In-Vitro study of the effect of anti-hypertensive drugs on placental hormones and angiogenic proteins synthesis in pre-eclampsia

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Gangooly, Subrata ^a   Muttukrishna, Shanthi ^a,b   Jauniaux, Eric ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN A; CHORIONIC GONADOTROPIN; ENDOGLIN; HYDRALAZINE; INHIBIN A; LABETALOL; METHYLDOPA; PRAVASTATIN; VASCULOTROPIN RECEPTOR 1; ACTIVIN; ANGIOGENIC PROTEIN; ANTIHYPERTENSIVE AGENT; CELL SURFACE RECEPTOR; ENG PROTEIN, HUMAN; FLT1 PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; PLACENTAL PEPTIDE HORMONE;

ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MEGADOSE; EXPLANT; FEMALE; HORMONE BLOOD LEVEL; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; HUMAN TISSUE; IMMUNOASSAY; IN VITRO STUDY; LOW DRUG DOSE; OXYGEN CONCENTRATION; PREECLAMPSIA; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; PROTEIN SYNTHESIS; CHORION VILLUS; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; METABOLISM; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; TIME; TISSUE CULTURE TECHNIQUE;

ACTIVINS; ANGIOGENIC PROTEINS; ANTIGENS, CD; ANTIHYPERTENSIVE AGENTS; CHORIONIC GONADOTROPIN; CHORIONIC VILLI; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; HYDRALAZINE; LABETALOL; METHYLDOPA; PLACENTA; PLACENTAL HORMONES; PRAVASTATIN; PRE-ECLAMPSIA; PREGNANCY; RECEPTORS, CELL SURFACE; TIME FACTORS; TISSUE CULTURE TECHNIQUES; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 84907464933     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107644     Document Type: Article

References (45)

