Neuropsychological syndromes associated with Alzheimer's/Vascular dementia: A latent class analysis

Journal of Alzheimer's Disease

Volumn 42, Issue 3, 2014, Pages 999-1014

  Libon, David J ^a   Drabick, Deborah A G ^b   Giovannetti, Tania ^b   Price, Catherine C ^c   Bondi, Mark W ^d,e   Eppig, Joel ^a   Devlin, Kathryn ^b   Nieves, Christine ^a   Lamar, Melissa ^f   Delano Wood, Lisa ^d,e   Nation, Daniel A ^g   Brennan, Laura ^a   Au, Rhoda ^h   Swenson, Rod ⁱ  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b TEMPLE UNIVERSITY   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^f UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^g UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^h BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ UND School of Medicine & Health Sciences Southeast Campus   (United States)

Author keywords

Alzheimer's disease; latent class analysis; mixed dementia; vascular dementia

Indexed keywords

AGED; ALZHEIMER DISEASE; AMNESIA; ANALYTICAL ERROR; ARTICLE; BRAIN SIZE; COGNITION; CONTROLLED STUDY; DISEASE ASSOCIATION; DYSEXECUTIVE DEMENTIA; EPISODIC MEMORY; EXECUTIVE FUNCTION; FOLLOW UP; HIPPOCAMPUS; HUMAN; MAJOR CLINICAL STUDY; MULTIINFARCT DEMENTIA; NEUROPSYCHOLOGICAL TEST; NEUROPSYCHOLOGY; NEURORADIOLOGY; RECALL; ANALYSIS OF VARIANCE; COGNITION DISORDERS; COMPLICATION; FEMALE; LEARNING DISORDERS; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PSYCHOLOGICAL RATING SCALE; SEMANTICS; SEVERITY OF ILLNESS INDEX; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANALYSIS OF VARIANCE; COGNITION DISORDERS; DEMENTIA, VASCULAR; EXECUTIVE FUNCTION; FEMALE; FOLLOW-UP STUDIES; HIPPOCAMPUS; HUMANS; LEARNING DISORDERS; MAGNETIC RESONANCE IMAGING; MALE; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; SEMANTICS; SEVERITY OF ILLNESS INDEX;

EID: 84907154006     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-132147     Document Type: Article

References (71)

