Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly

Nutrients

Volumn 6, Issue 9, 2014, Pages 3624-3640

  Baierle, MaríLia ^a   Vencato, PatríCia H ^a   Oldenburg, Luiza ^a   Bordignon, Suelen ^a   Zibetti, Murilo ^a   Trentini, Clarissa M ^a   Duarte, Marta M M F ^b   Veit, Juliana C ^c   Somacal, Sabrina ^c   Emanuelli, Tatiana ^c   Grune, Tilman ^d   Breusing, Nicolle ^e   Garcia, Solange C ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

^c FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^d FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^e UNIVERSITY OF HOHENHEIM   (Germany)

Author keywords

Aging; Cognitive decline; Fatty acids; Homocysteine; Inflammation; n 3 PUFA

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; FATTY ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; DOCOSAHEXAENOIC ACID; LIPID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; UNSATURATED FATTY ACID;

AGED; ARTICLE; CHEMILUMINESCENCE IMMUNOASSAY; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DIETARY INTAKE; EDUCATIONAL STATUS; FEMALE; GAS CHROMATOGRAPHY; HUMAN; LIPID COMPOSITION; MALE; MINI MENTAL STATE EXAMINATION; NEPHELOMETRY; QUESTIONNAIRE; WORD LIST RECALL; ALZHEIMER DISEASE; BLOOD; CARDIOVASCULAR DISEASES; CASE CONTROL STUDY; COGNITION; COGNITION DISORDERS; DEMENTIA; DIET; GERIATRIC ASSESSMENT; MEMORY; METABOLISM; NUTRITIONAL STATUS; RISK FACTOR; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; COGNITION; COGNITION DISORDERS; DEMENTIA; DIET; DOCOSAHEXAENOIC ACIDS; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FATTY ACIDS, UNSATURATED; FEMALE; GERIATRIC ASSESSMENT; HOMOCYSTEINE; HUMANS; LIPIDS; MALE; MEMORY; NUTRITIONAL STATUS; RISK FACTORS;

EID: 84907218755     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu6093624     Document Type: Article

References (49)

