Controlled delivery of carvedilol nanosuspension from osmotic pump capsule: In vitro and in vivo evaluation

International Journal of Pharmaceutics

Volumn 475, Issue 1, 2014, Pages 496-503

  Liu, Dandan ^a,b   Yu, Shihui ^a   Zhu, Zhihong ^a   Lyu, Chunyang ^a   Bai, Chunping ^b   Ge, Huiqi ^b   Yang, Xinggang ^a   Pan, Weisan ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b LIAONING INSTITUTE OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Carvedilol; Central composite design; Nanosuspensions; Oral bioavailability; Osmotic pump; Poorly water soluble drugs

Indexed keywords

CARVEDILOL; NANOPARTICLE; ANTIHYPERTENSIVE AGENT; CARBAZOLE DERIVATIVE; DELAYED RELEASE FORMULATION; MANNITOL; POVIDONE; PROPANOLAMINE DERIVATIVE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DOG; DRUG BIOAVAILABILITY; DRUG CAPSULE; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; NANOSUSPENSION; NONHUMAN; OSMOTIC PUMP CAPSULE; PARTICLE SIZE; SUSPENSION; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG RELEASE; MEDICINAL CHEMISTRY; OSMOSIS; PROCEDURES; SOLUBILITY;

ANIMALS; ANTIHYPERTENSIVE AGENTS; CARBAZOLES; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DOGS; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; MANNITOL; NANOPARTICLES; OSMOSIS; PARTICLE SIZE; POVIDONE; PROPANOLAMINES; SOLUBILITY;

EID: 84907262824     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.09.008     Document Type: Article

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