Reduction of specific circulating lymphocyte populations with metabolic risk factors in patients at risk to develop type 2 diabetes

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Cucak, Helena ^a   Vistisen, Dorte ^b   Witte, Daniel ^b   Philipsen, Annelotte ^b   Rosendahl, Alexander ^a  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

^b STENO DIABETES CENTER   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER; GLUCOSE; HEMOGLOBIN A1C; TOLL LIKE RECEPTOR 4; GLUCOSE BLOOD LEVEL; TLR4 PROTEIN, HUMAN;

ADULT; AGE; AGED; ARTICLE; BODY MASS; CD4+ T LYMPHOCYTE; CELL COMPOSITION; CELL EXPANSION; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FASTING INSULIN; FASTING PLASMA GLUCOSE; FEMALE; FLOW CYTOMETRY; FOOD INTAKE; HOMEOSTASIS MODEL ASSESSMENT OF BETA CELL FUNCTION; HOMEOSTASIS MODEL ASSESSMENT OF INSULIN SENSITIVITY; HUMAN; IMMUNOCOMPETENT CELL; IMPAIRED GLUCOSE TOLERANCE; LYMPHOCYTE COUNT; MALE; MEDICAL PARAMETERS; METABOLIC RISK FACTOR; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; REGULATORY T LYMPHOCYTE; RISK ASSESSMENT; RISK FACTOR; SEX DIFFERENCE; AGING; BLOOD; CELL COUNT; CYTOLOGY; EATING; ENDOTHELIAL PROGENITOR CELL; GLUCOSE BLOOD LEVEL; IMMUNOLOGY; LYMPHOCYTE; METABOLISM; MIDDLE AGED; MONOCYTE; T LYMPHOCYTE;

AGING; BLOOD GLUCOSE; CELL COUNT; DIABETES MELLITUS, TYPE 2; EATING; ENDOTHELIAL PROGENITOR CELLS; FEMALE; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED; MONOCYTES; RISK FACTORS; T-LYMPHOCYTES; TOLL-LIKE RECEPTOR 4;

EID: 84907457092     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107140     Document Type: Article

References (51)

