Effect of Th17 and Treg axis disorder on outcomes of pulmonary arterial hypertension in connective tissue diseases

Mediators of Inflammation

Volumn 2014, Issue , 2014, Pages

  Gaowa, Saren ^a   Zhou, Wenyong ^b   Yu, Lilei ^a   Zhou, Xiaohui ^b   Liao, Kai ^a   Yang, Kang ^a   Lu, Zhibin ^a   Jiang, Hong ^a   Chen, Xiaofeng ^c  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b Tongji University   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; RETINOID RELATED ORPHAN RECEPTOR GAMMA;

ADULT; ARTICLE; CELL COUNT; CONNECTIVE TISSUE DISEASE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PERIPHERAL CIRCULATION; PROGNOSIS; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; REGULATORY T LYMPHOCYTE; TH17 CELL; ADOLESCENT; AGED; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; PROSPECTIVE STUDY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CONNECTIVE TISSUE DISEASES; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; HYPERTENSION, PULMONARY; MALE; MIDDLE AGED; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PROSPECTIVE STUDIES; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; YOUNG ADULT;

EID: 84907228625     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2014/247372     Document Type: Article

References (35)

1. Simonneau G., Gatzoulis M. A., Adatia I., Updated clinical classification of pulmonary hypertension. Journal of the American College of Cardiology 2013 62 25, supplement D34 D41
2. Hachulla E., Gressin V., Guillevin L., Carpentier P., Diot E., Sibilia J., Kahan A., Cabane J., Francès C., Launay D., Mouthon L., Allanore Y., Tiev K. P., Clerson P., De Groote P., Humbert M., Early detection of pulmonary arterial hypertension in systemic sclerosis: a French nationwide prospective multicenter study. Arthritis and Rheumatism 2005 52 12 3792 3800 10.1002/art.21433 2-s2.0-29144536869
3. Mukerjee D., St George D., Coleiro B., Knight C., Denton C. P., Davar J., Black C. M., Coghlan J. G., Prevalence and outcome in systemic sclerosis associated pulmonary arterial hypertension: application of a registry approach. Annals of the Rheumatic Diseases 2003 62 11 1088 1093 10.1136/ard.62.11.1088 2-s2.0-0142187600
4. Yang X., Mardekian J., Sanders K. N., Mychaskiw M. A., Thomas J. III, Prevalence of pulmonary arterial hypertension in patients with connective tissue diseases: a systematic review of the literature. Clinical Rheumatology 2013 32 10 1519 1531 10.1007/s10067-013-2307-2 2-s2.0-84878900194
5. Kuwana M., Watanabe H., Matsuoka N., Sugiyama N., Pulmonary arterial hypertension associated with connective tissue disease: meta-analysis of clinical trials. BMJ Open 2013 3 8 e003113 10.1136/bmjopen-2013-003113
6. H17 cells in chronic inflammation. Nature Reviews Drug Discovery 2012 11 10 763 776 10.1038/nrd3794 2-s2.0-84866934694
7. Monteleone I., Pallone F., Monteleone G., Interleukin-23 and Th17 cells in the control of gut inflammation. Mediators of Inflammation 2009 2009 7 297645 10.1155/2009/297645 2-s2.0-67650233384
8. H17 cells in gastrointestinal diseases. Mediators of Inflammation 2009 2009 11 132028 10.1155/2009/132028 2-s2.0-77949379104
9. +regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annual Review of Immunology 2004 22 531 562 10.1146/annurev.immunol.21.120601.141122 2-s2.0-2442484053
