Small molecule compound induces chromatin de-condensation and facilitates induced pluripotent stem cell generation

Journal of Molecular Cell Biology

Volumn 6, Issue 5, 2014, Pages 409-420

  Wei, Xiaoyuan ^a,b   Chen, Yueting ^b   Xu, Yongyu ^a,b   Zhan, Yang ^b   Zhang, Ru ^a   Wang, Min ^b   Hua, Qiuhong ^a   Gu, Haifeng ^b   Nan, Fajun ^b   Xie, Xin ^a,b  

^a TONGJI UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Chromatin de condensation; Chromatin remodeling; CYT296; HP1 ; Induced pluripotent stem cells; Reprogramming; Small molecule compound

Indexed keywords

CHEMICAL COMPOUND; CYT 296; HETEROCHROMATIN PROTEIN 1; HETEROCHROMATIN PROTEIN 1 ALPHA; OCTAMER TRANSCRIPTION FACTOR 4; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; CHROMATIN; CYT296; FUSED HETEROCYCLIC RINGS; SPIRO COMPOUND;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL VIABILITY; CHROMATIN CONDENSATION; CHROMATIN DECONDENSATION; CHROMATIN STRUCTURE; CONTROLLED STUDY; EMBRYONIC STEM CELL; HETEROCHROMATIN; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; SOMATIC CELL; TETRAPLOIDY; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; CHROMATIN; CULTURE TECHNIQUE; CYTOLOGY; METABOLISM; ULTRASTRUCTURE;

MUS;

ANIMALS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELLS, CULTURED; CHROMATIN; HETEROCYCLIC COMPOUNDS, 2-RING; INDUCED PLURIPOTENT STEM CELLS; MICE; SPIRO COMPOUNDS;

EID: 84907304288     PISSN: 16742788     EISSN: 17594685     Source Type: Journal    
DOI: 10.1093/jmcb/mju024     Document Type: Article

References (35)

1. Bernstein, E., Duncan, E.M., Masui, O., et al. (2006). Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin. Mol. Cell. Biol. 26, 2560-2569.
2. Buganim, Y., Faddah, D.A., Cheng, A.W., et al. (2012). Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell 150, 1209-1222.
3. Carey, B.W., Markoulaki, S., Hanna, J.H., et al. (2011). Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells. Cell Stem Cell 9, 588-598.
4. Chan, K.M., Zhang, H., Malureanu, L., et al. (2011). Diverse factors are involved in maintaining X chromosome inactivation. Proc. Natl Acad. Sci. USA 108, 16699-16704.
5. Dillon, N. (2004). Heterochromatin structure and function. Biol. Cell 96, 631-637.
6. Efroni, S., Duttagupta, R., Cheng, J., et al. (2008). Global transcription in pluripotent embryonic stem cells. Cell Stem Cell 2, 437-447.
7. Feng, B., Jiang, J., Kraus, P., et al. (2009). Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat. Cell Biol. 11, 197-203.
8. Gao, Y., Chen, J., Li, K., et al. (2013). Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell 12, 453-469.
9. Gaspar-Maia, A., Alajem, A., Meshorer, E., et al. (2011). Open chromatin in pluripotency and reprogramming. Nat. Rev. Mol. Cell Biol. 12, 36-47.
10. Golob, J.L., Paige, S.L., Muskheli, V., et al. (2008). Chromatin remodeling during mouse and human embryonic stem cell differentiation. Dev. Dyn. 237, 1389-1398.
11. Gurdon, J.B., Laskey, R.A., De Robertis, E.M., et al. (1979). Reprogramming of transplanted nuclei in amphibia. Int. Rev. Cytol. Suppl. 161-178.
12. Hajkova, P., el-Maarri, O., Engemann, S., et al. (2002). DNA-methylation analysis by the bisulfite-assisted genomic sequencing method. Methods Mol. Biol. 200, 143-154.
13. Hansis, C., Barreto, G., Maltry, N., et al. (2004).Nuclear reprogramming of human somatic cells by xenopus egg extract requires BRG1. Curr. Biol. 14, 1475-1480.
14. Hochedlinger, K., and Plath, K. (2009). Epigenetic reprogramming and induced pluripotency. Development 136, 509-523.
15. Huangfu, D., Maehr, R., Guo, W., et al. (2008). Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat. Biotechnol. 26, 795-797.
16. Jullien, J., Astrand, C., Halley-Stott, R.P., et al. (2010). Characterization of somatic cell nuclear reprogramming by oocytes in which a linker histone is required for pluripotency gene reactivation. Proc. Natl Acad. Sci. USA 107, 5483-5488.
17. Koche, R.P., Smith, Z.D., Adli, M., et al. (2011). Reprogramming factor expression initiates widespread targeted chromatin remodeling. Cell Stem Cell 8, 96-105.
18. Lachner, M., O'Sullivan, R.J., and Jenuwein, T. (2003). An epigenetic roadmap for histone lysine methylation. J. Cell Sci. 116, 2117-2124.
19. Li, B., Carey, M., and Workman, J.L. (2007). The role of chromatin during transcription. Cell 128, 707-719.
20. Ma, J. (2011). Transcriptional activators and activation mechanisms. Protein Cell 2, 879-888.
21. Maison, C., and Almouzni, G. (2004). HP1 and the dynamics of heterochromatin maintenance. Nat. Rev. Mol. Cell Biol. 5, 296-304.
22. Marchion, D.C., Bicaku, E., Daud, A.I., et al. (2005). Valproic acid alters chromatin structure by regulation of chromatin modulation proteins. Cancer Res. 65, 3815-3822.
23. Meshorer, E., and Misteli, T. (2006). Chromatin in pluripotent embryonic stem cells and differentiation. Nat. Rev. Mol. Cell Biol. 7, 540-546.
24. Mikkelsen, T.S., Hanna, J., Zhang, X., et al. (2008). Dissecting direct reprogramming through integrative genomic analysis. Nature 454, 49-55.
25. Pasque, V., Jullien, J., Miyamoto, K., et al. (2011). Epigenetic factors influencing resistance to nuclear reprogramming. Trends Genet. 27, 516-525.
26. Plath, K., and Lowry, W.E. (2011). Progress in understanding reprogramming to the induced pluripotent state. Nat. Rev. Genet. 12, 253-265.
27. Singhal, N., Graumann, J., Wu, G., et al. (2010). Chromatin-remodeling components of the BAF complex facilitate reprogramming. Cell 141, 943-955.
28. Sommer, C.A., Stadtfeld, M., Murphy, G.J., et al. (2009). Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem Cells 27, 543-549.
29. Soufi, A., Donahue, G., and Zaret, K.S. (2012). Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genome. Cell 151, 994-1004.
30. Sridharan, R., Gonzales-Cope, M., Chronis, C., et al. (2013). Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1gamma in reprogramming to pluripotency. Nat. Cell Biol. 15, 872-882.
31. Tamada, H., Van Thuan, N., Reed, P., et al. (2006). Chromatin decondensation and nuclear reprogramming by nucleoplasmin. Mol. Cell. Biol. 26, 1259-1271.
32. Wang, Q., Xu, X., Li, J., et al. (2011). Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells. Cell Res. 21, 1424-1435.
33. Zhang, J., Gao, Q., Li, P., et al. (2011). S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance. Cell Res. 21, 1723-1739.
34. Zhang, R., Zhang, L.H., and Xie, X. (2013). iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery. Acta Pharmacol. Sin. 34, 765-776.
35. Zhao, X.Y., Li, W., Lv, Z., et al. (2009). iPS cells produce viable mice through tetraploid complementation. Nature 461, 86-90.