Effects of the Parkinsonian toxin MPP+ on electrophysiological properties of nigral dopaminergic neurons

NeuroToxicology

Volumn 45, Issue , 2014, Pages 1-11

  Yee, Andrew G ^a   Lee, Sun Min ^a   Hunter, Morag R ^a   Glass, Michelle ^a   Freestone, Peter S ^a   Lipski, Janusz ^a  

^a THE UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Brain slice; D2 autoreceptors; Dopamine; HCN channels; KATP channels

Indexed keywords

1 ETHYL 4 PHENYLPYRIDINIUM; 2 ETHYL 1,2,3,4,6,7 HEXAHYDRO 2 HYDROXY 3 ISOBUTYL 9,10 DIMETHOXY 11BH BENZO[A]QUINOLIZINE; 4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CYCLIC AMP; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE TRANSPORTER; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; NEUROTOXIN; RACLOPRIDE H 3; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; 1 METHYL 4 PHENYLPYRIDINIUM;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL DEATH; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINERGIC NERVE CELL; HUMAN; HUMAN CELL; HYPERPOLARIZATION; INHIBITION KINETICS; INTRACELLULAR RECORDING; INTRACELLULAR SIGNALING; ION CURRENT; MEMBRANE BINDING; MESENCEPHALON; NERVE CELL MEMBRANE POTENTIAL; NERVE FUNCTION; NEUROTOXICITY; NIGRAL DOPAMINERGIC NERVE CELL; NONHUMAN; PROTEIN DEPLETION; RAT; RECEPTOR BINDING; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TOXICOKINETICS; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; ELECTROPHYSIOLOGY; MEMBRANE POTENTIAL; METABOLISM; NERVE CELL INHIBITION; PARKINSONISM; SUBSTANTIA NIGRA; WISTAR RAT;

PARKINSONIA;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; DISEASE MODELS, ANIMAL; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINERGIC NEURONS; ELECTROPHYSIOLOGICAL PHENOMENA; KATP CHANNELS; MEMBRANE POTENTIALS; NEURAL INHIBITION; PARKINSONIAN DISORDERS; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE D2; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA;

EID: 84907465838     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2014.08.009     Document Type: Article

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