Inhibitory effects and analysis of RNA interference on thioredoxin glutathione reductase expression in schistosoma japonicum

Journal of Parasitology

Volumn 100, Issue 4, 2014, Pages 463-469

  Han, Yanhui ^a   Fu, Zhiqiang ^a   Hong, Yang ^a   Zhang, Min ^a   Han, Hongxiao ^a   Lu, Ke ^a   Yang, Jianmei ^a   Li, Xiangrui ^a   Lin, Jiaojiao ^a  

^a NANJING AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE REDUCTASE; OXYGEN RADICAL; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; THIOREDOXIN; THIOREDOXIN GLUTATHIONE REDUCTASE; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG;

DAMAGE; ENZYME ACTIVITY; FLATWORM; FREE RADICAL; GENE EXPRESSION; INHIBITOR; PARASITOLOGY; RNA; SCHISTOSOMIASIS;

ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSFECTION; IN VITRO STUDY; NONHUMAN; OXIDATIVE STRESS; PROTECTION; RNA INTERFERENCE; SCHISTOSOMA JAPONICUM;

ANIMALS; DNA, SUPERHELICAL; GENE KNOCKDOWN TECHNIQUES; HYDROGEN PEROXIDE; MALE; MICE; MICE, INBRED BALB C; MULTIENZYME COMPLEXES; NADH, NADPH OXIDOREDUCTASES; RABBITS; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SCHISTOSOMA JAPONICUM; SNAILS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 84907365018     PISSN: 00223395     EISSN: 19372345     Source Type: Journal    
DOI: 10.1645/13-397.1     Document Type: Article

References (49)

