Is it time for epigenetics in osteoarthritis?

Arthritis and Rheumatology

Volumn 66, Issue 9, 2014, Pages 2324-2327

  Blanco, Francisco J ^a,b   Rego Pérez, Ignacio ^a,b  

^a HOSPITAL JUAN CANALEJO   (Spain)

^b UNIVERSITY OF A CORUÑA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE;

CELL DIFFERENTIATION; CELL DIVISION; CPG ISLAND; DNA METHYLATION; DNA SEQUENCE; EDITORIAL; EMBRYO DEVELOPMENT; EPIGENETICS; GENE EXPRESSION; INFLAMMATION; OSTEOARTHRITIS; PHENOTYPE; PRIORITY JOURNAL; GENETIC EPIGENESIS; GENETICS; HUMAN;

DNA METHYLATION; EPIGENESIS, GENETIC; HUMANS; OSTEOARTHRITIS;

EID: 84907406781     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.38710     Document Type: Editorial

References (29)

1. Blanco FJ. Osteoarthritis: something is moving. Reumatol Clin 2014;10:4-5.
2. Valdes AM, Spector TD. Genetic epidemiology of hip and knee osteoarthritis. Nat Rev Rheumatol 2011;7:23-32.
3. Barter MJ, Bui C, Young DA. Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs. Osteoarthritis Cartilage 2012;20:339-49.
4. Feng S, Jacobsen SE, Reik W. Epigenetic reprogramming in plant and animal development. Science 2010;330:622-7.
5. Hellman A, Chess A. Gene body-specific methylation on the active X chromosome. Science 2007;315:1141-3. (Pubitemid 46328027)
6. Roach HI, Yamada N, Cheung KS, Tilley S, Clarke NM, Oreffo RO, et al. Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions. Arthritis Rheum 2005;52:3110-24. (Pubitemid 41447092)
7. Reynard LN, Loughlin J. Genetics and epigenetics of osteoarthritis. Maturitas 2012;71:200-4.
8. De Andres MC, Imagawa K, Hashimoto K, Gonzalez A, Roach HI, Goldring MB, et al. Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes. Arthritis Rheum 2013;65:732-42.
9. Rushton MD, Reynard LN, Barter MJ, Refaie R, Rankin KS, Young DA, et al. Characterization of the cartilage DNA methylome in knee and hip osteoarthritis. Arthritis Rheumatol 2014;66:2450-60.
10. Fernandez-Tajes J, Soto-Hermida A, Vazquez-Mosquera ME, Cortes-Pereira E, Mosquera A, Fernandez-Moreno M, et al. Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients. Ann Rheum Dis 2014;73:668-77.
11. Delgado-Calle J, Fernandez AF, Sainz J, Zarrabeitia MT, Sanudo C, Garcia-Renedo R, et al. Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis. Arthritis Rheum 2013;65:197-205.
12. Hashimoto K, Oreffo RO, Gibson MB, Goldring MB, Roach HI. DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes. Arthritis Rheum 2009;60:3303-13.
13. Taylor SE, Smeriglio P, Dhulipala L, Rath M, Bhutani N. A global increase in 5-hydroxymethylcytosine levels marks osteoarthritic chondrocytes. Arthritis Rheumatol 2014;66:90-100.
14. Berdasco M, Esteller M. Hot topics in epigenetic mechanisms of aging: 2011. Aging Cell 2012;11:181-6.
15. Portela A, Esteller M. Epigenetic modifications and human disease. Nat Biotechnol 2010;28:1057-68.
16. Johnson AA, Akman K, Calimport SR, Wuttke D, Stolzing A, de Magalhaes JP. The role of DNA methylation in aging, rejuvenation, and age-related disease. Rejuvenation Res 2012;15:483-94.
17. Blanco FJ, Rego I, Ruiz-Romero C. The role of mitochondria in osteoarthritis. Nat Rev Rheumatol 2011;7:161-9.
18. Horan MP, Cooper DN. The emergence of the mitochondrial genome as a partial regulator of nuclear function is providing new insights into the genetic mechanisms underlying age-related complex disease. Hum Genet 2014;133:435-58.
19. Bellizzi D, D'Aquila P, Giordano M, Montesanto A, Passarino G. Global DNA methylation levels are modulated by mitochondrial DNA variants. Epigenomics 2012;4:17-27.
20. Kelly RD, Rodda AE, Dickinson A, Mahmud A, Nefzger CM, Lee W, et al. Mitochondrial DNA haplotypes define gene expression patterns in pluripotent and differentiating embryonic stem cells. Stem Cells 2013;31:703-16.
21. Kenney MC, Chwa M, Atilano SR, Falatoonzadeh P, Ramirez C, Malik D, et al. Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: implications for population susceptibility to diseases. Biochim Biophys Acta 2014;1842:208-19.
22. Schroeder EA, Raimundo N, Shadel GS. Epigenetic silencing mediates mitochondria stress-induced longevity. Cell Metab 2013;17:954-64.
23. Sowers M, Karvonen-Gutierrez CA, Palmieri-Smith R, Jacobson JA, Jiang Y, Ashton-Miller JA. Knee osteoarthritis in obese women with cardiometabolic clustering. Arthritis Rheum 2009;61:1328-36.
24. Martinez JA, Milagro FI, Claycombe KJ, Schalinske KL. Epigenetics in adipose tissue, obesity, weight loss, and diabetes. Adv Nutr 2014;5:71-81.
25. Barua S, Kuizon S, Chadman KK, Flory MJ, Brown WT, Junaid MA. Single-base resolution of mouse offspring brain methylome reveals epigenome modifications caused by gestational folic acid. Epigenetics Chromatin 2014;7:3.
26. De Silva V, El-Metwally A, Ernst E, Lewith G, Macfarlane GJ, on behalf of the Arthritis Research UK Working Group on Complementary and Alternative Medicines. Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis: a systematic review. Rheumatology (Oxford) 2011;50:911-20.
27. Blanco FJ, Ruiz-Romero C. New targets for disease modifying osteoarthritis drugs: chondrogenesis and Runx1. Ann Rheum Dis 2013;72:631-4.
28. Ezura Y, Sekiya I, Koga H, Muneta T, Noda M. Methylation status of CpG islands in the promoter regions of signature genes during chondrogenesis of human synovium-derived mesenchymal stem cells. Arthritis Rheum 2009;60:1416-26.
29. Heyn H, Esteller M. DNA methylation profiling in the clinic: applications and challenges. Nat Rev Genet 2012;13:679-92.