RAGE, receptor of advanced glycation endoproducts, negatively regulates chondrocytes differentiation

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Kosaka, Tatsuya ^a   Fukui, Rino ^a   Matsui, Mio ^a   Kurosaka, Yuko ^a   Nishimura, Haruka ^a   Tanabe, Motoki ^a   Takakura, Yuuki ^a   Iwai, Keisuke ^a   Waki, Takuya ^a   Fujita, Takashi ^a  

^a RITSUMEIKAN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; COLLAGEN TYPE 10; COLLAGEN TYPE 10A1; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; ADVANCED GLYCOSYLATION END-PRODUCT RECEPTOR; CDX1 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; IHH PROTEIN, MOUSE; IMMUNOGLOBULIN RECEPTOR; RETINOIC ACID;

ANIMAL CELL; ARTICLE; BINDING SITE; CARTILAGE CELL; CDX1 GENE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; GENE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAGE GENE; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; ANIMAL EMBRYO; BONE; CELL LINE; CYTOLOGY; DRUG EFFECTS; EXTRACELLULAR MATRIX; GENETICS; METABOLISM;

ANIMALS; BONE AND BONES; CELL DIFFERENTIATION; CELL LINE; CHONDROCYTES; DOWN-REGULATION; EMBRYO, MAMMALIAN; EXTRACELLULAR MATRIX; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; MICE; NF-KAPPA B; RECEPTORS, IMMUNOLOGIC; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; TRETINOIN;

EID: 84907546605     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108819     Document Type: Article

References (48)

