Brain response to cecal infection with Campylobacter jejuni: Analysis with Fos immunohistochemistry

Brain, Behavior, and Immunity

Volumn 18, Issue 3, 2004, Pages 238-245

  Gaykema, Ronald P A ^a   Goehler, Lisa E ^a   Lyte, Mark ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b MINNEAPOLIS MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

Anxiety; Fos; Gram negative bacteria; Gut brain interaction; Interleukin 1; Interleukin 6; Nucleus of the solitary tract; Parabrachial nucleus; Paraventricular hypothalamus

Indexed keywords

BIOCHEMICAL MARKER; INTERLEUKIN 1BETA; INTERLEUKIN 6; PROTEIN C FOS; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARTICLE; BACTERIAL COLONIZATION; BRAIN REGION; BRAIN STEM; CAMPYLOBACTER JEJUNI; CONTROLLED STUDY; GRAM NEGATIVE INFECTION; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INOCULATION; INTESTINE INFECTION; INTESTINE INNERVATION; MALE; MOUSE; NONHUMAN; PARABRACHIAL NUCLEUS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SENSATION; SOLITARY TRACT NUCLEUS;

ANALYSIS OF VARIANCE; ANIMALS; BIOLOGICAL MARKERS; BRAIN; CAMPYLOBACTER INFECTIONS; CAMPYLOBACTER JEJUNI; CECUM; CYTOKINES; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED STRAINS; NEUROIMMUNOMODULATION; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PROTO-ONCOGENE PROTEINS C-FOS; SOLITARY NUCLEUS; TEGMENTUM MESENCEPHALI;

EID: 1842579124     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2003.08.002     Document Type: Article

References (27)

1. Berthoud H.R., Kressel M., Raybould H.E., Neuhuber W.L. Vagal sensors in the rat duodenal mucosa: distribution and structure as revealed by DiI-tracing. Anat Embryol. (Berl.). 191:1995;203-212.
2. Berthoud H.R., Neuhuber W.L. The functional and chemical anatomy of the afferent vagal system. Auton. Neurosci. 85:2000;1-17.
3. Besedovsky H.O., del Rey A., Sorkin E., Dinarello C.A. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science. 233:1996;652-654.
4. Blalock J.E. A molecular basis for bi-directional communication betweenthe immune and neuroendocrine systems. Physiol. Rev. 69:1989;1-32.
5. Bradfield J.F., Schachtman T.R., McLaughlin R.M., Steffen E.K. Behavioral and physiologic effects of inapparent wound infection in rats. Lab. Anim. Sci. 42:1992;572-578.
6. Day H.E.W., Curran E.J., Watson S.J., Akil H. Distinct neurochemical populations in the rat central nucleus of the amygdala and bed nucleus of the stria terminalis: evidence for their selective activation by interleukin-1beta. J. Comp. Neurol. 413:1999;113-128.
7. Dantzer R. Cytokine-induced sickness behavior: where do we stand? Brain Behav. Immun. 15:2001;7-24.
8. Elmquist J.L., Scammel T.E., Jacobson C.D., Saper C.B. Distribution of Fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration. J. Comp. Neurol. 371:1996;85-103.
9. Ericsson A., Kovacs K.J., Sawchenko P.E. A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons. J. Neurosci. 20:1994;565-570.
10. Gaykema R.P.A., Goehler L.E., Tilders F.J.H., Bol J.G.M., McGorry M.M., Maier S.F., Watkins L.R. Bacterial endotoxin induces Fos immunoreactivity in primary afferent neurons of the vagus nerve. Neuroimmunomodulation. 5:1998;234-240.
11. Goehler L.E., Gaykema R.P.A., Anderson K., Hansen M.K., Maier S.F., Watkins L.R. Vagally mediated fever: a visceral chemoreceptive pathway. Auton. Neurosci. 85:2000;49-59.
12. Koutroumanidis M., Binnie C.D., Hennessy M.J., Alarcon G., Elwes R.D., Toone B.K., Chandler C., Selway R., Polkey C.E., O'Connor S.A. VNS in patients with previous unsuccessful resective epilepsy surgery: antiepileptic and psychotropic effects. Acta Neurol. Scand. 107:2003;117-121.
13. Kent S., Bluthe R.M., Kelley K., Dantzer R. Sickness behavior as a new target for drug development. Trends Pharmacol. Sci. 13:1992;24-28.
14. Larson S.J., Dunn A.J. Behavioral effects of cytokines. Brain Behav. Immun. 15:2001;371-387.
15. Lyte M., Varcoe J.J., Bailey M.T. Anxiogenic effect of subclinical bacterial infection in mice in the absence of overt immune activation. Physiol. Behav. 65:1998;63-68.
16. Maier S.F. Bi-directional immune-brain communication: implications for understanding stress, pain, and cognition. Brain Behav. Immun. 17:2003;69-85.
17. Miller C.C., Holmes P.V., Edwards G.L. Area postrema lesions elevate NPY levels and decrease anxiety-related behavior in rats. Physiol. Behav. 77:2002;135-140.
18. Price J.L. Prefrontal cortical networks related to visceral function and mood. Ann. N.Y. Acad. Sci. 877:1999;383-396.
19. Rivest S. How circulating cytokines trigger the neural circuits that control the hypothalamic-pituitary-adrenal axis. Psychoneuroendocrinology. 26:2001;761-788.
20. Saper C.B. Central autonomic system. Paxinos G. The Rat Nervous System. second ed. 1995;107-135 Academic Press, San Diego.
21. Silveira M.C.L., Zangrossi H. Jr., de Barros Viana M., Silveira R., Graeff F.G. Differential expression of Fos protein in the rat brain induced by performance of avoidance or escape in the elevated T-maze. Behav. Brain Res. 126:2001;13-21.
22. Sharkey K.A., Mawe G.M. Neuroimmune and epithelial interactions in intestinal inflammation. Curr. Opin. Pharmacol. 2:2002;669-677.
23. Singewald N., Sharp Y. Neuroanatomical targets of anxiogenic drugs in the hindbrain as revealed by Fos immunocytochemistry. Neuroscience. 98:2000;759-770.
24. Spiller R.C. Role of nerves in enteric infection. Gut. 51:2002;759-762.
25. Tkacs N.C., Li J. Immune stimulation induces Fos expression in brainstem amygdala afferents. Brain Res. Bull. 48:1999;223-231.
26. Wassenaar T.M., Blaser M.J. Pathophysiology of Campylobacter jejuni infections in humans. Microbes Infect. 1:1999;1023-1033.
27. Zagon A. Does the vagus nerve mediate the sixth sense? Trends Neurosci. 24:2001;671-673.