메뉴 건너뛰기




Volumn 44, Issue 3, 2014, Pages 775-788

Network medicine, multimorbidity and the lung in the elderly

Author keywords

[No Author keywords available]

Indexed keywords

AGED; AGING; ARTICLE; CELL DAMAGE; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMORBIDITY; DISEASE ASSOCIATION; ENVIRONMENT; GENOTYPE PHENOTYPE CORRELATION; HUMAN; MEDICINE; MORBIDITY; MULTIMORBIDITY; NETWORK MEDICINE; PATHOGENESIS; PRIORITY JOURNAL; SYSTEMS BIOLOGY; UNITED STATES; BIOLOGICAL MODEL; COMPLICATION; GERIATRICS; LUNG; LUNG DISEASES; PATHOPHYSIOLOGY; PROCEDURES; RESPIRATION DISORDERS;

EID: 84907211818     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00078714     Document Type: Article
Times cited : (60)

References (75)
  • 1
    • 84855166051 scopus 로고    scopus 로고
    • Facing a "slow-motion disaster" - The UN meeting on noncommunicable diseases
    • Rosenbaum L, Lamas D. Facing a "slow-motion disaster" - the UN meeting on noncommunicable diseases. N Engl J Med 2011; 365: 2345-2348.
    • (2011) N Engl J Med , vol.365 , pp. 2345-2348
    • Rosenbaum, L.1    Lamas, D.2
  • 2
    • 79959973314 scopus 로고    scopus 로고
    • Systems medicine and integrated care to combat chronic noncommunicable diseases
    • Bousquet J, Anto JM, Sterk PJ, et al. Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med 2011; 3: 43.
    • (2011) Genome Med , vol.3 , pp. 43
    • Bousquet, J.1    Anto, J.M.2    Sterk, P.J.3
  • 3
    • 84863426446 scopus 로고    scopus 로고
    • Epidemiology of multimorbidity and implications for health care, research, and medical education: A cross-sectional study
    • Barnett K, Mercer SW, Norbury M, et al. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet 2012; 380: 37-43.
    • (2012) Lancet , vol.380 , pp. 37-43
    • Barnett, K.1    Mercer, S.W.2    Norbury, M.3
  • 4
    • 66249129037 scopus 로고    scopus 로고
    • A dynamic network approach for the study of human phenotypes
    • Hidalgo CA, Blumm N, Barabási AL, et al. A dynamic network approach for the study of human phenotypes. PLoS Comput Biol 2009; 5: e1000353.
    • (2009) PLoS Comput Biol , vol.5
    • Hidalgo, C.A.1    Blumm, N.2    Barabási, A.L.3
  • 5
    • 35148893108 scopus 로고    scopus 로고
    • Systemic effects of chronic obstructive pulmonary disease: What we know and what we don't know (but should)
    • Agustí A. Systemic effects of chronic obstructive pulmonary disease: what we know and what we don't know (but should). Proc Am Thorac Soc 2007; 4: 522-525.
    • (2007) Proc Am Thorac Soc , vol.4 , pp. 522-525
    • Agustí, A.1
  • 6
    • 84873956600 scopus 로고    scopus 로고
    • Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary
    • Vestbo J, Hurd SS, Agustí AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2013; 187: 347-365.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 347-365
    • Vestbo, J.1    Hurd, S.S.2    Agustí, A.G.3
  • 7
    • 84865121012 scopus 로고    scopus 로고
    • Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
    • Faner R, Rojas M, MacNee W, et al. Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2012; 186: 306-313.
    • (2012) Am J Respir Crit Care Med , vol.186 , pp. 306-313
    • Faner, R.1    Rojas, M.2    MacNee, W.3
  • 8
    • 12244264853 scopus 로고    scopus 로고
    • Systemic effects of chronic obstructive pulmonary disease
    • Agustí AG, Noguera A, Sauleda J, et al. Systemic effects of chronic obstructive pulmonary disease. Eur Respir J 2003; 21: 347-360.
    • (2003) Eur Respir J , vol.21 , pp. 347-360
    • Agustí, A.G.1    Noguera, A.2    Sauleda, J.3
  • 9
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • Kirkwood TB. Understanding the odd science of aging. Cell 2005; 120: 437-447.
