Incorporation of triphenylphosphonium functionality improves the inhibitory properties of phenothiazine derivatives in Mycobacterium tuberculosis

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 19, 2014, Pages 5320-5328

  Dunn, Elyse A ^a   Roxburgh, Marina ^a   Larsen, Lesley ^a   Smith, Robin A J ^a   McLellan, Alexander D ^a   Heikal, Adam ^a   Murphy, Michael P ^b   Cook, Gregory M ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Alkyltriphenylphosphonium cation; Drug delivery; Energy generation; Mycobacteria

Indexed keywords

3 (10H PHENOTHIAZIN 10 YL)PROPYL TRIPHENYLPHOSPHONIUM CHLORIDE; 3 (2 CHLORO 10H PHENOTHIAZIN 10 YL)PROPYL TRIPHENYLPHOSPHONIUM CHLORIDE; 3 (2 TRIFLUOROMETHYL 10H PHENOTHIAZIN 10 YL)PROPYL TRIPHENYLPHOSPHONIUM CHLORIDE; PHENOTHIAZINE DERIVATIVE; PHOSPHONIUM DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ORGANOPHOSPHORUS COMPOUND; PHENOTHIAZINE;

ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OXIDATIVE PHOSPHORYLATION; RESPIRATORY CHAIN; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST; SYNTHESIS;

ANTI-BACTERIAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; ORGANOPHOSPHORUS COMPOUNDS; PHENOTHIAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84907550940     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.07.050     Document Type: Article

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