1. Jellinger KA (2007) The enigma of vascular cognitive disorder and vascular dementia. Acta Neuropathol 113, 349-388.
2. Kalaria RN, Akinyemi R, Ihara M (2012) Does vascular pathology contribute to Alzheimer changes? J Neurol Sci 322, 141-147.
3. Dubois B, Feldman HH, Jacova C, Cummings JL, DeKosky ST, Barberger-Gateau P, Delacourte A, Frisoni G, Fox NC, Galasko D, Gauthier S, Hampel H, Jicha GA, Meguro K, O'Brien J, Pasquier F, Robert P, Rossor M, Salloway S, Sarazin M, de Souza LC, Stern Y, Visser PJ, Scheltens P (2010) Revising the definition of Alzheimer's disease: A new lexicon. Lancet Neurol 9, 1118-1127.
4. Gorelick PB, Scuteri A, Black SE, DeCarli C, Greenberg SM, Iadecola C (2011) Vascular contributions to cognitive impairment and dementia: A statement for healthcare professionals from the American heart association/American stroke association. Stroke 42, 2672-2713.
5. McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR, Kawash CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, Thies B, Weintraub S, Phelps CH (2011) The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7, 263-269.
6. Román GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, Amaducci L, Orgogozo J-M, Brun A, Hofman A, Moody DM, O'Brien MD, Yamaguchi T, Grafman J, Drayer BP, Bennett DA, Fisher M, Ogata J, Kokmen E, Bermejo F,Wolf PA, Gorelick PB, Bick KL, Pajeau AK, Bell MA, DeCarli C, Culebras A, Korczyn AD, Bogousslavsky J, Hartmann A, Scheinberg P (1993) Vascular dementia: Diagnostic criteria for research studies: Report of the NINDSAIREN International Workshop. Neurology 43, 255-260.
7. Wharton SB, Brayne C, Savva GM, Matthews FE, Forster G, Simpson J, Lace G, Ince PG, on behalf of the Medical Research Council Cognitive Function, Aging, Study (2011) Epidemiological neuropathology: The MRC Cognitive Function and Aging study experience. J Alzheimers Dis 25, 359-372.
8. Schneider JA, Arvanitakis Z, Leurgans SE, BennettDA(2009) The neuropathology of probable Alzheimer disease and mild cognitive impairment. Ann Neurol 66, 200-208.
9. White L, Petrovitch H, Hardman J, Nelson J, Davis DG, Ross GW (2002) Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants. Ann NY Acad Sci 977, 9-23.
10. Wang BW, Lu E, Mackenzie IRA, Assaly M, Jacova C, Lee PE, Beattie BL, Hsiung GYR (2012) Multiple pathologies are common in Alzheimer patients in clinical trials. Can J Neurosci 39, 592-599.
11. Lim A, Tsuang D, Kukull W, Nochlin D, Leverenz J, McCormick W (1999) Clinico-neuropathological correlation of Alzheimer's disease in a community-based case series. JAGS 47, 564-569.
12. White L, Small BJ, Petrovitch H,Webster Ross G, Masaki K, Abbott RD, Hardman J, Davis D, Nelson J, Markesbery W (2005) Recent clinical-pathologic research on the causes of dementia in late life: Update from the Honolulu-Asia Aging Study. J Geriat Psychia Neurol 18, 224-227.
13. Viswanathan A, Rocca WA, Tzourio C (2009) Vascular risk factors and dementia: How to move forward? Neurology 72, 368-374.
14. Esiri MM, Nagy Z, Smith MZ, Barnetson L, Smith AD (1999) Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer's disease. Lancet 354, 919-920.
15. Langa KM, Foster NL, Larson EB (2004) Mixed dementia emerging concepts and therapeutic implications. JAMA 292, 2901-2908.
16. Price CC, Jefferson AL, Merino JG, Heilman KM, Libon DJ (2005) Subcortical vascular dementia: Integrating neuropsychological and neuroradiologic data. Neurology 65, 376-382.
17. Libon DJ, Price CC, Giovannetti T, Swenson R, Bettcher BM, Heilman KM, PennisiA(2008) Linking MRI subcortical vascular disease with patterns of neuropsychological impairment: Evidence for a threshold effect. Stroke 39, 806-813.
18. Clark L, Delano-Wood L, Libon DJ, McDonald C, Nation D, Bangen K, Jak A, Au R, Salmon D, Bondi MW (2013) Are empirically-derived subtypes of mild cognitive impairment consistent with conventional subtypes? J Int Neuropsychol Soc 19, 635-645.
19. Delano-Wood L, Bondi MW, Sacco J, Abeles N, Jak AJ, Libon DJ Bozoki (2009) A Heterogeneity in mild cognitive impairment: Differences in neuropsychological profile and associated white matter lesion pathology. J Int Neuropsychol Soc 15, 906-914.
20. Eppig J, Wambach DM, Nieves C, Price CC, Lamar M, Delano-Wood L, Giovannetti T, Bettcher BM, Penney DL, Swenson R, Lippa C, Kabasakalian A, Bondi MW, Libon DJ (2012) Dysexecutive functioning in mild cognitive impairment: Derailment in temporal gradients. J Int Neuropsychol Soc 18, 20-28.
