Silymarin alleviates bleomycin-induced pulmonary toxicity and lipid peroxidation in mice

Pharmaceutical Biology

Volumn 52, Issue 10, 2014, Pages 1267-1271

  Razavi Azarkhiavi, Kamal ^a   Ali Omrani, Mehdi ^b   Solgi, Reza ^b   Bagheri, Pezhman ^c   Haji Noormohammadi, Mehdi ^d   Amani, Nahid ^b   Sepand, Mohammad Reza ^b  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c JIROFT UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

Antioxidant enzymes; Inflammation; Lipid peroxidation; Pulmonary damage

Indexed keywords

BLEOMYCIN; CATALASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; INTERLEUKIN 6; MYELOPEROXIDASE; SILYMARIN; TUMOR NECROSIS FACTOR ALPHA; ANTIOXIDANT; AUTACOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; LIPID PEROXIDATION; LUNG PROTECTION; LUNG TOXICITY; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PROTECTION; SILYBUM MARIANUM; TREATMENT DURATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BLOOD; CHEMICALLY INDUCED; DRUG EFFECTS; LUNG INJURY; PHYSIOLOGY;

ANIMALS; ANTIOXIDANTS; BLEOMYCIN; INFLAMMATION MEDIATORS; LIPID PEROXIDATION; LUNG INJURY; MICE; MICE, INBRED BALB C; SILYMARIN;

EID: 84907045074     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2014.889176     Document Type: Article

References (42)

