Suppression of tumor growth by palm tocotrienols via the attenuation of angiogenesis

Nutrition and Cancer

Volumn 61, Issue 3, 2009, Pages 367-373

  Weng Yew, Wong ^a   Selvaduray, Kanga Rani ^a   Ming, Cheng Hwee ^b   Nesaretnam, Kalanithi ^a  

^a MALAYSIAN PALM OIL BOARD   (Malaysia)

^b UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; DELTA TOCOPHEROL; VASCULOTROPIN; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; PALM OIL; VASCULOTROPIN A; VEGETABLE OIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER SIZE; CELL MIGRATION; CHORIOALLANTOIS; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CELL MOTION; CELL PROLIFERATION; CHEMISTRY; CHICKEN; DRUG ANTAGONISM; TUMOR CELL LINE;

MUS;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTICARCINOGENIC AGENTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHICKENS; CHORIOALLANTOIC MEMBRANE; ENDOTHELIAL CELLS; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; PLANT OILS; TOCOTRIENOLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 67649407919     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1080/01635580802582736     Document Type: Article

References (41)

1. Martinez A: A new family of angiogenic factors. Mini Rev Cancer Lett 236, 157-163, 2005.
2. Claffey KP, Brown LF, Aguila LF, Tognazzi K, Yeo KT, et al.: Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis. Cancer Res 56, 172-181, 1996.
3. Bussolino F,Mantovani A, and Percisco G: Molecular mechanism of blood vessel formation. Trends Biochem Sci 22, 251-256, 1997.
4. Goldman CK, Kendall RL, Cabrera G, Soroceanu L, Heike Y, et al.: Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis and mortality rate. Proc Natl Acad Sci USA 95, 8795-8800, 1998.
5. Folkman J: Tumor angiogenesis: therapeutic implication.N Eng J Med 285, 1182-1186, 1971.
6. Hanathan D and Folkman J: Patterns and imaging mechanism of the angiogenic switch during tumorigenesis. Cell 186, 353-364, 1996.
7. Skobe M, Rockwell P, Goldstein N, Vosseler S, and Fusenig NE: Halting angiogenesis suppresses carcinoma cell invasion. Nat Med 3, 1222-1227, 1997.
8. Miyazawa T, Inokuchi H, Tsuzuki T, and Igarashi M: Anti-angiogenic Potential of Tocotrienol in vitro. Biochemistry 69, 67-69, 2004.
9. Nakagawa K, Eitsuka T, Inokuchi H, and Miyazawa T: DNA chip analysis of comprehensive food function: Inhibition of angiogenesis and telomerase activity with unsaturated vitamin E, tocotrienol. BioFactors 21, 5-10, 2004.
10. Sundram K and Gapor A: Vitamin E from palm oil: Its extraction and nutrition properties. In Lipid Technology, Peter JB (ed.). Bridgewater, England, 1992, pp. 137-141.
11. Rodriguez LG, Wu X, and Guan JL: Wound-healing assay. Methods Mol Biol 294, 23-29, 2005.
12. Tamilarasan KP, Kolluru GK, Rajaram M, Indhumathy M, Saranya R, et al.: Thalidomide attenuates nitric oxide mediated angiogenesis by blocking migration of endothelial cells. BMC Cell Biol 7, 17, 2006.
13. Tomayko MM and Reynolds CP: Determination of subcutaneous tumor size in athymic (nude) mice. Cancer Chemother Pharmacol 24, 148-154, 1989.
14. Nesaretnam K, Stephen R, and Darbre PD: Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status. Ibid 33, 461-469, 1998.
15. Nesaretnam K, Dorasamy S, and Dabre D: Tocotrienol inhibit growth of ZR-75-1 breast cancer cells. Int J Food Sci Nutr 51, S95-S105, 2000.
16. Guthrie N, Gapor A, Chambers AF, and Carroll KK: Inhibition of proliferation of estrogen receptor-negative MDA-MB-435 and positive MCF-7 human breast cancer cells by palm oil tocotrienol and tamoxifen, alone and in combination. J Nutr 127, 544S-548S, 1997.
17. Nesaretnam K,Wong WY, and Basri MW: Tocotrienols and cancer: Beyond antioxidant activity. Eur J Lipid Sci Technol 109, 445-452, 2007.
18. Griffioen AW and Molema G: Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic in ammation. Pharmacol Rev 52, 237-268, 2000.