1. Pijnenborg R, Vercruysse L, Brosens I. (2011) Deep placentation. Best Pract Res Clin Obstet Gynaecol 25: 273-285.
2. Jauniaux E, Poston L, Burton G.J. (2006) Placental-related diseases of pregnancy: Involvement of oxidative stress and implications in human evolution. Hum Reprod Update 12: 747-755.
3. Khong Y, Brosens I. (2011) Defective deep placentation. Best Pract Res Clin Obstet Gynaecol. 25: 301-311.
4. Brosens I, Pijnenborg R, Vercruysse L., Romero R. (2011) The "Great Obstetrical Syndromes" are associated with disorders of deep placentation. Am J Obstet Gynecol. 204: 193-201.
5. Burton GJ, Charnock-Jones DS, Jauniaux E. (2006) Working with oxygen and oxidative stress in vitro. Methods Mol Med 122: 413-25.
6. Kimura C, Watanabe K, Iwasaki A., Mori T, Matsushita H, et al (2012) The severity of hypoxic changes and oxidative DNA damage in the placenta of early-onset preeclamptic women and fetal growth restriction. J Matern Fetal Neonatal Med 26: 491-496.
7. Hung TH, Skepper JN, Burton G.J. (2001) In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnancies. Am J Pathol 159: 1031-1043.
8. Hung T, Charnock-Jones D, Skepper J., Burton G. (2004) Secretion of tumour necrosis factor alpha from human placental tissues induced by hypoxia-reoxygenation causes endothelial cell activation in vitro: a potential mediator of inflammatory response in pre-eclampsia. Am J Pathol 164: 1049-1061.
9. Vanderlie J, Venardos K, Clifton V.L., Gude NM, Clarke FM, et al. (2005) Increased biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentae. Placenta 26: 53-58.
10. Lee SM, Romero R, Lee Y.J., Park IS, Park CW, et al. (2012) Systemic inflammatory stimulation by microparticles derived from hypoxic trophoblast as a model for inflammatory response in preeclampsia. Am J Obstet Gynecol 207: 337. e1-8.
11. Williams PJ, Morgan L. (2012) The role of genetics in pre-eclampsia and potential pharmacogenomic interventions. Pharmgenomics Pers Med 5: 37-51.
12. Vatten LJ, Asvold BO, Eskild A. (2012) Angiogenic factors in maternal circulation and preeclampsia with or without fetal growth restriction. Acta Obstet Gynecol Scand 91: 1388-1394.
13. Redman CW, Tannetta DS, Dragovic R.A., Gardiner C., Southcombe JH, et al. (2012) Review: Does size matter? Placental debris and the pathophysiology of pre-eclampsia. Placenta 33: S48-54.
14. Anderson UD, Olsson MG, Kristensen K.H., Åkerström B, Hansson SR (2012) Biochemical markers to predict preeclampsia. Placenta 33: S42-47.
15. Kleinrouweler CE, Wiegerinck MM, Ris-Stalpers C, Bossuyt P.M., van der Post JA, et al. (2012) Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia: a systematic review and meta-analysis. BJOG 119: 778-787.
16. Khalil A, Muttukrishna S, Harrington K., Jauniaux E. (2008) Effect of Antihypertensive Therapy with Alpha Methyldopa on Levels of Angiogenic Factors in Pregnancies with Hypertensive Disorders. PLoS ONE 3: e2766.
17. Khalil A, Jauniaux E, Harrington K., Muttukrishna S. (2009) Placental production and maternal serum and urine levels of inhibin A and activin A are modified by antihypertensive therapy in hypertensive disorders of pregnancy. Clin Endocrinol 70: 924-391.
18. Kucukgoz Gulec U., Ozgunen FT, Buyukkurt S, Guzel A.B., Urunsak IF, et al. (2013) Comparison of Clinical and Laboratory Findings in Early- and Late-Onset Preeclampsia. J Matern Fetal Neonatal Med 26: 1228-1233.
19. Brown MA, Lindheimer MD, de Swiet M, Van Assche A, Moutquin J.M. (2001) The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP) Hypertens Pregnancy 20: IX-XIV.
20. Xu B, Makris A, Thornton C., Ogle R, Horvath JS, et al (2006) Antihypertensive drugs clonidine, diazpxide, hydralazine and furosemide regulate the production of cytokines by placenta and peripheral blood mononuclear cells in normal pregnancy. J Hypertension 24: 915-922.
21. Xu B, Thornton C, Tooher J., Ogle R, Lim S, et al (2009) Effects of anti-hypertensive drugs on production of soluble fms-like tyrosine kinase 1 and soluble endoglin from human normal and pre-eclamptic placentas in vitro. Clin Exp Pharmacol Physiol 36: 839-842.
22. Muttukrishna S, Fowler PA, George L, Groome N.P., Knight P.G. (1996) Changes in peripheral serum levels of total activin A during the human menstrual cycle and pregnancy. J Clin Endocrinol Metab 81: 3328-3334.
