Alternative causes of hypopituitarism: Traumatic brain injury, cranial irradiation, and infections

Handbook of Clinical Neurology

Volumn 124, Issue , 2014, Pages 271-290

  Pekic, Sandra ^a   Popovic, Vera ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Cranial irradiation; Hypopituitarism; Infectious diseases; Pituitary gland; Traumatic brain injury

Indexed keywords

ADVERSE EFFECTS; ANIMAL; BRAIN INJURIES; CENTRAL NERVOUS SYSTEM INFECTIONS; COMPLICATION; HUMAN; HYPOPHYSIS; HYPOPITUITARISM; HYPOTHALAMUS; METABOLISM; MICROBIOLOGY; PATHOLOGY; RISK FACTOR; SKULL IRRADIATION;

ANIMALS; BRAIN INJURIES; CENTRAL NERVOUS SYSTEM INFECTIONS; CRANIAL IRRADIATION; HUMANS; HYPOPITUITARISM; HYPOTHALAMUS; PITUITARY GLAND; RISK FACTORS;

EID: 84907535405     PISSN: 00729752     EISSN: 22124152     Source Type: Book Series    
DOI: 10.1016/B978-0-444-59602-4.00018-6     Document Type: Chapter

References (172)

1. Adem A., Jossan S.S., d'Argy R., et al. Insulin-like growth factor I (IGF-1) receptors in the human brain: quantitative autoradiographic localization. Brain Res 1989, 503:299-303.
2. Agha A., Rogers B., Sherlock M., et al. Anterior pituitary dysfunction in survivors of traumatic brain injury. J Clin Endocrinol Metab 2004, 89:4929-4936.
3. Agha A., Rogers B., Mylotte D., et al. Neuroendocrine dysfunction in the acute phase of traumatic brain injury. Clin Endocrinol (Oxf) 2004, 60:584-591.
4. Agha A., Sherlock M., Thompson C.J. Post-traumatic hyponatraemia due to acute hypopituitarism. QJM 2005, 98:463-464.
5. Agha A., Phillips J., O'Kelly P., et al. The natural history of post-traumatic hypopituitarism: implications for assessment and treatment. Am J Med 2005, 118:1416e1-1416e7.
6. Agha A., Sherlock M., Brennan S., et al. Hypothalamic-pituitary dysfunction after irradiation of nonpituitary brain tumors in adults. J Clin Endocrinol Metab 2005, 90:6355-6360.
7. Ahmed S.R., Shalet S.M., Beardwell C.G. The effects of cranial irradiation on growth hormone secretion. Acta Paediatr Scand 1986, 75:255-260.
8. Aimaretti G., Ambrosio M., Di Somma C., et al. Traumatic brain injury and subarachnoid haemorrhage are conditions at high risk for hypopituitarism: screening study at 3 months after the brain injury. Clin Endocrinol (Oxf) 2004, 61:320-326.
9. Aimaretti G., Ambrosio M.R., Di Somma C., et al. Residual pituitary function after brain injury-induced hypopituitarism: a prospective 12-month study. J Clin Endocrinol Metab 2005, 90:6085-6092.
10. Appelman-Dijkstra N.M., Kokshoorn N.E., Dekkers O.M., et al. Pituitary dysfunction in adult patients after cranial radiotherapy: systematic review and meta-analysis. J Clin Endocrinol Metab 2011, 96:2330-2340.
11. Arunkumar M.J., Rajshekhar V. Intrasellar tuberculoma presenting as pituitary apoplexy. Neurol India 2001, 49:407-410.
12. Bach-y-Rita P. Theoretical basis for brain plasticity after a TBI. Brain Inj 2003, 17:643-651.
13. Beca S.G., High W.M., Masel B.E., et al. What are critical outcome measures for patients receiving pituitary replacement following brain injury?. Pituitary 2012, 15:10-19.
14. Benvenga S., Campenni A., Ruggeri R., et al. Hypopituitarism secondary to head trauma. J Clin Endocrinol Metab 2000, 85:1353-1361.
15. Bhandare N., Kennedy L., Malyapa R.S., et al. Hypopituitarism after radiotherapy for extracranial head and neck cancers. Head Neck 2008, 30:1182-1192.
16. Bondanelli M., De Marinis L., Ambrosio M.R., et al. Occurrence of pituitary dysfunction following traumatic brain injury. J Neurotrauma 2004, 21:685-696.
