Mechanisms underlying capsaicin effects in canine coronary artery: Implications for coronary spasm

Cardiovascular Research

Volumn 103, Issue 4, 2014, Pages 607-618

  Hiett, S Christopher ^a   Owen, Meredith K ^a   Li, Wennan ^a   Chen, Xingjuan ^a   Riley, Ashley ^a   Noblet, Jillian ^a   Flores, Sarah ^a   Sturek, Michael ^a   Tune, Johnathan D ^a   Obukhov, Alexander G ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

Coronary artery; Pro inflammatory prostaglandin thromboxane hormones; TRPV1

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; CALCIUM ION; CAPSAICIN; PHOSPHOLIPASE C; PROSTAGLANDIN F2 ALPHA; PROTEIN KINASE C; VANILLOID RECEPTOR 1; CALCIUM; VANILLOID RECEPTOR; VANILLOID RECEPTOR SUBTYPE 1; VASOCONSTRICTOR AGENT; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 2,5 PYRROLIDINEDIONE; 4 [3 (TRIFLUOROMETHYL) 2 PYRIDINYL] N [5 (TRIFLUOROMETHYL) 2 PYRIDINYL] 1 PIPERAZINECARBOXAMIDE; DIMETHYL SULFOXIDE; NIFEDIPINE; RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DILATATION; CORONARY ARTERY SPASM; DOG; ENDOTHELIUM; FLUORESCENCE IMAGING; MALE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; ANIMAL; CORONARY BLOOD VESSEL; DRUG EFFECTS; METABOLISM; MUSCLE SPASM; SMOOTH MUSCLE CELL; VASCULAR SMOOTH MUSCLE; VASCULARIZATION; VASODILATATION; CELL ISOLATION; CORONARY ARTERY PRESSURE; DEPOLARIZATION; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; PROTEIN EXPRESSION; SMOOTH MUSCLE;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; CALCIUM; CAPSAICIN; CORONARY VESSELS; DOGS; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; SPASM; TRPV CATION CHANNELS; VASOCONSTRICTOR AGENTS; VASODILATION;

EID: 84907354543     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvu152     Document Type: Article

References (49)

