Non-enzymatic glycation alters microdamage formation in human cancellous bone

Bone

Volumn 46, Issue 1, 2010, Pages 148-154

  Tang, S Y ^a   Vashishth, D ^a  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

Advanced glycation end products; Biomechanics; Bone; Diabetes; microCT; Microdamage; Non enzymatic glycation

Indexed keywords

ADVANCED GLYCATION END PRODUCT; URANYL ACETATE;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ADULT; ARTICLE; BONE INJURY; BONE MASS; BONE MATRIX; CANCELLOUS BONE; CONTROLLED STUDY; DAMAGED SURFACE PER DAMAGED VOLUME; DAMAGED VOLUME PER BONE VOLUME; FRACTURE; GLYCATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MALE; MECHANICAL STRESS; MICRO-COMPUTED TOMOGRAPHY; MUSCULOSKELETAL SYSTEM PARAMETERS; THREE DIMENSIONAL IMAGING; TIBIA;

BIOMECHANICS; BONE AND BONES; GLYCOSYLATION; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 72049112298     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.09.003     Document Type: Article

References (32)

1. Wenzel T.E., Schaffler M.B., and Fyhrie D.P. In vivo trabecular microcracks in human vertebral bone. Bone 19 2 (1996) 89-95
2. Burr D.B., Turner C.H., Naick P., Forwood M.R., Ambrosius W., Hasan M.S., et al. Does microdamage accumulation affect the mechanical properties of bone. J. Biomech. 21 1998 (1998) 337-345
3. Vashishth D., Koontz J., Qiu S.J., Lundin-Cannon D., Yeni Y.N., Schaffler M.B., et al. In vivo diffuse damage in human vertebral trabecular bone. Bone 26 2 (2000) 147-152
4. Vashishth D., Behiri J.C., and Bonfield W. Crack growth resistance in cortical bone: Concept of microcrack toughening. J. Biomech. 30 8 (1997) 763-769
5. Vashishth D., Tanner K.E., and Bonfield W. Experimental validation of a microcracking-based toughening mechanism for cortical bone. J. Biomech. 36 1 (2003) 121-124
6. Diab T., and Vashishth D. Effects of damage morphology on cortical bone fragility. Bone 37 1 (2005) 96-102
7. Bloebaum R.D., Lundeen G.A., Shea J.E., and Whitaker E.L. Age-related mineralization heterogeneity changes in trabecular bone of the proximal femur. Anat. Rec. A Discov. Mol. Cell. Evol. Biol. 281 2 (2004) 1296-1302
8. Diab T., Condon K.W., Burr D.B., and Vashishth D. Age-related change in damage morphology of human cortical bone and its role in bone fragility. Bone 38 3 (2006) 427-431
9. Bailey A.J., Sims T.J., Avery N.C., and Halliagan E.P. Non-enzymatic glycation of fibrous collagen: reaction products of glucose and ribose. Biochem. J. 305 (1995) 385-390
10. Odetti P., Rossi S., Monacelli F., Poggi A., Cirnigliaro F., Federici M., et al. Advanced glycation end-products and bone loss during aging. Ann. N. Y. Acad. Sci. 1043 (2005) 710-717
11. Monnier V.M., Sell D.R., Abdul-Karim F.W., and Emancipator S.N. Collagen browning and cross-linking are increased in chronic experimental hyperglycemia: relevance to diabetes and ageing. Diabetes 37 (1988) 867-872
12. Reiser K.M. Nonenzymatic glycation of collagen in aging and diabetes. Proc. Soc. Exp. Biol. Med. 196 1 (1984) 17-29
13. Tang S.Y., Allen M.R., Phipps R., Burr D.B., and Vashishth D. Changes in non-enzymatic glycation and its association with altered mechanical properties following 1-year treatment with risedronate or alendronate. Osteoporos. Int. 20 6 (2009) 887-894
