Effect of polyunsaturated fatty acids on homocysteine metabolism through regulating the gene expressions involved in methionine metabolism

The Scientific World Journal

Volumn 2013, Issue , 2013, Pages

  Huang, Tao ^a,b,c   Hu, Xiaojie ^a,b   Khan, Nicholas ^c   Yang, Jing ^a,b   Li, Duo ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b APCNS Centre of Nutrition and Food Safety   (China)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; 5 METHYLTETRAHYDROFOLIC ACID; BETAINE ALDEHYDE DEHYDROGENASE; CYSTATHIONINE BETA SYNTHASE; GLYCINE METHYLTRANSFERASE; HOMOCYSTEINE; LINOLEIC ACID; MESSENGER RNA; METHIONINE; POLYUNSATURATED FATTY ACID; UNSATURATED FATTY ACID;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROL GROUP; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; MALE; NONHUMAN; RAT; UPREGULATION; ANIMAL; BLOOD; DRUG EFFECT; GENE EXPRESSION REGULATION; LIVER; METABOLISM; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

ADMINISTRATION, ORAL; ANIMALS; FATTY ACIDS, UNSATURATED; GENE EXPRESSION REGULATION; HOMOCYSTEINE; LIVER; MALE; METHIONINE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84878628229     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1155/2013/931626     Document Type: Article

References (31)