1. Bayer RA, Gaynor ER, Fisher RI. (1992). Bleomycin in non-Hodgkin's lymphoma. Semin Oncol 19:46-52.
2. Buege JA, Aust SD. (1978). Microsomal lipid peroxidation. Methods Enzymol 52:302-10.
3. Burger RM, Peisach J, Horwitz SB. (1981). Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA. J Biol Chem 256:11636-44.
4. Chen CH, Huang TS, Wong CH, et al. (2009). Synergistic anticancer effect of baicalein and silymarin on human hepatoma HepG2 Cells. Food Chem Toxicol 47:638-44.
5. Chen K, Wei Y, Sharp GC, Braley-Mullen H. (2007). Decreasing TNF-a results in less fibrosis and earlier resolution of granulomatous experimental autoimmune thyroiditis. J Leukoc Biol 81:306-14.
6. Cheresh P, Kim SJ, Tulasiram S, Kamp DW. (2012). Oxidative stress and pulmonary fibrosis. Biochim Biophys Acta 1832:1028-40.
7. Day BJ. (2008). Antioxidants as potential therapeutics for lung fibrosis. Antioxid Redox Signal 10:355-70.
8. Faner R, Rojas M, Macnee W, Agusti A. (2012). Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 186:306-13.
9. Gazak R, Walterova D, Kren V. (2007). Silybin and silymarin - New and emerging applications in medicine. Curr Med Chem 14:315-38.
10. Habig WH, Jakoby WB. (1981). Assays for differentiation of glutathione S-transferases. Methods Enzymol 77:398-405.
11. Hogan FS, Krishnegowda NK, Mikhailova M, Kahlenberg MS. (2007). Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer. J Surg Res 143:58-65.
12. Janero DR. (1990). Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med 9:515-40.
13. Jones DP. (2006). Extracellular redox state: Refining the definition of oxidative stress in aging. Rejuvenation Res 9:169-81.
14. Kara H, Karatas F, Tug T, et al. (2010). Protective effect of octreotide on intra-tracheal bleomycin-induced oxidative damage in rats. Exp Toxicol Pathol 62:235-41.
15. Kettle AJ, Van Dalen CJ, Winterbourn CC. (1997). Peroxynitrite and myeloperoxidase leave the same footprint in protein nitration. Redox Rep 3:257-8.
16. Khan SM. (2006). Protective effect of black tea extract on the levels of lipid peroxidation and antioxidant enzymes in liver of mice with pesticideinduced liver injury. Cell Biochem Funct 24:327-32.
17. Kiruthiga PV, Shafreen RB, Pandian SK, et al. (2007). Protective effect of silymarin on erythrocyte hemolysate against benzo(a)pyrene and exogenous reactive oxygen species (HO) induced oxidative stress. Chemosphere 68:1511-18.
18. Kliment CR, Oury TD. (2010). Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis. Free Radic Biol Med 49: 707-17.
19. Larki-Harchegani A, Hemmati AA, Arzi A, et al. (2013). Evaluation of the effects of caffeic acid phenethyl ester on prostaglandin E2 and two key cytokines involved in bleomycin-induced pulmonary fibrosis. Iran J Basic Med Sci 16:850-7.
20. Levi JA, Raghavan D, Harvey V, et al. (1993). The importance of bleomycin in combination chemotherapy for good-prognosis germ cell carcinoma. Australasian germ cell trial group. J Clin Oncol 11: 1300-5.
21. Marnett LJ. (1999). Lipid peroxidation-DNA damage by malondialdehyde. Mutat Res 424:83-95.
22. Martin WG, Ristow KM, Habermann TM, et al. (2005). Bleomycin pulmonary toxicity has a negative impact on the outcome of patients with Hodgkin's lymphoma. J Clin Oncol 23:7614-20.
23. Mata M, Rui{dotless}z A, Cerda M, et al. (2003). Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats. Eur Respir J 22:900-5.
24. Meeran SM, Katiyar S, Elmets CA, Katiyar SK. (2006). Silymarin inhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice. Mol Cancer Ther 5:1660-8.
25. Mukarram Shah SM, Khan FA, Hassan Shah SM, et al. (2011). Evaluation of phytochemicals and antimicrobial activity of white and blue capitulum and whole plant of Silybum Marianum. World Appl Sci J 12:1139-44.
26. Murthy S, Adamcakova-Dodd A, Perry SS, et al. (2009). Modulation of reactive oxygen species by Rac1 or catalase prevents asbestosinduced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 297: 846-55.
27. Nazemian F, Karimi G, Moatamedi M, et al. (2010). Effect of silymarin administration on TNF-α serum concentration in peritoneal dialysis patients. Phytother Res 24:1654-7.
28. Oliveira C, Lopasso FP, Laurindo F, et al. (2001). Protection against liver ischemiareperfusion injury in rats by silymarin or verapamil. Transplant Proc 33:3010-14.
29. Pandey G, Sahni YP. (2011). A review on hepatoprotective activity of silymarin. IJRAP 2:75-9.
30. Piguet PF, Collart MA, Grau GE, et al. (1989). Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J Exp Med 170:655-63.
31. Pradeep K, Mohan CVR, Gobianand K, Karthikeyan S. (2007). Silymarin modulates the oxidant-antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats. Eur J Pharmacol 560:110-16.
32. Quinlan T, Spivack S, Mossman BT. (1994). Regulation of antioxidant enzymes in lung after oxidant injury. Environ Health Perspect 2: 79-87.
33. Schumann J, Prockl J, Kiemer AK, et al. (2003). Silibinin protects mice from T cell-dependent liver injury. J Hepatol 39:333-40.
34. Sedlak J, Lindsay RH. (1968). Estimation of total protein bound and non-protein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 25:192-205.
35. Sener G, Topaloglu N, Sehirli AO, et al. (2007). Resveratrol alleviates bleomycin-induced lung injury in rats. Pulm Pharmacol Ther 20: 642-9.
36. Singh RP, Agarwal R. (2004). Prostate cancer prevention by silibinin. Curr Cancer Drug Targets 4:1-11.
37. Soto C, Recoba R, Barron H, et al. (2003). Silymarin increases antioxidant enzymes in alloxan-induced diabetes in rat pancreas. Comp Biochem Physiol C Toxicol Pharmacol 136:205-12.
38. Tobwala S, Fan W, Stoeger T, Ercal N. (2013). N-Acetylcysteine amide, a thiol antioxidant, prevents bleomycin-induced toxicity in human alveolar basal epithelial cells (A549). Free Radic Res 47:740-9.
39. Townsend, DM, Tew KD, Tapiero H. (2003). The importance of glutathione in human disease. Biomed Pharmacother 57:145-55.
40. Wei H, Frenkel K. (1993). Relationship of oxidative events and DNA oxidation in Sencar mice to in vivo promoting activity of phorbol ester-type tumor promoters. Carcinogenesis 14:1195-201.
41. Yang SH, Lin JK, Chen WS, Chiu JH. (2003). Antiangiogenic effect of silymarin on colon cancer LoVo cell line. J Surg Res 113: 133-8.
42. Yildirim Z, Kotuk M, Iraz M, et al. (2005). Attenuation of bleomycininduced lung fibrosis by oral sulfhydryl containing antioxidants in rats: Erdosteine and N-acetylcysteine. Pulm Pharmacol Ther 18: 367-73.