17. Burman P., Hetta J., Karlssonn A. Effect of growth hormone on brain neurotransmitters. Lancet 1993, 342:1492-1493.
18. Burman P., Hetta J., Wide L., et al. Growth hormone treatment affects brain neurotransmitters and thyroxone. Clin Endocrinol (Oxf) 1996, 44:319-324.
19. Bushnik T., Englander J., Katznelson L. Fatigue after TBI: association with neuroendocrine abnormalities. Brain Inj 2007, 21:559-566.
20. Casanueva F.F., Leal A., Kotlowska-Haggstrom M., et al. Traumatic brain injury as a relevant cause of growth hormone deficiency in adults: a KIMS-based study. Arch Phys Med Rehabil 2008, 86:463-468.
21. Casanueva F.F., Catro A.I., Micic D., et al. New guidelines for the diagnosis of growth hormone deficiency in adults. Horm Res 2009, 71(suppl 1):112-115.
22. CDC Traumatic brain injury in the United States. Emergency department visits, hospitalizations and deaths 2002-2006 2010, Available at, (accessed July 11, 2012). http://www.cdc.gov/TraumaticBrainInjury.
23. Chen M.S., Lin F.J., Huang M.J., et al. Prospective hormone study of hypothalamic-pituitary function in patients with nasopharyngeal carcinoma after high dose irradiation. Jpn J Clin Oncol 1989, 19:265-270.
24. Chieng P.U., Huang T.S., Chang C., et al. Reduced hypothalamic blood flow after radiation treatment of nasopharyngeal cancer: SPECT studies in 34 patients. AJNR Am J Neuroradiol 1991, 12:661-665.
25. Ciappetta P., Calace A., D'Urso P.I., et al. Endoscopic treatment of pituitary abscess: two case reports and literature review. Neurosurg Rev 2008, 31:237-246.
26. Constine L.S., Rubin P., Woolf P.D., et al. Hyperprolactinemia and hypothyroidism following cytotoxic therapy for central nervous system malignancies. J Clin Oncol 1987, 5:1841-1851.
27. Constine L.S., Woolf P.D., Cann D., et al. Hypothalamic-pituitary dysfunction after radiation for brain tumors. N Engl J Med 1993, 328:87-94.
28. Cyran E. Hypophysenschadigung durch Schadelbasisfraktur. Dtsch Med Wochenschr 1918, 44:1261.
29. Dalan R., Leow M.K. Pituitary abscess: our experience with a case and a review of the literature. Pituitary 2008, 11:299-306.
30. Daniel P., Prichard M., Treip C. Traumatic infarction of the anterior lobe of the pituitary gland. Lancet 1959, 2:927-930.
31. Daniel P.M., Treip C.S. Lesions of the pituitary gland associated with head injuries. The Pituitary Gland 1966, Vol. 2:519-534. Butterworth, London. G.W. Harris, B.T. Donovan (Eds.).
32. Darzy K.H., Shalet S.M. Radiation-induced growth hormone deficiency. Horm Res 2003, 59(Suppl 1):1-11.
33. Darzy K.H., Shalet S.M. Hypopituitarism as a consequence of brain tumours and radiotherapy. Pituitary 2005, 8:203-211.
34. Darzy K.H., Pezzoli S.S., Thorner M.O., et al. Cranial irradiation and growth hormone neurosecretory dysfunction: a critical appraisal. J Clin Endocrinol Metab 2007, 92:1666-1672.
35. Darzy K.H., Shalet S.M. Hypopituitarism following radiotherapy. Pituitary 2009, 12:40-50.
36. Darzy K.H., Shalet S.M. Hypopituitarism following radiotherapy revisited. Endocr Dev 2009, 15:1-24.
37. Darzy K.H., Thorner M.O., Shalet S.M. Cranially irradiated adult cancer survivors may have normal spontaneous GH secretion in the presence of discordant peak GH responses to stimulation tests (compensated GH deficiency). Clin Endocrinol (Oxf) 2009, 70:287-293.
38. Darzy K.H. Radiation-induced hypopituitarism after cancer therapy: who, how and when to test. Nat Clin Pract Endocrinol Metab 2009, 5:88-99.
39. De Bellis A., Bizzarro A., Pivonello R., et al. Prolactin and autoimmunity. Pituitary 2005, 8:25-30.
40. Deijen J., de Boer H., Blok G.J., et al. Cognitive impairments and mood disturbances in growth hormone deficient men. Psychoneuroendocrinology 1996, 21:313-322.
