Rapid binding of plasminogen to streptokinase in a catalytic complex reveals a three-step mechanism

Journal of Biological Chemistry

Volumn 289, Issue 40, 2014, Pages 28006-28018

  Verhamme, Ingrid M ^a   Bock, Paul E ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS;

6-AMINOHEXANOIC ACIDS; CATALYTIC COMPLEXES; COMPLEX FORMATIONS; DELETION MUTANTS; ENCOUNTER COMPLEX; FORWARD REACTIONS; LYSINE-BINDING SITES; THREE-STEP MECHANISM;

BINDING SITES;

AMINOCAPROIC ACID; BENZAMIDINE; LYSINE; PLASMIN; PLASMINOGEN; STREPTOKINASE; BACTERIAL PROTEIN; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; GENE DELETION; KRINGLE DOMAIN; MOLECULAR RECOGNITION; PROTEIN PROTEIN INTERACTION; BIOCATALYSIS; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; HUMAN; KINETICS; METABOLISM; MICROBIOLOGY; PROTEIN CONFORMATION; PROTEIN MOTIF; STREPTOCOCCUS; STREPTOCOCCUS INFECTION;

AMINO ACID MOTIFS; BACTERIAL PROTEINS; BINDING SITES; BIOCATALYSIS; FIBRINOLYSIN; HUMANS; KINETICS; PLASMINOGEN; PROTEIN BINDING; PROTEIN CONFORMATION; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS; STREPTOKINASE; SUBSTRATE SPECIFICITY;

EID: 84907486109     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.589077     Document Type: Article

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