Chronic cognitive sequelae after traumatic brain injury are not related to growth hormone deficiency in adults

European Journal of Neurology

Volumn 17, Issue 5, 2010, Pages 696-702

  Pavlovic, D ^a   Pekic, S ^a   Stojanovic, M ^a   Zivkovic, V ^a   Djurovic, B ^a   Jovanovic, V ^a   Miljic, N ^b   Medic Stojanoska, M ^c   Doknic, M ^a   Miljic, D ^a   Djurovic, M ^a   Casanueva, F ^d   Popovic, V ^a  

^a CLINICAL CENTER OF SERBIA   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c UNIVERSITY OF NOVI SAD   (Serbia)

^d HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

Author keywords

Brain injury; Cognition; Growth hormone deficiency; Hypopituitarism; Neuroendocrine dysfunction

Indexed keywords

FOLLITROPIN; GROWTH HORMONE RELEASING FACTOR; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; HYDROCORTISONE; LUTEINIZING HORMONE; PROLACTIN; SOMATOMEDIN C; TESTOSTERONE; THYROTROPIN; THYROXINE;

ADULT; AGE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HORMONE DETERMINATION; HUMAN; HYPOPITUITARISM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INJURY SEVERITY; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; TRAUMATIC BRAIN INJURY;

ADULT; BRAIN INJURIES; CHRONIC DISEASE; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; FEMALE; GROWTH HORMONE; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; NEUROPSYCHOLOGICAL TESTS; PITUITARY DISEASES; RETROSPECTIVE STUDIES; TIME;

EID: 77950876200     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2009.02910.x     Document Type: Article

References (35)

