A bioengineered hydrogel system enables targeted and sustained intramyocardial delivery of neuregulin, activating the cardiomyocyte cell cycle and enhancing ventricular function in a murine model of ischemic cardiomyopathy

Circulation: Heart Failure

Volumn 7, Issue 4, 2014, Pages 619-626

  Cohen, Jeffrey E ^a,b   Purcell, Brendan P ^c   MacArthur, John W ^a,b   Mu, Anbin ^d   Shudo, Yasuhiro ^a   Patel, Jay B ^a   Brusalis, Christopher M ^b   Trubelja, Alen ^b   Fairman, Alexander S ^b   Edwards, Bryan B ^a   Davis, Mollie S ^c   Hung, George ^b   Hiesinger, William ^b   Atluri, Pavan ^b   Margulies, Kenneth B ^d   Burdick, Jason A ^c   Woo, Y Joseph ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Division of Cardiovascular Surgery   (United States)

^c Department of Surgery Bioengineering ^*  (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Heart failure; Ischemia; Molecular biology; Muscle cells; Myocardial infarction

Indexed keywords

CASPASE 3; DNA; EDOXUDINE; HISTONE H3; KI 67 ANTIGEN; NEU DIFFERENTIATION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOENGINEERING; CELL CYCLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DNA SYNTHESIS; DRUG DELIVERY SYSTEM; ECHOCARDIOGRAPHY; ENCAPSULATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE CELL; HEART PROTECTION; HISTONE PHOSPHORYLATION; HYDROGEL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; ISCHEMIC CARDIOMYOPATHY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MITOSIS RATE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT MODEL; SPRAGUE DAWLEY RAT; SUSTAINED DRUG RELEASE; ANIMAL; C57BL MOUSE; CARDIOMYOPATHY; CELL CULTURE; CELL PROLIFERATION; DELAYED RELEASE FORMULATION; DISEASE MODEL; DRUG EFFECT; HEART FAILURE; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART MUSCLE ISCHEMIA; INJECTION; ISCHEMIA; METABOLISM; METHODOLOGY; MOLECULAR BIOLOGY; MOUSE; MUSCLE CELL; NEWBORN; PATHOLOGY; PATHOPHYSIOLOGY;

HEART FAILURE; ISCHEMIA; MOLECULAR BIOLOGY; MUSCLE CELLS; MYOCARDIAL INFARCTION;

ANIMALS; ANIMALS, NEWBORN; BIOENGINEERING; CARDIOMYOPATHIES; CELL PROLIFERATION; CELLS, CULTURED; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; HYDROGEL; IMMUNOHISTOCHEMISTRY; INJECTIONS; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; MYOCARDIAL ISCHEMIA; MYOCARDIUM; MYOCYTES, CARDIAC; NEUREGULIN-1; RATS; RATS, SPRAGUE-DAWLEY; VENTRICULAR FUNCTION, LEFT;

EID: 84907381188     PISSN: 19413289     EISSN: 19413297     Source Type: Journal    
DOI: 10.1161/CIRCHEARTFAILURE.113.001273     Document Type: Article

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