    • (2005) Cell , vol.120 , pp. 437-447
    • Kirkwood, T.B.1
  • 11
    • 84907324271 scopus 로고    scopus 로고
    • Strategic Research Agenda for Innovative Medicines Initiative 2. Brussels
    • The right prevention and treatment for the right patient at the right time. Strategic Research Agenda for Innovative Medicines Initiative 2. Brussels, European Federation of Pharmaceutical Industries and Associations, 2014. www.efpia.eu/uploads/Modules/Documents/def-efpia-brochure-sra-a4-web.pdf
    • (2014) The Right Prevention and Treatment for the Right Patient at the Right Time
  • 12
    • 0017402583 scopus 로고
    • The natural history of chronic airflow obstruction
    • Fletcher C, Peto R. The natural history of chronic airflow obstruction. Br Med J 1977; 1: 1645-1648.
    • (1977) Br Med J , vol.1 , pp. 1645-1648
    • Fletcher, C.1    Peto, R.2
  • 13
    • 67649777117 scopus 로고    scopus 로고
    • The natural history of chronic airflow obstruction revisited: An analysis of the Framingham offspring cohort
    • Kohansal R, Martinez-Camblor P, Agustí A, et al. The natural history of chronic airflow obstruction revisited: an analysis of the Framingham offspring cohort. Am J Respir Crit Care Med 2009; 180: 3-10.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 3-10
    • Kohansal, R.1    Martinez-Camblor, P.2    Agustí, A.3
  • 14
    • 42649088839 scopus 로고    scopus 로고
    • Complex chronic comorbidities of COPD
    • Fabbri LM, Luppi F, Beghé B, et al. Complex chronic comorbidities of COPD. Eur Respir J 2008; 31: 204-212.
    • (2008) Eur Respir J , vol.31 , pp. 204-212
    • Fabbri, L.M.1    Luppi, F.2    Beghé, B.3
  • 15
    • 43449101586 scopus 로고    scopus 로고
    • Comorbidities in chronic obstructive pulmonary disease
    • Chatila WM, Thomashow BM, Minai OA, et al. Comorbidities in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2008; 5: 549-555.
    • (2008) Proc Am Thorac Soc , vol.5 , pp. 549-555
    • Chatila, W.M.1    Thomashow, B.M.2    Minai, O.A.3
  • 16
    • 66749141807 scopus 로고    scopus 로고
    • Systemic manifestations and comorbidities of COPD
    • Barnes PJ, Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J 2009; 33: 1165-1185.
    • (2009) Eur Respir J , vol.33 , pp. 1165-1185
    • Barnes, P.J.1    Celli, B.R.2
  • 17
    • 78149361805 scopus 로고    scopus 로고
    • Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke: A comprehensive analysis using data from primary care
    • Feary JR, Rodrigues LC, Smith CJ, et al. Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke: a comprehensive analysis using data from primary care. Thorax 2010; 65: 956-962.
    • (2010) Thorax , vol.65 , pp. 956-962
    • Feary, J.R.1    Rodrigues, L.C.2    Smith, C.J.3
  • 18
    • 84862611004 scopus 로고    scopus 로고
    • Systemic inflammation and comorbidities in chronic obstructive pulmonary disease
    • Agustí A, Faner R. Systemic inflammation and comorbidities in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2012; 9: 43-46.
    • (2012) Proc Am Thorac Soc , vol.9 , pp. 43-46
    • Agustí, A.1    Faner, R.2
  • 19
    • 84863952703 scopus 로고    scopus 로고
    • Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease
    • Divo M, Cote C, de Torres JP, et al. Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2012; 186: 155-161.
    • (2012) Am J Respir Crit Care Med , vol.186 , pp. 155-161
    • Divo, M.1    Cote, C.2    De Torres, J.P.3
  • 20
    • 84880040954 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease and comorbidities
    • Decramer M, Janssens W. Chronic obstructive pulmonary disease and comorbidities. Lancet Respir Med 2013; 1: 73-83.
