Discovery of a benzofuran derivative (MBPTA) as a novel ROCK inhibitor that protects against MPP+-induced oxidative stress and cell death in SH-SY5Y cells

Free Radical Biology and Medicine

Volumn 74, Issue , 2014, Pages 283-293

  Chong, Cheong Meng ^a   Shen, Mingyun ^b   Zhou, Zhong Yan ^a   Pan, Peichen ^b   Hoi, Pui Man ^a   Li, Shang ^a   Liang, Wang ^a   Ai, Nana ^a   Zhang, Lun Qing ^a   Li, Cheuk Wing ^a   Yu, Huidong ^c   Hou, Tingjun ^b,d   Lee, Simon Ming Yuen ^a  

^a China jack1987168 163com   (Macao)

^b SOOCHOW UNIVERSITY   (China)

^c International Business Incubator   (China)

^d ZHEJIANG UNIVERSITY   (China)

Author keywords

Benzofuran; Free radicals; NO; Parkinson disease; ROCK; ROS

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 2 (5 METHYL 1 BENZOFURAN 3 YL) N (5 PROPYLSULFANYL 1,3,4 THIADIAZOL 2 YL)ACETAMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; BENZOFURAN DERIVATIVE; CASPASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; REACTIVE OXYGEN METABOLITE; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG; 2-(5-METHYL-1-BENZOFURAN-3-YL)-N-(5-PROPYLSULFANYL-1,3,4-THIADIAZOL-2-YL)ACETAMIDE; ACETAMIDE; ACETAMIDE DERIVATIVE; ALKANESULFONIC ACID; ANTIOXIDANT; BENZOFURAN; ONCOPROTEIN; OXIDIZING AGENT; PROPYLSULFONIC ACID; PYRIDINIUM DERIVATIVE; RHO KINASE; THIADIAZOLE DERIVATIVE;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CHEMICAL STRUCTURE; CYTOTOXICITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MORPHOLOGY; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; METABOLISM; MOLECULARLY TARGETED THERAPY; PARKINSON DISEASE; TUMOR CELL LINE;

ACETAMIDES; ALKANESULFONIC ACIDS; ANTIOXIDANTS; BENZOFURANS; CELL DEATH; CELL LINE, TUMOR; CYTOPROTECTION; DRUG DISCOVERY; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MOLECULAR TARGETED THERAPY; ONCOGENE PROTEIN V-AKT; OXIDANTS; OXIDATIVE STRESS; PARKINSON DISEASE; PHOSPHATIDYLINOSITOL 3-KINASES; PYRIDINIUM COMPOUNDS; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; THIADIAZOLES;

EID: 84907348083     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.06.014     Document Type: Article

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