1. Brownlee M, Cweami A, Vlassara H. (1988) Advanvced glycation end products in tissue and biochemical basis of diabetic complications. N Engl J Med 318: 1315-1321.
2. Yamagishi S, Yonekura H, Yamamoto Y., Katsuno K, Sato F, et al. (1997) Advanced glycation end products-driven angiogenesis in vitro. Induction of the growth and tube formation of human microvascular endothelial cells through autocrine vascular endothelial growth factor. J Biol Chem 272: 8723-8730.
3. Lalla E, Lamster IB, Feit M, Huang L., Spessot A, et al. (2000) Blockade of RAGE suppresses periodontitis-accociated bone loss in diabetic mice. J Clin Invest 105: 1117-1124.
4. Ramasamy R, Yan SF, Schmidt A. (2011) Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications. Ann N Y A-cad Sci 1243: 88-102.
5. Neeper M, Schmidt AM, Brett J, Yan S.D., Wang F., et al. (1992) Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J Biol Chem 267: 14998-15004.
6. Li YM, Mitsuhashi T, Wojciechowicz D., Shimizu N, Li J, et al. (1996) Molecular identity and cellular distribution of advanced glycation endproduct receptors: relationship of p60 to OST-48 and p90 to 80K-H membrane proteins. Proc Natl Acad Sci USA 93: 11047-11052.
7. Suzuki H, Kurihara Y, Takeya M., Kamada N, Kataoka M, et al. (1997) A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 386: 292-296.
8. Ohgami N, Nagai R, Miyazaki A., Ikemoto M, Arai H, et al. (2001) Scavenger receptor class B type I-mediated reverse cholesterol transport is inhibited by advanced glycation end products. J Biol Chem 276: 13348-13355.
9. Huttunen HJ, Fages C, Rauvala H. (1999) Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways. J Biol Chem 274: 19919-19924.
10. Sakaguchi T, Yan SF, Yan S.D., Belov D., Rong LL, et al. (2003) Central role of RAGE-dependent neointimal expansion in arterial restenosis. J Clin Invest 111: 959-972.
11. Taguchi A, Blood DC, del Toro G, Canet A, Lee D.C., et al. (2000) Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature 405: 354-360.
12. Lin L (2006) RAGE on the Toll Road? Cell Mol Immunol 3: 351-358.
13. Yan SF, Ramasamy R, Schmidt A.M. (2008) Mechanisms of disease: advanced glycation end-products and their receptor in inflammation and diabetes complications. Nat Clin Pract Endocrinol Metab 4: 285-293.
14. Rojas A, Figueroa H, Morales E. (2010) Fueling inflammation at tumor microenvironment: the role of multiligand/RAGE axis. Carcinogenesis 31: 334-341.
15. Zhou Z, Immel D, Xi C.X., Bierhaus A., Feng X, et al. (2006) Regulation of osteoclast function and bone mass by RAGE. J Exp Med 203: 1067-1080.
16. Wang Z, Jiang Y, Liu N., Ren L, Zhu Y, et al. (2012) Advanced glycation endproduct Necarboxymethyl-lysine accelerates progression of atherosclerotic calcification in diabetes. Atherosclerosis 221: 387-396.
17. Owen WF Jr, Hou FF, Stuart R.O., Kay J., Boyce J, et al. (1998) Beta2-microglobulin modified with advanced glycation end products modulates collagen synthesis by human fibroblasts. Kidney Int 53: 1365-1373.
18. Franke S, Rüster C, Pester J., Hofmann G, Oelzner P, et al. (2011) Advanced glycation end products affect growth and function of osteoblasts. Clin Exp Rheumato 29: 650-660.
19. Ding KH, Wang ZZ, Hamrick M.W., Deng ZB, Zhou L, et al. (2006) Disordered osteoclast formation in RAGE-deficient mouse establishes an essential role for RAGE in diabetes related bone loss. Biochem Biophys Res Commun 340: 1091-1097.
20. Hein GE (2006) Glycation endproducts in osteoporosis-is there a pathophys-iologic importance? Clin Chim Acta 371: 32-36.
21. Tang SY, Vashishth D. (2010) Non-enzymatic glycation alters microdamage formation in human cancellous bone. Bone 46: 148-154.
22. Loeser RF, Yammani RR, Carlson C.S., Chen H., Cole A, et al. (2005) Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis. Arthritis Rheum 52: 2376-2385.
23. DeGroot J, Verzijl N, Jacobs K.M., Budde M., Bank RA, et al. (2001) Accumulation of advanced glycation endproducts reduces chondrocytemediated extracellular matrix turnover in human articular cartilage. Osteoarthritis Cartilage 9: 720-726.
24. Clynes R, Moser B, Yan S.F., Ramasamy R., Herold K, et al. (2007) Receptor for AGE (RAGE): weaving tangled webs within the inflammatory response. Curr Mol Med 7: 743-751.
25. Lin L (2006) RAGE on the Toll Road? Cell Mol Immunol 3: 351-358.
26. van Beijnum JR, Buurman WA, Griffioen A.W. (2008) Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1). Angiogenesis 11: 91-99.
27. Bidwell JP, Yang J, Robling A.G. (2008) Is HMGB1 an osteocyte alarmin? J Cell Biochem 103: 1671-1680.
28. Gilbert SF (1997) Developmental Biology, 5th ed., Sinauer Associates, Sunder-land, MA. p351-357.
29. Fujita T, Azuma Y, Fukuyama R., Hattori Y, Yoshida C, et al. (2004) Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling. J Cell Biol 166: 85-95.
30. Morita S, Kojima T, Kitamura T. (2000) Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther 7: 1063-1066.
31. Yamaguchi N, Ito T, Azuma S., Ito E, Honma R, et al. (2009) Constitutive activation of nuclear factor-kappaB is preferentially involved in the proliferation of basal-like subtype breast cancer cell lines. Cancer Sci 100: 1668-1674.
32. Rokutanda S, Fujita T, Kanatani N., Yoshida CA, Komori H, et al. (2009) Akt regulates skeletal development through GSK3, mTOR, and FoxOs. Dev Biol 328: 78-93.
33. Tanaka N, Yonekura H, Yamagishi S., Fujimori H, Yamamoto Y, et al. (2000) The receptor for advanced glycation end products is induced by the glycation products themselves and tumor necrosis factor-alpha through nuclear factorkappa B, and by 17beta-estradiol through Sp-1 in human vascular endothelial cells. J Biol Chem 275: 25781-25790.
34. Yoshida CA, Yamamoto H, Fujita T., Furuichi T, Ito K, et al. (2004) Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev 18: 952-963.
35. Fujita T, Meguro T, Izumo N., Yasutomi C, Fukuyama R, et al. (2001) Phosphate stimulates differentiation and mineralization of the chondroprogeni-tor clone ATDC5. Jpn J Pharmacol 85: 278-281.
36. Guo RJ, Funakoshi S, Lee H.H., Kong J., Lynch J.P. (2010) The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting the beta-catenin-TCF protein complex. Carcinogenesis 31: 159-166.
37. Beier F, Loeser R.F. (2010) Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes. J Cell Biochem 110: 573-580.
38. Houle M, Prinos P, Iulianella A., Bouchard N, Lohnes D. (2000) Retinoic acid regulation of Cdx1: an indirect mechanism for retinoids and vertebral specification. Mol Cell Biol 20: 6579-6586.
39. Clynes R, Moser B, Yan S.F., Ramasamy R., Herold K, et al. (2007) Receptor for AGE (RAGE): weaving tangled webs within the inflammatory response. Curr Mol Med 7: 743-751.
40. Gaunt SJ, Drage D, Trubshaw R.C. (2008) Increased Cdx protein dose effects upon axial patterning in transgenic lines of mice. Development 135: 2511-2520.
41. Epstein M, Pillemer G, Yelin R., Yisraeli JK, Fainsod A. (1997) Patterning of the embryo along the anterior-posterior axis: the role of the caudal genes. Development 124: 3805-3814.
42. Marom K, Shapira E, Fainsod A. (1997) The chicken caudal genes establish an anterior-posterior gradient by partially overlapping temporal and spatial patterns of expression. Mech Dev 64: 41-52.
43. Charité J, de Graaff W, Consten D, Reijnen MJ, Korving J, et al. (1998) Transducing positional information to the Hox genes: critical interaction of cdx gene products with position-sensitive regulatory elements. Development 125: 4349-4358.
44. Pilon N, Oh K, Sylvestre J.R., Savory JG, Lohnes D. (2007) Wnt signaling is a key mediator of Cdx1 expression in vivo. Development 134: 2315-2323.
45. Houle M, Sylvestre JR, Lohnes D. (2003) Retinoic acid regulates a subset of Cdx1 function in vivo. Development 130: 6555-6567.
46. Lickert H, Kemler R. (2002) Functional analysis of cis-regulatory elements controlling initiation and maintenance of early Cdx1 gene expression in the mouse. Dev Dyn 225: 216-220.
47. Young T, Rowland JE, van de Ven C, Bialecka M, Novoa A, et al. (2009) Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Dev Cell 17: 516-526.
48. Kong YY, Yoshida H, Sarosi I., Tan HL, Timms E, et al. (1999) OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397: 315-323.