Expression of a novel stress-inducible protein, Sestrin 2, In rat glomerular parietal epithelial cells

American Journal of Physiology - Renal Physiology

Volumn 307, Issue 6, 2014, Pages F708-F717

  Hamatani, Hiroko ^a   Hiromura, Keiju ^a   Sakairi, Toru ^a   Takahashi, Satoshi ^a   Watanabe, Mitsuharu ^a   Maeshima, Akito ^a   Ohse, Takamoto ^b   Pippin, Jeffery W ^c   Shankland, Stuart J ^c   Nojima, Yoshihisa ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Glomerular parietal epithelial cells; Mammalian target of rapamycin; Sestrin 2

Indexed keywords

DOXORUBICIN; HEAT SHOCK PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN S6; PUROMYCIN AMINONUCLEOSIDE; SESTRIN 2; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; HERMES ANTIGEN; MTOR PROTEIN, RAT; NUCLEAR PROTEIN; SESTRIN 2 PROTEIN, RAT; SMALL INTERFERING RNA; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; DOWN REGULATION; GLOMERULAR PARIETAL EPITHELIAL CELL; GLOMERULONEPHRITIS; GLOMERULOSCLEROSIS; GLOMERULUS EPITHELIUM; KIDNEY DISEASE; KIDNEY FIBROSIS; MALE; NONHUMAN; PERIGLOMERULAR FIBROSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEINURIA; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED; EPITHELIUM CELL; GLOMERULUS; METABOLISM; MOUSE; WISTAR KYOTO RAT; WISTAR RAT;

ANIMALS; ANTIGENS, CD44; CELLS, CULTURED; DOWN-REGULATION; DOXORUBICIN; EPITHELIAL CELLS; KIDNEY DISEASES; KIDNEY GLOMERULUS; MALE; MICE; NUCLEAR PROTEINS; PUROMYCIN AMINONUCLEOSIDE; RATS; RATS, INBRED WKY; RATS, WISTAR; RIBOSOMAL PROTEIN S6; RNA, SMALL INTERFERING; TOR SERINE-THREONINE KINASES;

EID: 84907148346     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00625.2013     Document Type: Article

References (31)

