but not adenosine in isolated mouse hearts

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 307, Issue 7, 2014, Pages H1046-H1055

  Zhou, Xueping ^a,b   Teng, Bunyen ^a,b   Tilley, Stephen ^c   Ledent, Catherine ^d   Mustafa, S Jamal ^a,b  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

A2A adenosine receptor; A2B adenosine receptor; Adenosine receptor knockouts; ATP sensitive K+channels; Coronary metabolic hyperemia; Hydrogen peroxide

Indexed keywords

5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8 (4 SULFOPHENYL)THEOPHYLLINE; ADENOSINE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CATALASE; GLIBENCLAMIDE; HYDROGEN PEROXIDE; NITRIC OXIDE; 5-AMINO-7-(2-PHENYLETHYL)-2-(2-FURYL)PYRAZOLO(4,3-E)-1,2,4-TRIAZOLO(1,5-C)PYRIMIDINE; 8-(4-SULFOPHENYL)THEOPHYLLINE; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE RECEPTOR; N(G) NITROARGININE METHYL ESTER; POTASSIUM CHANNEL BLOCKING AGENT; PYRIMIDINE DERIVATIVE; SCAVENGER; THEOPHYLLINE; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; HEART LEFT VENTRICLE PRESSURE; HEART RATE; HYPEREMIA; ISOLATED HEART; MOUSE; NONHUMAN; SYNTHESIS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DRUG EFFECTS; GENETICS; HEART; HEART CONTRACTION; HEART MUSCLE; IN VITRO STUDY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADENOSINE; ADENOSINE A2 RECEPTOR ANTAGONISTS; ANIMALS; CORONARY CIRCULATION; FREE RADICAL SCAVENGERS; GLYBURIDE; HEART; HYDROGEN PEROXIDE; HYPEREMIA; IN VITRO TECHNIQUES; KATP CHANNELS; MICE; MICE, INBRED C57BL; MYOCARDIAL CONTRACTION; MYOCARDIUM; NG-NITROARGININE METHYL ESTER; POTASSIUM CHANNEL BLOCKERS; PYRIMIDINES; RECEPTORS, PURINERGIC P1; THEOPHYLLINE; TRIAZOLES;

EID: 84907652111     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00421.2014     Document Type: Article

References (57)