1. Tagliaferri F, Compagnone C, Korsic M, et al. A systematic review of brain injury epidemiology in Europe. Acta Neurochir (Wien) 2006 148 : 255 268. (Pubitemid 43341022)
2. Vogenthaler DR. An overview of head injury: its consequences and rehabilitation. Brain Inj 1987 1 : 113 127. (Pubitemid 18060754)
3. Aimaretti G, Ambrosio MR, Di Somma C, et al. Traumatic brain injury and subarachnoid haemorrhage are conditions at high risk for hypopituitarism: screening study at 3 months after the brain injury. Clin Endocrinol (Oxf) 2004 61 : 320 326. (Pubitemid 39287060)
4. Daniel P, Prichard M, Triep C. Traumatic infarction of anterior lobe of the pituitary gland. Lancet 1959 2 : 927 930.
5. Lieberman SA, Oberoi AL, Gilkison CR, et al. Prevalence of neuroendocrine dysfunction in patients recovering from traumatic brain injury. J Clin Endocrinol Metab 2001 86 : 2752 2756. (Pubitemid 32545734)
6. Kelly DF, Gonzalo IT, Cohan P, et al. Hypopituitarism following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a preliminary report. J Neurosurg 2000 93 : 743 752. (Pubitemid 32803395)
7. Agha A, Rogers B, Sherlock M, et al. Anterior pituitary dysfunction in survivors of traumatic brain injury. J Clin Endocrinol Metab 2004 89 : 4929 4936. (Pubitemid 39391430)
8. Schneider HJ, Kreitschmann-Andermahr I, Ghigo E, et al. Hypothalamopituitary dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a systematic review. JAMA 2007 298 : 1429 1438. (Pubitemid 47481609)
9. Vance ML. Hypopituitarism. N Engl J Med 1994 330 : 1651 1662.
10. Bulow B, Hagman L, Orbaek P, et al. High incidence of mental disorders, reduced mental well-being and cognitive function in hypopituitary women with GH deficiency treated for pituitary disease. Clin Endocrinol (Oxf) 2002 56 : 183 193. (Pubitemid 34234799)
11. León-Carrión J, Leal-Cerro A, Cabezas FM, et al. Cognitive deterioration due to GH deficiency in patients with traumatic brain injury: a preliminary report. Brain Inj 2007 21 : 871 875. (Pubitemid 47244203)
12. Soares CN, Musolino NR, Cunha NM, et al. Impact of recombinant human growth hormone (RH-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults. A placebo-controlled trial. Art Neuropsiquiatr 1999 57 : 182 189.
13. Oertel H, Schneider HJ, Stalla GK, et al. The effect of growth hormone substitution on cognitive performance in adult patients with hypopituitarism. Psychoneuroendocrinology 2004 29 : 839 850. (Pubitemid 38716109)
14. Clayton P, Gleeson H, Monson J, et al. Growth hormone replacement throughout life: insights into age-related responses to treatment. Growth Horm IGF Res 2007 17 : 369 382. (Pubitemid 47342322)
15. Popovic V, Pekic S, Pavlovic D, et al. Hypopituitarism as a consequence of traumatic brain injury (TBI) and its possible relation with cognitive and mental distress. J Endocrinol Invest 2004 27 : 1048 1054.
16. Popovic V, Leal A, Micic D, et al. GH-releasing hormone and GH-releasing peptide-6 for diagnostic testing in GH-defient adults. Lancet 2000 356 : 1137 1142.
17. Kelestimur F, Popovic V, Leal A, et al. Effect of obesity and morbid obesity on the growth hormone (GH) secretion elicited by the combined GHRH + GHRP-6 test. Clin Endocrinol 2006 64 : 667 671. (Pubitemid 43775005)
18. Folstein MF, Folstein SE, McHugh PR. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiat Res 1975 12 : 189 198.
19. Rey A. L'examen Clinique en Psychologie.
20. Reitan RM, Wolfson D. The Halstead-Reitan Neuropsychological Test Battery: Theory and Clinical Interpretation.
21. Kaplan EF, Goodglass H, Weintraub S. The Boston Naming Test.
22. Heaton RK. A Manual for the Wisconsin Card Sorting Test.
23. Micic D, Popovic D, Doknic M, et al. Preserved growth hormone (GH) secretion in aged and very old subjects after testing with the combined stimulus GH-releasing hormone plus GH-releasing hexapeptide-6. J Clin Endocrinol Metab 1998 83 : 2569 2572. (Pubitemid 28503064)
24. Falleti MG, Maruff P, Burman P, et al. The effects of growth hormone (GH) deficiency and GH replacement on cognitive performance in adults: A meta-analysis of the current literature. Psychoneuroendocrinology 2006 31 : 681 691.
25. Nyberg F. Growth hormone in the brain: characteristics of specific brain targets for the hormone and their functional significance. Front Neuroendocrinol 2000 21 : 330 348.
26. Lai Z, Emtner M, Roos P, et al. Characterisation of putative growth hormone receptors in human choroid plexus. Brain Res 1991 546 : 222 226.
27. Nyberg F, Burman P. Growth hormone and its receptors in the central nervous system - Location and functional significance. Horm Res 1996 45 : 18 22. (Pubitemid 26034758)
28. Adem A, Jossan SS, d'Argy R, et al. Insulin-like growth factor I (IGF-1) receptors in the human brain: quantitative autoradiographic localization. Brain Res 1989 503 : 299 303. (Pubitemid 19285523)
29. Stein T, Moritz C, Quigley M, et al. Functional connectivity in the thalamus and hippocampus studied with functional MR imaging. Am J Neuroradiol 2000 21 : 1397 1401. (Pubitemid 32163459)
30. Ranganath C, Heller A, Cohen MX, et al. Functional connectivity with the hippocampus during successful memory formation. Hippocampus 2005 15 : 997 1005. (Pubitemid 43056989)
31. Svensson AL, Bucht N, Hallberg M, et al. Reversal of opiate-induced apoptosis by human recombinant growth hormone in murine foetus primary hippocampal neuronal cell cultures. PNAS 2008 105 : 7304 7308. (Pubitemid 351754473)
32. Fernandez S, Fernandez AM, Lopez-Lopez C, et al. Emerging roles of insulin-like growth factor-I in the adult brain. Growth Horm IGF Res 2007 17 : 89 95. (Pubitemid 46523779)
33. Link K, Moell C, Osterberg K, et al. Adult survivors of childhood acute lymphoblastic lekaemia with GH deficiency have normal self-rated quality of life but impaired neuropsychological performance 20 years after cranial irradiation. Clin Endocrinol 2006 65 : 617 625. (Pubitemid 44583822)
34. Smith-Seemiller L, Lovell MR, Smith S, et al. Impact of skull fracture on neuropsychological functioning following closed head injury. Brain Inj 1997 11 : 191 196. (Pubitemid 27105459)
35. Gentry LR. Head trauma. In : Atlas SW, ed. Magnetic Resonance Imaging of the Brain and Spine.