Cyclooxygenase regulates human oropharyngeal carcinomas via the proinflammatory cytokine IL-6: A general role for inflammation?

FASEB Journal

Volumn 14, Issue 11, 2000, Pages 1499-1507

  Hong, S H ^a   Ondrey, F G ^a   Avis, I M ^a   Chen, Z ^a   Loukinova, E ^a   Cavanaugh P F , Jr ^a   Van Waes, C ^a   Mulshine, J L ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Arachidonic acid; Colon cancer; COX inhibitors; Inflammatory disease

Indexed keywords

CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; INTERLEUKIN 8; INTERLEUKIN RECEPTOR; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; STAT3 PROTEIN;

ARTICLE; CARCINOGENESIS; CYTOKINE PRODUCTION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INFLAMMATION; OROPHARYNX CARCINOMA; PARACRINE SIGNALING; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SIGNAL TRANSDUCTION;

EID: 0033870605     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.99-0802com     Document Type: Article

References (53)

1. Genotoxicity of tobacco smoke and tobacco smoke condensate
2. Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling
3. Arachidonic acid stimulates prostate cancer cell growth: Critical role of 5-lipoxygenase
4. Lipoxygenase metabolites of arachidonic acid modulate hematopoiesis
5. Regulation of the immune response by prostaglandins
6. Prostaglandin endoperoxide synthases-1 and -2
7. Cyclooxygenases 1 and 2
8. Benzo[a]pyrene up-regulates cyclooxygenase-2 gene expression in oral epithelial cells
9. Regulation of prostaglandin synthase-1 and prostaglandin synthase-2
10. Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation
11. Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck
12. Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas
13. Differential expression and regulation of cyclooxygenase-1 and -2 in two human breast cancer cell lines
14. Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer
15. Self-promotion? Intimate connections between APC and prostaglandin H synthase-2
16. Recent advances in chemoprevention of cancer
17. 2, and production of interleukins 1, 6 and 8, in human and porcine explants in organ culture
18. 2. Distinct roles of cyclooxygenase-1 and -2
19. Cyclooxygenase in biology and disease
20. The use of ketorolac tromethamine oral rinse for the treatment of periodontitis in adults
21. Cyclooxygenase inhibitors vary widely in potency for preventing cytokine-induced bone resorption
22. The analgesic and anti-inflammatory profile of ketorolac and its tromethamine salt
23. Preformulation salt selection. Physical property comparisons of the tris(hydroxymethyl)aminomethane (THAM) salts of four analgesic/antiinflammatory agents with the sodium salts and the free acids
24. Differentiation of monocytoid THP-1 cells with phorbol ester induces expression of prostaglandin endoperoxide synthase-1 (COX-1)
25. Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity
26. Cyclooxygenase regulates angiogenesis induced by colon cancer cells
27. Experimental plasmacytomagenesis in mice
28. Human squamous cell carcinoma. Establishment and characterization of new permanent cell lines
29. Metastatic variants derived following in vivo tumor progression of an in vitro transformed squamous cell carcinoma line acquire a differential growth advantage requiring tumor-host interaction
30. The host environment promotes the development of primary and metastatic squamous cell carcinomas that constitutively express proinflammatory cytokines IL-1alpha, IL-6, GM-CSF, and KC
31. The host environment promotes the constitutive activation of nuclear factor-kappaB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma
32. Relationship of arachidonic acid metabolizing enzyme expression in epithelial cancer cell lines to the growth effect of selective biochemical inhibitors
33. Growth factor effects on small cell lung cancer cells using a colorimetric assay: Can a transferrin-like factor mediate autocrine growth?
34. Prostaglandin synthesis by squamous carcinoma cells of head and neck, and its inhibition by non-steroidal anti-inflammatory drugs
35. 2 production in fresh tissues of head and neck cancer patients
36. Expression of a dominant-negative inhibitor - KBα of nuclear factor - KB in human head and neck cancer inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo
37. Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with a phorbol diester
38. Regression of head and neck carcinoma with a prostaglandin-synthesis inhibitor
39. A comparison of topical ketorolac, systemic flurbiprofen, and placebo for the inhibition of bone loss in adult periodontitis
40. 2 and IL-1 beta in the gingival crevicular fluid of adults with periodontitis: Its relationship to alveolar bone loss and disruption by twice daily treatment with ketorolac tromethamine oral rinse
41. Cytokines induce an epithelial cell cytokine response
42. 2 production and metabolism in human breast cancer cells and breast fibroblasts. Regulation by inflammatory mediators
43. Bacterial biofilms: A common cause of persistent infections
44. Aspirin and the risk of colorectal cancer in women
45. Colon cancer prevention by NSAIDs: What is the mechanism of action?
46. Mechanism of action of antiinflammatory drugs
47. Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis
48. Fenretinide: The death of a tumor cell
49. Cyclooxygenase-2 as a therapeutic target
50. Increased presence of interleukin-6 (IL-6) and IL-8 secreting fibroblast subpopulations in adult periodontitis
51. Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells
52. Periodontitis: A risk factor for coronary heart disease?
53. Does the mouth put the heart at risk?