41. Deijen J.B., de Boer H., van der Veen E.A. Cognitive changes during growth hormone replacement in adult men. Psychoneuroendocrinology 1998, 23:45-55.
42. Dhanwal D.K., Vyas A., Sharma A., et al. Hypothalamic pituitary abnormalities in tubercular meningitis at the time of diagnosis. Pituitary 2010, 13:304-310.
43. Edwards O.M., Clark J.D. Post-traumatic hypopituitarism. Six cases and a review of the literature. Medicine 1986, 65:281-290.
44. Einaudi S., Matarazzo P., Peretta P., et al. Hypothalamo-hypophyseal dysfunction after traumatic brain injury in children and adolescents: a preliminary retrospective and prospective study. J Pediatr Endocrinol Metab 2006, 19:691-703.
45. Escamilla R., Lisser H. Simmonds disease. J Clin Endocrinol Metab 1942, 2:65-96.
46. Escamilla R.F., Forsham P.H. Treatment with human growth hormone (Li) for overt eight years-effects of long-term therapy in a pituitary dwarf. Calif Med 1971, 115:72-76.
47. Fernandez A., Brada M., Zabuliene L., et al. Radiation-induced hypopituitarism. Endocr Relat Cancer 2009, 16:733-772.
48. Forslund T., Saltevo J., Anttinen J., et al. Complications of nephropathia epidemica: three cases. J Intern Med 1992, 232:87-90.
49. Gaetz M. The neurophysiology of brain injury. Clin Neurophysiol 2004, 115:4-18.
50. Gasco V., Prodam F., Pagano L., et al. Hypopituitarism following brain injury: when does it occur and how best to test?. Pituitary 2012, 15:20-24.
51. Growth Hormone Research Society Consensus guidelines for the diagnosis and treatment of adults with GH deficiency: summary statement of the Growth Hormone Research Society workshop on adult growth hormone deficiency. J Clin Endocrinol Metab 1998, 83:379-381.
52. Growth Hormone Research Society Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. J Clin Endocrinol Metab 2000, 85:3990-3993.
53. Gurney J.G., Kadan-Lottick N.S., Packer R.J., et al. Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors. Childhood Cancer Survivor Study. Cancer 2003, 97:663-673.
54. Hannon M.J., Sherlock M., Thompson C.J. Pituitary dysfunction following traumatic brain injury or subarachnoid haemorrhage - in "Endocrine Management in the Intensive Care Unit". Best Pract Res Clin Endocrinol Metab 2011, 25:783-798.
55. Hao L., Jing C., Bowen C., et al. Aspergillus sellar abscess: case report and review of the literature. Neurol India 2008, 56:186-188.
56. Hautala T., Sironen T., Vapalahti O., et al. Hypophyseal hemorrhage and panhypopituitarism during Puumala virus infection: magnetic resonance imaging and detection of viral antigen in the hypophysis. Clin Infect Dis 2002, 35:96-101.
57. Heather N.L., Jefferies C., Hofman P.L., et al. Permanent hypopituitarism is rare after structural traumatic brain injury in early childhood. J Clin Endocrinol Metab 2012, 97:599-604.
58. Herrmann B.L., Rehder J., Kahlke S., et al. Hypopituitarism following severe traumatic brain injury. Exp Clin Endocrinol Diabetes 2006, 114:316-321.
59. Heyman P., Cochez C., Ducoffre G., et al. Haemorrhagic fever with renal syndrome: an analysis of the outbreaks in Belgium, the Netherlands and Luxembourg in 2005. Euro Surveill 2007, 12:E15-E16.
60. High W.M., Briones-Galang M., Clark J.A., et al. Effect of growth hormone replacement therapy on cognition after traumatic brain injury. J Neurotrauma 2010, 27:1565-1575.
61. Ho K.K.Y. Diagnosis of adult GH deficiency. Lancet 2000, 356:1125.
62. Ho K.K. GH Deficiency Consensus Workshop Participants. Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II: a statement of the GH Research Society in association with the European Society for Pediatric Endocrinology, Lawson Wilkins Society, European Society of Endocrinology, Japan Endocrine Society, and Endocrine Society of Australia. Eur J Endocrinol 2007, 157:695-700.
63. Hoffman D.M., O'Sullivan A.J., Baxter R.C., et al. Diagnosis of growth hormone-deficiency in adults. Lancet 1994, 343:1064-1068.