1. Premkumar LS, Abooj M. TRP channels and analgesia. Life Sci 2013;92: 415-424.
2. Ho KW, Ward NJ, Calkins DJ. TRPV1: a stress response protein in the central nervous system. Am J Neurodegener Dis 2012;1: 1-14.
3. Yao X, Garland CJ. Recent developments in vascular endothelial cell transient receptor potential channels. Circ Res 2005;97: 853-863.
4. Cavanaugh DJ, Chesler AT, Jackson AC, Sigal YM, Yamanaka H, Grant R, O'Donnell D, Nicoll RA, Shah NM, Julius D, Basbaum AI. Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci 2011;31: 5067-5077.
5. Fernandes ES, Fernandes MA, Keeble JE. The functions of TRPA1 and TRPV1: moving away from sensory nerves. Br J Pharmacol 2012;166: 510-521.
6. Bratz IN, Dick GM, Tune JD, Edwards JM, Neeb ZP, Dincer UD, Sturek M. Impaired capsaicin-induced relaxation of coronary arteries in a porcine model of the metabolic syndrome. Am J Physiol Heart Circ Physiol 2008;294: H2489-H2496.
7. Ma L, Zhong J, Zhao Z, Luo Z, Ma S, Sun J, He H, Zhu T, Liu D, Zhu Z, Tepel M. Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis. Cardiovasc Res 2011;92: 504-513.
8. Robbins N, Koch SE, Rubinstein J. Targeting TRPV1 and TRPV2 for potential therapeutic interventions in cardiovascular disease. Transl Res 2013;161: 469-476.
9. Sogut O, Kaya H, Gokdemir MT, Sezen Y. Acute myocardial infarction and coronary vasospasm associated with the ingestion of cayenne pepper pills in a 25-year-old male. Int J Emerg Med 2012;5: 5.
10. Akcay AB, Ozcan T, Seyis S, Acele A. Coronary vasospasm and acute myocardial infarction induced by a topical capsaicin patch. Turk Kardiyol Dern Ars 2009;37: 497-500.
11. Patane S, Marte F, Di BG, Cerrito M, Coglitore S. Capsaicin, arterial hypertensive crisis and acute myocardial infarction associated with high levels of thyroid stimulating hormone. Int J Cardiol 2009;134: 130-132.
12. Sayin MR, KarabagT, Dogan SM, Akpinar I, Aydin M.Acase of acute myocardial infarction due to the use of cayenne pepper pills. Wien Klin Wochenschr 2012;124: 285-287.
13. Czikora A, Lizanecz E, Bako P, Rutkai I, Ruzsnavszky F, Magyar J, Porszasz R, Kark T, Facsko A, Papp Z, Edes I, Toth A. Structure-activity relationships of vanilloid receptor agonists for arteriolar TRPV1. Br J Pharmacol 2012;165: 1801-1812.
14. Kark T, Bagi Z, Lizanecz E, Pasztor ET, Erdei N, Czikora A, Papp Z, Edes I, Porszasz R, Toth A. Tissue-specific regulation of microvascular diameter: opposite functional roles of neuronal and smooth muscle located vanilloid receptor-1. Mol Pharmacol 2008;73: 1405-1412.
15. Hamilos MI, Kochiadakis GE, Skalidis EI, Igoumenidis NE, Zaharaki A, Vardas PE. Acute myocardial infarction in a patient with normal coronary arteries after an allergic reaction. Hellenic J Cardiol 2005;46: 79-82.
16. White M, Rouleau JL, Hall C, Arnold M, Harel F, Sirois P, Greaves S, Solomon S, Ajani U, Glynn R, Hennekens C, Pfeffer M. Changes in vasoconstrictive hormones, natriuretic peptides, and left ventricular remodeling soon after anterior myocardial infarction. Am Heart J 2001;142: 1056-1064.
17. Feng DL, Tofler GH. Diurnal physiologic processes and circadian variation of acute myocardial infarction. J Cardiovasc Risk 1995;2: 494-498.
18. Gasser R, Schafhalter-Zoppoth I, Schwarz T, Eber B, Koppel H, Lechleitner P, Puschendorf B, Dienstl F, Klein W. Cyclic phenomena in early myocardial infarction. Acta Med Austriaca 1995;22: 69-72.
19. Willerson JT. Conversion from chronic to acute coronary heart disease syndromes. Role of platelets and platelet products. Tex Heart Inst J 1995;22: 13-19.
20. Badimon L, Chesebro JH, Badimon JJ. Thrombus formation on ruptured atherosclerotic plaques and rethrombosis on evolving thrombi. Circulation 1992;86: III74-III85.
21. Tsuji S, Sawamura A, Watanabe H, Takihara K, Park SE, Azuma J. Plasma endothelin levels during myocardial ischemia and reperfusion. Life Sci 1991;48: 1745-1749.
22. Gasser RN. The interdependence of hypertension, calcium overload, and coronary spasm in the development of myocardial infarction. Angiology 1988;39: 761-772.
23. Owen MK, Witzmann FA, McKenney ML, Lai X, Berwick ZC, Moberly SP, Alloosh M, Sturek M, Tune JD. Perivascular adipose tissue potentiates contraction of coronary vascular smooth muscle: influence of obesity. Circulation 2013;128: 9-18.
24. Chakraborty S, Berwick ZC, Bartlett PJ, Kumar S, Thomas AP, Sturek M, Tune JD, Obukhov AG. Bromoenol lactone inhibits voltage-gated Ca2+ and transient receptor potential canonical channels. J Pharmacol Exp Ther 2011;339: 329-340.
