Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and βS-catenin signaling

Journal of Biological Chemistry

Volumn 289, Issue 38, 2014, Pages 26290-26301

  Xu, Huiming ^a,b   Tsang, Kam Sze ^c   Wang, Yonghui ^a,b   Chan, Juliana C N ^c   Xu, Gang ^c   Gao, Wei Qiang ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; MAMMALS; PROTEINS; STEM CELLS;

CATENIN SIGNALING; CELL FATE DECISION; CELLULAR DIFFERENTIATION; EMBRYONIC DEVELOPMENT; MOLECULAR MECHANISM; MOUSE EMBRYONIC STEM CELLS; UNFOLDED PROTEIN RESPONSE;

CELL SIGNALING;

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ACTIVIN A; BETA CATENIN; SMAD2 PROTEIN; TAUROURSODEOXYCHOLIC ACID; THAPSIGARGIN; TUNICAMYCIN; WNT PROTEIN; CTNNB1 PROTEIN, MOUSE; SMAD2 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL FATE; CELL FUNCTION; CELL LINEAGE; CELL THERAPY; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENDODERM; ENDOPLASMIC RETICULUM STRESS; IN VITRO STUDY; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; WNT SIGNALING PATHWAY;

ANIMALS; BETA CATENIN; CELL DIFFERENTIATION; CELLS, CULTURED; EMBRYONIC STEM CELLS; ENDODERM; ENDOPLASMIC RETICULUM STRESS; MICE; SMAD2 PROTEIN; THAPSIGARGIN; TRANSFORMING GROWTH FACTOR BETA; TUNICAMYCIN; UNFOLDED PROTEIN RESPONSE; WNT SIGNALING PATHWAY;

EID: 84907223749     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.572560     Document Type: Article

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