64. Holmin S., Mathiesen T. Long-term intracerebral inflammatory response after experimental focal brain injury in rat. Neuroreport 1999, 10:1889-1891.
65. Husain N., Husain M., Rao P. Pituitary tuberculosis mimicking idiopathic granulomatous hypophysitis. Pituitary 2008, 11:313-315.
66. Inoue H.K., Kohga H., Hirato M., et al. Pituitary adenomas treated by microsurgery with or without gamma-knife surgery: experience in 122 cases. Stereotact Funct Neurosurg 1999, 72(Supplement 1):125-131.
67. Iplikcioglu A.C., Bek S., Bikmaz K., et al. Aspergillus pituitary abscess. Acta Neurochir 2004, 146:521-524.
68. Jagganathan J., Sheehan J.P., Pouratian N., et al. Gamma-knife radiosurgery for acromegaly: outcomes after failed transsphenoidal surgery. Neurosurgery 2008, 62:1262-1269.
69. Johansson J., Larson G., Andersson M., et al. Treatment of growth hormone-deficient adults with recombinant human growth hormone increases concentration of growth hormone in cerebrospinal fluid and affects neurotransmitters. Neuroendocrinology 1995, 61:57-66.
70. Jorgensen E.V., Schwartz I.D., Hvizdala E., et al. Neurotransmitter control of growth hormone secretion in children after cranial radiation therapy. J Pediatr Endocrinol 1993, 6:131-142.
71. Kahler O. Die dauernde polyurie als cerebrales herdsymptom. Z Heilk 1886, 7:105-220.
72. Kasturi B.S., Stein D.G. Traumatic brain injury causes long-term reduction in serum growth hormone and persistent astrocytosis in the cortico-hypothalamo-pituitary axis of adult male rats. J Neurotrauma 2009, 26:1315-1324.
73. Kelestimur F., Tanriverdi F., Atmaca H., et al. Boxing as a sport activity associated with isolated GH. J Endocrinol Invest 2004, 27:RC28-RC32.
74. Kelly D.F., Gonzalo I.T., Cohan P., et al. Hypopituitarism following traumatic brain injury and aneurismal subarachnoid hemorrhage: a preliminary report. J Neurosurg 2000, 93:743-752.
75. Kim N.H., Cho J.G., Ahn Y.K., et al. A case of torsade de pointes associated with hypopituitarism due to hemorrhagic fever with renal syndrome. J Korean Med Sci 2001, 16:355-359.
76. Klebanov Iu.A. Analysis of fatal outcome in hemorrhagic fever with renal syndrome. Klin Med 1990, 68:64-67.
77. Klose M., Juul A., Poulsgaard L., et al. Prevalence and predictive factors of post-traumatic hypopituitarism. Clin Endocrinol (Oxf) 2007, 67:193-201.
78. Klose M., Watt T., Brennum J., et al. Posttraumatic hypopituitarism is associated with an unfavorable body composition and lipid profile, and decreased quality of life 12 months after injury. J Clin Endocrinol Metab 2007, 92:3861-3868.
79. Klose M., Feldt-Rasmussen U. Does the type and severity of brain injury predict hypothalamo-pituitary dysfunction? Does post-traumatic hypopituitarism predict worse outcome?. Pituitary 2008, 11:255-261.
80. Klose M., Jonsson B., Abs R., et al. From isolated GH deficiency to multiple pituitary hormone deficiency: an evolving continuum-a KIMS analysis. Eur J Endocrinol 2009, 161:S75-S83.
81. Kokshoorn N.E., Wassenaar M.J.E., Biermasz N.R., et al. Hypopituitarism following traumatic brain injury: prevalence is affected by the use of different dynamic tests and different normal values. Eur J Endocrinol 2010, 162:11-18.
82. Kokshoorn N.E., Smit J.W.A., Nieuwlaat W.A., et al. Low prevalence of hypopituitarism after traumatic brain injury: a multicenter study. Eur J Endocrinol 2011, 165:225-231.
83. Kreitschmann-Andermahr I., Hartmann Y., Poll E., et al. The German database on hypopituitarism after traumatic brain injury and aneurysmal subarachnoid hemorrhage - description, objectives and design. Exp Clin Endocrinol Diabetes 2011, 119:15-20.
84. Lam K.S., Tse V.K., Wang C., et al. Effects of cranial irradiation on hypothalamic-pituitary function - a 5-year longitudinal study in patients with nasopharyngeal carcinoma. Q J Med 1991, 78:165-176.