    • (2013) Lancet Respir Med , vol.1 , pp. 73-83
    • Decramer, M.1    Janssens, W.2
  • 21
    • 84891845870 scopus 로고    scopus 로고
    • Risk factors and comorbidities in the preclinical stages of chronic obstructive pulmonary disease
    • Van Remoortel H, Hornikx M, Langer D, et al. Risk factors and comorbidities in the preclinical stages of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2014; 189: 30-38.
    • (2014) Am J Respir Crit Care Med , vol.189 , pp. 30-38
    • Van Remoortel, H.1    Hornikx, M.2    Langer, D.3
  • 22
    • 16344376370 scopus 로고    scopus 로고
    • Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity
    • De Martinis M, Franceschi C, Monti D, et al. Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Lett 2005; 579: 2035-2039.
    • (2005) FEBS Lett , vol.579 , pp. 2035-2039
    • De Martinis, M.1    Franceschi, C.2    Monti, D.3
  • 23
    • 33646518593 scopus 로고    scopus 로고
    • Inflammation markers predicting frailty and mortality in the elderly
    • De Martinis M, Franceschi C, Monti D, et al. Inflammation markers predicting frailty and mortality in the elderly. Exp Mol Pathol 2006; 80: 219-227.
    • (2006) Exp Mol Pathol , vol.80 , pp. 219-227
    • De Martinis, M.1    Franceschi, C.2    Monti, D.3
  • 24
    • 84862100999 scopus 로고    scopus 로고
    • Persistent systemic inflammation is associated with poor clinical outcomes in COPD: A novel phenotype
    • Agustí A, Edwards LD, Rennard SI, et al. Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One 2012; 7: e37483.
    • (2012) PLoS One , vol.7
    • Agustí, A.1    Edwards, L.D.2    Rennard, S.I.3
  • 25
    • 69249106988 scopus 로고    scopus 로고
    • Systems biology and emerging technologies will catalyze the transition from reactive medicine to predictive, personalized, preventive and participatory (P4) medicine
    • Galas DJ, Hood L. Systems biology and emerging technologies will catalyze the transition from reactive medicine to predictive, personalized, preventive and participatory (P4) medicine. IBC 2009; 1: 1-5.
    • (2009) IBC , vol.1 , pp. 1-5
    • Galas, D.J.1    Hood, L.2
  • 26
    • 77953303583 scopus 로고    scopus 로고
    • An integrative systems biology approach to understanding pulmonary diseases
    • Auffray C, Adcock IM, Chung KF, et al. An integrative systems biology approach to understanding pulmonary diseases. Chest 2010; 137: 1410-1416.
    • (2010) Chest , vol.137 , pp. 1410-1416
    • Auffray, C.1    Adcock, I.M.2    Chung, K.F.3
  • 27
    • 0035895505 scopus 로고    scopus 로고
    • The sequence of the human genome
    • Venter JC, Adams MD, Myers EW, et al. The sequence of the human genome. Science 2001; 291: 1304-1351.
    • (2001) Science , vol.291 , pp. 1304-1351
    • Venter, J.C.1    Adams, M.D.2    Myers, E.W.3
  • 28
    • 0037464588 scopus 로고    scopus 로고
    • A vision for the future of genomics research
    • Collins FS, Green ED, Guttmacher AE, et al. A vision for the future of genomics research. Nature 2003; 422: 835-847.
    • (2003) Nature , vol.422 , pp. 835-847
    • Collins, F.S.1    Green, E.D.2    Guttmacher, A.E.3
  • 29
    • 79955498646 scopus 로고    scopus 로고
    • Addressing the complexity of chronic obstructive pulmonary disease: From phenotypes and biomarkers to scale-free networks, systems biology, and P4 medicine
    • Agustí A, Sobradillo P, Celli B. Addressing the complexity of chronic obstructive pulmonary disease: from phenotypes and biomarkers to scale-free networks, systems biology, and P4 medicine. Am J Respir Crit Care Med 2011; 183: 1129-1137.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 1129-1137
    • Agustí, A.1    Sobradillo, P.2    Celli, B.3
  • 30
    • 84890316396 scopus 로고    scopus 로고
    • Moving from the Oslerian paradigm to the post-genomic era: Are asthma and COPD outdated terms?