19. Nakagawa K, Shibata A, Yamashita A, Tsuzuki T, Kariya J, et al.: In vivo angiogenesis is suppressed by unsaturated vitamin E, tocotrienol. J Nutr 137, 1938-1943, 2007.
20. Fan TP, Yeh JC, Leung KW, Yue PYK, and Wong RNS: Angiogenesis: from plants to blood vessels. Trends Pharmacol Sci 27, 297-309, 2006.
21. Suzuki YJ, Tsuchiya M, Wassall SR, Choo YM, Govil G, et al.: Structural and dynamic membrane properties of alpha tocopherol and alpha tocotrienol: implication to the molecular mechanism of their antioxidant potency. Biochemistry 32, 10692-10699, 1993.
22. Meydani M: Vitamin E. Lancet 345, 70-175, 1995.
23. Ribatti D, Nico B, Vacca A, Roncali L, Burrim PH, et al.: Chorioallantoic membrane capillary bed: a useful target for studying angiogenesis and antiangiogenesis in vivo. Anat Rec 264, 317-324, 2001.
24. Carmeliet P: Angiogenesis in health and disease. Nat Med 9, 653-660, 2003.
25. Ribatti D, Vacca A, Roncali L, and Dammacco F: The chick embryo chorioallantoic membrane as a model for in vivo research on antiangiogenesis. Curr Pharm Biotechnol 1, 73-82, 2000.
26. Stone WL, Krishnan K, Campbell SE, QU M, Whaley SG, et al.: Tocopherols and the treatment of colon cancer. Ann NY Acad Sci USA 1031, 223-233, 2004.
27. Nesaretnam K, Guthrie N, Chambers AF, and Carroll KK: Effect of tocotrienol on the growth of a human breast cancer cell line in culture. Lipids 30, 1139-1143, 1995.
28. Agarwal MK, Agarwal ML, Athar M, and Gupta S: Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association. Cell Cycle 3, 1-7, 2004.
29. Srivastava JK and Gupta S: Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells Biochemical and Biophysical. Research Comm 346, 447-453, 2006.
30. Gould MN, Haag JD, Kennan WS, Tanner MA, and Elson CE: A comparison of tocopherol and tocotrienol for the chemoprevention of chemically induced rat mammary tumors. Am J Clin Nutr 53, 1068S-1070S, 1991.
31. Nesaretnam K, Khor HT, Ganeson J, Chong YH, Sundram K, et al.: The effects of vitamin E tocotrienols from palm oil on chemically induced mammary carcinogenesis in female rats. Nutr Res 12, 879-892, 1992.
32. Nesaretnam K, Roberto A, Selvaduray KR, Radhakrishnan A, Reimann K, et al.: Tocotrienol-rich fraction from palm oil affects gene expression in tumors resulting from MCF-7 cell inoculation in athymic mice. Lipids 39, 459-467, 2004.
33. Poon RTP, Lau CPY, Cheung ST, Yu WC, and Fan ST: Quantitative correlation of serum levels and tumor expression of vascular endothelial growth factor in patients with hepatocellular carcinoma. Cancer Res 63, 3121-3126, 2003.
34. Poon RTP, Fan ST, and Wong J: Clinical implications of circulating angiogenic factors in cancer patients. J Clin Oncol 19, 1207-1225, 2001.
35. Ferrarar N and Gerber HP: The role of vascular endothelial growth factor in angiogenesis. Acta Haematol 106, 148-156, 2001.
36. Senger DR, Perruzzi CA, Feder J, and Dvorak HF: A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res 46, 5629-5632, 1986.
37. Volm M, Koomagi R, and Mattern J: PD-ECGF, bFGF, and VEGF expression in non-small cell lung carcinomas and their association with lymph node metastasis. Anticancer Res 19, 651-655, 1999.
38. Salven P, Teerenhovi L, and Joensuu H: A high pretreatment serum vascular endothelial growth factor concentration is associated with poor outcome in non-Hodgkin's lymphoma. Blood 90, 3167-3172, 1997.
39. Kumar H, Heer K, Lee PW, Duthie GS, MacDonald AW, et al.: Preoperative serum vascular endothelial growth factor can predict stage in colorectal cancer. Clin Cancer Res 4, 1279-1285, 1998.
40. Karayiannakis AJ, Syrigos KN, Polychronidis A, Zbar A, Kouraklis G, et al.: Circulating VEGF levels in the serum of gastric cancer patients: correlation with pathological variables, patient survival, and tumor surgery. Ann Surg 236, 37-42, 2002.
41. Toi M, Kondo S, Suzuki H, Yamamoto Y, Inada K, et al.: Quantitative analysis of vascular endothelial growth factor in primary breast cancer. Cancer 77, 1101-1106, 1996. (Pubitemid 26080900)