1. Nguyen DM, El-Serag HB (2010) The epidemiology of obesity. Gastroenterol Clin North Am 39: 1-7.
2. Leibson CL, Williamson DF, Melton LJ 3rd, Palumbo PJ, Smith SA, et al. (2001) Temporal trends in BMI among adults with diabetes. Diabetes Care 24: 1584-1589.
3. Naser KA, Gruber A, Thomson GA (2006) The emerging pandemic of obesity and diabetes: are we doing enough to prevent a disaster? Int J Clin Pract 60: 1093-1097.
4. Shaw JE, Sicree RA, Zimmet PZ (2010) Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 87: 4-14.
5. Carlsson LMS, Peltonen M, Ahlin S, Anveden Å, Bouchard C, et al. (2012) Bariatric Surgery and Prevention of Type 2 Diabetes in Swedish Obese Subjects. New England Journal of Medicine 367: 695-704.
6. Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, et al. (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344: 1343-1350.
7. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, et al. (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346: 393-403.
8. Donath MY, Shoelson SE (2011) Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 11: 98-107.
9. Wellen KE, Hotamisligil GS (2005) Inflammation, stress, and diabetes. The Journal of Clinical Investigation 115: 1111-1119.
10. Fabrizi M, Marchetti V, Mavilio M, Marino A, Casagrande V, et al. (2014) IL-21 is a major negative regulator of IRF4-dependent lipolysis affecting Tregs in adipose tissue and systemic insulin sensitivity. Diabetes.
11. Kintscher U, Hartge M, Hess K, Foryst-Ludwig A, Clemenz M, et al. (2008) T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol 28: 1304-1310.
12. Samad F, Yamamoto K, Pandey M, Loskutoff DJ (1997) Elevated expression of transforming growth factor-beta in adipose tissue from obese mice. Mol Med 3: 37-48.
13. Rimmele T, Kaynar A, McLaughlin J, Bishop J, Fedorchak M, et al. (2013) Leukocyte capture and modulation of cell-mediated immunity during human sepsis: an ex vivo study. Critical Care 17: R59.
14. Vozarova B, Weyer C, Lindsay RS, Pratley RE, Bogardus C, et al. (2002) High White Blood Cell Count Is Associated With a Worsening of Insulin Sensitivity and Predicts the Development of Type 2 Diabetes. Diabetes 51: 455-461.
15. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. (2001) C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286: 327-334.
16. Cucak H, Mayer C, Tonnesen M, Thomsen LH, Grunnet LG, Rosendahl A. (2014) Macrophage contact dependent and independent TLR4 mechanisms induce beta-cell dysfunction and apoptosis in a mouse model of type 2 diabetes. PLoS One 9: e90685.
17. Baker C, Chang L, Elsegood KA, Bishop AJ, Gannon DH, et al. (2007) Activated T cell subsets in human type 1 diabetes: evidence for expansion of the DR+ CD30+ subpopulation in new-onset disease. Clin Exp Immunol 147: 472-482.
18. Xu X, Shi Y, Cai Y, Zhang Q, Yang F, et al. (2013) Inhibition of Increased Circulating Tfh Cell by Anti-CD20 Monoclonal Antibody in Patients with Type 1 Diabetes. PLoS One 8: e79858.
19. Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, et al. (2000) Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 408: 57-63.
20. Deenick EK, Tangye SG (2007) Autoimmunity: IL-21: a new player in Th17-cell differentiation. Immunol Cell Biol 85: 503-505.
21. Beutler B, Hoebe K, Du X, Ulevitch RJ (2003) How we detect microbes and respond to them: the Toll-like receptors and their transducers. Journal of Leukocyte Biology 74: 479-485.
22. Caramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, et al. (2003) Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide. The Journal of Experimental Medicine 197: 403-411.
23. Liu G, Zhao Y (2007) Toll-like receptors and immune regulation: their direct and indirect modulation on regulatory CD4+ CD25+ T cells. Immunology 122: 149-156.
24. Johansen NB, Hansen AL, Jensen TM, Philipsen A, Rasmussen SS, et al. (2012) Protocol for ADDITION-PRO: a longitudinal cohort study of the cardiovascular experience of individuals at high risk for diabetes recruited from Danish primary care. BMC Public Health 12: 1078.
25. Breiman L (2001) Random forests. Machine Learning 45: 5-32.
26. Breiman L (1984) Classification and regression trees. Belmont, Calif.: Wads-worth International Group. x, 358 p.
27. Benjamini Y, Drai D, Elmer G, Kafkafi N, Golani I (2001) Controlling the false discovery rate in behavior genetics research. Behav Brain Res 125: 279-284.