    • Vanfleteren LE, Kocks JW, Stone IS, et al. Moving from the Oslerian paradigm to the post-genomic era: are asthma and COPD outdated terms? Thorax 2014; 69: 72-79.
    • (2014) Thorax , vol.69 , pp. 72-79
    • Vanfleteren, L.E.1    Kocks, J.W.2    Stone, I.S.3
  • 31
    • 0036500993 scopus 로고    scopus 로고
    • Systems biology: A brief overview
    • Kitano H. Systems biology: a brief overview. Science 2002; 295: 1662-1664.
    • (2002) Science , vol.295 , pp. 1662-1664
    • Kitano, H.1
  • 32
    • 34547146985 scopus 로고    scopus 로고
    • Network medicine - From obesity to the "diseasome"
    • Barabási AL. Network medicine - from obesity to the "diseasome". N Engl J Med 2007; 357: 404-407.
    • (2007) N Engl J Med , vol.357 , pp. 404-407
    • Barabási, A.L.1
  • 33
    • 78650373804 scopus 로고    scopus 로고
    • Network medicine: A network-based approach to human disease
    • Barabási AL, Gulbahce N, Loscalzo J. Network medicine: a network-based approach to human disease. Nat Rev Genet 2011; 12: 56-68.
    • (2011) Nat Rev Genet , vol.12 , pp. 56-68
    • Barabási, A.L.1    Gulbahce, N.2    Loscalzo, J.3
  • 34
    • 0037079054 scopus 로고    scopus 로고
    • Computational systems biology
    • Kitano H. Computational systems biology. Nature 2002; 420: 206-210.
    • (2002) Nature , vol.420 , pp. 206-210
    • Kitano, H.1
  • 35
    • 84861149240 scopus 로고    scopus 로고
    • A population approach to precision medicine
    • Khoury MJ, Gwinn ML, Glasgow RE, et al. A population approach to precision medicine. Am J Prev Med 2012; 42: 639-645.
    • (2012) Am J Prev Med , vol.42 , pp. 639-645
    • Khoury, M.J.1    Gwinn, M.L.2    Glasgow, R.E.3
  • 36
    • 65349180167 scopus 로고    scopus 로고
    • Maximal extraction of biological information from genetic interaction data
    • Carter GW, Galas DJ, Galitski T. Maximal extraction of biological information from genetic interaction data. PLoS Comput Biol 2009; 5: e1000347.
    • (2009) PLoS Comput Biol , vol.5
    • Carter, G.W.1    Galas, D.J.2    Galitski, T.3
  • 37
    • 78149236787 scopus 로고    scopus 로고
    • DisGeNET: A Cytoscape plugin to visualize, integrate, search and analyze gene-disease networks
    • Bauer-Mehren A, Rautschka M, Sanz F, et al. DisGeNET: a Cytoscape plugin to visualize, integrate, search and analyze gene-disease networks. Bioinformatics 2010; 26: 2924-2926.
    • (2010) Bioinformatics , vol.26 , pp. 2924-2926
    • Bauer-Mehren, A.1    Rautschka, M.2    Sanz, F.3
  • 38
    • 77953381289 scopus 로고    scopus 로고
    • Bridging the gap between systems biology and medicine
    • Clermont G, Auffray C, Moreau Y, et al. Bridging the gap between systems biology and medicine. Genome Med 2009; 1: 88.
    • (2009) Genome Med , vol.1 , pp. 88
    • Clermont, G.1    Auffray, C.2    Moreau, Y.3
  • 40
    • 44249122799 scopus 로고    scopus 로고
    • The collective dynamics of smoking in a large social network
    • Christakis NA, Fowler JH. The collective dynamics of smoking in a large social network. N Engl J Med 2008; 358: 2249-2258.
    • (2008) N Engl J Med , vol.358 , pp. 2249-2258
    • Christakis, N.A.1    Fowler, J.H.2
  • 41
    • 80052435472 scopus 로고    scopus 로고
    • Current controversies and future perspectives in chronic obstructive pulmonary disease
    • Agustí A, Vestbo J. Current controversies and future perspectives in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2011; 184: 507-513.