10. Boldt A., Borte S., Fricke S., Kentouche K., Emmrich F., Borte M., Kahlenberg F., Sack U., Eight-color immunophenotyping of T-, B-, and NK-cell subpopulations for characterization of chronic immunodeficiencies. Cytometry Part B: Clinical Cytometry 2014 86 3 191 206
11. Maecker H. T., McCoy J. P., Nussenblatt R., Standardizing immunophenotyping for the Human Immunology Project. Nature Reviews Immunology 2012 12 3 191 200 10.1038/nri3158 2-s2.0-84857647499
12. Buc M., Role of regulatory T cells in pathogenesis and biological therapy of multiple sclerosis. Mediators of Inflammation 2013 2013 11 963748 10.1155/2013/963748 2-s2.0-84878633653
13. Nie H., Zheng Y., Li R., Guo T. B., He D., Fang L., Liu X., Xiao L., Chen X., Wan B., Chin Y. E., Zhang J. Z., Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF- α in rheumatoid arthritis. Nature Medicine 2013 19 3 322 328 10.1038/nm.3085 2-s2.0-84875153425
14. Garcia-Rodriguez S., Callejas-Rubio J., Ortego-Centeno N., Zumaquero E., Ríos-Fernandez R., Arias-Santiago S., Navarro P., Sancho J., Zubiaur M., Altered AKT1 and MAPK1 gene expression on peripheral blood mononuclear cells and correlation with T-helper-transcription factors in systemic lupus erythematosus patients. Mediators of Inflammation 2012 2012 14 495934 10.1155/2012/495934 2-s2.0-84869020815
15. Fenoglio D., Battaglia F., Parodi A., Stringara S., Negrini S., Panico N., Rizzi M., Kalli F., Conteduca G., Ghio M., De Palma R., Indiveri F., Filaci G., Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis. Clinical Immunology 2011 139 3 249 257 10.1016/j.clim.2011.01.013 2-s2.0-79955974107
16. Andreassen A. K., Wergeland R., Simonsen S., Geiran O., Guevara C., Ueland T., N-terminal pro-B-type natriuretic peptide as an indicator of disease severity in a heterogeneous group of patients with chronic precapillary pulmonary hypertension. The American Journal of Cardiology 2006 98 4 525 529 10.1016/j.amjcard.2006.02.061 2-s2.0-33746698900
17. Allanore Y., Borderie D., Avouac J., Zerkak D., Meune C., Hachulla E., Mouthon L., Guillevin L., Meyer O., Ekindjian O. G., Weber S., Kahan A., High N-terminal pro-brain natriuretic peptide levels and low diffusing capacity for carbon monoxide as independent predictors of the occurrence of precapillary pulmonary arterial hypertension in patients with systemic sclerosis. Arthritis & Rheumatism 2008 58 1 284 291 10.1002/art.23187 2-s2.0-38149040974
18. Yang J., Chu Y., Yang X., Gao D., Zhu L., Wan L., Li M., Th17 and natural treg cell population dynamics in systemic lupus erythematosus. Arthritis & Rheumatism 2009 60 5 1472 1483 10.1002/art.24499 2-s2.0-66049151440
19. Niu Q., Cai B., Huang Z., Wang L., Shi Y., Disturbed Th17/Treg balance in patients with rheumatoid arthritis. Rheumatology International 2012 32 9 2731 2736 10.1007/s00296-011-1984-x 2-s2.0-84866346472
20. +) expansion in systemic sclerosis correlates with disease activity and severity. Cellular Immunology 2010 261 2 77 80 10.1016/j.cellimm.2009.12.009 2-s2.0-77649178968
21. Antiga E., Quaglino P., Bellandi S., Volpi W., Del Bianco E., Comessatti A., Osella-Abate S., De Simone C., Marzano A., Bernengo M. G., Fabbri P., Caproni M., Regulatory T cells in the skin lesions and blood of patients with systemic sclerosis and morphoea. British Journal of Dermatology 2010 162 5 1056 1063 10.1111/j.1365-2133.2010.09633.x 2-s2.0-77951238591