28. Lippi G, Lima-Oliveira G, Salvagno GL, Montagnana M, Gelati M, et al. (2010) Influence of a light meal on routine haematological tests. Blood Transfus 8: 94-99.
29. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, et al. (2006) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 203: 1701-1711.
30. Loomans CJM, de Koning EJP, Staal FJT, Rookmaaker MB, Verseyden C, et al. (2004) Endothelial Progenitor Cell Dysfunction: A Novel Concept in the Pathogenesis of Vascular Complications of Type 1 Diabetes. Diabetes 53: 195-199.
31. Tepper OM, Galiano RD, Capla JM, Kalka C, Gagne PJ, et al. (2002) Human Endothelial Progenitor Cells From Type II Diabetics Exhibit Impaired Proliferation, Adhesion, and Incorporation Into Vascular Structures. Circulation 106: 2781-2786.
32. Lages CS, Suffia I, Velilla PA, Huang B, Warshaw G, et al. (2008) Functional Regulatory T Cells Accumulate in Aged Hosts and Promote Chronic Infectious Disease Reactivation. The Journal of Immunology 181: 1835-1848.
33. Scotland RS, Stables MJ, Madalli S, Watson P, Gilroy DW (2011) Sex differences in resident immune cell phenotype underlie more efficient acute inflammatory responses in female mice. Blood 118: 5918-5927.
34. Holden SH, Barnett AH, Peters JR, Jenkins-Jones S, Poole CD, et al. (2013) The incidence of type 2 diabetes in the United Kingdom from 1991 to 2010. Diabetes Obes Metab 15: 844-852.
35. Wilson PWF, D'Agostino RB, Parise H, Sullivan L, Meigs JB (2005) Metabolic Syndrome as a Precursor of Cardiovascular Disease and Type 2 Diabetes Mellitus. Circulation 112: 3066-3072.
36. Kolberg JA, Jørgensen T, Gerwien RW, Hamren S, McKenna MP, et al. (2009) Development of a Type 2 Diabetes Risk Model From a Panel of Serum Biomarkers From the Inter99 Cohort. Diabetes Care 32: 1207-1212.
37. Wang X, Bao W, Liu J, OuYang Y-Y, Wang D, et al. (2013) Inflammatory Markers and Risk of Type 2 Diabetes: A systematic review and meta-analysis. Diabetes Care 36: 166-175.
38. Ehses JA, Lacraz G, Giroix M-H, Schmidlin F, Coulaud J, et al. (2009) IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat. Proceedings of the National Academy of Sciences 106: 13998-14003.
39. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, et al. (2005) IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11: 191-198.
40. Jagannathan-Bogdan M, McDonnell ME, Shin H, Rehman Q, Hasturk H, et al. (2011) Elevated Proinflammatory Cytokine Production by a Skewed T Cell Compartment Requires Monocytes and Promotes Inflammation in Type 2 Diabetes. The Journal of Immunology 186: 1162-1172.
41. Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, et al. (2009) Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 15: 930-939.
42. Tian J, Zekzer D, Hanssen L, Lu Y, Olcott A, et al. (2001) Lipopolysaccharide-Activated B Cells Down-Regulate Th1 Immunity and Prevent Autoimmune Diabetes in Nonobese Diabetic Mice. The Journal of Immunology 167: 1081-1089.
43. Catalan V, Gomez-Ambrosi J, Ramirez B, Rotellar F, Pastor C, et al. (2007) Proinflammatory cytokines in obesity: impact of type 2 diabetes mellitus and gastric bypass. Obes Surg 17: 1464-1474.
44. Itoh M, Takahashi T, Sakaguchi N, Kuniyasu Y, Shimizu J, et al. (1999) Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance. The Journal of Immunology 162: 5317-5326.
45. Dejaco C, Duftner C, Grubeck-Loebenstein B, Schirmer M (2006) Imbalance of regulatory T cells in human autoimmune diseases. Immunology 117: 289-300.
46. Raynor J, Lages CS, Shehata H, Hildeman DA, Chougnet CA (2012) Homeostasis and function of regulatory T cells in aging. Current Opinion in Immunology 24: 482-487.
47. Santner-Nanan B, Seddiki N, Zhu E, Quent V, Kelleher A, et al. (2008) Accelerated age-dependent transition of human regulatory T cells to effector memory phenotype. International Immunology 20: 375-383.
48. Hoechst B, Gamrekelashvili J, Manns MP, Greten TF, Korangy F (2011) Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells. Blood 117: 6532-6541.
49. Yadav H, Quijano C, Kamaraju Anil K, Gavrilova O, Malek R, et al. (2011) Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling. Cell Metabolism 14: 67-79.
50. Stentz FB, Kitabchi AE (2003) Activated T lymphocytes in Type 2 diabetes: implications from in vitro studies. Curr Drug Targets 4: 493-503.
51. Mikirova N, Jackson J, Hunninghake R, Kenyon J, Chan K, et al. (2009) Circulating endothelial progenitor cells: a new approach to anti-aging medicine? Journal of Translational Medicine 7: 106.