25. Kromer BM, Tippins JR. Coronary artery constriction by the isoprostane 8-epi prostaglandin F2a. Br J Pharmacol 1996;119: 1276-1280.
26. Choi SY, Ha H, Kim KT. Capsaicin inhibits platelet-activating factor-induced cytosolic Ca2+ rise and superoxide production. J Immunol 2000;165: 3992-3998.
27. Wang JP, Tseng CS, Sun SP, Chen YS, Tsai CR, Hsu MF. Capsaicin stimulates the non-store-operated Ca2+ entry but inhibits the store-operated Ca2+ entry in neutrophils. Toxicol Appl Pharmacol 2005;209: 134-144.
28. Kobayashi M, Watanabe K, Yokoyama S, Matsumoto C, Hirata M, Tominari T, Inada M, Miyaura C. Capsaicin, a TRPV1 Ligand, suppresses bone resorption by inhibiting the prostaglandin E production of osteoblasts, and attenuates the inflammatory bone loss induced by lipopolysaccharide. ISRN Pharmacol 2012;2012: 439860.
29. Ben-Chaim Y, Tour O, Dascal N, Parnas I, Parnas H. The M2 muscarinic G-protein-coupled receptor is voltage-sensitive. J Biol Chem 2003;278: 22482-22491.
30. Martinez-Pinna J, Gurung IS, Vial C, Leon C, Gachet C, Evans RJ, Mahaut-SmithMP. Direct voltage control of signaling via P2Y1 and other Galphaq-coupled receptors. J Biol Chem 2005;280: 1490-1498.
31. Voets T, Droogmans G, Wissenbach U, Janssens A, Flockerzi V, Nilius B. The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature 2004; 430: 748-754.
32. Bhave G, Hu HJ, Glauner KS, Zhu W, Wang H, Brasier DJ, Oxford GS, Gereau RW. Protein kinaseCphosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc Natl Acad Sci USA 2003;100: 12480-12485.
33. Lopshire JC, Nicol GD. The cAMP transduction cascade mediates the prostaglandin E2 enhancement of the capsaicin-elicited current in rat sensory neurons: whole-cell and single-channel studies. J Neurosci 1998;18: 6081-6092.
34. Hempel A, Lindschau C, Maasch C, Mahn M, Bychkov R, Noll T, Luft FC, Haller H. Calcium antagonists ameliorate ischemia-induced endothelial cell permeability by inhibiting protein kinase C. Circulation 1999;99: 2523-2529.
35. Allen V, Swigart P, Cheung R, Cockcroft S, Katan M. Regulation of inositol lipid-specific phospholipase cdelta by changes in Ca2+ ion concentrations. Biochem J 1997;327(Pt 2): 545-552.
36. Macmillan D, McCarron JG. The phospholipase C inhibitor U-73122 inhibits Ca2+ release from the intracellular sarcoplasmic reticulum Ca2+ store by inhibiting Ca2+ pumps in smooth muscle. Br J Pharmacol 2010;160: 1295-1301.
37. Hu G, Oboukhova EA, Kumar S, Sturek M, Obukhov AG. Canonical transient receptor potential channels expression is elevated in a porcine model of metabolic syndrome. Mol Endocrinol 2009;23: 689-699.
38. Jarret RL, Baldwin E, Perkins B, Bushway R, Guthrie K. Diversity of fruit quality characteristics in Capsicum frutescens. HortScience 2007;42: 16-19.
39. Chaiyasit K, KhovidhunkitW, Wittayalertpanya S. Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level. J Med Assoc Thai 2009; 92: 108-113.
40. Crossman DC, LarkinSW, FullerRW, Davies GJ, Maseri A. Substance P dilates epicardial coronary arteries and increases coronary blood flow in humans. Circulation 1989;80: 475-484.
41. Srinivasan R, Wolfe D, Goss J, Watkins S, de Groat WC, Sculptoreanu A, Glorioso JC. Protein kinaseCepsilon contributes to basal and sensitizing responses of TRPV1 to capsaicin in rat dorsal root ganglion neurons. Eur J Neurosci 2008;28: 1241-1254.
42. Phelps PT, Anthes JC, Correll CC. Cloning and functional characterization of dog transient receptor potential vanilloid receptor-1 (TRPV1). Eur J Pharmacol 2005;513: 57-66.
43. Mandadi S, Tominaga T, Numazaki M, Murayama N, Saito N, Armati PJ, Roufogalis BD, Tominaga M. Increased sensitivity of desensitized TRPV1 by PMA occurs through PKCepsilon-mediated phosphorylation at S800. Pain 2006;123: 106-116.
44. MohapatraDP, Nau C. Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway. J Biol Chem 2003;278: 50080-50090.
45. Kim S, Kang C, Shin CY, HwangSW, Yang YD, Shim WS, ParkMY, Kim E, Kim M, Kim BM, Cho H, Shin Y, Oh U. TRPV1 recapitulates native capsaicin receptor in sensory neurons in association with Fas-associated factor 1. J Neurosci 2006;26: 2403-2412.
46. Chen X, SunW, Gianaris NG, Riley AM, Cummins TR, Fehrenbacher JC, Obukhov AG. Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel. J Biol Chem 2014;289: 9600-9610.
47. Lanza GA, Careri G, Crea F. Mechanisms of coronary artery spasm. Circulation 2011;124: 1774-1782.
48. Hansson GK. Inflammatory mechanisms in atherosclerosis. J Thromb Haemost 2009; 7(suppl.): 328-331.
49. Berg AH, Scherer PE. Adipose tissue, inflammation, and cardiovascular disease. Circ Res 2005;96: 939-949.