21. Libon DJ, Eppig J, Xie XS,Wicas G, Lippa C, Bettcher BM, Price C, Giovannetti T, Lamar M, Swenson R, Wambach D (2010) The heterogeneity of mild cognitive impairment: A neuropsychological analysis. J Int Neuropsychol Soc 6, 84-93.
22. Libon DJ, Bondi MW, Price CC, Lamar M, Eppig J,Wambach DM, Nieves C, Delano Wood L, Giovannetti T, Lippa C, Kabasakalian A, Cosentino S, Swenson R, Penney DL (2011) Verbal serial list learning In mild cognitive impairment: A profile analysis of interference, forgetting, and errors. J Int Neuropsychol Soc 17, 905-914.
23. Gold G, Giannakopoulos P, Herrmann FR, Bouras C,Kovari E (2007) Identification of Alzheimer and vascular lesion thresholds for mixed dementia. Brain 130, 2830-2836.
24. Kaplan E (1988) A process approach to neuropsychological assessment. In Clinical neuropsychology and brain functions: Research, measurement, and practice: Master lectures, Boll T, Bryant BR, eds. The American Psychological Association, Washington, DC.
25. Kaplan E (1990) The process approach to neuropsychological assessment of psychiatric patients. J Neuropsychiatry Clin Neurosci 2, 72-87.
26. Libon DJ, Swenson R, Ashendorf L, Baue RM, Bowers D (2013) Edith Kaplan and the Boston Process Approach. Clin Neuropsychol 27, 1223-1233.
27. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
28. Chui H, Victoroff J, Margolin D, Jagust W, Shankle R, Katzman R (1992) Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers. Neurology 42, 473-480.
29. Junque C, Pujol J, Vendrell P, Bruna O, Jodar M, Ribas JC, Vinas J, Capevila A, Marti-Vilalta JL (1990) Leukoaraiosis on magnetic resonance imaging and speed of mental processing. Arch Neurol 47, 151-156.
30. Libon DJ, Bogdanoff B, Cloud BS, Skalina S, Giovannetti T, Gitlin HL, Bonavita J (1998) Declarative and procedural learning, quantitative measures of the hippocampus, and subcortical white alterations in Alzheimer's disease and ischaemic vascular dementia. J Clin Exp Neuropsychol 20, 30-41.
31. Lamar M, Price CC, Libon DJ, Penney DL, Kaplan E, Grossman M, Heilman KM (2007) Alterations in working memory as a function of leukoaraiosis in dementia. Neuropsychologia 45, 245-254.
32. Lamar M, Catani M, Price CC, Heilman KM, Libon DJ (2008) The impact of region specific leukoaraiosis on working memory deficits in dementia. Neuropsychologia 46, 2597-2601.
33. Libon DJ, Price CC, Davis Garrett K, Giovannetti T (2004) From Binswanger's disease to leukoaraiosis: What we have learned about subcortical vascular dementia. Clin Neuropsychol 18, 83-100.
34. Duvernoy HM (2005) The human hippocampus: Functional anatomy, vascularization, and serial sections with MRI, 3rd edition. Springer, Berlin, New York.
35. Yushkevich PA, Piven J, Hazlett HC, Smith RG,Ho S, Gee JC, Gerig G (2006) User-guided 3D active contour segmentation of anatomical structures: Significantly improved efficiency and reliability. NeuroImage 31, 1116-1128.
36. Bigler ED, Neeley ES, Miller MJ, Tate DF, Rice SA, Cleavinger H, Welsh-Bohmer K (2004) Cerebral volume loss, cognitive deficit and neuropsychological performance: Comparative measures of brain atrophy: I. Dementia. J Int Neuropsychol Soc 10, 442-452.
37. Bigler ED, TateDF(2011) Brain volume, intracranial volume, and dementia. Invest Radiol 36, 539-546.
38. Shattuck DW, Leahy RM (2000) Brainsuite: An automated cortical surface identification tool. In: MICCAI 2000, LNCS 1935, Delp SL, DiGioiaAM,Jaramaz B, eds. Springer-Verlag, Berlin, pp. 50-61.
39. Smith SM(2002) Fast robust automated brain extraction.Hum Brain Mapp 17, 143-155.
40. Lamar M, Price CC, Davis KL, Kaplan E, Libon DJ (2002) Capacity to maintain mental set in dementia. Neuropsychologia 40, 435-445.
41. Wechsler D (1945) A standardized memory scale for clinical use. J Psychology 19, 87-95.
42. Spreen O, Strauss E (1998) A compendium of neuropsychological tests, 2nd edition, Oxford University Press, NewYork.
43. Kaplan E, Goodglass H, Weintraub S (1983) Boston Naming Test: Revised edition. Lea & Febiger, Philadelphia.
44. Carew TG, Lamar M, Cloud BS, Grossman M, Libon DJ (1997) Impairment in category fluency in ischaemic vascular dementia. Neuropsychology 11, 400-412.
45. Price CC, Garrett KD, Jefferson AL, Cosentino S, Tanner J, Penney DL, Swenson R, Giovannetti T, Bettcher BM, Libon DJ (2009) The role of leukoaraiosis severity on learning and memory in dementia: Performance differences on a 9-word list learning test. Clin Neuropsychol 23, 1-18.
