Crystallographic evidence of drastic conformational changes in the active site of a flavin-dependent N -hydroxylase

Biochemistry

Volumn 53, Issue 38, 2014, Pages 6063-6077

  Setser, Jeremy W ^a   Heemstra, John R ^b,c   Walsh, Christopher T ^b   Drennan, Catherine L ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CONFORMATIONAL CHANGE; FLAVIN-DEPENDENT; HYDROXYLASES;

ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; BROMIDE ION; KUTZNERIDE; N HYDROXYLASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXYGENASE; QUERCETIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SODIUM DITHIONITE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; FLAVINE ADENINE NUCLEOTIDE; MIXED FUNCTION OXIDASE;

ACTINOBACTERIA; ANTIFUNGAL ACTIVITY; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTALLIZATION; ENZYME ACTIVE SITE; HYDROGEN BOND; NONHUMAN; OXIDATION REDUCTION STATE; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; PSEUDOMONAS AERUGINOSA; REACTION ANALYSIS; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; PROTEIN CONFORMATION;

ACTINOBACTERIA; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; FLAVIN-ADENINE DINUCLEOTIDE; GENE EXPRESSION REGULATION, BACTERIAL; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; NADP; OXIDATION-REDUCTION; PROTEIN CONFORMATION;

EID: 84907452582     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi500655q     Document Type: Article

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