Psychiatric and neuropsychological changes in growth hormone-deficient patients after traumatic brain injury in response to growth hormone therapy

Journal of Endocrinological Investigation

Volumn 33, Issue 11, 2010, Pages 770-775

  Maric, Nadja P ^a,b   Doknic, M ^b,c   Pavlovic, D ^b,c   Pekic, S ^b,c   Stojanovic, M ^c   Jasovic Gasic, M ^a,b   Popovic, V ^b,c  

^a UCC   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c Belgrade University   (Serbia)

Author keywords

Depression; GH deficiency; GH therapy; Psychiatric symptoms; Traumatic brain injury

Indexed keywords

HUMAN GROWTH HORMONE; VENLAFAXINE;

ADULT; ANXIETY; APTITUDE TEST; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG WITHDRAWAL; FEMALE; GROWTH HORMONE DEFICIENCY; HORMONAL THERAPY; HOSTILITY; HUMAN; MAJOR DEPRESSION; MALE; NEUROPSYCHOLOGY; OBSESSIVE COMPULSIVE DISORDER; PARANOIA; PHOBIA; PSYCHIATRY; PSYCHOLOGIC TEST; PSYCHOSIS; RANDOMIZED CONTROLLED TRIAL; SEMI STRUCTURED INTERVIEW; SOCIAL DISABILITY; SOMATIZATION; SYMPTOM CHECKLIST 90; TRAUMATIC BRAIN INJURY; TREATMENT DURATION; VERBAL MEMORY; ZUNG DEPRESSION INVENTORY;

ADULT; ANXIETY; BRAIN INJURIES; COGNITION DISORDERS; DEPRESSION; FEMALE; HORMONE REPLACEMENT THERAPY; HUMAN GROWTH HORMONE; HUMANS; HYPOPITUITARISM; MALE; MIDDLE AGED; QUALITY OF LIFE; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 79952658005     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.3275/7045     Document Type: Article

References (29)

