An anti-neuroinflammatory that targets dysregulated glia enhances the efficacy of CNS-directed gene therapy in murine infantile neuronal ceroid lipofuscinosis

Journal of Neuroscience

Volumn 34, Issue 39, 2014, Pages 13077-13082

  Macauley, Shannon L ^a   Wong, Andrew M S ^c   Shyng, Charles ^a   Augner, David P ^c   Dearborn, Joshua T ^a   Pearse, Yewande ^c   Roberts, Marie S ^a   Fowler, Stephen C ^b   Cooper, Jonathan D ^c   Watterson, Martin ^d   Sands, Mark S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Batten disease; Lysosomal storage disease; Neurodegeneration; Neuroinflammation; Neuronal ceroid lipofuscinosis

Indexed keywords

CD68 ANTIGEN; CENTRAL NERVOUS SYSTEM AGENTS; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; MW 151; ONCOSTATIN M; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; CYTOKINE; MW01-2-069A-SRM; PALMITOYL-PROTEIN THIOESTERASE; PYRIDAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; THIOL ESTER HYDROLASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN ATROPHY; FEMALE; GENE THERAPY; IMMUNOHISTOCHEMISTRY; LIFESPAN; MALE; MICROGLIA; MOTOR PERFORMANCE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEURONAL CEROID LIPOFUSCINOSIS; NONHUMAN; PROTEIN EXPRESSION; ROTAROD TEST; SEIZURE; ANIMAL; BLOOD BRAIN BARRIER; C57BL MOUSE; DEPENDOPARVOVIRUS; DRUG EFFECTS; GENETICS; LOCOMOTION; METABOLISM; NEURONAL CEROID-LIPOFUSCINOSES; SEIZURES;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOOD-BRAIN BARRIER; CYTOKINES; DEPENDOVIRUS; GENETIC THERAPY; LOCOMOTION; MICE; MICE, INBRED C57BL; MICROGLIA; NEURONAL CEROID-LIPOFUSCINOSES; PYRIDAZINES; PYRIMIDINES; SEIZURES; THIOLESTER HYDROLASES;

EID: 84907291790     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2518-14.2014     Document Type: Article

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