1. Akatsuka Y, Egashira K, Katsuda Y, Narishige T, Ueno H, Shimokawa H, Takeshita A. ATP sensitive potassium channels are involved in adenosine A2 receptor mediated coronary vasodilatation in the dog. Cardiovasc Res 28: 906-911, 1994.
2. Aversano T, Ouyang P, Silverman H. Blockade of the ATP-sensitive potassium channel modulates reactive hyperemia in the canine coronary circulation. Circ Res 69: 618-622, 1991.
3. Bacchus AN, Ely SW, Knabb RM, Rubio R, Berne RM. Adenosine and coronary blood flow in conscious dogs during normal physiological stimuli. Am J Physiol Heart Circ Physiol 243: H628-H633, 1982.
4. Bache RJ, Dai XZ, Schwartz JS, Homans DC. Role of adenosine in coronary vasodilation during exercise. Circ Res 62: 846-853, 1988.
5. Beech DJ, Zhang H, Nakao K, Bolton TB. Single channel and whole-cell K-currents evoked by levcromakalim in smooth muscle cells from the rabbit portal vein. Br J Pharmacol 110: 583-590, 1993.
6. Berne RM. Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. Am J Physiol 204: 317-322, 1963.
7. Berne RM. The role of adenosine in the regulation of coronary blood flow. Circ Res 47: 807-813, 1980.
8. ATPchannels. Microcirculation 17: 600-607, 2010.
9. Boerth RC, Covell JW, Seagren SC, Pool PE. High-energy phosphate concentrations in dog myocardium during stress. Am J Physiol 216: 1103-1106, 1969.
10. Daut J, Maier-Rudolph W, von Beckerath N, Mehrke G, Gunther K, Goedel-Meinen L. Hypoxic dilation of coronary arteries is mediated by ATP-sensitive potassium channels. Science 247: 1341-1344, 1990.
11. Dick GM, Tune JD. Role of potassium channels in coronary vasodilation. Exp Biol Med (Maywood) 235: 10-22, 2010.
12. Duncker DJ, Bache RJ. Regulation of coronary blood flow during exercise. Physiol Rev 88: 1009-1086, 2008.
13. ATPchannels in regulation of systemic, pulmonary, and coronary vasomotor tone in exercising swine. Am J Physiol Heart Circ Physiol 280: H22-H33, 2001.
14. Duncker DJ, Stubenitsky R, Verdouw PD. Role of adenosine in the regulation of coronary blood flow in swine at rest and during treadmill exercise. Am J Physiol Heart Circ Physiol 275: H1663-H1672, 1998.
15. ATPchannels in coronary vasodilation during exercise. Circulation 88: 1245-1253, 1993.
16. ATPchannels and adenosine in the regulation of coronary blood flow during exercise with normal and restricted coronary blood flow. J Clin Invest 97: 996-1009, 1996.
17. ATPchannel blockade. J Clin Invest 95: 285-295, 1995.
18. Edlund A, Sollevi A. Theophylline increases coronary vascular tone in humans: evidence for a role of endogenous adenosine in flow regulation. Acta Physiol Scand 155: 303-311, 1995.
19. Ely SW, Knabb RM, Bacchus AN, Rubio R, Berne RM. Measurements of coronary plasma and pericardial infusate adenosine concentrations during exercise in conscious dog: relationship to myocardial oxygen consumption and coronary blood flow. J Mol Cell Cardiol 15: 673-683, 1983.
20. Graham TP Jr, Covell JW, Sonnenblick EH, Ross J Jr, Braunwald E. Control of myocardial oxygen consumption: relative influence of contractile state and tension development. J Clin Invest 47: 375-385, 1968.
21. Headrick JP, Ely SW, Matherne GP, Berne RM. Myocardial adenosine, flow, and metabolism during adenosine antagonism and adrenergic stimulation. Am J Physiol Heart Circ Physiol 264: H61-H70, 1993.
22. 2A receptors mediate coronary microvascular dilation to adenosine: role of nitric oxide and ATP-sensitive potassium channels. J Pharmacol Exp Ther 291: 655-664, 1999.
23. Ishibashi Y, Duncker DJ, Zhang J, Bache RJ. ATP-sensitive K channels, adenosine, and nitric oxide-mediated mechanisms account for coronary vasodilation during exercise. Circ Res 82: 346-359, 1998.
24. ATPchannels, adenosine, nitric oxide and prostaglandins. Br J Pharmacol 132: 1209-1216, 2001.
25. Kroll K, Feigl EO. Adenosine is unimportant in controlling coronary blood flow in unstressed dog hearts. Am J Physiol Heart Circ Physiol 249: H1176-H1187, 1985.
26. Mallet RT, Lee SC, Downey HF. Endogenous adenosine increases O2 utilisation efficiency in isoprenaline-stimulated canine myocardium. Cardiovasc Res 31: 102-116, 1996.
27. Merrill GF, Downey HF, Jones CE. Adenosine deaminase attenuates canine coronary vasodilation during systemic hypoxia. Am J Physiol Heart Circ Physiol 250: H579-H583, 1986.
28. Minamino T, Kitakaze M, Matsumura Y, Nishida K, Kato Y, Hashimura K, Matsu-Ura Y, Funaya H, Sato H, Kuzuya T, Hori M. Impact of coronary risk factors on contribution of nitric oxide and adenosine to metabolic coronary vasodilation in humans. J Am Coll Cardiol 31: 1274-1279, 1998.
