Brain suppression of AP-1 by inhaled diesel exhaust and reversal by cerium oxide nanoparticles

Inhalation Toxicology

Volumn 26, Issue 10, 2014, Pages 636-641

  Lung, Shyang ^a   Cassee, Flemming R ^b   Gosens, Ilse ^b   Campbell, Arezoo ^a  

^a WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

C Jun; Nanoceria; Stress; Transcription factors

Indexed keywords

APOLIPOPROTEIN E; CERIUM OXIDE; CERIUM OXIDE NANOPARTICLE; DIESEL FUEL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NANOPARTICLE; PROTEIN C JUN; PROTEIN FOS; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; CERIC OXIDE; CERIUM; EXHAUST GAS; GASOLINE; PROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; BRAIN PROTECTION; BRAIN REGION; CEREBELLUM; CONTROLLED STUDY; EXHAUST GAS; EXPOSURE; GEL MOBILITY SHIFT ASSAY; GENETIC PREDISPOSITION; KNOCKOUT MOUSE; LIPID DIET; MALE; MOUSE; NONHUMAN; PILOT STUDY; PRIORITY JOURNAL; SUBCORTEX; TOXIC INHALATION; WESTERN BLOTTING; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; ATHEROSCLEROSIS; BRAIN; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM; TOXICITY;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BLOTTING, WESTERN; BRAIN; CERIUM; DIET, HIGH-FAT; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GASOLINE; INHALATION EXPOSURE; MICE, KNOCKOUT; NANOPARTICLES; PILOT PROJECTS; PROTECTIVE AGENTS; TRANSCRIPTION FACTOR AP-1; VEHICLE EMISSIONS;

EID: 84907325336     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2014.948651     Document Type: Article

References (36)

