Tocotrienol-rich fraction, [6]-gingerol and epigallocatechin gallate inhibit proliferation and induce apoptosis of glioma cancer cells

Molecules

Volumn 19, Issue 9, 2014, Pages 14528-14541

  Rahman, Amirah Abdul ^a   Makpol, Suzana ^b   Jamal, Rahman ^a   Harun, Roslan ^a   Mokhtar, Norfilza ^a   Ngah, Wan Zurinah Wan ^a,b  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^b DEPARTMENT OF PHARMACOLOGY   (Malaysia)

Author keywords

Asiaticoside; Epigallocatechin gallate; Glioma; Synergy; Tocotrienol rich fraction; 6 gingerol

Indexed keywords

ALPHA TOCOTRIENOL; CATECHIN; CATECHOL DERIVATIVE; EPIGALLOCATECHIN GALLATE; FATTY ALCOHOL; GINGEROL;

ANALOGS AND DERIVATIVES; APOPTOSIS; CELL PROLIFERATION; DRUG EFFECTS; DRUG POTENTIATION; GLIOMA; HUMAN; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; CATECHIN; CATECHOLS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SYNERGISM; FATTY ALCOHOLS; GLIOMA; HUMANS; TOCOTRIENOLS;

EID: 84907157860     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules190914528     Document Type: Article

References (37)