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 507-513
    • Agustí, A.1    Vestbo, J.2
  • 42
    • 34547170053 scopus 로고    scopus 로고
    • The spread of obesity in a large social network over 32 years
    • Christakis NA, Fowler JH. The spread of obesity in a large social network over 32 years. N Engl J Med 2007; 357: 370-379.
    • (2007) N Engl J Med , vol.357 , pp. 370-379
    • Christakis, N.A.1    Fowler, J.H.2
  • 44
  • 45
    • 67749140118 scopus 로고    scopus 로고
    • Scale-free networks: A decade and beyond
    • Barabási AL. Scale-free networks: a decade and beyond. Science 2009; 325: 412-413.
    • (2009) Science , vol.325 , pp. 412-413
    • Barabási, A.L.1
  • 46
    • 11144248635 scopus 로고    scopus 로고
    • The topological relationship between the large-scale attributes and local interaction patterns of complex networks
    • Vázquez A, Dobrin R, Sergi D, et al. The topological relationship between the large-scale attributes and local interaction patterns of complex networks. Proc Natl Acad Sci USA 2004; 101: 17940-17945.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 17940-17945
    • Vázquez, A.1    Dobrin, R.2    Sergi, D.3
  • 47
    • 34547488336 scopus 로고    scopus 로고
    • Probing genetic overlap among complex human phenotypes
    • Rzhetsky A, Wajngurt D, Park N, et al. Probing genetic overlap among complex human phenotypes. Proc Natl Acad Sci USA 2007; 104: 11694-11699.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 11694-11699
    • Rzhetsky, A.1    Wajngurt, D.2    Park, N.3
  • 48
    • 84862254919 scopus 로고    scopus 로고
    • An aging program at the systems level?
    • Han JD. An aging program at the systems level? Birth Defects Res C Embryo Today 2012; 96: 206-211.
    • (2012) Birth Defects Res C Embryo Today , vol.96 , pp. 206-211
    • Han, J.D.1
  • 49
    • 0035930836 scopus 로고    scopus 로고
    • A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA
    • Sozou PD, Kirkwood TB. A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA. J Theor Biol 2001; 213: 573-586.
    • (2001) J Theor Biol , vol.213 , pp. 573-586
    • Sozou, P.D.1    Kirkwood, T.B.2
  • 50
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon CJ. The genetics of ageing. Nature 2010; 464: 504-512.
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.J.1
  • 51
    • 34249888736 scopus 로고    scopus 로고
    • PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
    • Panowski SH, Wolff S, Aguilaniu H, et al. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature 2007; 447: 550-555.
    • (2007) Nature , vol.447 , pp. 550-555
    • Panowski, S.H.1    Wolff, S.2    Aguilaniu, H.3
  • 53
    • 59049083941 scopus 로고    scopus 로고
    • The human ageing genomic resources: Online databases and tools for biogerontologists
    • de Magalhães JP, Budovsky A, Lehmann G, et al. The human ageing genomic resources: online databases and tools for biogerontologists. Aging Cell 2009; 8: 65-72.
    • (2009) Aging Cell , vol.8 , pp. 65-72
    • De Magalhães, J.P.1    Budovsky, A.2    Lehmann, G.3
  • 54
    • 36849004497 scopus 로고    scopus 로고
    • A modular network model of aging
    • Xue H, Xian B, Dong D, et al. A modular network model of aging. Mol Syst Biol 2007; 3: 147.
    • (2007) Mol Syst Biol , vol.3 , pp. 147
    • Xue, H.1    Xian, B.2    Dong, D.3
  • 56
    • 48249158278 scopus 로고    scopus 로고
    • The implications of human metabolic network topology for disease comorbidity
    • Lee DS, Park J, Kay KA, et al. The implications of human metabolic network topology for disease comorbidity. Proc Natl Acad Sci USA 2008; 105: 9880-9885.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 9880-9885
    • Lee, D.S.1    Park, J.2    Kay, K.A.3
  • 57
    • 64349109427 scopus 로고    scopus 로고
    • The impact of cellular networks on disease comorbidity
    • Park J, Lee DS, Christakis NA, et al. The impact of cellular networks on disease comorbidity. Mol Syst Biol 2009; 5: 262.