1. Baeuerle PA, Henkel T. (1994). Function and activation of NF-κB in the immune system. Ann Rev Immunol 12:141-79.
2. Block ML, Calderón-Garciduenǎs L. (2009). Air pollution: mechanisms of neuroinflammation and CNS disease. Trends Neurosci 32:506-16.
3. Block ML, Wu X, Pei Z, et al. (2004). Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase. FASEB J 18:1618-20.
4. Bos I, De Boever P, Emmerechts J, et al. (2012). Changed gene expression in brains of mice exposed to traffic in a highway tunnel. Inhal Toxicol 24:676-86.
5. Campbell A, Araujo JA, Li H, et al. (2009). Particulate matter induced enhancement of inflammatory markers in the brains of Apolipoprotein E knockout mice. J Nanosci Nanotechnol 9:5099-104.
6. Cassee FR, Campbell A, Boere AJ, et al. (2012). The biological effects of subacute inhalation of diesel exhaust following addition of cerium oxide nanoparticles in atherosclerosis-prone mice. Environ Res 115: 1-10.
7. Donaldson K, Tran L, Jimenez LA, et al. (2005). Combustionderived nanoparticles: a review of their toxicology following inhalation exposure. Part Fibre Toxicol 2:10. doi:10.1186/1743-8977-2-10.
8. Duan RS, Chen Z, Dou YC, et al. (2006). Apolipoprotein E deficiency increased microglial activation/CCR3 expression and hippocampal damage in kainic acid exposed mice. Exp Neurol 202: 373-80.
9. Frampton MW. (2001). Systemic and cardiovascular effects of airway injury and inflammation: ultrafine particle exposure in humans. Environ Health Perspect 109:529-53.
10. Geraets L, Oomen AG, Schroeter JD, et al. (2012). Tissue distribution of inhaled micro- and nano-sized cerium oxide particles in rats: results from a 28-day exposure study. Toxicol Sci 127:463-73.
11. Gerlofs-Nijland M, Berlo D, Cassee F, et al. (2010). Effect of subchronic exposure to diesel engine exhaust on proinflammatory markers in different regions of the rat brain. Part Fibre Toxicol 7:12. doi:10.1186/1743-8977-7-12.
12. Gius D, Botero A, Shah S, Curry HA. (1999). Intracellular oxidation/reduction status in the regulation of transcription factors NF-κB and AP-1. Toxicol Lett 106:93-106.
13. Hardas SS, Sultana R, Warrier G, et al. (2012). Rat brain pro-oxidant effects of peripherally administered 5 nm ceria 30 days after exposure. Neurotoxicology 33:1147-55.
14. Hatada EN, Krappmann D, Scheidereit C. (2000). NF-jB and the innate immune response. Curr Opin Immunol 12:52-8.
15. Heckert EG, Karakoti AS, Seal S, Self WT. (2008). The role of cerium redox state in the SOD mimetic activity of nanoceria. Biomaterials 29: 2705-9.
16. Herdegen T, Waetzig V. (2001). AP-1 proteins in the adult brain: facts and fiction about effectors of neuroprotection and neurodegeneration. Oncogene 20:2424-37.
17. Hess J, Angel P, Schropp-Kistner M. (2004). AP-1 subunits: quarrel and harmony among siblings. J Cell Sci 117:5965-73.
18. Klusa V, Muceniece R, Isajevs S, et al. (2013). Mildronate enhances learning/memory and changes hippocampal protein expression in trained rats. Pharmacol Biochem Behav 106:68-76.
19. Lahiri D, Ge Y. (2000). Electrophoretic mobility shift assay for the detection of specific DNA-protein complex in nuclear extracts from the cultured cells and frozen autopsy human brain tissue. Brain Res Protoc 5:257-65.
20. Lynch JR, Morgan D, Mance J, et al. (2001). Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. J Neuroimmunol 114:107-13.
21. Mehan S, Meena H, Sharma D, Sankhla R. (2011). JNK: a stressactivated protein kinase therapeutic strategies and involvement in Alzheimer's and various neurodegenerative abnormalities. J Mol Neurosci 43:376-90.
22. Methia N, Andre P, Hafezi-Moghadam A, et al. (2001). ApoE deficiency compromises the blood brain barrier especially after injury. Mol Med 7:810-15.
23. Morgan TE, Davis DA, Iwata N, et al. (2011). Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro. Environ Health Perspect 119:1003-9.
24. Oppenheim HA, Lucero J, Guyot A, et al. (2013). Exposure to vehicle emissions results in altered blood brain barrier permeability and expression of matrix metalloprotinases and tight junction proteins in mice. Part Fibre Toxicol 10:62. doi:10.1186/1743-8977-10-62.
25. Pairon JC, Roos F, Sebastien P, et al. (1995). Biopersistence of cerium in the human respiratory tract and ultrastructural findings. Am J Ind Med 27:349-58.
26. Park EJ, Choi J, Park YK, Park K. (2008). Oxidative stress induced by cerium oxide nanoparticles in cultured BEAS-2B cells. Toxicology 245:90-100.
27. Park B, Martin P, Harris C, et al. (2007). Initial in vitro screening approach to investigate the potential health and environmental hazards of Envirox - a nanoparticulate cerium oxide diesel fuel additive. Part Fibre Toxicol 4:12. doi:10.1186/1743-8977-4-12.
28. Pérez-Cadahía B, Drobic B, Davie JR. (2011). Activation and function of immediate-early genes in the nervous system. Biochem Cell Biol 89: 61-73.
29. Pope CA, Burnett RT, Thun MJ, et al. (2002). Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA 287:1132-41.
30. Power MC, Weisskopf MG, Alexeeff SE, et al. (2011). Traffic related air pollution and cognitive function in a cohort of older men. Environ Health Perspect 119:682-7.
31. Raivich G, Behrens A. (2006). Role of AP-1 transcription factor c-Jun in developing, adult and injured brain. Prog Neurobiol 78:347-63.
32. Suglia SF, Gryparis A, Wright RO, et al. (2008). Association of black carbon with cognition among children in a prospective birth cohort study. Am J Epidemiol 167:280-6.
33. Weuve J, Puett RC, Schwartz J, et al. (2012). Exposure to particulate air pollution and cognitive decline in older women. Arch Intern Med 172: 219-27.
34. Wosiski-Kuhn M, Erion JR, Gomez-Sanchez EP, et al. (2014). Glucocorticoid receptor activation impairs hippocampal plasticity by suppressing BDNF expression in obese mice. Psychoneuroendocrinology 42:165-77.
35. Yokel RA, Au TC, MacPhail R, et al. (2012). Distribution, elimination, and biopersistence to 90 days of a systemically introduced 30 nm ceria-engineered nanomaterial in rats. Toxicol Sci 127:256-68.
36. Yokota S, Hori H, Umezawa M, et al. (2013). Gene expression changes in the olfactory bulb of mice induced by exposure to diesel exhaust are dependent on animal rearing environment. PLoS One 8: e70145.