Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 4, 2010, Pages 1402-1407

  Li, Ngjie ^a   Sun, Lei ^a   Gao, Furong ^a   Jiang, Jing ^b   Yang, Ying ^a   Li, Chunliang ^a   Gu, Junjie ^a   Wei, Zhe ^a   Yang, Acong ^a   Lu, Rui ^a   Yu, Ma ^a   Tang, Fan ^a   Kwon, Sung Won ^c   Zhao, Yingming ^c   Li, Jinsong ^b   Jin, Ying ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

Embryonic stem cells; Gata6; Ras; Rcn2

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN; PROTEIN STK40; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLASTOCYST; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; ENDODERM; ENZYME ACTIVATION; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENE TARGETING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TISSUE DIFFERENTIATION;

ANIMALS; CALCIUM-BINDING PROTEINS; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; EMBRYONIC STEM CELLS; ENDODERM; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; MAP KINASE SIGNALING SYSTEM; MICE; OCTAMER TRANSCRIPTION FACTOR-3; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE;

EID: 76549104704     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0905657107     Document Type: Article

References (33)

1. Rossant J (2007) Stem cells and lineage development in the mammalian blastocyst. Reprod Fertil Dev 19:111-118.
2. Tam PP, Loebel DA (2007) Gene function in mouse embryogenesis: get set for gastrulation. Nat Rev Genet 8:368-381.
3. Shimosato D, Shiki M, Niwa H (2007) Extra-embryonic endoderm cells derived from ES cells induced by GATA factors acquire the character of XEN cells. BMC Dev Biol 7:80-91.
4. Bielinska M, Narita N, Wilson DB (1999) Distinct roles for visceral endoderm during embryonic mouse development. Int J Dev Biol 43:183-205.
5. Evans MJ, Kaufman MH (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292:154-156.
6. Martin GR (1981) Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 78:7634-7638.
7. Thomson JA, et al. (1998) Embryonic stem cell lines derived from human blastocysts. Science 282:1145-1147.
8. Keller G (2005) Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev 19:129-1155.
9. Palmieri SL, Peter W, Hess H, Schöler HR (1994) Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev Biol 166:259-267.
10. Nichols J, et al. (1998) Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95:379-391.
11. Hay DC, Sutherland L, Clark J, Burdon T (2004) Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells. Stem Cells 22:225-235.
12. Zafarana G, Avery SR, Avery K, Moore HD, Andrews PW (2009) Specific knockdown of OCT4 in human embryonic stem cells by inducible short hairpin RNA interference. Stem Cells 27:776-782.
13. Niwa H, Miyazaki J, Smith AG (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24:372-376.
14. Strumpf D, et al. (2005) Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in themouse blastocyst. Development 132:2093-2102.
15. Scott IC, Anson-Cartwright L, Riley P, Reda D, Cross JC (2000) The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms. Mol Cell Biol 20:530-541.
16. Singh AM, Hamazaki T, Hankowski KE, Terada N (2007) A heterogeneous expression pattern for Nanog in embryonic stem cells. Stem Cells 25:2534-2542.
17. Chambers I, et al. (2003) Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113:643-655.
18. Rula ME, et al. (2007) Cell autonomous sorting and surface positioning in the formation of primitive endoderm in embryoid bodies. Genesis 45:327-338.
19. Yang DH, Cai KQ, Roland IH, Smith ER, Xu XX (2007) Disabled-2 is an epithelial surface positioning gene. J Biol Chem 282:13114-13122.
20. Afouda BA, Ciau-Uitz A, Patient R (2005) GATA4, 5 and 6 mediate TGFbeta maintenance of endodermal gene expression in Xenopus embryos. Development 132:763-774.
21. Chen YL, Li XF, Eswarakumar VP, Seger R, Lonai P (2000) Fibroblast growth factor (FGF) signaling through PI 3-kinase and Akt/PKB is required for embryoid body differentiation. Oncogene 19:3750-3756.
22. Yoshida-Koide U, et al. (2004) Involvement of Ras in extraembryonic endoderm differentiation of embryonic stem cells. Biochem Biophys Res Commun 313:475-481.
23. Imai T, et al. (1997) ERC-55, a binding protein for the papilloma virus E6 oncoprotein, specifically interacts with vitamin D receptor among nuclear receptors. Biochem Biophys Res Commun 233:765-769.
24. Gerbe F, Cox B, Rossant J, Chazaud C (2008) Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst. Dev Biol 313:594-602.
25. Kunath T, et al. (2005) Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts. Development 132:1649-1661.
26. Chazaud C, Yamanaka Y, Pawson T, Rossant J (2006) Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway. Dev Cell 10:615-624.
27. Cheng AM, et al. (1998) Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell 95:793-803.
28. Kim J, Chu J, Shen X, Wang J, Orkin SH (2008) An extended transcriptional network for pluripotency of embryonic stem cells. Cell 132:1049-1061.
29. Lu CW, et al. (2008) Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos. Nat Genet 40:921-926.
30. Kunath T, et al. (2007) FGF stimulation of the Erk1/2 signaling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development 134:2895-2902.
31. Rossant J, Tam PP (2009) Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development 136:701-713.
32. Toyooka Y, Shimosato D, Murakami K, Takahashi K, Niwa H (2008) Identification and characterization of subpopulations in undifferentiated ES cell culture. Development 135:909-918.
33. Zhang Z, Liao B, Xu M, Jin Y (2007) Post-translational modification of POU domain transcription factor Oct-4 by SUMO-1. FASEB J 21:3042-3051.