Activation of N-methyl-d-aspartate receptor downregulates inflammasome activity and liver inflammation via a-arrestin-2 pathway

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 307, Issue 7, 2014, Pages G732-G740

  Farooq, Ahmad ^a,c   Hoque, Rafaz ^a   Ouyang, Xinshou ^a   Farooq, Ahsan ^a   Ghani, Ayaz ^a   Ahsan, Kaimul ^a   Guerra, Mateus ^a   Mehal, Wajahat Zafar ^a,b  

^a YALE UNIVERSITY   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Aspartate

Indexed keywords

AMINO ACID RECEPTOR STIMULATING AGENT; ANTIINFLAMMATORY AGENT; ASPARTIC ACID; BETA ARRESTIN; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; IL1B PROTEIN, MOUSE; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN PRECURSOR; RETINA S ANTIGEN;

AGONISTS; ANIMAL; C57BL MOUSE; CELL LINE; DISEASE MODEL; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; GENETICS; HUMAN; IMMUNOLOGY; LIVER; MACROPHAGE; MALE; METABOLISM; PANCREATITIS; SIGNAL TRANSDUCTION; TIME;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARRESTINS; ASPARTIC ACID; CARRIER PROTEINS; CASPASE 1; CELL LINE; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; EXCITATORY AMINO ACID AGONISTS; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; LIVER; MACROPHAGES; MALE; MICE, INBRED C57BL; PANCREATITIS; PROTEIN PRECURSORS; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84907528204     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00073.2014     Document Type: Article

References (35)