46. Delis DC, Kramer JH, Kaplan E, Ober B (1987) California Verbal Learning Test: Adult Version Manual, The Psychological Corporation, Austin, TX.
47. Libon DJ, Mattson RE, Glosser G, Kaplan E (1996) A nineword dementia version of the CaliforniaVerbal Learning Test. Clin Neuropsychol 10, 237-244.
48. Giovannetti T, Lamar M, Cloud BS, Swenson R, Fein D, Kaplan K, Libon DJ (2001) Different underlying mechanisms for deficits in concept formation in dementia. Arch Clin Neuropsychol 16, 547-560.
49. Libon DJ, McMillan C, Powers C, Massimo L, Khan A, Morgan B, Farag C, Richmond L, Weinstein J, Moore P, Coslett HB, Chatterjee A, Aguirre G, Grossman M (2009) Neurocognitive contributions to verbal fluency deficits in frontotemporal lobar degeneration. Neurology 73, 535-542.
50. Francis WN, Kucera H (1982) The Frequency Analysis of English Usage. Houghton-Mifflin Co., Boston.
51. Muthén LK, Muthén BO (1998-2007) Mplus User's Guide, 5th edition. Muthén & Muthén, Los Angeles.
52. Nylund KL, Asparouhov T, Muthén BO (2007) Deciding on the number of classes in latent class analysis and growth mixture modeling: A Monte Carlo simulation study. Struct Equ Modeling 14, 535-569.
53. Nylund K, Bellmore A, Nishina A, Graham S (2007) Subtypes, severity, and structural stability of peer victimization: What does latent class analysis say? Child Dev 78, 1706-1722.
54. Beauchaine TP (2003) Taxometrics and developmental psychopathology. Dev Psychopathol 15, 501-527.
55. Akaike H (1987) Factor analysis and AIC. Psychometrika 52, 317-332.
56. Schwartz G (1978) Estimating the dimension of a model. Ann Statistics 6, 461-464.
57. Sclove SL (1987) Application of model-selection criteria to some problems in multivariate analysis. Psychometrika 52, 333-343.
58. Folstein MF, Folstein SE, McHugh PR, "Mini-Mental State" (1975) A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198.
59. Murray ME, Graff-Radford NR, Ross OA, Petersen RC, Duara R, Dickson DW (2011) Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: A retrospective study. Lancet Neurol 10, 785-786.
60. Snowden JS, Stopford CL, Julien CL, Thompson JC, Davidson Y, Gibbons L, Pritchard A, Lendon CL, Richardson AM, Varma A, Neary D, Mann D (2007) Cognitive phenotypes in Alzheimer's disease and genetic risk. Cortex 43, 835-845.
61. Stopford CL, Snowden JS, Thompson JC, Neary D (2007) Distinct memory profile in Alzheimer's disease. Cortex 43, 846-857.
62. Stopford CL, Snowden JS, Thompson JC, Neary D (2008) Variability in cognitive presentation of Alzheimer's disease. Cortex 44, 185-195.
63. Brickman AM (2013) Contemplating Alzheimer's disease and the contribution of white matter hyperintensities. Curr Neurol Neurosci 12, 415-417.
64. Lamar M, Price CC, Giovannetti T, Swenson R, Libon DJ (2010) The dysexecutive syndrome associated with subcortical white matter disease and related white matter pathology. Behav Neurol 22, 53-62.
65. Fuster JM (2008) The Prefrontal Cortex: Anatomy, Physiology, and Neuropsychology of the Executive Lobe, 4th edition, Lippincott-Raven Press, New York.
66. Davis KL, Price CC, Kaplan E, Libon DJ (2002) Error analysis of the nine-word California Verbal Learning Test (CVLT-9) among older adults with and without dementia. Clin Neuropsychol 16, 81-89.
67. Baldo JV, Delis D, Kramer J, Shimamura AP (2002) Memory performance on the California Verbal Learning Test-II: Findings from patients with focal frontal lesions. J Int Neuropsychol Soc 8, 539-546.
68. Sultzer D, Mahler M, Cummings J, Van Gorp W, Hinkin C, Brown C (1995) Cortical abnormalities associated with subcortical lesions in vascular dementia. Arch Neurol 52, 773-780.
69. Köhler S, Hamel R, Sistermans N, Koene T, Pijnenburg YA, van der Flier WM, Scheltens P, Visser PJ, Aalten P, Verhey FR, Ramakers I (2013) Progression to dementia in memory clinic patients without dementia: A latent profile analysis. Neurology 81, 1342-1349.
70. Schmand B, Rienstra A, Tamminga H, Richard E, van Gool WA, CaanMWA, Majoie CB (2014) Responsiveness of magnetic resonance imaging and neuropsychological assessment in memory clinic patients. J Alzheimers Dis 40, 409-418.
71. Stoub TR, deToledo-Morrell L, Dickerson BC (2014) Parahippocampal white matter volume predicts AD risk In cognitively normal old adults. Neurobiol Aging 35, 1855-1861.