1. Appel D, Kershaw DB, Smeets B, Yuan G, Fuss A, Frye B, Elger M, Kriz W, Floege J, Moeller MJ. Recruitment of podocytes from glomerular parietal epithelial cells. J Am Soc Nephrol 20: 333–343, 2009
2. Bariety J, Mandet C, Hill GS, Bruneval P. Parietal podocytes in normal human glomeruli. J Am Soc Nephrol 17: 2770–2780, 2006
3. Ben-Sahra I, Dirat B, Laurent K, Puissant A, Auberger P, Budanov A, Tanti JF, Bost F. Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death. Cell Death Differ 20: 611–619, 2013
4. Budanov AV. Stress-responsive sestrins link p53 with redox regulation and mammalian target of rapamycin signaling. Antioxid Redox Signal 15: 1679–1690, 2011
5. Budanov AV, Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134: 451–460, 2008
6. Budanov AV, Sablina AA, Feinstein E, Koonin EV, Chumakov PM. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science 304: 596–600, 2004
7. Budanov AV, Shoshani T, Faerman A, Zelin E, Kamer I, Kalinski H, Gorodin S, Fishman A, Chajut A, Einat P, Skaliter R, Gudkov AV, Chumakov PM, Feinstein E. Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability. Oncogene 21: 6017–6031, 2002
8. Chang AM, Ohse T, Krofft RD, Wu JS, Eddy AA, Pippin JW, Shankland SJ. Albumin-induced apoptosis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/2. Nephrol Dial Transplant 27: 1330–1343, 2012
9. Dowling RJ, Topisirovic I, Fonseca BD, Sonenberg N. Dissecting the role of mTOR: lessons from mTOR inhibitors. Biochim Biophys Acta 1804: 433–439, 2010
10. Fatima H, Moeller MJ, Smeets B, Yang HC, D’Agati VD, Alpers CE, Fogo AB. Parietal epithelial cell activation marker in early recurrence of FSGS in the transplant. Clin J Am Soc Nephrol 7: 1852–1858, 2012
11. Gödel M, Hartleben B, Herbach N, Liu S, Zschiedrich S, Lu S, Debreczeni-Mór A, Lindenmeyer MT, Rastaldi MP, Hartleben G, Wiech T, Fornoni A, Nelson RG, Kretzler M, Wanke R, Pavenstädt H, Kerjaschki D, Cohen CD, Hall MN, Rüegg MA, Inoki K, Walz G, Huber TB. Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest 121: 2197–2209, 2011
12. Hiramatsu N, Hiromura K, Shigehara T, Kuroiwa T, Ideura H, Sakurai N, Takeuchi S, Tomioka M, Ikeuchi H, Kaneko Y, Ueki K, Kopp JB, Nojima Y. Angiotensin II type 1 receptor blockade inhibits the development and progression of HIV-associated nephropathy in a mouse model. J Am Soc Nephrol 18: 515–527, 2007
13. Hiromura K, Pippin JW, Blonski MJ, Roberts JM, Shankland SJ. The subcellular localization of cyclin dependent kinase 2 determines the fate of mesangial cells: role in apoptosis and proliferation. Oncogene 21: 1750–1758, 2002
14. Huber TB, Walz G, Kuehn EW. mTOR and rapamycin in the kidney: signaling and therapeutic implications beyond immunosuppression. Kidney Int 79: 502–511, 2011
15. Inoki K, Mori H, Wang J, Suzuki T, Hong S, Yoshida S, Blattner SM, Ikenoue T, Ruegg MA, Hall MN, Kwiatkowski DJ, Rastaldi MP, Huber TB, Kretzler M, Holzman LB, Wiggins RC, Guan KL. mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. J Clin Invest 121: 2181–2196, 2011
16. Ishihara M, Urushido M, Hamada K, Matsumoto T, Shimamura Y, Ogata K, Inoue K, Taniguchi Y, Horino T, Fujieda M, Fujimoto S, Terada Y. Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury. Am J Physiol Renal Physiol 305: F495–F509, 2013
17. Kurayama R, Ito N, Nishibori Y, Fukuhara D, Akimoto Y, Higashihara E, Ishigaki Y, Sai Y, Miyamoto K, Endou H, Kanai Y, Yan K. Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis. Lab Invest 91: 992–1006, 2011
18. Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 327: 1223–1228, 2010
19. Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. Maintenance of metabolic homeostasis by sestrin2 and sestrin3. Cell Metab 16: 311–321, 2012
20. Liu SY, Lee YJ, Lee TC. Association of platelet-derived growth factor receptor beta accumulation with increased oxidative stress and cellular injury in sestrin 2 silenced human glioblastoma cells. FEBS Lett 585: 1853–1858, 2011
21. Mundel P, Shankland SJ. Podocyte biology and response to injury. J Am Soc Nephrol 13: 3005–3015, 2002
22. Ohse T, Chang AM, Pippin JW, Jarad G, Hudkins KL, Alpers CE, Miner JH, Shankland SJ. A new function for parietal epithelial cells: a second glomerular barrier. Am J Physiol Renal Physiol 297: F1566–F1574, 2009
23. Ohse T, Pippin JW, Chang AM, Krofft RD, Miner JH, Vaughan MR, Shankland SJ. The enigmatic parietal epithelial cell is finally getting noticed: a review. Kidney Int 76: 1225–1238, 2009
24. Ohse T, Pippin JW, Vaughan MR, Brinkkoetter PT, Krofft RD, Shankland SJ. Establishment of conditionally immortalized mouse glomerular parietal epithelial cells in culture. J Am Soc Nephrol 19: 1879–1890, 2008
25. Sakairi T, Abe Y, Kopp JB. TGF-b1 reduces Wilms’ tumor suppressor gene expression in podocytes. Nephrol Dial Transplant 26: 2746–2752, 2011
26. Shirato I, Asanuma K, Takeda Y, Hayashi K, Tomino Y. Protein gene product 9.5 is selectively localized in parietal epithelial cells of Bowman’s capsule in the rat kidney. J Am Soc Nephrol 11: 2381–2386, 2000
27. Smeets B, Kuppe C, Sicking EM, Fuss A, Jirak P, van Kuppevelt TH, Endlich K, Wetzels JF, Grone HJ, Floege J, Moeller MJ. Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis. J Am Soc Nephrol 22: 1262–1274, 2011
28. Smeets B, Uhlig S, Fuss A, Mooren F, Wetzels JF, Floege J, Moeller MJ. Tracing the origin of glomerular extracapillary lesions from parietal epithelial cells. J Am Soc Nephrol 20: 2604–2615, 2009
29. Takeuchi S, Hiromura K, Tomioka M, Takahashi S, Sakairi T, Maeshima A, Kaneko Y, Kuroiwa T, Nojima Y. The immunosuppressive drug mizoribine directly prevents podocyte injury in puromycin aminonucleoside nephrosis. Nephron Exp Nephrol 116: e3–e10, 2010
30. Wempe F, De-Zolt S, Koli K, Bangsow T, Parajuli N, Dumitrascu R, Sterner-Kock A, Weissmann N, Keski-Oja J, von Melchner H. Inactivation of sestrin 2 induces TGF-b signaling and partially rescues pulmonary emphysema in a mouse model of COPD. Dis Model Mech 3: 246–253, 2010
31. Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 124: 471–484, 2006.