Phosphate stimulates differentiation and mineralization of the chondroprogenitor clone ATDC5

Japanese Journal of Pharmacology

Volumn 85, Issue 3, 2001, Pages 278-281

  Fujita, T ^a   Meguro, T ^a   Izumo, N ^a   Yasutomi, C ^a   Fukuyama, R ^a   Nakamuta, H ^a   Koida, M ^a  

^a SETSUNAN UNIVERSITY   (Japan)

Author keywords

ATDC5; Endochondral osteogenesis; Phosphate

Indexed keywords

ASCORBIC ACID; COLLAGEN TYPE 2; LUCIFERASE; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; PHOSPHATE;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CARTILAGE CELL; CELL CLONE; CELL DIFFERENTIATION; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; IN VITRO STUDY; INHIBITION KINETICS; MINERALIZATION; MOUSE; NONHUMAN; NORTHERN BLOTTING; OSSIFICATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REGULATORY MECHANISM; STEM CELL;

EID: 0035070318     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.85.278     Document Type: Article

References (12)

1. Chondrocyte differentiation
2. A chondrogenic cell line derived from a differentiating culture of AT 805 teratocarcinoma cells
3. Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: Differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor
4. Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro
5. Type X collagen gene expression in mouse chondrocytes immortalized by a temperature-sensitive simian virus 40 large tumor antigen
6. Elevated extracellular calcium concentrations induce type X collagen synthesis in chondrocyte cultures
7. Enhanced Cbfa1 transactivation as a basic mechanism to trigger bone anabolic action of PTH(1 - 34)
8. Localization of silencer and enhancer elements in the human type X collagen gene
9. Pituitary adenylate cyclase-activating polypeptide (PACAP) receptor mRNA in the rat adrenal gland: Localization by in situ hybridization and identification of splice variants
10. A novel in vitro culture system for analysis of functional role of phosphate transport in endochondral ossification
11. Inorganic phosphate added exogenously or released from beta-glycerophosphate initiates mineralization of osteoid nodules in vitro
12. Phosphate is a specific signal for induction of osteopontin gene expression