    • (2009) Mol Syst Biol , vol.5 , pp. 262
    • Park, J.1    Lee, D.S.2    Christakis, N.A.3
  • 58
    • 44449119819 scopus 로고    scopus 로고
    • A protein interaction network associated with asthma
    • Hwang S, Son SW, Kim SC, et al. A protein interaction network associated with asthma. J Theor Biol 2008; 252: 722-731.
    • (2008) J Theor Biol , vol.252 , pp. 722-731
    • Hwang, S.1    Son, S.W.2    Kim, S.C.3
  • 59
    • 84907371840 scopus 로고    scopus 로고
    • A diVIsive Shuffling Approach (VIStA) for gene expression analysis to identify subtypes in chronic obstructive pulmonary disease
    • Menche J, Sharma A, Cho MH, et al. A diVIsive Shuffling Approach (VIStA) for gene expression analysis to identify subtypes in chronic obstructive pulmonary disease. BMC Systems Biology 2014; 8: Suppl. 2, S8.
    • (2014) BMC Systems Biology , vol.8 , Issue.SUPPL. 2
    • Menche, J.1    Sharma, A.2    Cho, M.H.3
  • 60
    • 84901022861 scopus 로고    scopus 로고
    • Revealing the pathogenic and aging-related mechanisms of the enigmatic idiopathic pulmonary fibrosis. An integral model
    • Selman M, Pardo A. Revealing the pathogenic and aging-related mechanisms of the enigmatic idiopathic pulmonary fibrosis. An integral model. Am J Respir Crit Care Med 2014; 189: 1161-1172.
    • (2014) Am J Respir Crit Care Med , vol.189 , pp. 1161-1172
    • Selman, M.1    Pardo, A.2
  • 61
    • 42949146028 scopus 로고    scopus 로고
    • Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE)
    • Vestbo J, Anderson W, Coxson HO, et al. Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE). Eur Respir J 2008; 31: 869-873.
    • (2008) Eur Respir J , vol.31 , pp. 869-873
    • Vestbo, J.1    Anderson, W.2    Coxson, H.O.3
  • 62
    • 84899784758 scopus 로고    scopus 로고
    • Should we view chronic obstructive pulmonary disease differently after ECLIPSE? A clinical perspective from the study team
    • Vestbo J, Agustí A, Wouters EF, et al. Should we view chronic obstructive pulmonary disease differently after ECLIPSE? A clinical perspective from the study team. Am J Respir Crit Care Med 2014; 189: 1022-1030.
    • (2014) Am J Respir Crit Care Med , vol.189 , pp. 1022-1030
    • Vestbo, J.1    Agustí, A.2    Wouters, E.F.3
  • 63
    • 84902164334 scopus 로고    scopus 로고
    • Lessons from ECLIPSE: A review of COPD biomarkers
    • Faner R, Tal-Singer R, Riley JH, et al. Lessons from ECLIPSE: a review of COPD biomarkers. Thorax 2014; 69: 666-672.
    • (2014) Thorax , vol.69 , pp. 666-672
    • Faner, R.1    Tal-Singer, R.2    Riley, J.H.3
  • 64
    • 84879409324 scopus 로고    scopus 로고
    • The COPD control panel: Towards personalised medicine in COPD
    • Agustí A, MacNeeW. The COPD control panel: towards personalised medicine in COPD. Thorax 2013; 68: 687-690.
    • (2013) Thorax , vol.68 , pp. 687-690
    • Agustí, A.1    MacNee, W.2
  • 65
    • 84879411561 scopus 로고    scopus 로고
    • Multidimensional assessment and tailored interventions for COPD: Respiratory utopia or common sense?
    • McDonald VM, Higgins I, Wood LG, et al. Multidimensional assessment and tailored interventions for COPD: respiratory utopia or common sense? Thorax 2013; 68: 691-694.
    • (2013) Thorax , vol.68 , pp. 691-694
    • McDonald, V.M.1    Higgins, I.2    Wood, L.G.3
  • 66
    • 84875847989 scopus 로고    scopus 로고
    • Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease
    • Vanfleteren LE, Spruit MA, Groenen M, et al. Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013; 187: 728-735.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 728-735
    • Vanfleteren, L.E.1    Spruit, M.A.2    Groenen, M.3
  • 67
    • 79551603829 scopus 로고    scopus 로고
    • Characterisation of COPD heterogeneity in the ECLIPSE cohort
    • Agustí A, Calverley PM, Celli B, et al. Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res 2010; 11: 122.
