Role of microRNA-29b in the ochratoxin A-induced enhanced collagen formation in human kidney cells

Toxicology

Volumn 324, Issue , 2014, Pages 116-122

  Hennemeier, Isabell ^a   Humpf, Hans Ulrich ^b   Gekle, Michael ^a   Schwerdt, Gerald ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Collagens; Fibrosis; Kidney; MiRNA 29b; Ochratoxin A

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 1A1; COLLAGEN TYPE 3; COLLAGEN TYPE 3A1; COLLAGEN TYPE 4; COLLAGEN TYPE 4A1; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; MICRORNA 29B; OCHRATOXIN; UNCLASSIFIED DRUG; COLLAGEN TYPE 2;

3' UNTRANSLATED REGION; ARTICLE; CELLULAR DISTRIBUTION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HEK293 CELL LINE; HUMAN; HUMAN CELL; KIDNEY CELL; KIDNEY FIBROSIS; LUCIFERASE ASSAY; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN SECRETION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; UPREGULATION; EXTRACELLULAR MATRIX; KIDNEY DISEASE; RNA PROCESSING;

COLLAGENS; FIBROSIS; KIDNEY; MIRNA-29B; OCHRATOXIN A;

3' UNTRANSLATED REGIONS; BINDING SITES; COLLAGEN TYPE I; FIBROSIS; GENES, REPORTER; HEK293 CELLS; HOMEOSTASIS; HUMANS; KIDNEY; MICRORNAS; OCHRATOXINS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; TRANSFECTION; UP-REGULATION;

EID: 84907348019     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2014.07.012     Document Type: Article

References (41)

1. Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
2. Bhattacharyya S.N., Habermacher R., Martine U., Closs E.I., Filipowicz W. Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell 2006, 125:1111-1124.
3. Bhattacharyya S.N., Habermacher R., Martine U., Closs E.I., Filipowicz W. Stress-induced reversal of microRNA repression and mRNA P-body localization in human cells. Cold Spring Harb. Symp. Quant. Biol. 2006, 71:513-521.
4. Boor P., Ostendorf T., Floege J. Renal fibrosis: novel insights into mechanisms and therapeutic targets. Nat. Rev. Nephrol. 2010, 6:643-656.
5. Cazalla D., Yario T., Steitz J.A. Down-regulation of a host microRNA by a Herpesvirus saimiri noncoding RNA. Science 2010, 328:1563-1566.
6. Coronel M.B., Sanchis V., Ramos A.J., Marin S. Ochratoxin A in adult population of Lleida Spain: presence in blood plasma and consumption in different regions and seasons. Food Chem. Toxicol. 2011, 49:2697-2705.
7. Ebert M.S., Sharp P.A. Emerging roles for natural microRNA sponges. Curr. Biol. 2010, 20:R858-R861.
8. Franco-Zorrilla J.M., Valli A., Todesco M., Mateos I., Puga M.I., Rubio-Somoza I., Leyva A., Weigel D., Garcia J.A., Paz-Ares J. Target mimicry provides a new mechanism for regulation of microRNA activity. Nat. Genet. 2007, 39:1033-1037.
9. Gagliano N., Torri C., Donetti E., Grizzi F., Costa F., Bertelli A.A., Migliori M., Filippi C., Bedoni M., Panichi V., Giovannini L., Gioia M. Ochratoxin A-induced renal cortex fibrosis and epithelial-to-mesenchymal transition: molecular aspects of ochratoxin A-injury and potential effects of red wine. Mol. Med. 2005, 11:30-38.
10. Gekle M., Sauvant C., Schwerdt G. Ochratoxin A at nanomolar concentrations: a signal modulator in renal cells. Mol. Nutr. Food Res. 2005, 49:118-130.
11. Gekle M., Sauvant C., Schwerdt G., Silbernagl S. Tubulotoxic mechanisms of ochratoxin A. Kidney Blood Press. Res. 1998, 21:277-279.
12. Gekle M., Schwerdt G., Freudinger R., Mildenberger S., Wilflingseder D., Pollack V., Dander M., Schramek H. Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. J. Pharmacol. Exp. Ther. 2000, 293:837-844.
13. Gekle M., Silbernagl S. Mechanism of ochratoxin A-induced reduction of glomerular filtration rate in rats. J. Pharmacol. Exp. Ther. 1993, 267:316-321.
14. Hansen T.B., Jensen T.I., Clausen B.H., Bramsen J.B., Finsen B., Damgaard C.K., Kjems J. Natural RNA circles function as efficient microRNA sponges. Nature 2013, 495:384-388.
15. Hennemeier I., Humpf H.U., Gekle M., Schwerdt G. The food contaminant and nephrotoxin ochratoxin A enhances Wnt1 inducible signaling protein 1 and tumor necrosis factor-α expression in human primary proximal tubule cells. Mol. Nutr. Food Res. 2012, 56:1375-1384.
16. Klahr S., Morrissey J. Obstructive nephropathy and renal fibrosis. Am. J. Physiol. Renal Physiol. 2002, 283:F861-F875.
17. Kriegel A.J., Liu Y., Fang Y., Ding X., Liang M. The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury. Physiol. Genomics 2012, 44:237-244.
18. Krol J., Loedige I., Filipowicz W. The widespread regulation of microRNA biogenesis function and decay. Nat. Rev. Genet. 2010, 11:597-610.
19. Kusenda B., Mraz M., Mayer J., Pospisilova S. MicroRNA biogenesis functionality and cancer relevance. Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc Czech Repub. 2006, 150:205-215.
20. Kwiecinski M., Noetel A., Elfimova N., Trebicka J., Schievenbusch S., Strack I., Molnar L., von Brandenstein M., Tox U., Nischt R., Coutelle O., Dienes H.P., Odenthal M. Hepatocyte growth factor (HGF) inhibits collagen I and IV synthesis in hepatic stellate cells by miRNA-29 induction. PLoS One 2011, 6:e24568.
21. Lane R.D., Federman D., Flora J.L., Beck B.L. Computer-assisted determination of protein concentrations from dye-binding and bicinchoninic acid protein assays performed in microtiter plates. J. Immunol. Methods 1986, 92:261-270.
22. Leung A.K., Sharp P.A. Function and localization of microRNAs in mammalian cells. Cold Spring Harb. Symp. Quant. Biol. 2006, 71:29-38.
23. Li Z.F., Liang Y.M., Lau P.N., Shen W., Wang D.K., Cheung W.T., Xue C.J., Poon L.M., Lam Y.W. Dynamic localisation of mature microRNAs in human nucleoli is influenced by exogenous genetic materials. PLoS One 2013, 8:e70869.
24. Liang H., Zhang J., Zen K., Zhang C.Y., Chen X. Nuclear microRNAs and their unconventional role in regulating non-coding RNAs. Protein Cell 2013, 4:325-330.
25. Liu Y., Taylor N.E., Lu L., Usa K., Cowley A.W., Ferreri N.R., Yeo N.C., Liang M. Renal medullary microRNAs in Dahl salt-sensitive rats: miR-29b regulates several collagens and related genes. Hypertension 2010, 55:974-982.
26. Miraglia, M., Brera, C., Pazzaglini, B., Grossi, S., 2002. Assessment of dietary intake of ochratoxin A by the population of EU member states. Task 3.2.7, 1-153.
27. Qin W., Chung A.C., Huang X.R., Meng X.M., Hui D.S., Yu C.M., Sung J.J., Lan H.Y. TGF-beta/Smad3 signaling promotes renal fibrosis by inhibiting miR-29. J. Am. Soc. Nephrol. 2011, 22:1462-1474.
28. Salmena L., Poliseno L., Tay Y., Kats L., Pandolfi P.P. A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?. Cell 2011, 146:353-358.
29. Sauvant C., Holzinger H., Gekle M. Proximal tubular toxicity of ochratoxin A is amplified by simultaneous inhibition of the extracellular signal-regulated kinases 1/2. J. Pharmacol. Exp. Ther. 2005, 313:234-241.
30. Sauvant C., Silbernagl S., Gekle M. Exposure to ochratoxin A impairs organic anion transport in proximal- tubule-derived opossum kidney cells. J. Pharmacol. Exp. Ther. 1998, 287:13-20.
31. Schwerdt G., Freudinger R., Mildenberger S., Silbernagl S., Gekle M. The nephrotoxin ochratoxin A induces apoptosis in cultured human proximal tubule cells. Cell. Biol. Toxicol. 1999, 15:405-415.
32. Schwerdt G., Freudinger R., Silbernagl S., Gekle M. Ochratoxin A-binding proteins in rat organs and plasma and in different cell lines of the kidney. Toxicology 1999, 135:1-10.
33. Schwerdt G., Holzinger H., Königs M., Humpf H.U., Gekle M. Effect of ochratoxin A on cell survival and collagen homeostasis in human mesangial cells in primary culture. Food Chem. Toxicol. 2009, 47:209-213.
34. Schwerdt G., Holzinger H., Sauvant C., Königs M., Humpf H.U., Gekle M. Long-term effects of ochratoxin A on fibrosis and cell death in human proximal tubule or fibroblast cells in primary culture. Toxicology 2007, 232:57-67.
35. Stachurska A., Ciesla M., Kozakowska M., Wolffram S., Boesch-Saadatmandi C., Rimbach G., Jozkowicz A., Dulak J., Loboda A. Cross-talk between microRNAs nuclear factor E2-related factor 2 and heme oxygenase-1 in ochratoxin A-induced toxic effects in renal proximal tubular epithelial cells. Mol. Nutr. Food Res. 2013, 57:504-515.
36. Studer-Rohr I., Schlatter J., Dietrich D.R. Kinetic parameters and intraindividual fluctuations of ochratoxin A plasma levels in humans. Arch. Toxicol. 2000, 74:499-510.
37. van Rooij E., Sutherland L.B., Thatcher J.E., DiMaio J.M., Naseem R.H., Marshall W.S., Hill J.A., Olson E.N. Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:13027-13032.
38. Wang B., Komers R., Carew R., Winbanks C.E., Xu B., Herman-Edelstein M., Koh P., Thomas M., Jandeleit-Dahm K., Gregorevic P., Cooper M.E., Kantharidis P. Suppression of microRNA-29 expression by TGF-beta1 promotes collagen expression and renal fibrosis. J. Am. Soc. Nephrol. 2012, 23:252-265.
39. Wang Y., Zhang X., Li H., Yu J., Ren X. The role of miRNA-29 family in cancer. Eur. J. Cell Biol. 2013, 92:123-128.
40. Xiao J., Meng X.M., Huang X.R., Chung A.C., Feng Y.L., Hui D.S., Yu C.M., Sung J.J., Lan H.Y. miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice. Mol. Ther. 2012, 20:1251-1260.
41. Yang J., Li J., Jiang Y., Duan X., Qu H., Yang B., Chen F., Sivakumar D. Natural occurrence analysis and prevention of mycotoxins in fruits and their processed products. Crit. Rev. Food Sci. Nutr. 2014, 54:64-83.