Deficient human β-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection

Science Translational Medicine

Volumn 6, Issue 249, 2014, Pages

  Diao, Ruiying ^a,b,c   Fok, Kin Lam ^b   Chen, Hao ^a,b,c   Yu, Mei Kuen ^b   Duan, Yonggang ^a,c   Chung, Chin Man ^b   Li, Zhao ^c,d   Wu, Hanwei ^a   Li, Zesong ^a   Zhang, Hu ^c,d   Ji, Ziliang ^c,d   Zhen, Wanhua ^a   Ng, Chi Fai ^b   Gui, Yaoting ^c   Cai, Zhiming ^a,c   Chan, Hsiao Chang ^b  

^a SHENZHEN UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c PEKING UNIVERSITY SHENZHEN HOSPITAL   (China)

^d SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN 1; CALCIUM ION; CHEMOKINE RECEPTOR CCR6; BETA DEFENSIN; CCR6 PROTEIN, HUMAN; DEFB1 PROTEIN, HUMAN; PROTEIN BINDING; RECOMBINANT PROTEIN;

ARTICLE; ASTHENOSPERMIA; BACTERICIDAL ACTIVITY; CALCIUM MOBILIZATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKOCYTOSPERMIA; MALE; MALE GENITAL TRACT INFECTION; MALE INFERTILITY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SEMEN ABNORMALITY; SPERM QUALITY; SPERMATOZOON MOTILITY; SPERMATOZOON PENETRATION; BIOLOGICAL MODEL; CALCIUM SIGNALING; DEFICIENCY; GENITAL TRACT INFECTION; METABOLISM; PATHOLOGY; SPERMATOZOON;

BETA-DEFENSINS; CALCIUM SIGNALING; HUMANS; INFERTILITY, MALE; MALE; MODELS, BIOLOGICAL; PROTEIN BINDING; RECEPTORS, CCR6; RECOMBINANT PROTEINS; REPRODUCTIVE TRACT INFECTIONS; SPERM MOTILITY; SPERMATOZOA;

EID: 84907416250     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3009071     Document Type: Article

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