Plasma homocysteine and MTHFRC677T polymorphism as risk factors for incident dementia

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 83, Issue 1, 2012, Pages 70-75

  Ford, Andrew H ^a   Flicker, Leon ^b   Alfonso, Helman ^a   Hankey, Graeme J ^b   Norman, Paul E ^c   Van Bockxmeer, Frank M ^c   Almeida, Osvaldo P ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN; HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

AGED; ARTICLE; BODY MASS; COHORT ANALYSIS; COMORBIDITY; DEMENTIA; DNA POLYMORPHISM; GENOTYPE; GLOMERULUS FILTRATION RATE; HUMAN; HYPERTENSION; INCIDENCE; INCIDENT DEMENTIA; ISCHEMIC HEART DISEASE; LIFESTYLE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR; SMOKING; STROKE;

5,10-METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); AGED; AGED, 80 AND OVER; DEMENTIA; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOMOCYSTEINE; HUMANS; LONGITUDINAL STUDIES; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84155172920     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2011.242446     Document Type: Article

References (42)

1. Clarke R, Daly L, Robinson K, et al. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 1991;324:1149-55.
2. Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 2002;288:2015-22.
3. Zoccolella S, dell'Aquila C, Specchio LM, et al. Elevated homocysteine levels in Parkinson's Disease: is there anything besides L-dopa treatment? Curr Med Chem 2010;17:213-21.
4. Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002;346:476-83. (Pubitemid 34441738)
5. McMahon JA, Green TJ, Skeaff CM, et al. A controlled trial of homocysteine lowering and cognitive performance. N Engl J Med 2006;354:2764-72. (Pubitemid 43974194)
6. Durga J, van Boxtel MP, Schouten EG, et al. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007;369:208-16. (Pubitemid 46107683)
7. Lewerin C, Matousek M, Steen G, et al. Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized study. Am J Clin Nutr 2005;81:1155-62. (Pubitemid 41724959)
8. Stott DJ, MacIntosh G, Lowe GD, et al. Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease. Am J Clin Nutr 2005;82:1320-6. (Pubitemid 43779732)
9. Ford AH, Flicker L, Alfonso H, et al. Vitamins B(12), B(6), and folic acid for cognition in older men. Neurology 2010;75:1540-7.
10. Wald DS, Kasturiratne A, Simmonds M. Effect of folic acid, with or without other B vitamins, on cognitive decline: meta-analysis of randomized trials. Am J Med 2010;123:522-7.e2.
11. Clarke R, Smith AD, Jobst KA, et al. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55:1449-55. (Pubitemid 28525506)
12. Zylberstein DE, Lissner L, Bjorkelund C, et al. Midlife homocysteine and late-life dementia in women. A prospective population study. Neurobiol Aging 2011;32:380-6.
13. Luchsinger JA, Tang MX, Shea S, et al. Plasma homocysteine levels and risk of Alzheimer disease. Neurology 2004;62:1972-6. (Pubitemid 38738206)
14. Ariogul S, Cankurtaran M, Dagli N, et al. Vitamin B12, folate, homocysteine and dementia: are they really related? Arch Gerontol Geriatr 2005;40:139-46. (Pubitemid 40186919)
15. Smith AD. The worldwide challenge of the dementias: a role for B vitamins and homocysteine? Food Nutr Bull 2008;29(2 Suppl):S143-72.
16. Smith GD, Ebrahim S. Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol 2004;33:30-42. (Pubitemid 38528650)
17. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-13.
18. Nitsch D, Molokhia M, Smeeth L, et al. Limits to causal inference based on Mendelian randomization: a comparison with randomized controlled trials. Am J Epidemiol 2006;163:397-403.
19. Norman PE, Flicker L, Almeida OP, et al. Cohort Profile: The Health In Men Study (HIMS). Int J Epidemiol 2009;38:48-52.
20. Holman CD, Bass AJ, Rosman DL, et al. A decade of data linkage in Western Australia: strategic design, applications and benefits of the WA data linkage system. Aust Health Rev 2008;32:766-77.
21. Araki A, Sako Y. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr 1987;422:43-52. (Pubitemid 17167357)
22. Refsum H, Smith AD, Ueland PM, et al. Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem 2004;50:3-32. (Pubitemid 38125696)
23. van Bockxmeer FM, Mamotte CD, Vasikaran SD, et al. Methylenetetrahydrofolate reductase gene and coronary artery disease. Circulation 1997;95:21-3. (Pubitemid 27029937)
24. Egger G, Donovan RJ, Giles-Corti B, et al. Developing national physical activity guidelines for Australians. Aust N Z J Public Health 2001;25:561-3. (Pubitemid 34044217)
25. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
26. Ganguli M, Rodriguez EG. Reporting of dementia on death certificates: a community study. J Am Geriatr Soc 1999;47:842-9. (Pubitemid 29326015)
27. Ravaglia G, Forti P, Maioli F, et al. Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr 2005;82:636-43.
28. Clarke R, Lewington S, Donald A, et al. Underestimation of the importance of homocysteine as a risk factor for cardiovascular disease in epidemiological studies. J Cardiovasc Risk 2001;8:363-9. (Pubitemid 34107234)
29. Obeid R, Herrmann W. Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia. FEBS Lett 2006;580:2994-3005. (Pubitemid 43744523)
30. Vafai SB, Stock JB. Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease. FEBS Lett 2002;518:1-4. (Pubitemid 34454953)
31. Sai X, Kawamura Y, Kokame K, et al. Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. J Biol Chem 2002;277:12915-20. (Pubitemid 34952658)
32. Xu D, Neville R, Finkel T. Homocysteine accelerates endothelial cell senescence. FEBS Lett 2000;470:20-4. (Pubitemid 30155616)
33. Orentreich N, Matias JR, DeFelice A, et al. Low methionine ingestion by rats extends life span. J Nutr 1993;123:269-74. (Pubitemid 23063011)
34. Elias MF, Sullivan LM, D'Agostino RB, et al. Homocysteine and cognitive performance in the Framingham offspring study: age is important. Am J Epidemiol 2005;162:644-53. (Pubitemid 41437363)
35. Smith AD, Smith SM, de Jager CA, et al. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One 2010;5:e12244.
36. Li K, Liu S, Yao S, et al. Interaction between interleukin-8 and methylenetetrahydrofolate reductase genes modulates Alzheimer's disease risk. Dement Geriatr Cogn Disord 2009;27:286-91.
37. Liu H, Yang M, Li GM, et al. The MTHFR C677T polymorphism contributes to an increased risk for vascular dementia: a meta-analysis. J Neurol Sci 2010;294:74-80.
38. Bi XH, Zhao HL, Zhang ZX, et al. Association of RFC1 A80G and MTHFR C677T polymorphisms with Alzheimer's disease. Neurobiol Aging 2009;30:1601-7.
39. Pandey P, Pradhan S, Modi DR, et al. MTHFR and ACE gene polymorphisms and risk of vascular and degenerative dementias in the elderly. Brain Cogn 2009;71:295-9.
40. Bertram L, McQueen MB, Mullin K, et al. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet 2007;39:17-23. (Pubitemid 46026496)
41. Selhub J, Jacques PF, Rosenberg IH, et al. Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations. Ann Intern Med 1999;131:331-9. (Pubitemid 29424626)
42. VITATOPS Trial Study Group. B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial. Lancet Neurol 2010;9:855-65.