    • (2010) Respir Res , vol.11 , pp. 122
    • Agustí, A.1    Calverley, P.M.2    Celli, B.3
  • 68
    • 84883053051 scopus 로고    scopus 로고
    • Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort
    • Miller J, Edwards LD, Agustí A, et al. Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort. Respir Med 2013; 107: 1376-1384.
    • (2013) Respir Med , vol.107 , pp. 1376-1384
    • Miller, J.1    Edwards, L.D.2    Agustí, A.3
  • 69
    • 77953389042 scopus 로고    scopus 로고
    • Clinical COPD phenotypes: A novel approach using principal component and cluster analyses
    • Burgel PR, Paillasseur JL, Caillaud D, et al. Clinical COPD phenotypes: a novel approach using principal component and cluster analyses. Eur Respir J 2010; 36: 531-539.
    • (2010) Eur Respir J , vol.36 , pp. 531-539
    • Burgel, P.R.1    Paillasseur, J.L.2    Caillaud, D.3
  • 70
    • 84897479214 scopus 로고    scopus 로고
    • An increased ratio of serum miR-21 to miR-181a levels is associated with the early pathogenic process of chronic obstructive pulmonary disease in asymptomatic heavy smokers
    • Xie L, Wu M, Lin H, et al. An increased ratio of serum miR-21 to miR-181a levels is associated with the early pathogenic process of chronic obstructive pulmonary disease in asymptomatic heavy smokers. Mol Biosyst 2014; 10: 1072-1081.
    • (2014) Mol Biosyst , vol.10 , pp. 1072-1081
    • Xie, L.1    Wu, M.2    Lin, H.3
  • 71
    • 84856045106 scopus 로고    scopus 로고
    • Gene expression networks in COPD: MicroRNA and mRNA regulation
    • Ezzie ME, Crawford M, Cho JH, et al. Gene expression networks in COPD: microRNA and mRNA regulation. Thorax 2012; 67: 122-131.
    • (2012) Thorax , vol.67 , pp. 122-131
    • Ezzie, M.E.1    Crawford, M.2    Cho, J.H.3
  • 72
    • 80053440986 scopus 로고    scopus 로고
    • A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease
    • Turan N, Kalko S, Stincone A, et al. A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease. PLoS Comput Biol 2011; 7: e1002129.
    • (2011) PLoS Comput Biol , vol.7
    • Turan, N.1    Kalko, S.2    Stincone, A.3
  • 73
    • 0032911881 scopus 로고    scopus 로고
    • Skeletal muscle dysfunction in chronic obstructive pulmonary disease. A statement of the American Thoracic Society and European Respiratory Society
    • Skeletal muscle dysfunction in chronic obstructive pulmonary disease. A statement of the American Thoracic Society and European Respiratory Society. Am J Respir Crit Care Med 1999; 159: S1-S40.
    • (1999) Am J Respir Crit Care Med , vol.159
  • 74
    • 84878563618 scopus 로고    scopus 로고
    • Pathophysiology of muscle dysfunction in COPD
    • Gea J, Agustí A, Roca J. Pathophysiology of muscle dysfunction in COPD. J Appl Physiol 2013; 114: 1222-1234.
    • (2013) J Appl Physiol , vol.114 , pp. 1222-1234
    • Gea, J.1    Agustí, A.2    Roca, J.3
  • 75
    • 84890506487 scopus 로고    scopus 로고
    • Lungs, bone marrow and adipose tissue. A network approach to the pathobiology of chronic obstructive pulmonary disease
    • Agustí A, Barberà JA, Wouters EF, et al. Lungs, bone marrow and adipose tissue. A network approach to the pathobiology of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013; 188: 1396-1406.
    • (2013) Am J Respir Crit Care Med , vol.188 , pp. 1396-1406
    • Agustí, A.1    Barberà, J.A.2    Wouters, E.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.