1. Kochhann, R.; Varela, J.S.; Lisboa, C.S.M.; Chaves, M.L.F. Review of cutoff points adjusted for schooling in a large Southern Brazilian sample. Dement. Neuropsychol. 2010, 4, 35–41.
2. UNFPA and HelpAge International. Ageing in the Twenty-First Century: A Celebration and a Challenge. 2012. Available online: http://unfpa.org/ageingreport (accessed on 25 March 2014).
3. Milte, C.M.; Sinn, N.; Street, S.J.; Buckley, J.D.; Coates, A.M.; Howe, P.R.C. Erythrocyte polyunsaturated fatty acid status, memory, cognition and mood in older adults with mild cognitive impairment and healthy controls. Prostaglandins Leukot. Essent. Fatty Acids 2011, 84, 153–161.
4. Velho, S.; Marques-Vidal, P.; Baptista, F.; Camilo, M.E. Dietary intake adequacy and cognitive function in free-living active elderly: A cross-sectional and short-term prospective study. Clin. Nutr. 2008, 27, 77–86.
5. Ramirez-Ramirez, V.; Macias-Islas, M.A.; Ortiz, G.G.; Pacheco-Moises, F.; Torres-Sanchez, E.D.; Sorto-Gomez, T.E.; Cruz-Ramos, J.A.; Orozco-Aviña, G.; de la Rosa, A.J.C. Efficacy of fish oil on serum of TNF alpha, IL-1 beta, and IL-6 oxidative stress markers in multiple sclerosis treated with interferon beta-1b. Oxid. Med. Cell. Longev. 2013, 2013, 709493, doi:10.1155/2013/709493.
6. Ubeda, N.; Achon, M.; Varela-Moreiras, G. Omega 3 fatty acids in the elderly. Br. J. Nutr. 2012, 107, S137–S151.
7. Barcelos, R.C.; Benvegnu, D.M.; Boufleur, N.; Reckziegel, P.; Müller, L.G.; Pase, C.; Emanuelli, T.; Bürger, M.E. Effects of omega-3 essential fatty acids (omega-3 EFAs) on motor disorders and memory dysfunction typical neuroleptic-induced: Behavioral and biochemical parameter. Neurotox. Res. 2010, 17, 228–237.
8. Trevizol, F.; Benvegnu, D.M.; Barcelos, R.C.; Boufleur, N.; Dolci, G.S.; Müller, L.G.; Pase, C.S.; Reckziegel, P.; Dias, V.T.; Segat, H. et al. Comparative study between n-6, trans and n-3 fatty acids on repeated amphetamine exposure: A possible factor for the development of mania. Pharmacol. Biochem. Behav. 2011, 97, 560–565.
9. Calviello, G.; Su, H.M.; Weylandt, K.H.; Fasano, E.; Serini, S.; Cittadini, A. Experimental evidence of omega-3 polyunsaturated fatty acid modulation of inflammatory cytokines and bioactive lipid mediators: Their potential role in inflammatory, neurodegenerative, and neoplastic diseases. Biomed. Res. Int. 2013, 2013, 743171, doi:10.1155/2013/743171.
10. Yurko-Mauro, K.; McCarthy, D.; Rom, D.; Nelson, E.B.; Ryan, A.S.; Blackwell, A.; Salem, N., Jr.; Stedman, M. Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement. 2010, 6, 456–464.
11. Kim, M.; Nam, J.H.; Oh, D.H.; Park, Y. Erythrocyte alpha-linolenic acid is associated with the risk for mild dementia in Korean elderly. Nutr. Res. 2010, 30, 756–761.
12. Kume, A.; Kurotani, K.; Sato, M.; Ejima, Y.; Pham, N.M.; Nanri, A.; Kuwahara, K.; Mizoue, T. Polyunsaturated fatty acids in serum and homocysteine concentrations in Japanese men and women: A cross-sectional study. Nutr. Metab. 2013, 10, 1–8.
13. Laurin, D.; Verreault, R.; Lindsay, J.; Dewailly, E.; Holub, B.J. Omega-3 fatty acids and risk of cognitive impairment and dementia. J. Alzheimers Dis. 2003, 5, 315–322.
14. Zanin, R.F.; Campesato, L.F.; Braganhol, E.; Schetinger, M.R.C.; Wyse, A.T.S.; Battastini, A.M.O. Homocysteine decreases extracellular nucleotide hydrolysis in rat platelets. Thromb. Res. 2010, 125, e87–e92.
15. Ford, A.H.; Flicker, L.; Alfonso, H.; Hankey, G.J.; Norman, P.E.; van Bockxmeer, F.M.; Almeida, O.P. Plasma homocysteine and MTHFRC677T polymorphism as risk factors for incident dementia. J. Neurol. Neurosurg. Psychiatry 2012, 83, 70–75.
16. Veryard, L.; Jones, E.; Weaving, G.; Smith, E.; Cheek, L.; Wickramasinghe, A.; Tabet, N. Pro-inflammatory cytokines IL-1beta and TNF-alpha are not associated with plasma homocysteine concentration in Alzheimer’s disease. Curr. Alzheimer Res. 2013, 10, 174–179.
17. Huang, T.; Zheng, J.; Chen, Y.; Yang, B.; Wahlqvist, M.L.; Li, D. High consumption of omega-3 polyunsaturated fatty acids decrease plasma homocysteine: A meta-analysis of randomized, placebo-controlled trials. Nutrition 2011, 27, 863–867.
18. Huang, T.; Hu, X.; Khan, N.; Yang, J.; Li, D. Effect of polyunsaturated fatty acids on homocysteine metabolism through regulating the gene expressions involved in methionine metabolism. Sci. World J. 2013, 2013, 931626, doi:10.1155/2013/931626.
19. O’Callaghan, N.; Parletta, N.; Milte, C.M.; Benassi-Evans, B.; Fenech, M.; Howe, P.R.C. Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: A randomized controlled pilot study. Nutrition 2013, 30, 489–491.
20. Sinn, N.; Milte, C.M.; Street, S.J.; Buckley, J.D.; Coates, A.M.; Petkov, J.; Howe, P.R.C. Effects of n-3 fatty acids, EPAv. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: A 6-month randomised controlled trial. Br. J. Nutr. 2012, 107, 1682–1693.
21. Sinn, N.; Milte, C.; Howe, P.R.C. Oiling the brain: A review of randomized controlled trials of omega-3 fatty acids in psychopathology across the lifespan. Nutrients 2010, 2, 128–170.
22. Folstein, M.F.; Folstein, S.E.; McHugh, P.R. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 1975, 12, 189–198.
