Rescue of the highly virulent classical swine fever virus strain "Koslov" from cloned cDNA and first insights into genome variations relevant for virulence

Virology

Volumn 468, Issue , 2014, Pages 379-387

  Fahnøe, Ulrik ^a   Pedersen, Anders Gorm ^a   Risager, Peter Christian ^a   Nielsen, Jens ^a,c   Belsham, Graham J ^a   Höper, Dirk ^b   Beer, Martin ^b   Rasmussen, Thomas Bruun ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^c STATENS SERUM INSTITUT   (Denmark)

Author keywords

Classical swine fever virus; CSFV; Flaviviridae; Full length cDNA clone; Koslov; Next generation sequencing; Pathogenesis; Pestivirus; Viral populations; Virulence

Indexed keywords

COMPLEMENTARY DNA; NONSTRUCTURAL PROTEIN 3;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CLASSICAL SWINE FEVER; CONTROLLED STUDY; FRAMESHIFT MUTATION; GENETIC VARIABILITY; IN VITRO STUDY; MOLECULAR CLONING; MORTALITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PESTIVIRUS; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS; SWINE; VIROGENESIS; VIRUS ATTENUATION; VIRUS INFECTIVITY; VIRUS STRAIN; VIRUS VIRULENCE; ANIMAL; CELL LINE; CLASSICAL SWINE FEVER VIRUS; CYTOLOGY; GENETICS; KIDNEY; METABOLISM; PATHOGENICITY; TIME; VIROLOGY; VIRULENCE; VIRUS GENOME;

CLASSICAL SWINE FEVER VIRUS; FLAVIVIRIDAE; PESTIVIRUS;

ANIMALS; CELL LINE; CLASSICAL SWINE FEVER; CLASSICAL SWINE FEVER VIRUS; CLONING, MOLECULAR; DNA, COMPLEMENTARY; GENETIC VARIATION; GENOME, VIRAL; KIDNEY; SWINE; TIME FACTORS; VIRULENCE;

EID: 84907462400     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2014.08.021     Document Type: Article

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