Rutin attenuates ethanol-induced neurotoxicity in hippocampal neuronal cells by increasing aldehyde dehydrogenase 2

Food and Chemical Toxicology

Volumn 72, Issue , 2014, Pages 228-233

  Song, Kibbeum ^a   Kim, Sokho ^a   Na, Ji Young ^a   Park, Jong Heum ^b   Kim, Jae Kyung ^b   Kim, Jae Hun ^b   Kwon, Jungkee ^a  

^a Chonbuk National University   (South Korea)

^b Korea Atomic Energy Research Institute   (South Korea)

Author keywords

Aldehyde dehydrogenase 2; Ethanol; Hippocampal neuronal cells; Neurotoxicity; Rutin

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; CASPASE 3; CYTOCHROME C; DAIDZIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; RUTOSIDE; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 2, MOUSE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; BAX PROTEIN, MOUSE; BCL2L1 PROTEIN, MOUSE; CASP3 PROTEIN, MOUSE; ISOFLAVONE DERIVATIVE; PLANT EXTRACT; PROTEIN BCL X;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG DETOXIFICATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; HIPPOCAMPUS; HT22 CELL; NERVE CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; TREATMENT RESPONSE; WESTERN BLOTTING; ANIMAL; APOPTOSIS; CELL LINE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; MITOCHONDRION; MOUSE; SIGNAL TRANSDUCTION;

ALDEHYDE DEHYDROGENASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CASPASE 3; CELL LINE; CELL SURVIVAL; CYTOCHROMES C; ETHANOL; HIPPOCAMPUS; ISOFLAVONES; MICE; MITOCHONDRIA; NEURONS; PLANT EXTRACTS; RUTIN; SIGNAL TRANSDUCTION;

EID: 84907372030     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.07.028     Document Type: Article

References (19)

1. Bishnoi M., Chopra K., Kulkarni S.K. Protective effect of rutin, a polyphenolic flavonoid against haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes. Fundam. Clin. Pharmacol. 2007, 21:521-529.
2. Chen C.-H., Budas G.R., Churchill E.N., Disatnik M.-H., Hurley T.D., Mochly-Rosen D. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 2008, 321:1493-1495.
3. Goodlett C.R., Horn K.H. Mechanisms of alcohol-induced damage to the developing nervous system. Alcohol Res. Health 2001, 25:175-184.
4. Kamalakkannan N., Stanely Mainzen Prince P. Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues. Mol. Cell. Biochem. 2006, 293:211-219.
5. Koda T., Kuroda Y., Imai H. Rutin supplementation in the diet has protective effects against toxicant-induced hippocampal injury by suppression of microglial activation and pro-inflammatory cytokines: protective effect of rutin against toxicant-induced hippocampal injury. Cell. Mol. Neurobiol. 2009, 29:523-531.
6. La Casa C., Villegas I., Alarcon de La Lastra C., Motilva V., Martin Calero M. Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. J. Ethnopharmacol. 2000, 71:45-53.
7. Li S.Y., Gomelsky M., Duan J., Zhang Z., Gomelsky L., Zhang X., Epstein P.N., Ren J. Overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene prevents acetaldehyde-induced cell injury in human umbilical vein endothelial cells: role of ERK and p38 mitogen-activated protein kinase. J. Biol. Chem. 2004, 279:11244-11252.
8. Lindahl M., Tagesson C. Flavonoids as phospholipase A2 inhibitors: importance of their structure for selective inhibition of group II phospholipase A2. Inflammation 1997, 21:347-356.
9. Miller M.W. Development of the Central Nervous System: Effects of Alcohol and Opiates 1992, Wiley-Liss, New York.
10. Monticone M., Panfoli I., Ravera S., Puglisi R., Jiang M.M., Morello R., Candiani S., Tonachini L., Biticchi R., Fabiano A., Cancedda R., Boitani C., Castagnola P. The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and cellular respiration. J. Cell. Physiol. 2010, 225:767-776.
11. Nuttall M.E., Nadeau D.P., Fisher P.W., Wang F., Keller P.M., Dewolf W.E., Goldring M.B., Badger A.M., Lee D., Levy M.A. Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro. J. Orthop. Res. 2000, 18:356-363.
12. Ohsawa I., Nishimaki K., Murakami Y., Suzuki Y., Ishikawa M., Ohta S. Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. J. Neurosci. 2008, 28:6239-6249.
13. Sheu J.R., Hsiao G., Chou P.H., Shen M.Y., Chou D.S. Mechanisms involved in the antiplatelet activity of rutin, a glycoside of the flavonol quercetin, in human platelets. J. Agric. Food Chem. 2004, 52:4414-4418.
14. Stewart M., Malek K., Crabb D.W. Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. J. Investigative Med.: Official Publ. Am. Federation Clin. Res. 1996, 44:42.
15. Stewart M.J., Malek K., Crabb D.W. Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. J. Investigative Med.: Official Publ. Am. Federation Clin. Res. 1996, 44:42-46.
16. Streissguth A.P., Sampson P.D., Olson H.C., Bookstein F.L., Barr H.M., Scott M., Feldman J., Mirsky A.F. Maternal drinking during pregnancy: attention and short-term memory in 14-year-old offspring-a longitudinal prospective study. Alcohol. Clin. Exp. Res. 1994, 18:202-218.
17. Sun A.Y., Sun G.Y. Ethanol and oxidative mechanisms in the brain. J. Biomed. Sci. 2001, 8:37-43.
18. Yang J.C., Cortopassi G.A. Induction of the mitochondrial permeability transition causes release of the apoptogenic factor cytochrome c. Free Radical Biol. Med. 1998, 24:624-631.
19. Zimatkin S.M., Rout U.K., Koivusalo M., Buhler R., Lindros K.O. Regional distribution of low-Km mitochondrial aldehyde dehydrogenase in the rat central nervous system. Alcohol. Clin. Exp. Res. 1992, 16:1162-1167.