Unexpected Neuronal Protection of SU5416 against 1-Methyl-4-Phenylpyridinium Ion-Induced Toxicity via Inhibiting Neuronal Nitric Oxide Synthase

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Cui, Wei ^a   Zhang, Zaijun ^b,c   Li, Wenming ^a,e   Mak, Shinghung ^a   Hu, Shengquan ^a   Zhang, Huan ^a   Yuan, Shuai ^b   Rong, Jianhui ^d   Choi, Tony Chunglit ^a   Lee, Simon M Y ^b   Han, Yifan ^a  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b University of Macau   (Macao)

^c JINAN UNIVERSITY   (China)

^d THE UNIVERSITY OF HONG KONG   (Hong Kong)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEURONAL NITRIC OXIDE SYNTHASE; SEMAXANIB; SHORT HAIRPIN RNA;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; CELL GRANULE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; EMBRYO; ENZYME ACTIVITY; LOCOMOTION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RAT; SWIMMING; WESTERN BLOTTING; ZEBRA FISH;

DANIO RERIO; RATTUS;

EID: 84866666308     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046253     Document Type: Article

References (31)

1. Sun L, Tran N, Tang F, App H, Hirth P, et al. (1998) Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem 41: 2588-2603.
2. Fong TA, Shawver LK, Sun L, Tang C, App H, et al. (1999) SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res 59: 99-106.
3. Stopeck A, Sheldon M, Vahedian M, Cropp G, Gosalia R, et al. (2002) Results of a Phase I dose-escalating study of the antiangiogenic agent, SU5416, in patients with advanced malignancies. Clin Cancer Res 8: 2798-2805.
4. Ye C, Sweeny D, Sukbuntherng J, Zhang Q, Tan W, et al. (2006) Distribution, metabolism, and excretion of the anti-angiogenic compound SU5416. Toxicol In Vitro 20: 154-162.
5. Shawver LK, Slamon D, Ullrich A, (2002) Smart drugs: tyrosine kinase inhibitors in cancer therapy. Cancer Cell 1: 117-123.
6. Kieran MW, Supko JG, Wallace D, Fruscio R, Poussaint TY, et al. (2009) Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR) in refractory pediatric central nervous system tumors. Pediatr Blood Cancer 52: 169-176.
7. Lees AJ, Hardy J, Revesz T, (2009) Parkinson's disease. Lancet 373: 2055-2066.
8. Grayson M, (2010) Parkinson's disease. Nature 466: S1.
9. Shin JH, Dawson VL, Dawson TM (2009) SnapShot: pathogenesis of Parkinson's disease. Cell 139: 440 e441-442.
10. Kavya R, Saluja R, Singh S, Dikshit M, (2006) Nitric oxide synthase regulation and diversity: implications in Parkinson's disease. Nitric Oxide 15: 280-294.
11. Muramatsu Y, Kurosaki R, Watanabe H, Michimata M, Matsubara M, et al. (2003) Cerebral alterations in a MPTP-mouse model of Parkinson's disease-an immunocytochemical study. J Neural Transm 110: 1129-1144.
12. Hantraye P, Brouillet E, Ferrante R, Palfi S, Dolan R, et al. (1996) Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nat Med 2: 1017-1021.
13. Li W, Xue J, Niu C, Fu H, Lam CS, et al. (2007) Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase. Mol Pharmacol 71: 1258-1267.
14. Li W, Lee NT, Fu H, Kan KK, Pang Y, et al. (2006) Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine. Neuroreport 17: 471-474.
15. Choi DY, Liu M, Hunter RL, Cass WA, Pandya JD, et al. (2009) Striatal neuroinflammation promotes Parkinsonism in rats. PLoS One 4: e5482.
16. Flinn L, Bretaud S, Lo C, Ingham PW, Bandmann O, (2008) Zebrafish as a new animal model for movement disorders. J Neurochem 106: 1991-1997.
17. Schweitzer J, Lohr H, Filippi A, Driever W (2011) Dopaminergic and noradrenergic circuit development in zebrafish. Dev Neurobiol.
18. Li W, Pi R, Chan HH, Fu H, Lee NT, et al. (2005) Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors. J Biol Chem 280: 18179-18188.
19. Sheng JZ, Wang D, Braun AP, (2005) DAF-FM (4-amino-5-methylamino-2',7'-difluorofluorescein) diacetate detects impairment of agonist-stimulated nitric oxide synthesis by elevated glucose in human vascular endothelial cells: reversal by vitamin C and L-sepiapterin. J Pharmacol Exp Ther 315: 931-940.
20. Westerfield M (1993) The Zebrafish book: a guide for the laboratory use of zebrafish (Brachydanio rerio). Eugene. Or.: University of Oregon Press. 1 v. (various pagings) p.
21. Zhang ZJ, Cheang LC, Wang MW, Lee SM, (2011) Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and pro-inflammation gene expression in PC12 cells and in zebrafish. Int J Mol Med 27: 195-203.
22. Sabaliauskas NA, Foutz CA, Mest JR, Budgeon LR, Sidor AT, et al. (2006) High-throughput zebrafish histology. Methods 39: 246-254.
23. Gal S, Zheng H, Fridkin M, Youdim MB, (2010) Restoration of nigrostriatal dopamine neurons in post-MPTP treatment by the novel multifunctional brain-permeable iron chelator-monoamine oxidase inhibitor drug, M30. Neurotox Res 17: 15-27.
24. Mahairaki V, Xu L, Farah MH, Hatfield G, Kizana E, et al. (2009) Targeted knock-down of neuronal nitric oxide synthase expression in basal forebrain with RNA interference. J Neurosci Methods 179: 292-299.
25. Przedborski S, Jackson-Lewis V, Yokoyama R, Shibata T, Dawson VL, et al. (1996) Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Proc Natl Acad Sci U S A 93: 4565-4571.
26. Zhu Y, Jin K, Mao XO, Greenberg DA, (2003) Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression. Faseb J 17: 186-193.
27. Cui W, Li W, Han R, Mak S, Zhang H, et al. (2011) PI3-K/Akt and ERK pathways activated by VEGF play opposite roles in MPP+-induced neuronal apoptosis. Neurochem Int 59: 945-953.
28. Gonzalez-Polo RA, Soler G, Fuentes JM, (2004) MPP+: mechanism for its toxicity in cerebellar granule cells. Mol Neurobiol 30: 253-264.
29. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA, (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A 87: 1620-1624.
30. Nagl F, Schonhofer K, Seidler B, Mages J, Allescher HD, et al. (2009) Retinoic acid-induced nNOS expression depends on a novel PI3K/Akt/DAX1 pathway in human TGW-nu-I neuroblastoma cells. Am J Physiol Cell Physiol 297: C1146-1156.
31. Thomas B, Saravanan KS, Mohanakumar KP, (2008) In vitro and in vivo evidences that antioxidant action contributes to the neuroprotective effects of the neuronal nitric oxide synthase and monoamine oxidase-B inhibitor, 7-nitroindazole. Neurochem Int 52: 990-1001.