Subdomain II of α-lsopropylmalate synthase is essential for activity

Journal of Biological Chemistry

Volumn 289, Issue 40, 2014, Pages 27966-27978

  Zhang, Zilong ^a,g   Wu, Jian ^c   Lin, Wei ^a   Wang, Jin ^a   Yan, Han ^a   Zhao, Wei ^d   Ma, Jun ^a   Ding, Jianping ^c   Zhang, Peng ^a,b   Zhao, Guo Ping ^a,d,e,f  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b INSTITUTE OF PLANT PHYSIOLOGY AND ECOLOGY   (China)

^c INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^d FUDAN UNIVERSITY   (China)

^e CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

^f CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^g Shanghai Entry Exit Inspection and Quarantine Bureau   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; BIOCHEMISTRY; CATALYSIS; CONFORMATIONS; ENZYME INHIBITION;

ALLOSTERIC ENZYMES; BINDING AFFINITIES; CONFORMATION TRANSITIONS; COOPERATIVE CATALYSIS; FEEDBACK INHIBITION; HYDROGEN-DEUTERIUM EXCHANGE; MYCOBACTERIUM TUBERCULOSIS; STRUCTURAL COMPARISON;

CATALYST ACTIVITY;

2 ISOPROPYLMALATE SYNTHASE; ACETYL COENZYME A; ARGININE; ASPARTIC ACID; GLYCINE; LEUCINE; PHENYLALANINE; SERINE; TYROSINE; VALINE; BACTERIAL PROTEIN;

AMINO ACID COMPOSITION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BIOCHEMISTRY; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE DELETION; LEPTOSPIRA; LEPTOSPIRA BIFLEXA; MYCOBACTERIUM TUBERCULOSIS; NEGATIVE FEEDBACK; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SEQUENCE ALIGNMENT; STRUCTURE ANALYSIS; THERMOSTABILITY; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; FEEDBACK SYSTEM; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

2-ISOPROPYLMALATE SYNTHASE; ACETYL COENZYME A; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; FEEDBACK, PHYSIOLOGICAL; KINETICS; LEPTOSPIRA; LEUCINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

EID: 84907495537     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.559716     Document Type: Article

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