14. Vashishth D., Gibson G.J., Khoury J.I., Schaffler M.B., Kimura J., and Fyhrie D.P. Influence of nonenzymatic glyation on biomechanical properties of cortical bone. Bone 22 2 (2001) 195-201
15. Wang X., Shen X., Li X., and Agrawal C.M. Age-related changes in the collagen network and toughness of bone. Bone 31 1 (2002) 1-7
16. Tang S.Y., Zeenath U., and Vashishth D. Effects of non-enzymatic glycation on cancellous bone fragility. Bone 40 4 (2007) 1144-1151
17. Hernandez C.J., Tang S.Y., Baumbach B.M., Hwu P.B., Sakkee A.N., van der Ham F., et al. Trabecular microfracture and the influence of pyridinium and non-enzymatic glycation-mediated collagen cross-links. Bone 37 6 (2005) 825-832
18. Tang S.Y., and Vashishth D. A non-invasive technique for the three-dimensional quantification of in vitro microdamage in trabecular bone. Bone 5 (2007) 1259-1264
19. Fazzalari N.L., Forwood M.R., Manthey B.A., Smith K., and Kolesik P. Three-dimensional confocal images of microdamage in cancellous bone. Bone 23 4 (1998) 373-378
20. Schaffler M.B., Pitchford W.C., Choi K., and Riddle J.M. Examination of compact bone microdamage using back-scattered electron microscopy. Bone 15 5 (1994) 483-488 Sep-Oct
21. Gimenez-Martin G., and Risueno M.C. A simple staining technique for electron microscopy with lead-uranyl acetate. Sep. Exp. 23 (1967) 316-318
22. Nagaraja S., Tracey C.L., and Guldberg R.E. Trabecular bone microdamage and microstructural stresses under uniaxial tension. J. Biomech. 38 3005 (2005) 707-716
23. Yeni Y.N., Hou F.J., Ciarelli T., Vashishsh D., and Fyhrie D.P. Trabecular shear stresses predict in vivo linear microcrack density but not diffuse damage in human vertebral cancellous bone. Ann. Biomed. Eng. 31 (2003) 726-732
24. Sobelman O.S., Gibeling J.C., Stover S.M., Hazelwood S.J., Yeh O.C., Shelton D.R., et al. Do microcracks decrease or increase fatigue resistance in cortical bone. J. Biomech. 37 (2004) 1295-1303
25. Nalla R.K., Stolken J.S., Kinney J.H., and Ritchie R.O. Fracture in human cortical bone: local fracture criteria and toughening mechanisms. J. Biomech. 38 7 (2005) 1517-1525
26. Bazant Z.P., and Chen E.B. Scaling of structural failure. ASME Appl. Mech. Rev. 50 (1997) 593
27. Liu X., Wang X., and Neibur G.L. Effects of damage on the orthotropic material symmetry of bovine tibial trabecular bone. J. Biomech. 36 12 (2003) 1753-1759
28. Nagaraja S., and Lin A.S. Guldberg RE. Age-related changes in trabecular bone microdamage initiation. Bone 40 4 (2007) 973-980
29. Breunig T.M., Stock S.R., Guvenilir A., and Elliott J.C. Damage in aligned-fibre SiC/Al quantified using a laboratory X-ray tomographic microscope. Composites 24 3 (1993) 209
30. Schwartz A.V. Diabetes mellitus: does it affect bone. Calcif. Tissue Int. 73 (2003) 515-519
31. Burr D.B., Forwood M.R., Fyhrie D.P., Martin R.B., Schaffler M.B., and Turner C.H. Bone microdamage and skeletal fragility in osteoporotic and stress fractures. J. Bone Miner. Res. 12 1 (1997) 6-15
32. Norman T.L., Yeni T.N., Brown C.U., and Wang Z. Influence of microdamage on fracture toughness of the human femur and tibia. Bone 23 3 (1998) 303-306