85. Lam K.S., Sham M.M., Tam S.C., et al. Hypopituitarism after tuberculous meningitis in childhood. Ann Intern Med 1993, 118:701-706.
86. Lamberts S.W.J., de Herder W.W., van der Lely A.J. Pituitary insufficiency. Lancet 1998, 352:127-134.
87. Laskowitz D.T., Goel S., Bennett E.R., et al. Apolipoprotein E suppresses glial cell secretion of TNF alpha. J Neuroimmunol 1997, 76:70-74.
88. Leal-Cerro A., Flores J.M., Rincon M., et al. Prevalence of hypopituitarism and growth hormone deficiency in adults long-term after severe traumatic brain injury. Clin Endocrinol (Oxf) 2005, 62:525-532.
89. Leiper A.D., Stanhope R., Kitching P., et al. Precocious and premature puberty associated with treatment of acute lymphoblastic leukamia. Arch Dis Child 1987, 62:1107-1112.
90. Leon-Carrion J., Dominguez-Morales M del R., Barrosoy Martin J.M., et al. Epidemiology of traumatic brain injury and subarachnoid hemorrhage. Pituitary 2005, 8:197-202.
91. Lieberman S.A., Oberoi A.L., Gilkinson C.R., et al. Prevalence of neuroendocrine dysfunction in patients recovering from traumatic brain injury. J Clin Endocrinol Metab 2001, 86:2752-2756.
92. Lim T.H., Chang K.H., Han M.C., et al. Pituitary atrophy in Korean (epidemic) hemorrhagic fever: CT correlation with pituitary function and visual field. AJNR Am J Neuroradiol 1986, 7:633-637.
93. Lissett C.A., Saleem S., Rahim A., et al. The impact of irradiation on growth hormone responsiveness to provocative agents is stimulus dependent: results in 161 individuals with radiation damage to the somatotropic axis. J Clin Endocrinol Metab 2001, 86:663-668.
94. Littley M.D., Shalet S.M., Beardwell C.G., et al. Hypopituitarism following exernal radiotherapy for pituitary tumours in adults. Q J Med 1989, 70:145-160.
95. Liu W., Chen H., Cai B., et al. Successful treatment of sellar aspergillus abscess. J Clin Neurosci 2010, 17:1587-1589.
96. Mahajan T., Lightman S.L. A simple test for growth hormone deficiency in adults. J Clin Endocrinol Metab 2000, 85:1473-1476.
97. Maranon G., Pintos G. Lésion traumatique pure de l'hypophyse. Syndrome adiposo-génital et diabète insipide. Nouv Iconogr Salpet 1917, 28:185-195.
98. Maric N.P., Doknic M., Pavlovic D., et al. Psychiatric and neuropsychological changes in growth hormone-deficient patients after traumatic brain injury in response to growth hormone therapy. J Endocrinol Invest 2010, 33:770-775.
99. Medic-Stojanoska M. Traumatic brain injury induced hypopituitarism in children and adolescents. Pediatr Helath 2009, 3:1-9.
100. Military Health System DoD Worldwide Numbers for Traumatic Brain Injury 2011, Available at, (accessed May 12, 2014). http://http:www.health.mil/Research/TBI_Numbers.aspx.
101. Milligan S.A., Katz M.S., Craven P.C., et al. Toxoplasmosis presenting as panhypopituitarism in a patient with the acquired immune deficiency syndrome. Am J Med 1984, 77:760-764.
102. Minniti G., Scaringi C., Amelio D., et al. Stereotactic irradiation of GH-secreting pituitary adenomas. Int J Endocrinol 2012, 2012:482861.
103. Moses A.M., Thomas D.G., Canfield M.C., et al. Central diabetes insipidus due to cytomegalovirus infection of the hypothalamus in a patient with acquired immunodeficiency syndrome: a clinical, pathological, and immunohistochemical case study. J Clin Endocrinol Metab 2003, 88:51-54.
104. Mukherjee A., Shalet S.M. The value of IGF1 estimation in adults with GH deficiency. Eur J Endocrinol 2009, 161:S33-S39.
105. Nishida Y., Yoshioka M., Armand J. The top 10 most abundant transcripts are sufficient to characterize the organ's functional specificity: evidence from the cortex, hypothalamus and pituitary gland. Gene 2005, 334:133-141.
