Spred-2 deficiency exacerbates lipopolysaccharide-induced acute lung inflammation in mice

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Xu, Yang ^a   Ito, Toshihiro ^a   Fushimi, Soichiro ^a   Takahashi, Sakuma ^a   Itakura, Junya ^a   Kimura, Ryojiro ^a   Sato, Miwa ^a   Mino, Megumi ^a   Yoshimura, Akihiko ^b   Matsukawa, Akihiro ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CXCL2 CHEMOKINE; CYTOKINE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; REGULATOR PROTEIN; SMALL INTERFERING RNA; SPROUTY RELATED EVH1 DOMAIN CONTAINING PROTEIN 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CCL2 PROTEIN, MOUSE; NITRILE; REPRESSOR PROTEIN; SPRED2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE EXACERBATION; ENZYME ACTIVATION; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNOPATHOLOGY; IN VITRO STUDY; LUNG ALVEOLUS MACROPHAGE; MALE; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PNEUMONIA; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; ACUTE DISEASE; ANIMAL; C57BL MOUSE; CELL LINE; DEFICIENCY; DISEASE COURSE; DRUG EFFECTS; ENZYMOLOGY; EPITHELIUM CELL; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

MUS;

ACUTE DISEASE; ANIMALS; BUTADIENES; CELL LINE; CHEMOKINE CCL2; CHEMOKINE CXCL2; DISEASE PROGRESSION; ENZYME ACTIVATION; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES, ALVEOLAR; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRILES; PNEUMONIA; REPRESSOR PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84907486843     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108914     Document Type: Article

References (38)