23. Friedewald, W.T.; Levy, R.I.; Fredrickson, D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 1972, 18, 499–502.
24. Lepage, G.; Roy, C.C. Direct transesterification of all classes of lipids in a one-step reaction. J. Lipid Res. 1986, 27, 114–120.
25. Morris, J.C.; Heyman, A.; Mohs, R.C.; Hughs, J.P.; van Belle, G.; Fillenbaum, G.; Mellits, E.D.; Clark, C.; CERAD investigators. The consortium to establish a registry for Alzheimer’s disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer’s disease. Neurology 1989, 39, 1159–1165.
26. Burtis, C.; Ashwood, E.; Bruns, D.E. Tietz Fundamentals of Clinical Chemistry, 6th ed.; Saunders Elsevier: St. Louis, MO, USA, 2008.
27. Simon, J.A.; Hodgkins, M.L.; Browner, W.S.; Neuhaus, J.M.; Bernert, J.T., Jr.; Hulley, S.B. Serum fatty acids and the risk of coronary heart disease. Am. J. Epidemiol. 1995, 142, 469–476.
28. Schmitz, G.; Ecker, J. The opposing effects of n-3 and n-6 fatty acids. Prog. Lipid Res. 2008, 47, 147–155.
29. Simopoulos, A.P. Essential fatty acids in health and chronic disease. Am. J. Clin. Nutr. 1999, 70, 560S–569S.
30. Bazan, N.G. Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection. Curr. Opin. Clin. Nutr. Metab. Care 2007, 10, 136–141.
31. Kishino, T.; Watanabe, K.; Urata, T.; Takano, U.; Uemura, T.; Nishikawa, K.; Mine, Y.; Matsumoto, M.; Ohtsuka, K.; Ohnishi, H. et al. Visceral fat thickness in overweight men correlates with alterations in serum fatty acid composition. Clin. Chim. Acta 2008, 398, 57–62.
32. Akbar, M.; Calderon, F.; Wen, Z.; Kim, H.Y. Docosahexaenoic acid: A positive modulator of Akt signaling in neuronal survival. Proc. Natl. Acad. Sci. USA 2005, 102, 10858–10863.
33. Bazan, N.G. The onset of brain injury and neurodegeneration triggers the synthesis of docosanoid neuroprotective signaling. Cell. Mol. Neurobiol. 2006, 26, 901–913.
34. Cervellati, C.; Cremonini, E.; Bosi, C.; Magon, S.; Zurlo, A.; Bergamini, C.M.; Zuliani, G. Systemic oxidative stress in older patients with mild cognitive impairment or late onset Alzheimer’s disease. Curr. Alzheimer Res. 2013, 10, 365–372.
35. Rothenburg, L.S.; Herrmann, N.; Swardfager, W.; Black, S.E.; Tennen, G.; Kiss, A.; Gladstone, D.J.; Ween, J.; Snaiderman, A.; Lanctôt, K.L. The relationship between inflammatory markers and post stroke cognitive impairment. J. Geriatr. Psychiatry Neurol. 2010, 23, 199–205.
36. Chen, J.R.; Hsu, S.F.; Hsu, C.D.; Hwang, L.H.; Yang, S.C. Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan. J. Nutr. Biochem. 2004, 15, 467–472.
37. Laasonen, M.; Hokkanen, L.; Leppamaki, S.; Tani, P.; Erkkila, A.T. Project DyAdd: Fatty acids in adult dyslexia, ADHD, and their comorbid combination. Prostaglandins Leukot. Essent. Fatty Acids 2009, 81, 89–96.
38. Naqvi, A.Z.; Harty, B.; Mukamal, K.J.; Stoddard, A.M.; Vitolins, M.; Dunn, J.E. Monounsaturated, trans, and saturated fatty acids and cognitive decline in women. J. Am. Geriatr. Soc. 2011, 59, 837–843.
39. Briante, R.; Febbraio, F.; Nucci, R. Antioxidant properties of low molecular weight phenols present in the Mediterranean diet. J. Agric. Food Chem. 2003, 51, 6975–6981.
40. Schwingshackl, L.; Hoffmann, G. Monounsaturated fatty acids and risk of cardiovascular disease: Synopsis of the evidence available from systematic reviews and meta-analyses. Nutrients 2012, 4, 1989–2007.
41. Perreault, M.; Roke, K.; Badawi, A.; Nielsen, D.E.; Abdelmagid, S.A.; el-Sohemy, A.; Ma, D.W.L.; Mutch, D.M. Plasma levels of 14:0, 16:0, 16:1n-7, and 20:3n-6 are positively associated, but 18:0 and 18:2n-6 are inversely associated with markers of inflammation in young healthy adults. Lipids 2014, 49, 255–263.
42. Snigdha, S.; Astarita, G.; Piomelli, D.; Cotman, C.W. Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain. Neuroscience 2012, 202, 326–333.
43. Hussain, G.; Schmitt, F.; Loeffler, J.P.; de Aguilar, J.L. Fatting the brain: A brief of recent research. Front. Cell. Neurosci. 2013, 7, 144.
44. Micha, R.; Mozaffarian, D. Saturated fat and cardiometabolic risk factors, coronary heart disease, stroke, and diabetes: A fresh look at the evidence. Lipids 2010, 45, 893–905.
45. Sheikh, J.I.; Yesavage, J.A. Geriatric Depression Scale (GDS): Recent evidence and development of a shorter version. Clin. Gerontol. 1986, 5, 165–173.
46. Marc, L.G.; Raue, P.J.; Bruce, M.L. Screening performance of the geriatric depression scale (GDS-15) in a diverse elderly home care population. Am. J. Geriatr. Psychiatry 2008, 16, 914–921.
47. Devlin, A.M.; Lentz, S.R. ApoA-I: A missing link between homocysteine and lipid metabolism? Circ. Res. 2006, 98, 431–433.
48. Voon, P.T.; Ng, T.K.; Lee, V.K.; Nesaretnam, K. Diets high in palmitic acid (16:0), lauric and myristic acids (12:0 + 14:0), or oleic acid (18:1) do not alter postprandial or fasting plasma homocysteine and inflammatory markers in healthy Malaysian adults. Am. J. Clin. Nutr. 2011, 94, 1451–1457.
49. Aisen, P.S.; Schneider, L.S.; Sano, M.; Diaz-Arrastia, R.; van Dyck, C.H.; Weiner, M.F.; Bottiglieri, T.; Jin, S.; Stokes, K.T.; Thomas, R.G. et al. High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: A randomized controlled trial. JAMA 2008, 300, 1774–1783.