1. Furnari, F.B.; Fenton, T.; Bachoo, R.M.; Mukasa, A.; Stommel, J.M.; Stegh, A.; Hahn, W.C.; Ligon, K.L.; Louis, D.N.; Brennan, C.; et al. Malignant astrocytic glioma: Genetics, biology, and paths to treatment. Gene. Dev. 2007, 21, 2683-2710.
2. Wagner, H.; Ulrich-Merzenich, G. Synergy research: Approaching a new generation of phytopharmaceuticals. Phytomedicine 2009, 16, 97-110.
3. Straetemans, R.; O'Brien, T.; Wouters, L.; van Dun, J.; Janicot, M.; Bijnens, L.; Burzykowski, T.; Aerts, M. Design and analysis of drug combination experiments. Biom. J. 2005, 47, 299-308.
4. Imming, P.; Sinning, C.; Meyer, A. Drugs, their targets and the nature and number of drug targets. Nat. Rev. Drug Discov. 2006, 5, 821-834.
5. Ulrich-Merzenich, G.; Panek, D.; Zeitler, H.; Vetter, H.; Wagner, H. Drug development from natural products: Exploiting synergistic effects. Indian J. Exp. Biol. 2010, 48, 208-219.
6. Ong, F.B.; wan Ngah, W.Z.; Marzuki, A.; Kadir, K.A.; Abdullah, N.; Top, A.G.M.; Shamaan, N.A. Effect of vitamin E supplementation on the immune response during chemically induced hepatocarcinogenesis in the rat. J. Clin. Biochem. Nutr. 1994, 17, 161-169.
7. Nigam, N.; George, J.; Srivastava, S.; Roy, P.; Bhui, K.; Singh, M.; Shukla, Y. Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesis. Cancer Chemoth. Pharmacol. 2010, 65, 687-696.
8. Meeran, S.M.; Ahmed, A.; Tollefsbol, T.O. Epigenetic targets of bioactive dietary components for cancer prevention and therapy. Clin. Epigenet. 2010, 1, 101-116.
9. Bunpo, P.; Kataoka, K.; Arimochi, H.; Nakayama, H.; Kuwahara, T.; Bando, Y.; Izumi, K.; Vinitketkumnuen, U.; Ohnishi, Y. Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats. Food Chem. Toxicol. 2004, 42, 1987-1997.
10. Viola, V.; Pilolli, F.; Piroddi, M.; Pierpaoli, E.; Orlando, F.; Provinciali, M.; Betti, M.; Mazzini, F.; Galli, F. Why tocotrienols work better: Insights into the in vitro anti-cancer mechanism of vitamin E. Gene. Nutr. 2012, 7, 29-41.
11. Nigam, N.; Bhui, K.; Prasad, S.; George, J.; Shukla, Y. [6]-Gingerol induces reactive oxygen species regulated mitochondrial cell death pathway in human epidermoid carcinoma A431 cells. Chem. Biol. Interact. 2009, 181, 77-84.
12. Al-Saeedi, F.J.; Bitar, M.; Pariyani, S. Effect of asiaticoside on 99mTc-tetrofosmin and 99mTc-sestamibi uptake in MCF-7 cells. J. Nucl. Med. Technol. 2011, 39, 279-283.
13. Leaver, K.R.; Allbutt, H.N.; Creber, N.J.; Kassiou, M.; Henderson, J.M. Oral pre-treatment with epigallocatechin gallate in 6-OHDA lesioned rats produces subtle symptomatic relief but not neuroprotection. Brain Res. Bull. 2009, 80, 397-402.
14. Hwang, J.T.; Ha, J.; Park, I.J.; Lee, S.K.; Baik, H.W.; Kim, Y.M.; Park, O.J. Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway. Cancer Lett. 2007, 247, 115-121.
15. Park, Y.J.; Wen, J.; Bang, S.; Park, S.W.; Song, S.Y. [6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells. Yonsei Med. J. 2006, 47, 688-697.
16. Park, S.K.; Sanders, B.G.; Kline, K. Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling. Breast Cancer Res. Treat. 2010, 124, 361-375.
17. Kunysz, E.A.; Michel, A.D.; Whiting, R.L.; Woods, K. The human astrocytoma cell line 1321 N1 contains M2-glandular type muscarinic receptors linked to phosphoinositide turnover. Br. J. Pharmacol. 1989, 96, 271-278.
18. Meléndez, B.; García-Claver, A.; Ruano, Y.; Campos-Martín, Y.; de Lope, Á.R.; Pérez-Magán, E.; Mur, P.; Torres, S.; Lorente, M.; Velasco, G.; et al. Copy number alterations in glioma cell lines. In Glioma-Exploring Its Biology and Practical Relevance; Ghosh, D.A., Ed.; InTech: Rijeka, Croatia, 2011; pp. 429-448.
19. Garcia-Claver, A.; Lorente, M.; Mur, P.; Campos-Martin, Y.; Mollejo, M.; Velasco, G.; Melendez, B. Gene expression changes associated with erlotinib response in glioma cell lines. Eur. J. Cancer 2013, 49, 1641-1653.
20. Diserens, A.C.; de Tribolet, N.; Martin-Achard, A.; Gaide, A.C.; Schnegg, J.F.; Carrel, S.; Characterization of an established human malignant glioma cell line: LN-18. Acta Neuropathol. 1981, 53, 21-28.
21. Ishii, N.; Maier, D.; Merlo, A.; Tada, M.; Sawamura, Y.; Diserens, A.C.; van Meir, E.G. Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines. Brain Pathol. 1999, 9, 469-479.
22. Kok, T.M.; Breda, S.G.; Briede, J.J. Genomics-based identification of molecular mechanisms behind the cancer preventive action of phytochemicals: Potential and challenges. Curr. Pharm. Biotechnol. 2012, 13, 255-264.
23. Kannappan, R.; Gupta, S.C.; Kim, J.H.; Aggarwal, B.B. Tocotrienols fight cancer by targeting multiple cell signaling pathways. Gene. Nutr. 2012, 7, 43-52.
24. Weng-Yew, W.; Selvaduray, K.R.; Ming, C.H.; Nesaretnam, K. Suppression of tumor growth by palm tocotrienols via the attenuation of angiogenesis. Nutr. Cancer 2009, 61, 367-373.
25. Sen, C.K.; Khanna, S.; Roy, S. Tocotrienols in health and disease: The other half of the natural vitamin E family. Mol. Aspects Med. 2007, 28, 692-728.
26. Huang, W.Y.; Cai, Y.Z.; Zhang, Y. Natural phenolic compounds from medicinal herbs and dietary plants: Potential use for cancer prevention. Nutr. Cancer 2010, 62, 1-20.
27. Singh, B.N.; Shankar, S.; Srivastava, R.K. Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochem. Pharm. 2011, 82, 1807-1821.
28. Zhang, R.; Banik, N.L.; Ray, S.K. Combination of all-trans retinoic acid and interferon-gamma upregulated p27(kip1) and down regulated CDK2 to cause cell cycle arrest leading to differentiation and apoptosis in human glioblastoma LN18 (PTEN-proficient) and U87MG (PTEN-deficient) cells. Cancer Chemoth. Pharm. 2008, 62, 407-416.
29. Gupta, R.A.; Brockman, J.A.; Sarraf, P.; Willson, T.M.; DuBois, R.N. Target genes of peroxisome proliferator-activated receptor gamma in colorectal cancer cells. J. Biol. Chem. 2001, 276, 29681-29687.
30. Hsieh, T.C.; Wu, J.M. Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin. Anticancer Res. 2009, 29, 4025-4032.
31. Tan, S.W.; Ramasamy, R.; Abdullah, M.; Vidyadaran, S. Inhibitory effects of palm α-, γ- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Cell. Immunol. 2011, 271, 205-209.
32. 3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue. Carcinogenesis 1998, 19, 1771-1776.
33. Jiang, S.Z.; Wang, N.S.; Mi, S.Q. Plasma pharmacokinetics and tissue distribution of [6]-gingerol in rats. Biopharm. Drug Dispos. 2008, 29, 529-537.
34. Aqil, F.; Munagala, R.; Jeyabalan, J.; Vadhanam, M.V. Bioavailability of phytochemicals and its enhancement by drug delivery systems. Cancer Lett. 2013, doi:10.1016/j.canlet.2013.02.032.
35. Smith, A.; Giunta, B.; Bickford, P.C.; Fountain, M.; Tan, J.; Shytle, R.D. Nanolipidic particles improve the bioavailability and alpha-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease. Int. J. Pharm. 2010, 389, 207-212.
36. Chou, T.C.; Talalay, P. Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors. Adv. Enzym. Regul. 1984, 22, 27-55.
37. Zhao, L.; Wientjes, M.G.; Au, J.L. Evaluation of combination chemotherapy: Integration of nonlinear regression, curve shift, isobologram, and combination index analyses. Clin. Cancer Res. 2004, 10, 7994-8004.