1. Bauernfeind F, Ablasser A, Bartok E, Kim S, Schmid-Burgk J, Cavlar T, Hornung V. Inflammasomes: current understanding and open questions. Cell Mol Life Sci 68: 765–783, 2011.
2. Brothwell SL, Barber JL, Monaghan DT, Jane DE, Gibb AJ, Jones S. NR2Band NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones. J Physiol 586: 739–750, 2008.
3. Cava F, Lam H, de Pedro MA, Waldor MK. Emerging knowledge of regulatory roles of D-amino acids in bacteria. Cell Mol Life Sci 68: 817–831, 2011.
4. Cynober LA. Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition 18: 761–766, 2002.
5. Fan H, Luttrell LM, Tempel GE, Senn JJ, Halushka PV, Cook JA. Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression. Mol Immunol 44: 3092–3099, 2007.
6. Feng B, Wu S, Lv S, Liu F, Chen H, Yan X, Li Y, Dong F, Wei L. Metabolic profiling analysis of a D-galactosamine/lipopolysaccharide-induced mouse model of fulminant hepatic failure. J Proteome Res 6: 2161–2167, 2007.
7. Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482: 179–185, 2012.
8. Henao-Mejia J, Elinav E, Strowig T, Flavell RA. Inflammasomes: far beyond inflammation. Nat Immunol 13: 321–324, 2012.
9. Kash TL, Matthews RT, Winder DG. Alcohol inhibits NR2B-containing NMDA receptors in the ventral bed nucleus of the stria terminalis. Neuropsychopharmacology 33: 1379–1390, 2008.
10. Krawczyk CM, Holowka T, Sun J, Blagih J, Amiel E, DeBerardinis RJ, Cross JR, Jung E, Thompson CB, Jones RG, Pearce EJ. Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood 115: 4742–4749, 2010.
11. Kubes P, Mehal WZ. Sterile Inflammation in the liver. Gastroenterology 143: 1158–1172, 2012.
12. Lam H, Oh DC, Cava F, Takacs CN, Clardy J, de Pedro MA, Waldor MK. D-Amino acids govern stationary phase cell wall remodeling in bacteria. Science 325: 1552–1555, 2009.
13. Malik AF, Hoque R, Ouyang X, Ghani A, Hong E, Khan K, Moore LB, Ng G, Munro F, Flavell RA, Shi Y, Kyriakides TR, Mehal WZ. Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response. Proc Natl Acad Sci USA 108: 20095–20100, 2011.
14. Mariathasan S, Monack DM. Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol 7: 31–40, 2007.
15. McBain CJ, Kleckner NW, Wyrick S, Dingledine R. Structural requirements for activation of the glycine coagonist site of N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Mol Pharmacol 36: 556–565, 1989.
16. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H, Olefsky JM, Brenner DA, Seki E. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology 139: 323–334, 2010.
17. Nagata Y, Fujiwara T, Kawaguchi-Nagata K, Fukumori Y, Yamanaka T. Occurrence of peptidyl D-amino acids in soluble fractions of several eubacteria, archaea and eukaryotes. Biochim Biophys Acta 1379: 76–82, 1998.
18. Nagy J. Alcohol related changes in regulation of NMDA receptor functions. Curr Neuropharmacol 6: 39–54, 2008.
19. Nishikawa M, Kimura S, Akaike N. Facilitatory effect of docosahexaenoic acid on N-methyl-D-aspartate response in pyramidal neurones of rat cerebral cortex. J Physiol 475: 83–93, 1994.
20. O’Neill LA, Hardie DG. Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature 493: 346–355, 2013.
21. Ockenga J, Borchert K, Stuber E, Lochs H, Manns MP, Bischoff SC. Glutamine-enriched total parenteral nutrition in patients with inflammatory bowel disease. Eur J Clin Nutr 59: 1302–1309, 2005.
22. Parameswaran N, Pao CS, Leonhard KS, Kang DS, Kratz M, Ley SC, Benovic JL. Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages. J Biol Chem 281: 34159–34170, 2006.
23. Petrasek J, Bala S, Csak T, Lippai D, Kodys K, Menashy V, Barrieau M, Min SY, Kurt-Jones EA, Szabo G. IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. J Clin Invest 122: 3476–3489, 2012.
24. Pontrello CG, Sun MY, Lin A, Fiacco TA, DeFea KA, Ethell IM. Cofilin under control of beta-arrestin-2 in NMDA-dependent dendritic spine plasticity, long-term depression (LTD), and learning. Proc Natl Acad Sci USA 109: E442–451, 2012.
25. Porter KJ, Gonipeta B, Parvataneni S, Appledorn DM, Patial S, Sharma D, Gangur V, Amalfitano A, Parameswaran N. Regulation of lipopolysaccharide-induced inflammatory response and endotoxemia by beta-arrestins. J Cell Physiol 225: 406–416, 2010.
26. Pullan LM, Olney JW, Price MT, Compton RP, Hood WF, Michel J, Monahan JB. Excitatory amino acid receptor potency and subclass specificity of sulfur-containing amino acids. J Neurochem 49: 1301–1307, 1987.
27. Rodriguez-Prados JC, Traves PG, Cuenca J, Rico D, Aragones J, Martin-Sanz P, Cascante M, Bosca L. Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation. J Immunol 185: 605–614, 2010.
28. Samuel BS, Shaito A, Motoike T, Rey FE, Backhed F, Manchester JK, Hammer RE, Williams SC, Crowley J, Yanagisawa M, Gordon JI. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci USA 105: 16767–16772, 2008.
29. Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, Chi H. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med 208: 1367–1376, 2011.
30. Sobolevsky AI, Rosconi MP, Gouaux E. X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature 462: 745–756, 2009.
31. Tonack S, Tang C, Offermanns S. Endogenous metabolites as ligands for G protein-coupled receptors modulating risk factors for metabolic and cardiovascular disease. Am J Physiol Heart Circ Physiol 304: H501–H513, 2013.
32. Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R. Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev 62: 405–496, 2010.
33. Wang Y, Tang Y, Teng L, Wu Y, Zhao X, Pei G. Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 7: 139–147, 2006.
34. Watanabe A, Sohail MA, Gomes DA, Hashmi A, Nagata J, Sutterwala FS, Mahmood S, Jhandier MN, Shi Y, Flavell RA, Mehal WZ. Inflammasome-mediated regulation of hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 296: G1248–G1257, 2009.
35. Yin Y, Pastrana JL, Li X, Huang X, Mallilankaraman K, Choi ET, Madesh M, Wang H, Yang XF. Inflammasomes: sensors of metabolic stresses for vascular inflammation. Front Biosci 18: 638–649, 2013.