29. Miyai N, Arita M, Miyashita K, Morioka I, Shiraishi T, Nishio I. Blood pressure response to heart rate during exercise test and risk of future hypertension. Hypertension 39: 761-766, 2002.
30. 2B receptors. Am J Physiol Heart Circ Physiol 282: H437-H444, 2002.
31. Mustafa SJ, Morrison RR, Teng B, Pelleg A. Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophysiology. Handb Exp Pharmacol 161-188, 2009.
32. Narishige T, Egashira K, Akatsuka Y, Imamura Y, Takahashi T, Kasuya H, Takeshita A. Glibenclamide prevents coronary vasodilation induced by 1-adrenoceptor stimulation in dogs. Am J Physiol Heart Circ Physiol 266: H84-H92, 1994.
33. ATPchannels. Am J Physiol Regul Integr Comp Physiol 303: R1003-R1010, 2012.
34. ATPchannels and adenosine in the control of coronary blood flow during exercise. J Appl Physiol 89: 529-536, 2000.
35. ATPchannels in local metabolic coronary vasodilation. Am J Physiol Heart Circ Physiol 277: H2115-H2123, 1999.
36. Sadraei H, Beech DJ. Ionic currents and inhibitory effects of glibenclamide in seminal vesicle smooth muscle cells. Br J Pharmacol 115: 1447-1454, 1995.
37. Saitoh S, Zhang C, Tune JD, Potter B, Kiyooka T, Rogers PA, Knudson JD, Dick GM, Swafford A, Chilian WM. Hydrogen peroxide: a feed-forward dilator that couples myocardial metabolism to coronary blood flow. Arterioscler Thromb Vasc Biol 26: 2614-2621, 2006.
38. Samaha FF, Heineman FW, Ince C, Fleming J, Balaban RS. ATP-sensitive potassium channel is essential to maintain basal coronary vascular tone in vivo. Am J Physiol Cell Physiol 262: C1220-C1227, 1992.
39. Schenkman KA. Cardiac performance as a function of intracellular oxygen tension in buffer-perfused hearts. Am J Physiol Heart Circ Physiol 281: H2463-H2472, 2001.
40. Schenkman KA, Beard DA, Ciesielski WA, Feigl EO. Comparison of buffer and red blood cell perfusion of guinea pig heart oxygenation. Am J Physiol Heart Circ Physiol 285: H1819-H1825, 2003.
41. 2A/2B double knockout mice. Am J Physiol Heart Circ Physiol 301: H2322-H2333, 2011.
42. ATPchannels in coronary reactive hyperemia. Am J Physiol Heart Circ Physiol 304: H1294-H1301, 2013.
43. 2B receptors in mice. J Cardiovasc Pharmacol 41: 562-570, 2003.
44. Teng B, Fil D, Tilley SL, Ledent C, Krahn T, Mustafa SJ. Functional and RNA expression profile of adenosine receptor subtypes in mouse mesenteric arteries. J Cardiovasc Pharmacol 61: 70-76, 2013.
45. 2A adenosine receptor knockout mouse coronary artery. J Mol Cell Cardiol 44: 905-914, 2008.
46. Tune JD, Gorman MW, Feigl EO. Matching coronary blood flow to myocardial oxygen consumption. J Appl Physiol (1985) 97: 404-415, 2004.
47. ATPchannels, nitric oxide, and adenosine are not required for local metabolic coronary vasodilation. Am J Physiol Heart Circ Physiol 280: H868-H875, 2001.
48. Tune JD, Richmond KN, Gorman MW, Feigl EO. Role of nitric oxide and adenosine in control of coronary blood flow in exercising dogs. Circulation 101: 2942-2948, 2000.
49. Tune JD, Richmond KN, Gorman MW, Olsson RA, Feigl EO. Adenosine is not responsible for local metabolic control of coronary blood flow in dogs during exercise. Am J Physiol Heart Circ Physiol 278: H74-H84, 2000.
50. Van Bibber R, Stepp DW, Kroll K, Feigl EO. Role of adenosine in norepinephrine-induced coronary vasodilation. Am J Physiol Heart Circ Physiol 273: H557-H565, 1997.
51. Vanelli G, Chang HY, Gatensby AG, Hussain SN. Contribution of potassium channels to active hyperemia of the canine diaphragm. J Appl Physiol (1985) 76: 1098-1105, 1994.
52. Yada T, Richmond KN, Van Bibber R, Kroll K, Feigl EO. Role of adenosine in local metabolic coronary vasodilation. Am J Physiol Heart Circ Physiol 276: H1425-H1433, 1999.
53. Yada T, Shimokawa H, Hiramatsu O, Kajita T, Shigeto F, Goto M, Ogasawara Y, Kajiya F. Hydrogen peroxide, an endogenous endothelium-derived hyperpolarizing factor, plays an important role in coronary autoregulation in vivo. Circulation 107: 1040-1045, 2003.
54. Yada T, Shimokawa H, Hiramatsu O, Shinozaki Y, Mori H, Goto M, Ogasawara Y, Kajiya F. Important role of endogenous hydrogen peroxide in pacing-induced metabolic coronary vasodilation in dogs in vivo. J Am Coll Cardiol 50: 1272-1278, 2007.
55. ATPchannels and coronary vasodilation produced by isoprenaline. Br J Pharmacol 164: 2064-2072, 2011.
56. Zatta AJ, Headrick JP. Mediators of coronary reactive hyperaemia in isolated mouse heart. Br J Pharmacol 144: 576-587, 2005.
57. ATPopening in isolated mouse hearts. Am J Physiol Heart Circ Physiol 305: H1668-H1679, 2013.