1. de Bree A., Verschuren W. M. M., Kromhout D., Kluijtmans L. A. J., Blom H. J., Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. Pharmacological Reviews 2002 54 4 599 618 2-s2.0-0036890065 10.1124/pr.54.4.599 (Pubitemid 35351198)
2. Huang T., Yuan G., Zhang Z., Zou Z., Li D., Cardiovascular pathogenesis in hyperhomocysteinemia. Asia Pacific Journal of Clinical Nutrition 2008 17 1 8 16 2-s2.0-51649096936
3. McCully K. S., Wilson R. B., Homocysteine theory of arteriosclerosis. Atherosclerosis 1975 22 2 215 227 2-s2.0-0016743933
4. Blom H. J., Determinants of plasma homocysteine. The American Journal of Clinical Nutrition 1998 67 2 188 189 2-s2.0-0031988993
5. Hu F. B., Stampfer M. J., Manson J. E., Rimm E. B., Wolk A., Colditz G. A., Hennekens C. H., Willett W. C., Dietary intake of α -linolenic acid and risk of fatal ischemic heart disease among women. American Journal of Clinical Nutrition 1999 69 5 890 897 2-s2.0-0032949296 (Pubitemid 29205061)
6. Iso H., Rexrode K. M., Stampfer M. J., Manson J. E., Colditz G. A., Speizer F. E., Hennekens C. H., Willett W. C., Intake of fish and omega-3 fatty acids and risk of stroke in women. Journal of the American Medical Association 2001 285 3 304 312 2-s2.0-0035900936 (Pubitemid 32095033)
7. Li D., Yu X. M., Xie H. B., Zhang Y. H., Wang Q., Zhou X. Q., Yu P., Wang L. J., Platelet phospholipid n-3 PUFA negatively associated with plasma homocysteine in middle-aged and geriatric hyperlipaemia patients. Prostaglandins Leukotrienes and Essential Fatty Acids 2007 76 5 293 297 2-s2.0-34249093550 10.1016/j.plefa.2007.02.003 (Pubitemid 46803263)
8. Li D., Mann N. J., Sinclair A. J., A significant inverse relationship between concentrations of plasma homocysteine and phospholipid docosahexaenoic acid in healthy male subjects. Lipids 2006 41 1 85 89 2-s2.0-33644596828 10.1007/s11745-006-5074-x
9. Zeman M., Zak A., Vecka M., Tvrzicka E., Pisarikova A., Stankova B., N-3 fatty acid supplementation decreases plasma homocysteine in diabetic dyslipidemia treated with statin-fibrate combination. Journal of Nutritional Biochemistry 2006 17 6 379 384 2-s2.0-33646553621 10.1016/j.jnutbio.2005.08.007 (Pubitemid 43729351)
10. Grundt H., Nilsen D. W. T., Mansoor M. A., Hetland Ø., Nordøy A., Reduction in homocysteine by n-3 polyunsaturated fatty acids after 1 year in a randomised double-blind study following an acute myocardial infarction: no effect on endothelial adhesion properties. Pathophysiology of Haemostasis and Thrombosis 2003 33 2 88 95 2-s2.0-0344493770 10.1159/000073852 (Pubitemid 37449283)
11. Huang T., Zheng J., Chen Y., Yang B., Wahlqvist M. L., Li D., High consumption of omega-3 polyunsaturated fatty acids decrease plasma homocysteine: a meta-analysis of randomized, placebo-controlled trials. Nutrition 2011 27 9 863 867 2-s2.0-79955105645 10.1016/j.nut.2010.12.011
12. Huang T., Wahlqvist M. L., Li D., Docosahexaenoic acid decreases plasma homocysteine via regulating enzyme activity and mRNA expression involved in methionine metabolism. Nutrition 2010 26 1 112 119 2-s2.0-71949093334 10.1016/j.nut.2009.05.015
13. Huang T., Tucker K., Lee Y., Crott J., Parnell L., Shen J., Smith C., Ordovas J., Li D., Lai C., MAT1A variants modulate the effect of dietary fatty acids on plasma homocysteine concentrations. Nutrition, Metabolism & Cardiovascular Diseases 2010 22 4 362 368 10.1016/j.numecd.2010.07.015
14. Huang T., Tucker K. L., Lee Y. C., Crott J. W., Parnell L. D., Shen J., Smith C. E., Ordovas J. M., Li D., Lai C. Q., Methylenetetrahydrofolate reductase variants associated with hypertension and cardiovascular disease interact with dietary polyunsaturated fatty acids to modulate plasma homocysteine in Puerto Rican adults. Journal of Nutrition 2011 141 4 654 659 2-s2.0-79955506457 10.3945/jn.110.134353
15. Pooya S., Jalali M. D., Jazayery A. D., Saedisomeolia A., Eshraghian M. R., Toorang F., The efficacy of omega-3 fatty acid supplementation on plasma homocysteine and malondialdehyde levels of type 2 diabetic patients. Nutrition, Metabolism and Cardiovascular Diseases 2010 20 326 331 2-s2.0-67149124047 10.1016/j.numecd.2009.04.002
16. Vizcaíno G., Diez-Ewald M., Herrmann F. H., Schuster G., Torres-Guerra E., Arteaga-Vizcaíno M., Homocysteinemia and its relationship with the methylentetrahydrofolate reductase polymorphism in various ethnic groups from western Venezuela. Investigacion Clinica 2005 46 4 347 355 2-s2.0-33244488721
17. Mann N. J., Li D., Sinclair A. J., Dudman N. P. B., Guo X. W., Elsworth G. R., Wilson A. K., Kelly F. D., The effect of diet on plasma homocysteine concentrations in healthy male subjects. European Journal of Clinical Nutrition 1999 53 11 895 899 2-s2.0-0032715498 (Pubitemid 29532999)
18. Uthus E. O., Brown-Borg H. M., Methionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse. Mechanisms of Ageing and Development 2006 127 5 444 450 2-s2.0-33645864368 10.1016/j.mad.2006.01.001
19. Burr M. L., Fehily A. M., Gilbert J. F., Rogers S., Holliday R. M., Sweetnam P. M., Elwood P. C., Deadman N. M., Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). The Lancet 1989 2 8666 757 761 2-s2.0-0024363690 (Pubitemid 19234807)
20. Huang T., Andrew J. S., Lirong S., Yang B., Li D., Comparative effects of tuna oil and salmon oil on liver lipid metabolism and fatty acid concentrations in rats. Journal of Food Lipids 2009 16 4 436 451 2-s2.0-73449117897 10.1111/j.1745-4522.2009.01157.x
21. Appel L. J., Miller E. R. III, Seidler A. J., Whelton P. K., Does supplementation of diet with 'fish oil' reduce blood pressure? A meta-analysis of controlled clinical trials. Archives of Internal Medicine 1993 153 12 1429 1438 2-s2.0-0027233392 10.1001/archinte.153.12.1429 (Pubitemid 23191050)
22. Huang T., Bhulaidok S., Cai Z., Xu T., Xu F., Wahlqvist M. L., Li D., Plasma phospholipids n-3 polyunsaturated fatty acid is associated with metabolic syndrome. Molecular Nutrition and Food Research 2010 54 11 1628 1635 2-s2.0-78349257835 10.1002/mnfr.201000025
23. Huang T., Wahlqvist M. L., Xu T., Xu A., Zhang A., Li D., Increased plasma n-3 polyunsaturated fatty acid is associated with improved insulin sensitivity in type 2 diabetes in China. Molecular Nutrition and Food Research 2010 54 supplement 1 S112 S119 2-s2.0-77952389187 10.1002/mnfr.200900189
24. Piolot A., Blache D., Boulet L., Fortin L. J., Dubreuil D., Marcoux C., Davignon J., Lussier-Cacan S., Effect of fish oil on LDL oxidation and plasma homocysteine concentrations in health. The Journal of Laboratory and Clinical Medicine 2003 141 1 41 49 2-s2.0-0037225154 10.1067/mlc.2003.3 (Pubitemid 36065085)
25. Durand P., Prost M., Loreau N., Lussier-Cacan S., Blache D., Impaired homocysteine metabolism and atherothrombotic disease. Laboratory Investigation 2001 81 5 645 672 2-s2.0-0035016253 (Pubitemid 32466529)
26. Saedisomeolia A., Wood L. G., Garg M. L., Gibson P. G., Wark P. A. B., Lycopene enrichment of cultured airway epithelial cells decreases the inflammation induced by rhinovirus infection and lipopolysaccharide. Journal of Nutritional Biochemistry 2009 20 8 577 585 2-s2.0-67649757295 10.1016/j.jnutbio.2008.06.001
27. Noga A. A., Stead L. M., Zhao Y., Brosnan M. E., Brosnan J. T., Vance D. E., Plasma homocysteine is regulated by phospholipid methylation. The Journal of Biological Chemistry 278 5952 5955
28. Jacobs R. L., Stead L. M., Devlin C., Tabas I., Brosnan M. E., Brosnan J. T., Vance D. E., Physiological regulation of phospholipid methylation alters plasma homocysteine in mice. Journal of Biological Chemistry 2005 280 31 28299 28305 2-s2.0-23344449775 10.1074/jbc.M501971200 (Pubitemid 41105726)
29. Hartz C. S., Schalinske K. L., Phosphatidylethanolamine N-methyltransferase and regulation of homocysteine. Nutrition Reviews 2006 64 10 465 467 2-s2.0-33750039653 10.1301/nr.2006.oct.465-467 (Pubitemid 44582078)
30. da Costa K. A., Sanders L. M., Fischer L. M., Zeisel S. H., Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine A/-methyltransferase activity in humans. American Journal of Clinical Nutrition 2011 93 5 968 974 2-s2.0-79955371821 10.3945/ajcn.110.011064
31. Ratnam S., Wijekoon E. P., Hall B., Garrow T. A., Brosnan M. E., Brosnan J. T., Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver. American Journal of Physiology-Endocrinology and Metabolism 2006 290 5 E933 E939 2-s2.0-33646431671 10.1152/ajpendo.00498.2005