22. Rodŕguez-Reyna T. S., Furuzawa-Carballeda J., Cabiedes J., Fajardo-Hermosillo L. D., Martnez-Reyes C., Daz-Zamudio M., Llorente L., Th17 peripheral cells are increased in diffuse cutaneous systemic sclerosis compared with limited illness: a cross-sectional study. Rheumatology International 2012 32 9 2653 2660 10.1007/s00296-011-2056-y 2-s2.0-84866405411
23. Radstake T. R. D. J., van Bon L., Broen J., Wenink M., Santegoets K., Deng Y., Hussaini A., Simms R., Cruikshank W. W., Lafyatis R., Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGF β expression. PLoS ONE 2009 4 6 e5981 10.1371/journal.pone.0005981 2-s2.0-67650128154
24. +T cells in systemic sclerosis patients contribute to the secretion of IL-17 and immunosuppression dysfunction. PLoS ONE 2013 8 6 e64531 10.1371/journal.pone.0064531 2-s2.0-84878922773
25. Xiao H., Wang S., Miao R., Kan W., TRAIL is associated with impaired regulation of CD4+CD25- T cells by regulatory T cells in patients with rheumatoid arthritis. Journal of Clinical Immunology 2011 31 6 1112 1119 10.1007/s10875-011-9559-x 2-s2.0-84857036632
26. Herrath J., Müller M., Amoudruz P., Janson P., Michaëlsson J., Larsson P. T., Trollmo C., Raghavan S., Malmström V., The inflammatory milieu in the rheumatic joint reduces regulatory T-cell function. European Journal of Immunology 2011 41 8 2279 2290 10.1002/eji.201041004 2-s2.0-79960735971
27. +T cells in patients with systemic lupus erythematosus. The Journal of Immunology 2009 182 3 1689 1695 10.4049/jimmunol.182.3.1689 2-s2.0-63149094153
28. Flores-Borja F., Jury E. C., Mauri C., Ehrenstein M. R., Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis. Proceedings of the National Academy of Sciences of the United States of America 2008 105 49 19396 19401 10.1073/pnas.0806855105 2-s2.0-58049196774
29. Bonelli M., Savitskaya A., von Dalwigk K., Steiner C. W., Aletaha D., Smolen J. S., Scheinecker C., Quantitative and qualitative deficiencies of regulatory T cells in patients with systemic lupus erythematosus (SLE). International Immunology 2008 20 7 861 868 10.1093/intimm/dxn044 2-s2.0-45849145442
30. Tamosiuniene R., Tian W., Dhillon G., Wang L., Sung Y. K., Gera L., Patterson A. J., Agrawal R., Rabinovitch M., Ambler K., Long C. S., Voelkel N. F., Nicolls M. R., Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension. Circulation Research 2011 109 8 867 879 10.1161/CIRCRESAHA.110.236927 2-s2.0-80053571093
31. Shetty S., Weston C. J., Oo Y. H., Westerlund N., Stamataki Z., Youster J., Hubscher S. G., Salmi M., Jalkanen S., Lalor P. F., Adams D. H., Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium. The Journal of Immunology 2011 186 7 4147 4155 10.4049/jimmunol.1002961 2-s2.0-79955016730
32. Nicolls M. R., Taraseviciene-Stewart L., Rai P. R., Badesch D. B., Voelkel N. F., Autoimmunity and pulmonary hypertension: a perspective. European Respiratory Journal 2005 26 6 1110 1118 10.1183/09031936.05.00045705 2-s2.0-29244486514
33. Bettelli E., Carrier Y., Gao W., Korn T., Strom T. B., Oukka M., Weiner H. L., Kuchroo V. K., Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006 441 7090 235 238 10.1038/nature04753 2-s2.0-33646577466
34. +regulatory T cells in humans. Proceedings of the National Academy of Sciences of the United States of America 2009 106 12 4793 4798 10.1073/pnas.0900408106 2-s2.0-63849183918
35. Beriou G., Costantino C. M., Ashley C. W., Yang L., Kuchroo V. K., Baecher-Allan C., Hafler D. A., IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood 2009 113 18 4240 4249 10.1182/blood-2008-10-183251 2-s2.0-65549088243