1. Aimaretti G, Ambrosio M, Di Somma C, et al. Traumatic brain injury and subarachnoid haemorrhage are conditions at high risk for hypopituitarism: screening study at 3 months after the brain injury. Clin Endocrinol (Oxf) 2004, 61: 320-6. (Pubitemid 39287060)
2. Popovic V, Pekic S, Pavlovic D, et al. Hypopituitarism as a consequence of traumatic brain injury (TBI) and its possible relation with cognitive disabilities and mental distress. J Endocrinol Invest 2004, 11: 1048-54.
3. Agha A, Rogers B, Sherlock M, et al. Anterior pituitary dysfunction in survivors of traumatic brain injury. J Clin Endocrinol Metab 2004, 89: 4929-36. (Pubitemid 39391430)
4. Deijen JB, de Boer H, van der Veen EA. Cognitive changes during growth hormone replacement in adult men. Psychoneuroendocrinology 1998, 23: 45-55. (Pubitemid 28252966)
5. Soares CN, Musolino NR, Cunha NM, et al. Impact of recombinant human growth hormone (RH-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults. A placebo-controlled trial. Art Neuropsiquiatr 1999, 57: 182-9. (Pubitemid 29247147)
6. Oertel H, Schneider HJ, Stalla GK, et al. The effect of growth hormone substitution on cognitive performance in adult patients with hypopituitarism. Psychoneuroendocrinology 2004, 29: 839-50. (Pubitemid 38716109)
7. Arwert LI, Deijen JB, Witlox J, Drent ML. The influence of growth hormone (GH) substitution on patient-reported outcomes and cognitive functions in GH-deficient patients: a meta-analysis. Growth Horm IGF Res 2005, 15: 47-54. (Pubitemid 40220855)
8. Springer J, Chollet A. A traumatic car crash. Lancet 2001, 357: 1848.
9. Ho KK, 2007 GH Deficiency Consensus Workshop Participants. Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II: a statement of the GH Research Society in association with the European Society for Pediatric Endocrinology, Lawson Wilkins Society, European Society of Endocrinology, Japan Endocrine Society, and Endocrine Society of Australia. Eur J Endcocrinol 2007, 157: 695-700.
10. Popovic V, Leal A, Micic D, et al. GH-releasing hormone and GH-releasing peptide-6 for diagnostic testing in GH-deficient adults. Lancet 2000, 356: 1137-42.
11. Zung WWK. A self-rating depression scale. Arch Gen Psychiatry 1965, 12: 63-70.
12. Derogatis LR, Rickels K, Rock AF. The SCL-90 and the MMPI: A step in the validation of a new self-report scale. Br J Psychiatry 1976, 128: 280-9.
13. Hoofien D, Barak O, Vakil E, Gilboa A. Symptom checklist-90 revised scores in persons with traumatic brain injury: affective reactions or neurobehavioral outcomes of the injury?. Appl Neuropsychol 2005, 12: 30-9. (Pubitemid 40546160)
14. Folstein MF, Folstein SE, McHugh PR. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975, 12: 189-98.
15. Rey A. L'examen clinique en psychologie. Paris: Presses Universitaires de France 1964.
16. Reitan RM, Wolfson D. The Halstead-Reitan Neuropsychological Test Battery: Theory and clinical interpretation. Tucson, AZ: Neuropsychology Press, 1993.
17. Kaplan EF, Goodglass H, Weintraub S. The Boston Naming Test. Boston MA: Kaplan and Goodglass, 1978.
18. Heaton RK. A manual for the Wisconsin Card Sorting Test. Odessa Fl: Psychological Assessment Resources Inc, 1981.
19. Adem A, Jossan SS, d'Argy R, et al. Insulin-like growth factor I (IGF-I) receptors in the human brain: quantitative autoradiographic localization. Brain Res 1989, 503: 299-303.
20. Creyghton WM, van Dam PS, Koppeschaar HP. The role of the somatotropic system in cognition and other cerebral functions. Semin Vasc Med 2004, 4: 167-72. (Pubitemid 39433668)
21. Ranganath C, Heller A, Cohen MX, et al. Functional connectivity with the hippocampus during successful memory formation. Hippocampus 2005, 15: 997-1005. (Pubitemid 43056989)
22. Bonne O, Vythilingam M, Inagaki M, et al. Reduced posterior hippocampal volume in posttraumatic stress disorder. J Clin Psychiatry 2008, 69: 1087-91. (Pubitemid 352031591)
23. Johansson J, Larson G, Andersson M, et al. Treatment of growth hormone-deficient adults with recombinant human growth hormone increases concentration of growth hormone in cerebrospinal fluid and affects neurotransmitters. Neuroendocrinology 1995,61: 57-66.
24. Schneider HJ, Pagotto U, Stalla GK. Central effects of the somatotropic system. Eur J Endocrinol 2003, 149: 377-92. (Pubitemid 37461517)
25. Newcomer J, Krystal J. NMDA receptor regulation of memory and behaviour in humans. Hippocampus 2001,11: 529-42. (Pubitemid 33100374)
26. Lasaite L, Bunevicius R, Lasiene D, et al. Psychological functioning after growth hormone therapy in adult growth hormone deficient patients: endocrine and body composition correlates. Medicina (Kaunas) 2004, 40: 740-4.
27. Clayton P, Gleeson H, Monson J, et al. Growth hormone replacement throughout life: insights into age-related responses to treatment. Growth Horm IGF Res 2007, 17: 369-82. (Pubitemid 47342322)
28. Nilsson AG, Svensson JJ, Johannsson G. Management of growth hormone deficiency in adults. Growth Horm IGF Res 2007, 17: 441-62. (Pubitemid 350063727)
29. Huisman J, Aukema EJ, Deijen JB, et al. The usefulness of growth hormone treatment for psychological status in young adult survivors of childhood leukaemia: an open-label study. BMC Pediatrics 2008, 8: 25-32.