Structural insight into the mechanism of oxygen activation and substrate selectivity of flavin-dependent N-hydroxylating monooxygenases

Biochemistry

Volumn 51, Issue 36, 2012, Pages 7043-7045

  Franceschini, Stefano ^a   Fedkenheuer, Michael ^b   Vogelaar, Nancy J ^b   Robinson, Howard H ^c   Sobrado, Pablo ^b   Mattevi, Andrea ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE GROUPS; ASPERGILLUS FUMIGATUS; FLAVIN-DEPENDENT; HUMAN PATHOGENS; MONOOXYGENASES; OXYGEN ACTIVATIONS; SIDEROPHORES; STRUCTURAL ELUCIDATION; STRUCTURAL INSIGHTS; SUBSTRATE SELECTIVITY;

ASPERGILLUS; BIOCHEMISTRY; ENZYMES; HYDROGEN BONDS; HYDROXYLATION;

AMINO ACIDS;

AMINE; ARGININE; FUNGAL ENZYME; LYSINE; N5 HYDROXYORNITHINE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; ORNITHINE DERIVATIVE; OXYGEN; QUERCETIN; SIDA PROTEIN; SIDEROPHORE; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS FUMIGATUS; BIOCATALYSIS; CRYSTAL STRUCTURE; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SYNTHESIS; FUNGAL VIRULENCE; HYDROGEN BOND; HYDROXYLATION; NONHUMAN; PRIORITY JOURNAL; STATIC ELECTRICITY;

ASPERGILLUS FUMIGATUS; CATALYTIC DOMAIN; FLAVINS; HYDROXYLATION; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; NITROGEN; OXYGEN; SUBSTRATE SPECIFICITY;

ASPERGILLUS FUMIGATUS;

EID: 84866061118     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301072w     Document Type: Article

References (15)

1. Horn, F., Heinekamp, T., Kniemeyer, O., Pollmacher, J., Valiante, V., and Brakhage, A. A. (2012) Front. Microbiol. 3, 108
2. He, H., Ding, L., Li, F., and Zhan, Q. (2011) Crit. Care 15, R5
3. Hissen, A. H., Wan, A. N., Warwas, M. L., Pinto, L. J., and Moore, M. M. (2005) Infect. Immun. 73, 5493
4. van Berkel, W. J., Kamerbeek, N. M., and Fraaije, M. W. (2006) J. Biotechnol. 124, 670
5. Chocklett, S. W. and Sobrado, P. (2010) Biochemistry 49, 6777
6. Mayfield, J. A., Frederick, R. E., Streit, B. R., Wencewicz, T. A., Ballou, D. P., and DuBois, J. L. (2010) J. Biol. Chem. 285, 30375
7. Romero, E., Fedkenheuer, M., Chocklett, S. W., Qi, J., Oppenheimer, M., and Sobrado, P. (2012) Biochim. Biophys. Acta 1824, 850
8. Frederick, R. E., Mayfield, J. A., and DuBois, J. L. (2011) J. Am. Chem. Soc. 133, 12338
9. Olucha, J., Meneely, K. M., Chilton, A. S., and Lamb, A. L. (2011) J. Biol. Chem. 286, 31789
10. Orru, R., Dudek, H. M., Martinoli, C., Torres Pazmino, D. E., Royant, A., Weik, M., Fraaije, M. W., and Mattevi, A. (2011) J. Biol. Chem. 286, 29284
11. Orru, R., Pazmino, D. E., Fraaije, M. W., and Mattevi, A. (2010) J. Biol. Chem. 285, 35021
12. Meneely, K. M. and Lamb, A. L. (2007) Biochemistry 46, 11930
13. Chaiyen, P., Fraaije, M. W., and Mattevi, A. (2012) Trends Biochem. Sci. 37, 373
14. Franceschini, S., van Beek, H. L., Pennetta, A., Martinoli, C., Fraaije, M. W., and Mattevi, A. (2012) J. Biol. Chem. 287, 22626
15. Beaty, N. B. and Ballou, D. P. (1981) J. Biol. Chem. 256, 4619