1. Matthay MA, Zemans R.L. (2011) The acute respiratory distress syndrome: pathogenesis and treatment. Annu Rev Pathol 6: 147-163.
2. Matthay MA, Ware LB, Zimmerman G.A. (2012) The acute respiratory distress syndrome. J Clin Invest 122: 2731-2740.
3. Bhatia M, Moochhala S. (2004) Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol 202: 145-156.
4. Jarrar D, Kuebler JF, Rue L.W., Matalon S., Wang P, et al. (2002) Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NF-kappaB and MAPK/ERK mechanisms. Am J Physiol Lung Cell Mol Physiol 283: L799-L805.
5. Wang L, Taneja R, Wang W., Yao LJ, Veldhuizen RA, et al. (2013) Human alveolar epithelial cells attenuate pulmonary microvascular endothelial cell permeability under septic conditions. PLoS One 8: e55311.
6. Meduri GU, Headley S, Kohler G., Stentz F, Tolley E, et al. (1995) Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1 beta and IL-6 levels are consistent and efficient predictors of outcome over time. Chest 107: 1062-1073.
7. Guha M, Mackman N. (2001) LPS induction of gene expression in human monocytes. Cell Signal 13: 85-94.
8. Arthur JS, Ley S.C. (2013) Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol 13: 679-692.
9. Nick JA, Young SK, Arndt P.G., Lieber JG, Suratt BT, et al. (2002) Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase. J Immunol 169: 5260-5269.
10. Lee HS, Kim HJ, Moon C.S., Chong YH, Kang J.L. (2004) Inhibition of c-Jun NH2-terminal kinase or extracellular signal-regulated kinase improves lung injury. Respir Res 5: 23.
11. Schuh K, Pahl A. (2009) Inhibition of the MAP kinase ERK protects from lipopolysaccharide-induced lung injury. Biochem Pharmacol 77: 1827-1834.
12. Fang WF, Cho JH, He Q, Lin M.C., Wu CC, et al. (2007) Lipid A fraction of LPS induces a discrete MAPK activation in acute lung injury. Am J Physiol Lung Cell Mol Physiol 293: L336-L344.
13. Wakioka T, Sasaki A, Kato R., Shouda T, Matsumoto A, et al. (2001) Spred is a Sprouty-related suppressor of Ras signalling. Nature 412: 647-651.
14. Engelhardt CM, Bundschu K, Messerschmitt M., Renne T, Walter U, et al. (2004) Expression and subcellular localization of Spred proteins in mouse and human tissues. Histochem Cell Biol 122: 527-538.
15. Kato R, Nonami A, Taketomi T., Wakioka T, Kuroiwa A, et al. (2003) Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. Biochem Biophys Res Commun 302: 767-772.
16. Nobuhisa I, Kato R, Inoue H., Takizawa M, Okita K, et al. (2004) Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation. J Exp Med 199: 737-742.
17. Taniguchi K, Kohno R, Ayada T., Kato R, Ichiyama K, et al. (2007) Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling. Mol Cell Biol 27: 4541-4550.
18. Matsukawa A, Kaplan MH, Hogaboam C.M., Lukacs NW, Kunkel S.L. (2001) Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis. J Exp Med 193: 679-688.
19. Matsukawa A, Kudo S, Maeda T., Numata K, Watanabe H, et al. (2005) Stat3 in resident macrophages as a repressor protein of inflammatory response. J Immunol 175: 3354-3359.
20. Suntharalingam G, Perry MR, Ward S, Brett S.J., Castello-Cortes A, et al. (2006) Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 355: 1018-1028.
21. Li X, Jiang S, Tapping R.I. (2010) Toll-like receptor signaling in cell proliferation and survival. Cytokine 49: 1-9.
22. Maus UA, Koay MA, Delbeck T, Mack M., Ermert M, et al. (2002) Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice. Am J Physiol Lung Cell Mol Physiol 282: L1245-L1252.
23. Musah S, DeJarnett N, Hoyle G.W. (2012) Tumor necrosis factor-alpha mediates interactions between macrophages and epithelial cells underlying proinflamma-tory gene expression induced by particulate matter. Toxicology 299: 125-132.
24. Rubenfeld GD, Caldwell E, Peabody E., Weaver J, Martin DP, et al. (2005) Incidence and outcomes of acute lung injury. N Engl J Med 353: 1685-1693.
25. Asti C, Ruggieri V, Porzio S., Chiusaroli R, Melillo G, et al. (2000) Lipopolysaccharide-induced lung injury in mice. I. Concomitant evaluation of inflammatory cells and haemorrhagic lung damage. Pulm Pharmacol Ther 13: 61-69.
26. Hussell T, Bell T.J. (2014) Alveolar macrophages: plasticity in a tissue-specific context. Nat Rev Immunol 14: 81-93.
27. Lohmann-Matthes ML, Steinmuller C, Franke-Ullmann G (1994) Pulmonary macrophages. Eur Respir J 7: 1678-1689.
28. Ryu JH, Kim CH, Yoon J.H. (2010) Innate immune responses of the airway epithelium. Mol Cells 30: 173-183.
29. Sharma AK, Fernandez LG, Awad A.S., Kron IL, Laubach V.E. (2007) Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-alpha during pulmonary ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol 293: L105-L113.
30. Medzhitov R, Horng T. (2009) Transcriptional control of the inflammatory response. Nat Rev Immunol 9: 692-703.
31. Junttila MR, Li SP, Westermarck J. (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J 22: 954-965.
32. Aksamitiene E, Kiyatkin A, Kholodenko B.N. (2012) Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance. Biochem Soc Trans 40: 139-146.
33. Menges CW, McCance D.J. (2008) Constitutive activation of the Raf-MAPK pathway causes negative feedback inhibition of Ras-PI3K-AKT and cellular arrest through the EphA2 receptor. Oncogene 27: 2934-2940.
34. Fey D, Croucher DR, Kolch W, Kholodenko B.N. (2012) Crosstalk and signaling switches in mitogen-activated protein kinase cascades. Front Physiol 3: 355.
35. Carter AB, Monick MM, Hunninghake G.W. (1998) Lipopolysaccharide-induced NF-kappaB activation and cytokine release in human alveolar macrophages is PKC-independent and TK- and PC-PLC-dependent. Am J Respir Cell Mol Biol 18: 384-391.
36. Aga M, Watters JJ, Pfeiffer Z.A., Wiepz GJ, Sommer JA, et al. (2004) Evidence for nucleotide receptor modulation of cross talk between MAP kinase and NF-kappa B signaling pathways in murine RAW 264.7 macrophages. Am J Physiol Cell Physiol 286: C923-C930.
37. Favata MF, Horiuchi KY, Manos E.J., Daulerio AJ, Stradley DA, et al. (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273: 18623-18632.
38. Matute-Bello G, Frevert CW, Martin T.R. (2008) Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol 295: L379-L399.