106. Nonaka M., Chen X.N., Pierce J.E., et al. Prolonged activation of NF-kappaB following traumatic brain injury in rats. J Neurotrauma 1999, 16:1023-1034.
107. Nyberg F., Burman P. Growth hormone and its receptors in the central nervous system - location and functional significance. Horm Res 1996, 45:18-22.
108. Nyberg F. Growth hormone in the brain: characteristics of specific brain targets for the hormone and their functional significance. Front Neuroendocrinol 2000, 21:300-348.
109. Oeffinger K.C., Mertens A.C., Sklar C.A., et al. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med 2006, 355:1572-1582.
110. Ogilvy-Stuart A., Wallace W., Shalet S. Radiation and neuroregulatory control of growth hormone secretion. Clin Endocrinol (Oxf) 1994, 41:163-168.
111. Ogilvy-Stuart A.L., Clayton P.E., Shalet S.M. Cranial irradiation and early puberty. J Clin Endocrinol Metab 1994, 78:1282-1286.
112. Park J.E., Pyo H.J. Delayed onset of diuresis in a patient with acute renal failure due to hemorrhagic fever with renal syndrome who also developed anterior hypopituitarism. Clin Nephrol 1996, 46:141-145.
113. Pavlovic D., Pekic S., Stojanovic M., et al. Chronic cognitive sequelae after traumatic brain injury are not related to growth hormone deficiency in adults. Eur J Neurol 2010, 17:696-702.
114. Pekic S., Cvijovic G., Stojanovic M., et al. Hypopituitarism as a late complication of hemorrhagic fever. Endocrine 2005, 26:79-82.
115. Pekic S., Arsenijevic V.A., Gazibara M.S., et al. What lurks in the sellar?. Lancet 2010, 375:432.
116. Pepene C.E., Ilie I., Mihu D., et al. Primary pituitary abscess followed by empty sella syndrome in an adolescent girl. Pituitary 2010, 13:385-389.
117. Płociński P., Dzitko K., Długońska H. Prolactin as a modulator of antiparasitic immunity. Wiad Parazytol 2007, 53:263-270.
118. Poomthavorn P., Maixner W., Zacharin M. Pituitary function in pediatric survivors of severe traumatic brain injury. Arch Dis Child 2008, 93:133-137.
119. Popovic V., Pekic S., Golubicic I., et al. The impact of cranial irradiation on GH responsiveness to GHRH plus GH-releasing peptide-6. J Clin Endocrinol Metab 2002, 87:2095-2099.
120. Popovic V., Pekic S., Pavlovic D., et al. Hypopituitarism as a consequence of traumatic brain injury (TBI) and its possible relation with cognitive disabilities and mental distress. J Endocrinol Invest 2004, 11:1048-1054.
121. Popovic V., Aimaretti G., Casanueva F.F., et al. Hypopituitarism following traumatic brain injury. Growth Horm IGF Res 2005, 15:177-184.
122. Popovic V. GH deficiency as the most common pituitary defect after TBI: clinical implications. Pituitary 2005, 8:239-243.
123. Roth C., Schmidberger H., Lakomek M., et al. Reduction of gamma-aminobutryic acid-ergic neurotransmission as a putative mechanism of radiation induced activation of the gonadotropin releasing-hormone-pulse generator leading to precocious puberty in female rats. Neurosci Lett 2001, 297:45-48.
124. Salehi F., Kovacs K., Scheithauer B.W., et al. Histologic study of the human pituitary gland in acute traumatic brain injury. Brain Inj 2007, 21:651-656.
125. Samaan N.A., Vieto R., Schultz P.N., et al. Hypothalamic, pituitary and thyroid dysfunction after radiotherapy to the head and neck. Int J Radiat Oncol Biol Phys 1982, 8:1857-1867.
126. Samaan N.A., Schultz P.N., Yang K.P., et al. Endocrine complications after radiotherapy for tumors of the head and neck. J Lab Clin Med 1987, 109:364-372.
127. Schaefer S., Boegershausen N., Meyer S., et al. Hypothalamic-pituitary insufficiency following infectious diseases of the central nervous system. Eur J Endocrinol 2008, 158:3-9.
128. Scheinpflug K., Schalk E., Reschke K., et al. Diabetes insipidus due to herpes encephalitis in a patient with diffuse large cell lymphoma. A case report. Exp Clin Endocrinol Diabetes 2006, 114:31-34.