1. Agorio, A., C. Chalar, S. Cardozo, AND G. Salinas. 2003. Alternative mRNAs arising from trans-splicing code for mitochondrial and cytosolic variants of Echinococcus granulosus thioredoxin glutathione reductase. Journal of Biological Chemistry 278: 12920-12928
2. Aigner, A. 2006. Gene silencing through RNA interference (RNAi) in vivo: Strategies based on the direct application of siRNAs. Journal of Biotechnology 124: 12-25
3. Alger, H. M., A. A. Sayed, M. J. Stadecker, AND D. L. Williams. 2002. Molecular and enzymatic characterisation of Schistosoma mansoni thioredoxin. International Journal for Parasitology 32: 1285-1292
4. Alger, H. M., AND D. L. Williams. 2002. The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase. Molecular and Biochemical Parasitology 121: 129-139
5. Bayne, C. J., J. S. Menino, D. J.HOBBS, AND D. W. Barnes. 1994. In vitro cultivation of cells from larval Schistosoma mansoni. Journal of Parasitology 80: 29-35
6. Boyle, J. P., X. J. Wu, C. B. Shoemaker, AND T. P. Yoshino. 2003. Using RNA interference to manipulate endogenous gene expression in Schistosoma mansoni sporocysts. Molecular and Biochemical Parasitology 128: 205-215
7. Butterworth, A. E. 1984. Cell-mediated damage to helminths. Advances in Parasitology 23: 143-235
8. Cheng, G., Z. Fu, J. Lin, Y. Shi, Y. Zhou, Y. Jin, AND Y. CAI. 2009. In vitro and in vivo evaluation of small interference RNA-mediated gynaecophoral canal protein silencing in Schistosoma japonicum. Journal of Gene Medicine 11: 412-421
9. Chopra, M., C. Pachuk, C. Satishchandran, AND T. Giordano. 2002. Using RNA interference to modulate gene expression. Targets 1: 102-108
10. Correnti, J. M., P. J. Brindley, AND E. J. Pearce. 2005. Long-Term suppression of cathepsin B levels by RNA interference retards schistosome growth. Molecular and Biochemical Parasitology 143: 209-215
11. Dykxhoorn, D. M., C. D. Novina, AND P. A. Sharp. 2003. Killing the messenger: Short RNAs that silence gene expression. Nature Reviews Molecular Cell Biology 4: 457-467
12. Elbashir, S. M., J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, AND T. Tuschl. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498
13. Fire, A., S. Xu, M.K. Montgomery, S. A. Kostas, S. E. Driver, AND C. C. Mello. 1998. Potent and specific genetic interference by doublestranded RNA in Caenorhabditis elegans. Nature 391: 806-811
14. Grishok, A. And C. C. Mello. 2002. RNAi (Nematodes: Caenorhabditis elegans). Advances in Genetics Incorporating Molecular Genetic Medicine 46: 339-360
15. Guevara-FLORES, A., J. P. Pardo, AND J. L. Rendon. 2011. Hysteresis in thioredoxin-glutathione reductase (TGR) from the adult stage of the liver fluke Fasciola hepatica. Parasitology International 60: 156-160
16. Han, Y., M. Zhang, Y. Hong, Z. Zhu, D. Li, X. Li, Z. Fu, AND J. Lin. 2012. Characterization of thioredoxin glutathione reductase in Schiotosoma japonicum. Parasitology International 61: 475-480
17. Harborth, J., S. M. Elbashir, K. Bechert, T. Tuschl, AND K. Weber. 2001. Identification of essential genes in cultured mammalian cells using small interfering RNAs. Journal of Cell Science 114: 4557-4565
18. Hofmann, B., H. J. Hecht, AND L. Flohe. 2002. Peroxiredoxins. Biological Chemistry 383: 347-364
19. Hunter, C. P. 1999. Genetics: A touch of elegance with RNAi. Current Biology 9: R440-R442
20. Kazura, J. W., M. M. Fanning, J. L. Blumer, AND A. A. Mahmoud. 1981. Role of cell-generated hydrogen peroxide in granulocytemediated killing of schistosomula of Schistosoma mansoni in vitro. Journal of Clinical Investigation 67: 93-102
21. Kim, K., I. H. Kim, K. Y. Lee, S. G. Rhee, AND E. R. Stadtman. 1988. The isolation and purification of a specific""protector'"protein which inhibits enzyme inactivation by a thiol/Fe(III)/O2 mixed-function oxidation system. Journal of Biological Chemistry 263: 4704-4711
22. Krautz-Peterson, G., M. Radwanska, D. Ndegwa, C. B. Shoemaker, AND P. J. Skelly. 2007. Optimizing gene suppression in schistosomes using RNA interference. Molecular and Biochemical Parasitology 153: 194-202
23. Kumagai, T., Y. Osada, AND T. Kanazawa. 2006. 2-Cys peroxiredoxins from Schistosoma japonicum: The expression profile and localization in the life cycle. Molecular and Biochemical Parasitology 149: 135-143
24. Kuntz, A. N., E. Davioud-Charvet, A. A. Sayed, L. L. Califf, J. Dessolin, E. S. Arner, AND D. L. Williams. 2007. Thioredoxin glutathione reductase from Schistosoma mansoni: An essential parasite enzyme and a key drug target. PLoS Medicine 4: E206
25. Kwatia, M. A., D. J. Botkin, AND D. L. Williams. 2000. Molecular and enzymatic characterization of Schistosoma mansoni thioredoxin peroxidase. Journal of Parasitology 86: 908-915
26. Li, J., W. B. Zhang, A. Loukas, R. Y. Lin, A. Ito, L. H. Zhang, M. Jones, AND D. P. Mcmanus. 2004. Functional expression and characterization of Echinococcus granulosus thioredoxin peroxidase suggests a role in protection against oxidative damage. Gene 326: 157-165