23. Muttukrishna S, Jauniaux E, McGarrigle H., Groome N, Rodeck C.H. (2004) In-vivo concentrations of inhibins, activin A and follistatin in human early pregnancy. Reprod Biomed Online 8: 712-719.
24. Royle C, Lim S, Xu B., Tooher J, Ogle R, et al (2009) Effect of hypoxia and exogenous IL-10 on the pro-inflammatory cytokine TNF-alpha and the anti-angiogenic molecule soluble Flt-1 in placental villous explants. Cytokine 47: 56-60.
25. Orendi K, Kivity V, Sammar M., Grimpel Y, Gonen R, et al (2011) Placental and trophoblastic in vitro models to study preventive and therapeutic agents for preeclampsia. Placenta 32: S49-54.
26. Vest AR, Cho L.S. (2012) Hypertension in pregnancy. Cardiol Clin 30: 407-423.
27. Kattah AG, Garovic V.D. (2013) The management of hypertension in pregnancy. Adv Chronic Kidney Dis 20: 229-239.
28. Cohn JN, McInnes GT, Shepherd A.M. (2011) Direct-acting vasodilators. J Clin Hypertens 13: 690-692.
29. Head GA, Chan CK, Burke S.L. (1998) Relationship between imidazoline and alpha2-adrenoceptors involved in the sympatho-inhibitory actions of centrally acting antihypertensive agents. J Auton Nerv Syst 72: 163-169.
30. Head GA (1999) Central imidazoline- and alpha 2-receptors involved in the cardiovascular actions of centrally acting antihypertensive agents. Ann N Y A-cad Sci 881: 279-286.
31. Falkay G, Melis K, Kovacs L. (1994) Correlation between beta- and alpha-adrenergic receptor concentrations in human placenta. J Recept Res 14: 187-195.
32. Leitch IM, Read MA, Boura A.L., Walters W.A. (1994) Effect of inhibition of nitric oxide synthase and guanylatecyclase on hydralazine-induced vasodilatation of the human fetal placental circulation. Clin Exp Pharmacol Physiol 2: 615-622.
33. Sibai BM, Caritis SN, Thom E, Klebanoff M., McNellis D, et al. (1993) Prevention of preeclampsia with low-dose aspirin in healthy, nulliparous pregnant women. The National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. N Engl J Med 329: 1213-1218.
34. Duggan ST (2012) Pitavastatin: a review of its use in the management of hypercholesterolaemia or mixed dyslipidaemia. Drugs 72: 565-584.
35. Costantine MM, Cleary K. (2013) Eunice Kennedy Shriver National Institute of Child Health and Human Development Obstetric-Fetal Pharmacology Research Units Network. Pravastatin for the prevention of preeclampsia in high-risk pregnant women. Obstet Gynecol 121: 349-353.
36. Reddy A, Suri S, Sargent I.L., Redman CW, Muttukrishna S. (2009) Maternal circulating levels of activin A, inhibin A, sFlt-1 and endoglin at parturition in normal pregnancy and pre-eclampsia. PLoS One 4:e4453.
37. Cindrova-Davies T., Yung HW, Johns J, Spasic-Boskovic O, Korolchuk S., et al. (2007) Oxidative stress, gene expression, and protein changes induced in the human placenta during labor. Am J Pathol 171: 1168-1179.
38. Watson AL, Skepper JN, Jauniaux E, Burton G.J. (1998) Susceptibility of human placental syncytiotrophoblastic mitochondria to oxygen-mediated damage in relation to gestational age. J Clin Endocrinol Metab 83: 1697-1705.
39. Jauniaux E, Watson AL, Hempstock J, Bao Y.P., Skepper JN, et al. (2000) Onset of maternal arterial blood flow and placental oxidative stress. A possible factor in human early pregnancy failure. Am J Pathol 2000; 157: 2111-2122.
40. Jauniaux E, Hempstock J, Greenwold N., Burton G.J. (2003) Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies. Am J Pathol 162: 115-125.
41. Muttukrishna S, Suri S, Groome N., Jauniaux E. (2008) Relationships between TGF-beta proteins and oxygen concentrations inside the first trimester human gestational sac. PLoS One 3:e2302.
42. Pidoux G, Gerbaud P, Cocquebert M., Segond N, Badet J, et al (2012) Human trophoblast fusion and differentiation: lessons from trisomy 21 placenta. Placenta 33: S81-86.
43. Bearfield C, Jauniaux E, Groome N., Sargent IL, Muttukrishna S. (2005) The secretion and effect of inhibin A, activin A and follistatin on first-trimester trophoblasts in vitro. Eur J Endocrinol 152: 909-916.
44. Nadeem L, Munir S, Fu G., Dunk C, Baczyk D, et al (2011) Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia. Am J Pathol 178: 1177-89.
45. Yu L, Li D, Liao Q.P., Yang HX, Cao B, et al. (2012) High levels of activin a detected in preeclamptic placenta induce trophoblast cell apoptosis by promoting nodal signalling. J Clin Endocrinol Metab 97: 1370-1379.