129. Schmiegelow M., Lasen S., Poulsen H.S., et al. Cranial radiotherapy of childhood brain tumours: growth hormone deficiency and its relation to the biological effective dose of irradiation in a large population based study. Clin Endocrinol (Oxf) 2000, 53:191-197.
130. Schneider H.J., Schneider M., Saller B., et al. Prevalence of anterior pituitary insufficiency 3 and 12 months after traumatic brain injury. Eur J Endocrinol 2006, 154:259-265.
131. Schneider H.J., Aimaretti G., Kreitschmann-Andermahr I., et al. Hypopituitarism. Lancet 2007, 369:1461-1470.
132. Schneider H.J., Kreitschmann-Andermahr I., Ghigo E., et al. Hypothalamopituitary dysfunction following traumatic brain injury and aneurismal subarachnoid hemorrhage. JAMA 2007, 298:1429-1438.
133. Schneider M., Schneider H.J., Yassouridis A., et al. Predictors of anterior pituitary insufficiency after traumatic brain injury. Clin Endocrinol (Oxf) 2008, 68:206-212.
134. Schneider H.J., Schneider M., Kreitschmann-Andermahr I., et al. Structured assessment of hypopituitarism after traumatic brain injury and aneurysmal subarachnoid hemorrhage in 1242 patients: the German Interdisciplinary Database. J Neurotrauma 2011, 28:1693-1698.
135. Settergren B., Boman J., Linderholm M., et al. A case of nephropathia epidemica associated with panhypopituitarism and nephrotic syndrome. Nephron 1992, 61:234-235.
136. Shalet S.M., Beardwell C.G., Jones P.H., et al. Growth hormone deficiency after treatment of acute leukaemia in children. Arch Dis Child 1976, 51:489-493.
137. Shalet S.M., Beardwell C.G., Morris-Jones P., et al. Growth hormone deficiency in children with brain tumors. Cancer 1976, 37:1144-1148.
138. Shalet S.M., Beardwell C.G., MacFarlane I.A., et al. Endocrine morbidity in adults treated with cerebral irradiation for brain tumours during childhood. Acta Endocrinol 1977, 84:673-680.
139. Shalet S. Cytotoxic endocrinopathy: a legacy of insults. J R Soc Med 1997, 90:192-199.
140. Sharma M.C., Arora R., Mahapatra A.K., et al. Intrasellar tuberculoma - an enigmatic pituitary infection: a series of 18 cases. Clin Neurol Neurosurg 2000, 102:72-77.
141. Sicignano G., Losa M., del Vecchio A., et al. Dosimetric factors associated with pituitary function after Gamma Knife surgery (GKS) of pituitary adenomas. Radiother Oncol 2012, 104:119-124.
142. Smith D.H., Chen X.N., Pierce J.E., et al. Progressive atrophy and neuron death for one year following brain trauma in the rat. J Neurotrauma 1997, 14:715-727.
143. Springer J., Chollet A. A traumatic car crash. Lancet 2001, 357:1848.
144. Starke R.M., Williams B.J., Jane J.A., et al. Gamma Knife surgery for patients with nonfunctioning pituitary macroadenomas: predictors of tumor control, neurological deficits and hypopituitarism. J Neurosurg 2012, 117:129-135.
145. Stein T.D., Fedynyshyn J.P., Kalil R.E. Circulating autoantibodies recognize and bind dying neurons following injury to the brain. J Neuropathol Exp Neurol 2002, 61:1100-1108.
146. Stojanovic M., Pekic S., Cvijovic G., et al. High risk of hypopituitarism in patients who recovered from hemorrhagic fever with renal syndrome. J Clin Endocrinol Metab 2008, 93:2722-2728.
147. Suh D.C., Park J.S., Park S.K., et al. Pituitary hemorrhage as a complication of hantaviral disease. AJNR Am J Neuroradiol 1995, 16:175-178.
148. Tanriverdi F., Senyurek H., Uhluhizarci K., et al. High risk of hypopituitarism after traumatic brain injury: a prospective investigation of anterior pituitary function in the acute phase and 12 months after trauma. J Clin Endocrinol Metab 2006, 91:2105-2111.
149. Tanriverdi F., Unluhizarci K., Coksevim B., et al. Kickboxing sport as a new cause of traumatic brain injury-mediated hypopituitarism. Clin Endocrinol (Oxf) 2007, 66:360-366.
150. Tanriverdi F., Ulutabanca H., Unluhizarci K., et al. Three years prospective investigation of anterior pituitary function after traumatic brain injury: a pilot study. Clin Endocrinol (Oxf) 2008, 68:573-579.