27. Lim, Y. S., M. K. Cha, H. K. Kim, T. B. Uhm, J. W. Park, K. Kim, AND I. H. Kim. 1993. Removals of hydrogen peroxide and hydroxyl radical by thiol-specific antioxidant protein as a possible role in vivo. Biochemical and Biophysical Research Communications 192: 273-280
28. Loverde, P T. 1998. Do antioxidants play a role in schistosome host-parasite interactionŠ Parasitology Today 14: 284-289
29. Maiorino, M., C. Roche, M. Kiess, K. Koenig, D. Gawlik, M. Matthes, E. Naldini, R. Pierce, AND L. Flohe. 1996. A selenium-containing phospholipid-hydroperoxide glutathione peroxidase in Schistosoma mansoni. European Journal of Biochemistry 238: 838-844
30. Mcgonigle, L., A. Mousley, N. J. Marks, G. P. Brennan, J. P. Dalton, T. W. Spithill, T. A. Day, AND A. G. Maule. 2008. The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference reduces gut penatration. International Journal for Parasitology 38: 149-155
31. Mcgonigle, S., J. P. Dalton, AND E. R. James. 1998. Peroxidoxins: A new antioxidant family. Parasitology Today 14: 139-145
32. Mkoji, G. M., J. M. Smith, AND R. K. Prichard. 1988. Antioxidant systems in Schistosoma mansoni: Correlation between susceptibility to oxidant killing and the levels of scavengers of hydrogen peroxide and oxygen free radicals. International Journal for Parasitology 18: 661-666
33. Montressor, A., D. W. T. Crompton, T. W. Gyorkos, AND L. Savioli. 2002. Helminth control in school-Age children. In Background,World Health Organization, Geneva, Switzerland, p. 1-11
34. Morales, M. E., G. Rinaldi, G. N. Gobert, K. J. Kines, J. F. Tort, AND P. J. Brindley. 2008. RNA interference of Schistosoma mansoni cathepsin D, the apical enzyme of the hemoglobin proteolysis cascade. Molecular and Biochemical Parasitology 157: 160-168.
35. Ndegwa, D., G. Krautz-Peterson, AND P. J. Skelly. 2007. Protocols for gene silencing in schistosomes. Experimental Parasitology 117: 284-291
36. Osman, A., E. G. Niles, S. Verjovski-Almeida, AND P. T. loverde. 2006. Schistosoma mansoni TGF-beta receptor II: Role in host ligandinduced regulation of a schistosome target gene. PLoS Pathogens 2: E54
37. Patocka, N., AND P. Ribeiro. 2013. The functional role of a serotonin transporter in Schistosoma mansoni elucidated through immunolocalization and RNA interference (RNAi). Molecular and Biochemical Parasitology 187: 32-42
38. Rendon, J. L., I. P. Del Arenal, A. Guevara-Flores, A. Uribe, A. Plancarte, AND G. Mendoza-Hernandez. 2004. Purification, characterization and kinetic properties of the multifunctional thioredoxin-glutathione reductase from Taenia crassiceps metacestode (cysticerci). Molecular and Biochemical Parasitology 133: 61-69
39. Rhee, S. G., S. W. Kang, T. S. Chang, W. Jeong, AND K. Kim. 2001. Peroxiredoxin, a novel family of peroxidases. IUBMB Life 52: 35-41
40. Samarasinghe, B., D. P. Knox, AND C. Britton. 2011. Factors affecting susceptibility to RNA interference in Haemonchus contortus and in vivo silencing of H11 aminopeptidase gene. International Journal for Parasitology 41: 51-59
41. Sayed, A. A., AND D. L. Williams. 2004. Biochemical characterization of 2-Cys peroxiredoxins from Schistosoma mansoni. Journal of Biological Chemistry 279: 26159-26166
42. Simurda, M. C., H. Van Keulen, D. M. Rekosh, AND P. T. Loverde. 1988. Schistosoma mansoni: Identification and analysis of an mRNA and a gene encoding superoxide dismutase (Cu/Zn). Experimental Parasitology 67: 73-84
43. Skelly, P. J., A. Da'dara, AND D. A. Harn. 2003. Suppression of cathepsin B expression in Schistosoma mansoni by RNA interference. International Journal for Parasitology 33: 363-369
44. Song, L., J. Li, S. Xie, C. Qian, J. Wang, W. Zhang, X. Yin, Z. Hua, AND C. YU. 2012. Thioredoxin glutathione reductase as a novel drug target: Evidence from Schistosoma japonicum. PLoS One 7: E31456
45. Sun, Q. A., L. Kirnarsky, S. Sherman, AND V. N. Gladyshev. 2001. Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems. Proceedings of the National Academy of Science of the United States of America 98: 3673-3678
46. Tabara, H., A. Grishok, AND C. C. Mello. 1998. RNAi in C. elegans: Soaking in the genome sequence. Science 282: 430-431
47. Tavernarakis, N., S. L. Wang, M. Dorovkov, A. Ryazanov, AND M. Driscoll. 2000. Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes. Nature Genetics 24: 180-183
48. Williams, D. L., H. Asahi, D. J. Botkin, AND M. J. Stadecker. 2001. Schistosome infection stimulates host CD4 T helper cell and B-cell responses against a novel egg antigen, thioredoxin peroxidase. Infection and Immunity 69: 1134-1141
49. Williams, D, R. J. Pierce, E. Cookson, AND A. Capron. 1992. Molecular cloning and sequencing of glutathione peroxidase from Schistosoma mansoni. Molecular and Biochemical Parasitology 52: 127-130