151. Tanriverdi F., Unluhizarci K., Kocyigit I., et al. Brief communication: pituitary volume and function in competing and retired male boxers. Ann Intern Med 2008, 148:827-831.
152. Tanriverdi F., De Bellis A., Bizzaro A., et al. Antipituitary antibodies after traumatic brain injury: is head trauma-induced pituitary dysfunction associated with autoimmunity?. Eur J Endocrinol 2008, 159:7-13.
153. Tanriverdi F., Taheri S., Ulutabanca H., et al. Apolipoprotein E3/E3 genotype decrease the risk of pituitary dysfunction after traumatic brain injury due to various causes: preliminary data. J Neurotrauma 2008, 25:1071-1077.
154. Tanriverdi F., Alp E., Demiraslan H., et al. Investigation of pituitary functions in patients with acute meningitis: a pilot study. J Endocrinol Invest 2008, 31:489-491.
155. Tanriverdi F., Unluhizarci K., Kelestimur F. Pituitary function in subjects with mild tramatic brain injury: a review of literature and proposal of a screening strategy. Pituitary 2010, 13:146-153.
156. Tanriverdi F., De Bellis A., Bataglia M., et al. Investigation of antihypothalamus and antipituitary antibodies in amateur boxers: is chronic repetitive head trauma-induced pituitary dysfunction associated with autoimmunity?. Eur J Endocrinol 2010, 162:861-867.
157. Tanriverdi F., Unluhizarci K., Karaca Z., et al. Hypopituitarism due to sports related head trauma and the effects of growth hormone replacement in retired amateur boxers. Pituitary 2010, 13:111-114.
158. Tanriverdi F., Agha A., Aimaretti G., et al. Manifesto for the current understanding and management of traumatic brain injury-induced hypopituitarism. J Endocrinol Invest 2011, 34:541-543.
159. Torres A.M., Kazee A.M., Simon H., et al. Central diabetes insipidus due to herpes simplex in a patient immunosuppressed by Cushing's syndrome. Endocr Pract 2000, 6:26-28.
160. Treip C.S. Hypothalamic and pituitary injury. J Clin Pathol 1970, 23(Suppl):178-186.
161. Tsiakalos A., Xynos I.D., Sipsas N.V., et al. Pituitary insufficiency after infectious meningitis: a prospective study. J Clin Endocrinol Metab 2010, 957:3277-3281.
162. Urban R.J. Hypopituitarism after acute brain injury. Growth Horm IGF Res 2006, 16(Suppl A):S25-S29.
163. Valtonen M., Kauppila M., Kotilainen P., et al. Four fatal cases of nephropathia epidemica. Scand J Infect Dis 1995, 27:515-517.
164. Van den Berghe G., de Zegher F., Bouillon R. Clinical review 95: acute and prolonged critical illness as different neuroendocrine paradigms. J Clin Endocrinol Metab 1998, 83:1827-1834.
165. Van der Eerden A., Twickler M., Sweep F., et al. Should anterior pituitary function be tested during follow-up of all patients presenting at the emergency department because of traumatic brain injury?. Eur J Endocrinol 2010, 162:19-28.
166. Van Nieuwpoort I.C., Drent M.L. Cognition in the adult with childhood-onsed GH deficiency. Eur J Endocrinol 2008, 159:S53-S57.
167. Vance M.L. Hypopituitarism. N Engl J Med 1994, 330:1651-1662.
168. Vates G.E., Berger M.S., Wilson C.B. Diagnosis and management of pituitary abscess: a review of twenty-four cases. J Neurosurg 2001, 95:233-241.
169. Wachter D., Gundling K., Oertel M.F., et al. Pituitary insufficiency after traumatic brain injury. J Clin Neurosci 2009, 16:202-208.
170. Wilkinson C.W., Pagulayan K.F., Petrie E.C., et al. High prevalence of chronic pituitary and target-organ hormone abnormalities after blast-related mild traumatic brain injury. Front Neurol 2012, 3:1-12.
171. Zhang X., Li Q., Hu P., et al. Two case reports of pituitary adenoma associated with Toxoplasma gondii infection. J Clin Pathol 2002, 55:965-966.
172. Zhang X., Sun J., Shen M., et al. Diagnosis and minimally invasive surgery for the pituitary abscess: a review of twenty nine cases. Clin Neurol Neurosurg 2012, 114:957-961.